Formulation Of Matrix Tablets Research Articles

Formulation and Evaluation of Sustained release matrix tablets of Atomoxetine HCl by using Natural and Synthetic Polymers

Formulation and Evaluation of Sustained release matrix tablets of Atomoxetine HCl by using Natural and Synthetic Polymers

Formulation and evaluation of oxcarbazepine sustained release matrix tablets

Formulation and evaluation of oxcarbazepine sustained release matrix tablets

Formulation and evaluation of sustained release matrix tablets of capparis erythrocarpos roots extract to improve patient compliance in management of arthritis

Abstract Capparis erythrocarpos is used in the management of arthritis in Ghana and some other African countries. In Ghana, the powdered form of Capparis erythrocarpos is prescribed and dispensed to patients for the management of arthritis. In the present study, Capparis erythrocarpos controlled release tablets were successfully prepared by wet granulation method. Hydroxypropyl methyl cellulose and Xanthan gum were used as drug release modifying polymers in varying ratios of (1;1), (1;2) and (1;3) respectively. The formulated tablets passed the uniformity of weight, friability, uniformity of thickness and uniformity of diameter tests respectively. The formulated tablets had crushing strength ranging from 73.39-78.42 N and good tensile strength. Ratios of 1:1 and 1:2 (F1 and F2) combinations of HPMC and Xanthan gum respectively are able to provide the desired drug release over a twenty-four (24) hour period. Higher proportions of Xanthan gum in combination with HPMC (3:1) retarded the release of Capparis erythrocarpos and did not provide the desired drug release after 24 hours.

DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE TABLETS OF CANDESARTAN CILEXETIL/Β-CYCLODEXTRIN INCLUSION COMPLEX

Objective: Matrix tablet approach is one of the delivery systems intended for poorly water-soluble drugs like candesartan cilexetil. Candesartan cilexetil is a class II drug used for the treatment of hypertension.
 Methods: Matrix tablets from (F1x to F18z) were prepared in the presence of β-cyclodextrin. Matrix tablet formulation ensures control release of the drug and higher dissolution by β-cyclodextrin. Fourier transform infrared spectroscopy and differential scanning calorimetry were used to study compatibility.
 Results:The angle of repose determination showed good flow for most of the formulas besides having good compressibility. Weight variation test for all formulas showed accepted value. Drug content measurement showed accepted values. Friability and hardness of tablets were within the allowed values. Higher tablet swelling was obtained for the formulas containing hydroxy propyl methyl cellulose (HPMC) K100M (F3x and F15z) in which the ratio of the polymer was (1:1) and (1:3) respectively. In vitro release showed that F1x to F13z were studied depends on the type and amount of polymer i.e. (1:1), (1:2) and (1:3) respectively. F1x release after 8h was 95% which contain (1:1) polymer ratio in compare to F3x, which showed 85% after 8h, Which include 1:3 (drug: HPMC K100). Kinetic studies showed a zero-order model.
 Conclusion: The use of β-cyclodextrin modify the release profile of the drug, and control the sustained release formulas. The lower the time of the release but in a range that a sustained release of the drug was observed in compare with the formulas prepared without β-cyclodextrin.

Development of the recipe for matrix compositions of 2-ethyl-3-methyl-6-hydroxymethylpyridine succinate for tablets of prolonged action based on polymeric bondin

The kinetics of the release of 2-ethyl-3-methyl-6-hydroxypyridine succinate from extended-release tablets obtained using K4M, K15M, K100M and K200M hydroxypropyl methylcellulose polymers was studied. The hypothesis about the possibility of accepting for the samples the normal distribution of response - the degree of release of the drug was tested. A weak effect of the nature of the polymer on the kinetics of release was revealed — the maximum relative difference between the average values for each polymer does not exceed 15%. A series of experimental studies in buffer solutions at pH 1.2; 4.5 and 6.8 to identify the effect of pH on the kinetics of release. A significant effect of pH on the release rate was revealed - at pH 1.2 a faster release is observed. Dissolution curves at pH 4.5 and 6.8 practically coincide. Using the substance of 2-ethyl-3-methyl-6-hydroxypyridine succinate as an example, a mathematical model of the kinetics of in vivo release has been developed, which reflects the effect of pH on the rate of release of ionized drugs from matrix tablets in aqueous media. The model is based on a statistical study of in vitro release kinetics data at pH 1.2; 4,5; 6.8, with the subsequent construction on their basis of cubic splines for the averaged curves and revealing the presence of the influence of pH. These data are used at the in vivo modeling stage, taking into account the degree of release at pH in the gastrointestinal tract preceding the current one. A condition for the application of the model is the presence of a normal distribution of in vitro measurement errors with the same dispersion, independent of pH. The dispersion value is used to model the boundaries of the dissolution profile using the Monte Carlo method. A procedure has been developed for assessing the upper and lower boundaries of release profiles in the body by the Monte Carlo method by generating release values for 100 trials based on the developed release kinetics model. The model was used in the development and industrial implementation of the formulation of matrix tablets of a prolonged form of 2-ethyl-3-methyl-6-hydroxypyridine succinate (trade name “Armadin”) in LLC “Mikrokhim”.

Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

AbstractIn the present investigation, the synthesis, the biology and the development of matrix tablet formulations for the in vitro controlled release of new adamantane diarylketone antimycobacterial derivatives, is presented. In the skeleton of the new compounds, a diarylketone, functionalized by a 2‐hydroxypropylenoxy‐3‐butylamine, a 2‐hydroxypropylenoxy‐3‐hexylamine and a 1‐(2‐hydroxyoctyl)piperidin‐4‐yl moiety, is incorporated at the C‐1 adamantane position. The new derivatives were tested against the H37Rv Mycobacterium tuberculosis strain and exhibited satisfactory activity. In view of their lipophilic character, it was intriguing to examine their in vitro dissolution profile in buffer solutions simulating the gastric and intestinal environments. To this end, matrix tablets of the most active compound, {4‐[(adamantan‐1‐yl)phenyl‐4‐(3‐(butylamino)‐2‐hydroxypropoxy)]phenyl}methanone (A), incorporating the appropriate excipients, were prepared using the direct compression method. The preliminary test results show that its dissolution profile is in alignment with the desired pattern for the per os administration of tuberculocidal agents.

Formulation and Evaluation of Metoprolol Tartrate Sustained Release Matrix Tablets

The objective of the present work was to develop sustained release matrix tablets of Metoprolol tartrate using different polymers viz. Guar gum, Xanthan gum, Kondagogu gum and HPMC K100M. The release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling materials. After evaluation of physical properties of tablet, the in-vitro release study was performed in phosphate buffer pH 6.8 up to 12 hrs. Dissolution data was analyzed for release kinetics. It was observed that matrix tablets contained polymer Xanthan gum was successfully sustained the release of drug up to 12 hrs. Among all the formulations, F6 which contains 45 % of Xanthan gum, release of drug which follows zero order kinetics via, swelling, diffusion and the release profile of formulation F6 was compared with marketed product. The FTIR study revealed that there was no chemical interaction between drug and excipient.

Formulation and evaluation of sustained release matrix tablet of captopril

The objective of the present study was to study the effect of polymers on sustained release of Captopril from tablets. Compatibility was studied by Fourier transform infrared spectroscopy and DSC. The tablets were prepared by direct compression technique using Xanthan gum and Ethyl Cellulose. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in-vitro dissolution. Pre and post compression parameters were evaluated and all the parameters were found within the limit. The drug release data were subjected to different models in order to evaluate release kinetics and mechanism of drug release. Formulation F4 was selected as best formulation. The dissolution of formulation F4 can be Shows Non-fickian drug release mechanism.

In vitro and in vivo assessment of Adansonia digitata mucilage as a matrix former in modified release tablets of metoprolol tartrate

The study was aimed to investigate the ability of Adansonia digitata mucilage (ADM) a new hydrophilic plant polymeric material, in modifying metoprolol tartrate (MPT) release from matrix tablet formulations in comparison with a semi -synthetic polymer-HPMC60SH 4000. Modified release tablets of MPT were directly compressed in the ratios of 1:1 and 1:4 drug/polymer amounts. The tablets properties were evaluated and further, in vivo studies were carried out on 1:4 drug/polymer matrix tablets formulated with ADM and compared with Slow- Lopressor Divitab®. In vitro drug release of MPT was controlled over 24 h for tablets with 1:4 drug/polymer ratios. Release profiles of formulations showed pH independent release and no burst effect at high drug loading. Matrix integrity was maintained throughout dissolution with ADM matrices, an indication of good gel strength contrary to HPMC matrices. Statistical analysis confirmed that MPT release from ADM and HPMC (1:4 drug/polymer) was not significantly different (P > 0.05) likewise similarity factor (f2). The in vivo bioavailability after oral administration of the test formulation (1:4 MPT/ADM) to dogs did not differ significantly from the reference marketed sustained release product.

An Innovative Approach in Developing Sustained Release Matrix Tablets using Isolated and Characterized Novel Ceasalpinia sappan L. Seed Galactomannan

Abstract: Introduction: The aim of the study is to develop a galactomannan-based drug delivery system. In this work galactomannan, a biocompatible polymer was isolated from a novel plant source. The seeds of the indigenous plant Caesalpinia sappan L. of the family Caesalpiniaceae were used for the extraction of galactomannan. Materials and Methods: The galactomannan was extracted by maceration and then purified. The purified polymer was characterized by physicochemical methods, FTIR studies, DSC study, SEM, thixotropic studies, microbial load and cytotoxic studies. In order to demonstrate its sustained release character a tablet formulation was prepared and propranalol was used as the model drug. The tablets were evaluated. The data obtained from in in-vitro drug release were fitted into different drug release models and the mechanism of drug release was determined. Results and Discussion: The FTIR studies of the isolated galactomannan revealed the presence of specific peaks for galactose, mannose and for glycosidic bonds. The DSC study showed a peak at 115ºC. The flow curve resulted in a pseudoplastic flow which is suitable for controlled drug delivery. A 72% recovery from sol to gel form was observed in the thixotropic studies. Cytotoxicity study proved the safety of the polymer and microbial load was found to be within the accepted limit. Sustained release property is demonstrated by formulating a matrix tablet of propranolol HCl using the isolated polymer. The formulated tablets complied with all the evaluation tests. The drug release pattern for about 16 hr was obtained through in vitro dissolution testing and the release mechanism was found to be fitting to Korsmeyer Peppa’s model. Conclusion: Galactomannan was successfully isolated and purified from Caesalpinia sappan seed and all the properties have been studied extensively. Galactomannan isolated from Caesalpinia sappan L seed can be used as an excellent pharmaceutical excipient for the formulation of matrix tablets. Key words: Caesalpinia sappan, Galactomannan, Sustained drug release, Rheology, Thixotropy, Gum, Herbal formulation.

Formulation and Evaluation of Bilayer Matrix Tablets of Nebivolol Hydrochloride and Valsartan

The present study is an attempt to develop bilayer matrix tablets of Nebivolol Hydrochloride and Valsartan with immediate release for Nebivolol Hydrochloride and sustained release for Valsartan. Superdisintegrants such as sodium starch glycolate and Crosscarmellose sodium were evaluated for immediate release of Nebivolol Hydrochloride and polymers HPMC K100M and K4M for sustained release of Valsartan. Preformulation studies were performed prior to compression. The compressed bilayer tablets were evaluated for weight variation, thickness, hardness, friability, drug content and in vitro drug release using USP dissolution apparatus type 2 in 0.01N HCl and phosphate buffer pH 6.8. All the pre and post compression parameters were found to be within the acceptable limits. The results of dissolution show that the formulations B3 was the best of all immediate and sustained release layer batches. The release kinetics of Valsartan was subject to curve fitting analysis in order to identify the best fit kinetic model. The regression analysis proves that the best formulations follow zero order release and drug release by diffusion process based on Fick’s law of diffusion. The data for stability studies infer no considerable change in drug content and dissolution rates as per ICH guidelines. The best formulation B3 was subjected to in vivo pharmacokinetic studies in rabbit model. In vitro, In vivo correlation (IVIVC) showed considerable linearity. Hence a novel bilayer tablet formulation of Nebivolol Hydrochloride and Valsartan was successfully developed by combining both immediate (IR) and sustained (SR) release layers.
 Keywords: Bilayer tablets, fixed unit dosage form, Nebivolol hydrochloride, Valsartan, LC-MS analysis.

Formulation and Characterization of Ondansetron Hydrochloride Matrix Tablets for Sustained Drug Delivery

The objective of proposed work was to develop Ondansetron Hydrochloride (OND HCl) sustained release matrix tablets for the better treatment of vomiting for extended period of time. Sustained release matrix tablet is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The matrix tablets of OND HCl were prepared by direct compression method using varying ratio of hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose. The bends of tablets were evaluated for bulk and tapped density, % compressibility index and angle of repose and powder of all formulations blend exhibited that low interparticle friction and excellent flow characteristics. The prepared matrix tablets were then assessed for different physical tests like consistency of weight, thickness, hardness, friability, drug content and in vitro drug release. Each batch of the OND HCl matrix tablets were of good quality as to hardness, thickness, friability and % medicament content. The in vitro drug release study was done for 2 hours by utilizing paddle technique in 0.1N HCl (pH 1.2) as dissolution media and 6 hours using phosphate buffer (pH 6.8) as dissolution media. The drug release study showed that all formulation FMT-1, FMT-2, FMT-3, FMT-4, FMT-5 and FMT-6 were provide the drug release on sustained manner up to 8 hrs. Amongst the developed matrix tablets formulations, FMT-2 containing ethyl cellulose (100 mg) was optimized as best because FMT-2 show highest drug release profile and promoting the sustained release of drug, which could potentially improve the patient compliance.

Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets

Prulifloxacin is a chemotherapeutic antibiotic of Fluor quinolone drug used to treat a various urinary tract infections. It has short half-life, makes the sustained release (SR) forms extremely advantageous. Sustained release tablets results in increased bioavailability. The purpose of the present study was to develop a sustain release matrix drug delivery system (SR) containing Prulifloxacin as a model drug by using various proportions of polymers such as HPMC E15, HPMC K15. The sustained release formulations of Prulifloxacin were prepared by direct compression method. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT-IR studies indicated absence of any interaction between Prulifloxacin, polymers (HPMC E15 and HPMC K15) and excipients. Ten formulations were prepared and Formulation F8 possesses good drug release property. The tablets were also evaluated for its hardness, friability and other In-vitro evaluation tests. All parameters complied with IP limits. Drug release was diffusion controlled and followed Zero order kinetics. Non-Fickian diffusion was the drug release mechanism for all the tablets formulated. Keywords: Sustained drug delivery system, Prulifloxacin, HPMCE15, HPMCK15

Evaluation of <i>Opuntia stricta</i> mucilage as sustained release excipient in diclofenac sodium matrix tablet formulations

Over the last few decades, plant derived polymers have received increasing attention due to their diverse pharmaceutical applications including modified and controlled drug delivery. Among these natural polymers, mucilages and gums are versatile excipients for pharmaceutical formulation. The main objective of the present study was to evaluate cactus (Opuntia stricta) mucilage as a matrix forming polymer for sustained release tablet formulations using diclofenac sodium as a model drug. The mucilage from cactus cladode was extracted using distilled water as extracting solvent and ethanol as mucilage precipitant. The mucilage powder was characterized for its physical properties. A 1% w/v solution of the mucilage in water gave a pH of 6.40 ensuring low irritability potential when used in uncoated tablets. Evaluation of the powder flow profile demonstrated fair flow showing the need for incorporating other compressible excipients or using granulation to enhance the flow pattern. The solubility and swelling power of the O. stricta were generally low at low temperature (20 oC), but increased significantly at higher temperature (85 oC) (p < 0.05). The percentage moisture sorption ranged from 7.61% at 15% to 79.9% at 100% relative humidity (RH). The granules prepared with water as granulating solvent showed excellent flow property. The crushing strength of wet granulated formulations was higher than directly compressed formulations. The in vitro dissolution study demonstrated that both directly compressed and wet granulated formulations of O. stricta mucilage effectively sustained diclofenac release for over 12 h even at a lower concentration of 10%. However, granulation showed a better matrix performance for sustaining the drug release. All the formulations showed good linearity with respect to Korsmeyer-Peppas equation with 0.45 ≤ n ≤ 0.89 indicating that, non Fickian diffusion was the predominant mechanism of drug release from these formulations. So, O. stricta mucilage can be used as alternative pharmaceutical excipient in the formulation and manufacture of sustained release matrix tablets.Keywords: Opuntia stricta mucilage, direct compression, in vitro drug release, wet granulation, matrix tablets

Formulation Development and In Vitro Characterization of Zolmitriptan Controlled Release Drug Delivery Systems

Background: Zolmitriptan is an artificial tryptamine, employed for the acute cure of migraine attack with or exclusive of aura and cluster headaches.&#x0D; Objective: It is an attempt to develop the extended release (ER) of Zolmitriptan matrix (ZMT) tablets to treat migraine safely and effectively.&#x0D; Methods: All formulations were prepared with natural polymers or gums like guar gum, xanthan gum, karaya gum through direct compression method using 6mm punch.&#x0D; Results: Powder blend of all formulations (F1 - F12) using different ratios of the above mentioned gums (5%, 10%, 15% and 20%) were characterized with pre-compression parameters (angle of repose, bulk density, tapped density, compressibility index, hausner ratio, compatibility studies) and post-compression parameters (weight variation, thickness, friability, hardness, assay, in vitro dissolution studies). F1 - F4 formulations were prepared with gum karaya and compared with remaining gums; gum karaya shows more retardance capacity. F9 - F12 (with guar gum) formulations were unable to produce the desired release, whereas F5 - F8 formulations containing with xanthan gum exhibited more retarding effect with increasing concentration of polymer.&#x0D; Conclusion: All prepared formulations (F1 - F12) were characterized and F3 formulation was optimized (97.3% drug released in 8 hours). All prepared formulations (F1 - F12) showed good flow properties and release patterns. Hence, formulations of ZMT matrix tablets have a promising delivery system which will enhance bio-availability and achieve greater therapeutic efficacy.

ESTIMATION OF BACOSIDE-A IN BACOPA MONNIERI AERIAL PARTS USING TLC DENSITOMETRY

Objective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers.&#x0D; Methods: A gastro-retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floating time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 32 full factorial designs were used for selection of suitable polymer concentration and effervescent system. Nonenteric film coating was applied to mask GP odour.&#x0D; Results: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT.&#x0D; Conclusion: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formulation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.

FORMULATION AND EVALUATION OF GARLIC POWDER LOADED FLOATING MATRIX TABLET

Objective: The objective of the present work was to formulate and evaluate a stable, odour free garlic powder loaded floating matrix tablet for the treatment of peptic ulcers.&#x0D; Methods: A gastro-retentive floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of hydroxypropyl methylcellulose K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable floating time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. 32 full factorial designs were used for selection of suitable polymer concentration and effervescent system. Nonenteric film coating was applied to mask GP odour.&#x0D; Results: It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h with FT up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during the stability study of FMT.&#x0D; Conclusion: A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formulation can overcome problems of taste and odour masking, gastric irritation, and loss of active constituents present in garlic.

DESIGN AND IN VITRO/IN VIVO EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF NATEGLINIDE

Aim: Nateglinide is a quick acting anti-diabetic medication whose potent activity lasts for a short duration. One of the dangerous side effects of nateglinide administration is rapid hypoglycemia, a condition that needs to be monitored carefully to prevent unnecessary fatalities. The aim of the study was to develop a longer lasting and slower releasing formulation of nateglinide that could be administered just once daily.&#x0D; Methods: Matrix tablets of nateglinide were prepared in combination with the polymers hydroxypropylmethylcellulose (HPMC), eudragits, ethyl cellulose and polyethylene oxide and the formulated drug release patterns were evaluated using in vitro and in vivo studies.&#x0D; Conclusion: Of the seventeen formulated matrix tablets tested, only one formulation labelled HA-2 that contained 15% HPMC K4M demonstrated release profile we had aimed for. Further, swelling studies and scanning electron microscopic analysis confirmed the drug release mechanism of HA-2. The optimized formulation HA-2 was found to be stable at accelerated storage conditions for 3 months with respect to drug content and physical appearance. Mathematical analysis of the release kinetics of HA-2 indicated a coupling of diffusion and erosion mechanisms. In-vitro release studies and pharmacokinetic in vivo studies of HA-2 in rabbits confirmed the sustained drug release profile we had aimed for.&#x0D; Keywords: Hydroxypropylmethylcellulose, Matrix tablets, Nateglinide, Sustained release

Formulation and Evaluation of Eplerenone Matrix Tablets using Aloe Vera, Guar Gum and Povidone K-30

Purpose: In the existing work different sustained release matrix tablets of eplerenone were prepared with dried mucilage of Aloe vera, guar gum and povidone K30 by using different binder: tablet weight ratios viz. 1:20, 2:20, 3:20, 4:20 and 5:20. Method: During this process Aloe vera leaves are procured, extracted, dried and characterized to obtain Aloe vera mucilage powder. Pre-formulation studies were performed and studied for the functional groups and also compatibility studies were conducted. The formulations that were prepared using Aloe vera were named as EPA, for Guar gum as EPG, for Povidone K30 as EPP and finally combination of Aloe vera and Povidone K30 was named as EPAP. Results: From the graphs, kinetic evaluation was done and observed that the drug release is governed by diffusion mechanism and this is confirmed by r values. The regression coefficient values, clearly indicates that the drug release is governed by zero order and almost all formulations showing Fickian release. Among all the formulations that were prepared EPAP-5 is selected as best. The best formulation is compared with the marketed formulation. Conclusion: Aloe vera gel dried powder is a suitable matrix agent in formulating sustained release tablets of eplerenone. It may be useful in similar preparations of other drugs.

Formulation and Evaluation of Galantamine Hydrobromide Floating Matrix Tablet

The aim of the present work was to prepare floating tablets of galantamine HBr using sodium alginate and xanthan gum as matrix forming carriers. Galantamine HBr is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. The matrix tablet formulations were prepared by varying the concentrations of sodium alginate and xanthan gum. The tablets were prepared by direct compression technique using PVP K-30 as a binder and sodium bicarbonate for development of CO2. The prepared matrix tablets were evaluated for properties such as hardness, thickness, friability, weight variation, floating lag time, compatibility using DSC and FTIR. In vitro dissolution was carried out for 12 hrs in 0.1N HCl at 37±0.5 ºC using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium by maintaining the matrix integrity. The drug release from prepared tablets was found to vary with varying concentration of the polymers, sodium alginate and xanthan gum. From the study it was concluded that floating drug delivery system for galantamine HBr can be prepared by using sodium alginate and xanthan gum as a carrier.