This investigation studied the effect of maternal region of birth and education on the psychomotor development of 512 two-year-old children born in Jerusalem. Children of immigrants from Western countries scored significantly higher in the Brunet-Lézine test than children whose parents came from Eastern countries. No statistically significant differences were found in the scores of children of Israeli-born mothers whether they originated from Eastern or Western countries. Mothers' education was significantly related to the developmental quotient (DQO of the child, whereas the effect of region of birth of mother was not significant when education was statistically controlled. A rise in education and acculturation of immigrants from Eastern countries in Israel may explain the lack of difference in the DQ score in the second-generation Israel children studied.