This paper is based on the drag resistance test data of the high-speed monohull model, a mathematical model for comprehensive optimization of the navigation performance of a high-speed monohull taking into account the rapidity, maneuverability, seakeeping and static performance of the ship is constructed. The optimization calculation software based on particle swarm, standard genetic algorithm and growth mechanism genetic algorithm is designed and written. Taking a high-speed monolithic sea-going ship with a displacement of 1500 tons and a large inclination-measuring single propeller as the object of discussion, the comparison of optimization methods, the comprehensive navigation performance of different ship types and the sensitivity analysis of design variables are carried out respectively. It provides a practical approach and an effective and practical scientific method for analysis and evaluation of how to maintain the comprehensive optimal navigation performance of high-speed monohull ships. At the same time, it provides a way to quickly evaluate the comprehensive performance of similar high-speed monolithic ships in the preliminary design stage, and can also obtain the model diagram with the best comprehensive performance through this software or method, which is useful for shortening the preliminary design cycle of the ship and improving the design quality of the ship. It has important reference value.