This article explores the integration of Operations Research (OR) principles in the design and management of on-site construction organizations. The first section introduces Operations Research as a multidisciplinary field that employs mathematical modelling, statistical analysis, and optimization techniques to enhance decision-making processes across various sectors. Key aspects such as mathematical modelling, optimization, decision analysis, simulation, queueing theory, linear programming, and game theory are highlighted. The second section focuses on the design of on-site construction organizations, emphasizing the structure and organization of resources, personnel, and processes essential for efficient project execution. Various key elements, including project management, site personnel, project support teams, engineering and design teams, health and safety personnel, procurement and supply chain, communication and coordination, equipment and maintenance, and environmental compliance, are discussed. The third section delves into the application of Operations Research techniques in the design and management of on-site construction organizations. It outlines how OR principles can be employed for resource allocation and optimization, project scheduling and planning, inventory management, equipment utilization, project costing and budgeting, risk management, supply chain management, human resource management, facility layout and design, and the development of decision support systems. The conclusion highlights that the strategic application of Operations Research methodologies contributes to enhanced efficiency, optimized resources, and improved decision-making throughout the construction project lifecycle. The integration of OR principles not only enhance the overall effectiveness of on-site construction organizations but also leads to cost savings, timely project completion, and improved project outcomes. As construction projects continue to grow in scale and complexity, the systematic and analytical approach provided by Operations Research becomes increasingly valuable in addressing the intricate challenges faced by construction stakeholders.