Maternal Protection Research Articles

Immunization with Multiple Virulence Factors Provides Maternal and Neonatal Protection against Group B Streptococcus Serotypes.

Group B streptococcus (GBS) commonly colonizes the vaginal tract and is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. No effective vaccine is clinically available. Conserved bacterial virulence factors, including those of GBS, have been employed as vaccine components. We investigated serotype-independent protection against GBS by intranasal immunization with six conserved GBS virulence factors (GBSV6). GBSV6 induced systemic and vaginal antibodies and T cell responses in mice. The immunity reduced mouse mortality and vaginal colonization by various GBS serotypes and protected newborn mice of immunized dams against GBS challenge. Intranasal GBSV6 immunization also provided long-lasting protective immunity and had advantages over intramuscular GBSV6 immunization regarding restricting vaginal GBS colonization. Our findings indicate that intranasal immunization targeting multiple conserved GBS virulence factors induces serotype-independent immunity, which protects against GBS infection systemically and vaginally in dams and prevents newborn death. The study presents valuable strategies for GBS vaccine development.

모·부성보호제도의 강도가 일·생활균형과 조직몰입·직무만족에 미치는 영향: 제도 내재화의 매개효과와 조직내 소통의 조절효과

This study tried to confirm the hypothesis that the strength of maternal/paternal protection systems, such as parental leave, has an effect on work-life balance and organizational commitment & job satisfaction. To this end, this study empirically demonstrated the effect of the strength of the maternal and paternal protection system on work-life balance and organizational commitment & job satisfaction, as well as the mediating effect of internalization and the moderating effect of communication within the organization. A survey was conducted on workers, and a total of 412 copies were analyzed. To verify the main effect, multiple regression analysis was conducted, the mediating effect was verified through bootstrapping, and the moderating effect was verified through hierarchical regression analysis. As a result, the strength of the maternal/paternal protection system had a positive(+) impact on work-life balance, and organizational commitment/job satisfaction. In addition, it was confirmed that the strength of the maternal/paternal protection system had a positive(+) impact on internali zation. Internalization had a positive(+) impact on work-life balance, organizational commitment/ job satisfaction. There was no mediating effect of internalization in the relationship between the strength of the maternal/paternal protection system and work-life balance, but there was a mediating effect of internalization in the relationship between the strength of the maternal/ paternal protection system and organizational commitment & job satisfaction. The moderating effect of communication within the organization was found to be insignificant in the relationship between the strength of the maternal/paternal protection system and work-life balance. The moderating effect of communication within the organization had a significant negative(-) impact in the relationship between the strength of the maternal/paternal protection system and organizational commitment & job satisfaction. It is opposite to the hypothesis. Focusing on these research results, the implications of the study were discussed, and finally, the limitations of this study and future research directions were suggested.

Leukolectin is expressed in lectophages, a distinct population of zebrafish embryonic macrophages

Leukolectins (LL) belong to the tectonin-family of proteins, with functions in innate immunity. Fish larvae compensating for loss of maternal chorionic protection post-hatching, provide a model-system for studying how lectins contribute to immunity. Atlantic salmon (Ssal) LL-proteins function after secretion in mucus from dermal lectocytes, as this mucus envelops embryos and larvae. The Ssalll-gene possesses multiple putative binding sites for diverse transcription-factors, suggestive of LL-functions in non-epithelial cells. Since zebrafish (zF) perivitelline fluid (PVF) contains LL-proteins, this study aims to characterize zF-leukolectins, their cellular origin, expression and gene structure. Extracts of (10 hpf) zF-embryos contained LL-proteins, and whole mount immuno-histochemistry revealed dispersed LL-positive cells including zF-lectocytes, accounting for exocrine LL-secretion by embryos. Lectocytes are lcp1-negative, but other zF-cells co-expressed LL-proteins and lcp1-transcripts, which (at this stage) identified such non-lectocytes as early macrophages (termed lectophages). In sections, LL-expression characterized large macrophage-progenitors and smaller colonizing macrophages. RT- and RACE-PCR yielded zF-LLcDNA including parts of untranslated regions. ORF encoded 255 AAs including (19 AA) signal peptide. Processing of a primary LL-transcript to (∼1.300 nt) LL-mRNA was suggested by Northern blots. Most zebrafish-egg lectins (zFELs) possess four TECPR-domains, while five TECPR-domains were predicted for zF-LL. Minor sequence variations suggested nearly identical zF-LL isoforms. Alignment of zFEL-proteins predicted a zFEL-tree with a separate leukolectin-branch. LL-amplification using zF-DNA, revealed five exons and four introns. Predicted structures of zF- and Ssal-leukolectins showed strong structural conservation (92% sequence-identity) with shorter zF-introns 2&4, but identical introns 1&3. Non-lectocytic LL-functions were investigated further by dual in situ hybridization, revealing that only some embryonic lcp1-expressing cells in early zF-embryos co-expressed LL-transcripts. Macrophages from erythro-myeloid progenitor (EMP) are known to colonize zebrafish tissues as resident macrophages (TRM), e.g. nervous system (CNS) and epiderm. Unlike Ssal-larvae relying on yolk for months, zF-larvae switch within days to nutrition from the digestive-tract, necessitating additional immuno-protection possibly from TRMs. EMP also gives rise to microglia, the TRM of CNS. The neural tube of zF-embryos exhibited numerous small, LL-positive cells, presumably stemming from lectophage-progenitors. Functions of these LL-positive embryonic microglia (lectoglia) appear more relevant for tissue remodelling than for pathogenic threats. Lectoglia sustaining CNS-neurons suggests physiological LL-roles relevant for adult health and disease. The data focus the need for resolving whether lectophages represent an unrecognized myelogenic lineage, or whether instead, LL-expression occurs in a subpopulation of the early macrophage-lineage.

Assessment of an Enterobactin Conjugate Vaccine in Layers to Protect Their Offspring from Colibacillosis.

Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is an important infectious disease in chickens and a major cause of mortality in young chicks. Therefore, protecting young chickens from colibacillosis is important for improving welfare and productivity in the poultry industry. Recently, we developed a novel enterobactin (Ent) conjugate vaccine that could induce high titers of anti-Ent immunoglobulin Y (IgY) in chicken serum and consequently mitigate the organ lesions caused by APEC infection. Considering that maternal immunization is a practical approach to confer instant immune protection to the hatchlings, in this study, we immunized breeder hens with the Ent conjugate vaccine and evaluated the maternal immune protection on the progenies challenged with APEC. Three doses of the vaccine induced high titers of anti-Ent IgY in the hens (about 16- and 64-fold higher than the control group in the sera and egg yolks, respectively), resulting in an eight-fold of increase in anti-Ent IgY in the sera of progenies. However, the anti-Ent maternal immunity did not display significant protection against APEC challenge in the young chicks as there was no significant difference in APEC load (in liver, lung, and spleen) or organ lesions (in heart, liver, spleen, lung, and air sac) between the vaccinated and control groups. In future studies, the APEC infection model needs to be optimized to exhibit proper pathogenicity of APEC, and the maternal immunization regimen can be further improved to boost the maternally derived anti-Ent IgY in the hatchlings.

Attitudes Toward COVID-19 Vaccination Among Pregnant Persons in Urban Hospital-Affiliated Practices: Exploring Themes in Vaccine Hesitancy.

To explore beliefs and attitudes toward the COVID-19 vaccine among vaccinated and unvaccinated pregnant persons in order to identify reasons for both vaccine hesitancy and vaccine uptake. From June-August 2021, we conducted a qualitative study consisting of semi-structured interviews with pregnant persons (n = 30). Participants were recruited from university-owned obstetric practices during prenatal and ultrasound appointments. Interviews were audio recorded and transcribed; transcripts were coded and analyzed to identify themes and subthemes. Of the participants, one-third (n = 10) had received the COVID-19 vaccine, while two-thirds (n = 20) were unvaccinated. Primary themes for unvaccinated participants were concern about the paucity of research on the vaccine in pregnancy and potential impact of the vaccine on both fetal development and maternal health. For vaccinated participants, main themes included potential maternal and fetal protection from COVID-19 and anticipated health complications from contracting COVID-19 as their motivations to get vaccinated. While most participants cited healthcare providers as the most trusted source of vaccine information, a majority reported that the internet was their primary source of vaccine information. Many participants wanted to learn more about the COVID-19 vaccine from their obstetric providers, and notably, most vaccinated participants reported the importance of their obstetrician in their vaccine decision-making process. COVID-19 vaccine hesitancy is prevalent among pregnant persons, with concerns for vaccine safety for their fetus, as well as for themselves, being common. Obstetric providers must therefore be prepared to address common concerns with patients during prenatal appointments, taking the time to actively recommend vaccination.

Cholesterol Metabolic Profiling of HDL in Women with Late-Onset Preeclampsia.

A specific feature of dyslipidemia in pregnancy is increased high-density lipoprotein (HDL) cholesterol concentration, which is probably associated with maternal endothelium protection. However, preeclampsia is most often associated with low HDL cholesterol, and the mechanisms behind this change are scarcely explored. We aimed to investigate changes in HDL metabolism in risky pregnancies and those complicated by late-onset preeclampsia. We analyze cholesterol synthesis (cholesterol precursors: desmosterol, 7-dehydrocholesterol, and lathosterol) and absorption markers (phytosterols: campesterol and β-sitosterol) within HDL particles (NCSHDL), the activities of principal modulators of HDL cholesterol's content, and major HDL functional proteins levels in mid and late pregnancy. On the basis of the pregnancy outcome, participants were classified into the risk group (RG) (70 women) and the preeclampsia group (PG) (20 women). HDL cholesterol was lower in PG in the second trimester compared to RG (p < 0.05) and followed by lower levels of cholesterol absorption markers (p < 0.001 for campesterolHDL and p < 0.05 for β-sitosterolHDL). Lowering of HDL cholesterol between trimesters in RG (p < 0.05) was accompanied by a decrease in HDL phytosterol content (p < 0.001), apolipoprotein A-I (apoA-I) concentration (p < 0.05), and paraoxonase 1 (PON1) (p < 0.001), lecithin-cholesterol acyltransferase (LCAT) (p < 0.05), and cholesterol ester transfer protein (CETP) activities (p < 0.05). These longitudinal changes were absent in PG. Development of late-onset preeclampsia is preceded by the appearance of lower HDL cholesterol and NCSHDL in the second trimester. We propose that reduced capacity for intestinal HDL synthesis, decreased LCAT activity, and impaired capacity for HDL-mediated cholesterol efflux could be the contributing mechanisms resulting in lower HDL cholesterol.

Self‐superparasitism, oviposition order, and delay: does offspring survival explain host exploitation strategies of females under interspecific competition in a solitary parasitoid wasp?

AbstractIf the risk of larval competition is high and its consequence on offspring mortality is important, we expect female behavioural strategies favouring the survival of their offspring to be selected for. In parasitoids, hosts can be parasitized several times, in some cases by females of different species (i.e., multiparasitism). In solitary parasitoids, only one offspring can develop per host: supernumerary individuals are eliminated through larval competition. Under these conditions, mothers can lay additional eggs in/on the same host (i.e., self‐superparasitism) to increase the chances of one of their offspring winning the competition. They can also aggressively protect their offspring against competing females to prevent them from multiparasitism and ovicide. Both strategies (self‐superparasitism and host defence) are observed in females of the solitary ectoparasitoid wasp, Dinarmus basalis Rondani (Hymenoptera: Pteromalidae), when facing females of another solitary ectoparasitoid species, Eupelmus vuilleti (Hymenoptera: Eupelmidae), during host exploitation. Here, we aimed to explore whether D. basalis females' behaviours relate to their offspring survival chances during larval competition: we expect mothers to defend their hosts only during the vulnerability period of their offspring and self‐superparasitize to increase the chances of their offspring winning the larval competition. We thus measured the effect of oviposition order (D. basalis females oviposited first or second), delay between ovipositions (30–60 min or 3–4 h) and the occurrence of D. basalis females' self‐superparasitism on D. basalis offspring survival when competing with E. vuilleti juveniles. Our results showed D. basalis offspring constantly had a lower survival probability than E. vuilleti offspring. Only being laid first increased D. basalis offspring survival rate, whereas the time delay between ovipositions and self‐superparasitism did not significantly increase it further. The fact that offspring survival chances under interspecific competition may not be the main driver of maternal host protection and self‐superparasitism is discussed.

Proportion of births protected against neonatal tetanus and its associated factors among mothers who gave birth within the past 6 months in Gozamn district, Northwest Ethiopia, 2022

ABSTRACT Today, neonatal tetanus accounts for a significant portion of newborn and under−5 mortality – 40% and 57%, respectively – and is the most prevalent cause of neonatal mortality and morbidity, particularly in developing nations. As a result, more study on birth protection against neonatal tetanus is required because it is such a terrible condition with such a high death rate and there is a need for more recent evidence on it. From April 1 to 30, 2022, a community-based cross-sectional survey was carried out in the Gozamn district of Northwest Ethiopia. A two-stage stratified sampling procedure was applied, with an overall sample size of 831. The data were gathered using a pre-tested, structured questionnaire. It was then checked, cleaned, and entered into Epidata software version 4.6 before being exported to Stata version 14 for analysis. The proportions of birth protected against neonatal tetanus were 58.57% (95% CI (55.15–61.89%) in the study. Mother who had radio (AOR = 3.09,95%CI: 2.09, 4.56), mother who travel less than one hour to reach nearest health facility (AOR = 1.96,95%CI: 1.23,3.10), mother who gave birth of their last child in the health institution (AOR = 4.17,95%CI:2.39,7.28), mothers who had information from health professional (AOR = 2.56,95%CI:1.56,4.19) and > 4 ANC visit (AOR = 2.57,95%CI:1.55,4.26) were positive predictors of birth protected against neonatal tetanus. Low levels of maternal protection against neonatal tetanus were seen in this study location. To enhance the percentage of births protected against neonatal tetanus, professional-based guidance regarding the TT vaccine are essential.

Maternal Immunity Transfer of Zebrafish (Danio rerio) following Vaccination with a Live-Attenuated Vibrio harveyi Vaccine

Vibriosis causes a major setback in the marine aquaculture industry. In controlling vibriosis, vaccination of the broodstock could help in transferring the initial immunity to the fry and perhaps giving immunity to them during the culture period. This study determines the efficacy of three live-attenuated Vibrio harveyi vaccine (LAVh) derivatives on zebrafish broodstock in providing immunological protection to their offspring against pathogenic Vibrio spp. Zebrafish were vaccinated intraperitoneally with full effective dose (ED80) and monitored for 14 weeks. On week 6, the specimens were intraperitoneally (i.p.) challenged with pathogenic 107 CFU/ml of Vibrio spp., and subsequently another batch was left to spawn. Thereafter, the antibody level of larvae was monitored for 4 weeks post-hatching. Groups of juvenile zebrafish were given booster vaccination via immersion (1 × 107 CFU/mL) with vaccines similar to their predecessor. The fish were sampled weekly for four weeks to determine their antibody profile and pro-inflammatory gene expression. Finally, at week 3, the juvenile fish were challenged with pathogenic strains of Vibrio spp. Results of antibody profiling in the adult zebrafish model indicated that freeze-dried and stale LAVh delivers a longer immunological protective duration, while the FKVh vaccination group failed to provide immunological protection against V. alginolyticus. However, the gene expression of pro-inflammatory interleukin 1β (IL-1β) in the FKVh vaccinated group was elevated longer than that in the freeze-dried LAVh vaccinated group. Nevertheless, the relative percent survival (RPS) of both vaccination groups against pathogenic Vibrio spp. displayed 100% immunity. Overall, the freeze-dried LAVh vaccine was found to confer maternal immune protection for its offspring, provide a long duration of immunological protection and cross-protection coverage against pathogenic Vibrio spp., and have a longer shelf life. It is proposed to be commercially available for farmers to protect against Vibrio spp. infection.

On the Issue of the Protection of Motherhood and Childhood in the First Decades of Soviet Power (Based on the Materials of the State Archive of the Kursk Region)

The relevance of the presented article is due to the processes of implementing the Concept of state family Policy in the Russian Federation for the period up to 2025 and the formation of a set of measures to support a mother woman. Holistic support of motherhood and childhood in modern Russia would be impossible without a study of the history of maternal and child protection of the Soviet period.The purpose of the article is to study the activities carried out by healthcare institutions in Kursk in the 1920s and 1930s in the field of maternity and infancy protection.Objectives: to determine the degree of protection of motherhood and infancy by the beginning of the study period, to characterize the activities of the Soviet government to organize a network of maternity hospitals, to study the process of creating and developing nurseries in Kursk.Methodology. The methods of objectivity, scientific, historicism were used in the work. In addition, historicalcomparative and chronological approaches were used.Results. The negative consequences of wars and revolutions have nullified the results of activities for the protection of motherhood and childhood of the Zemstvo period. The Soviet government aimed to improve the demographic situation. To this end, the fight against child mortality, support for women during pregnancy and childbirth, the organization of women's and children's consultations, maternity homes and departments were organized.Conclusions. During the period under review, the system of maternity and childhood protection was being established. The state has sent significant funds to this area, provided it with personnel, which made it possible to improve the demographic situation in the region and in Russia as a whole in a short time.

Effect of the emotional valence of autobiographical memory and parental bonding on depressive symptoms in a community sample

Retrospective perceptions of parental bonding may be a protective factor for emotional health. These perceptions are grounded in autobiographical memory, which plays a key role in the onset and maintenance of depressive symptomatology. The aim of the present study was to explore whether the emotional valence of autobiographical memories (positive and negative) and the dimensions of parental bonding (care and protection) have an impact on depressive symptomatology, examining the role of depressive rumination and possible age-related differences. A total of 139 young adults (18–28 years) and 124 older adults (65–88 years) completed the Parental Bonding Instrument, the Beck Depression Inventory (BDI-II), the Autobiographical Memory Test and the Short Depressive Rumination Scale. Our results show that positive autobiographical memories serve as a protective factor for depressive symptoms in both young and older adults. Additionally, in young adults, high paternal care and protection scores are associated with increased negative autobiographical memories, although this association has no effect on depressive symptomatology. In older adults, high maternal protection scores are directly related to greater depressive symptomatology. Depressive rumination significantly increases depressive symptoms in both young and older adults, with an increase in negative autobiographical memories in young adults, and a decrease in such memories in older adults. Our findings progress the understanding of the relationships between parental bonding and autobiographical memory with respect to emotional disorders, which, in turn, will help in the design of effective prevention measures.

Mother-offspring proximity maintenance as an infanticide avoidance strategy in bornean orangutans (Pongo pygmaeus wurmbii).

Sexually-selected infanticide by males is widespread across primates. Maternal protection is one of many infanticide avoidance strategies employed by female primates. Bornean orangutan (Pongo pygmaeus wurmbii) mothers with younger offspring are less social with males than mothers with older offspring. Additionally, the distance between a mother and offspring decreases in the presence of male conspecifics, but not female conspecifics. We hypothesized that mothers are responsible for the change in mother-offspring proximity when males are present. Using a year of behavioral data from orangutans in Gunung Palung National Park, we tested whether the Hinde Index, a ratio of the number of approaches and leaves between two individuals, was indicative of mother or offspring proximity maintenance across different social groupings. The semi-solitary social organization of orangutans allows us to observe different social groupings. We found that the mother-offspring Hinde Index was typically indicative of offspring maintenance of proximity. However, the presence of male conspecifics was associated with an increase in the Hinde Index which indicates that mothers are responsible for the decrease in mother-offspring distance when males are present. The decrease in mother-offspring distances and increase in Hinde Index when males are present indicates that mothers react to the presence of males in a protective manner. We suggest this may be an infanticide avoidance behavior by mother orangutans.

Type of Attitude Towards Pregnancy of Women in the Context of a New Coronavirus Infection Caused by COVID-19

The subject of the study is the type of attitude towards pregnancy in the context of a new coronavirus infection caused by COVID-19. The aim of the study is to identify relationships between the type of attitude towards pregnancy and early maladaptive patterns of women in the context of a new coronavirus infection caused by COVID-19. The author analyzes in detail the possible prerequisites for the occurrence of affective disorders in women in late pregnancy in conditions of instability, uncertainty of the world in the context of a new coronavirus infection caused by COVID-19. At the same time, pregnancy is considered as a crisis period in a woman's life. Research methodology: conceptual position on early maladaptive schemes by J. Young, methodological development on the types of attitude of a pregnant woman I.V. Dobryakova. The study was conducted on the basis of the Altai Regional Clinical Center for Maternal and Childhood Protection with pregnant women aged 18 to 40 years. Scientific novelty of the study: the existence of relationships between the types of attitudes in the context of a new coronavirus infection caused by COVID-19 and early maladaptive patterns has been theoretically substantiated and empirically proven. Qualitative differences in the types of attitudes towards pregnancy in women of different ages under the conditions of a new coronavirus infection caused by COVID-19 were determined. Beliefs that are significantly associated with understanding life in the context of a new coronavirus infection have a positive correlation with anxious and depressive types of attitudes towards pregnancy. Pregnant women under the age of 25 are more likely to worry about the possible fragility and uncertainty of reality than women of other age groups, which may be due to the actualization of early maladaptive schemes and the high level of infantility of women in this age group. Based on the research data, it seems important to further develop a correctional program for pregnant women in order to adaptively comprehend the existing reality and accept the low controllability of the world as a whole.

Alexithymia in adolescents treated for psychiatric disorders: A study of the relationship with Alexithymia in parents and with the parental link

IntroductionAlexithymia is defined as a disorder involving difficulties in identifying, describing feelings and an outward-oriented way of thinking with restricted imaginary processes. Our objectives were to study the link between parents’ alexithymia and that of adolescents treated for psychiatric disorders on the one hand, and to study the relationship between alexithymia in adolescents and the parental link perceived by them, on the other hand.ObjectivesTo study the relationship between the alexithymia of parents and that of adolescents followed for psychiatric disorders on the one hand, and to study the relationship between alexithymia in adolescents and the parental bond perceived by them on the other go.MethodsA descriptive and analytical cross-sectional study was carried out at the pediatric psychiatry consultation at the Hédi Chaker University Hospital in Sfax during a period of one year from January 2019 to December 2019. We recruited 116 people: 53 adolescents, 44 mothers and 19 fathers. . We used an information sheet, the TAS-20 score (Toronto Alexithymia Scale) and the PBI (Parental Bonding Instrument)ResultsTwo-thirds of the patients were alexithymic. A climate of domestic violence increased the adolescent’s emotional difficulties. Half of the mothers and one-third of the fathers were alexithymic. The total alexithymia score (TAS-20) in adolescents was positively correlated with the total alexithymia score (TAS-20) in the parents (p=0.03 for the mother and p = 0.02 for the father Adolescent difficulty in identifying emotions (DIE) was associated with difficulty describing emotions (DDE) in both parents (p=0.01 for mother and p&lt;10-3 for father). The teenager had difficulty describing his own emotions when his mother was having the same difficulty. Outward thinking in adolescents were associated with more alexithymic traits in the mother. Maternal care scores were significantly and negatively correlated with adolescent TAS-20, DIE, and DDE scores (p=0.01, p=0.01, and p=0.04). Maternal protection score was positively and significantly correlated with TAS-20, DIE, and DDE scores (p=0.01, p=0.01 and p=0.02). The father’s protection score was positively and significantly correlated with TAS-20, DIE and DDE scores (p&lt;10-3, p=0.04 and p=0.01). The overprotective attitude of parents perceived by the adolescent has therefore been associated with more alexithymia in adolescents.ConclusionsParticular attention must therefore be paid to the emotional difficulties of adolescents followed in child psychiatry, as well as those present with their parents. These difficulties can create interpersonal difficulties and affect the parental bond perceived by the child.Disclosure of InterestNone Declared

Leptin, Adiponectin, and Melatonin Modulate Colostrum Lymphocytes in Mothers with Obesity.

Pregnancy complicated by obesity is associated with adverse triggered gestational and neonatal outcomes, with reductions in the subtypes of CD4+ T-lymphocytes representing the modulators of inflammation. It needs to be better established how maternal nutritional statuses impact the neuroendocrine-immune system's action and affect the immunological mechanisms of the maternal-infant relationship via breastfeeding. This study examined the effects of maternal obesity on human colostrum lymphocytes and the intracellular mechanisms of lymphocyte modulation in the presence of leptin, adiponectin, and melatonin via cell proliferation; the release of intracellular calcium; and apoptosis induction. This cross-sectional study analyzed colostrum samples from 52 puerperal splits and divided them into overweight and eutrophic groups. Colostrum lymphocytes underwent immunophenotyping and cell proliferation by flow cytometry and intracellular calcium release and apoptosis assays by immunofluorescence in the presence or absence of hormones. Significant differences were considered when p < 0.05 by the chi-square or t-test. Maternal obesity reduced the population of T-lymphocytes and TCD4+ in human colostrum and proliferative activities (p < 0.05). These hormones restore lymphocyte proliferation to a level similar to the eutrophic group (p < 0.05). Leptin, adiponectin, melatonin hormones, and biological actions consolidated in the scientific literature also represent maternal and infant protection mechanisms via colostrum and the modulation of human colostrum lymphocytes.

Influência da percepção do cuidado e da proteção materna sobre as práticas de aleitamento materno em lactentes no terceiro mês de vida

Abstract Objectives: to evaluate the influence of perception of care and maternal protection on breastfeeding practices on the infants’ third month of life. Methods: longitudinal study with mother-infant pairs distributed in five groupsof gestational clinical conditions. The recruitment occurred in the period 2011 to 2016 at three hospitals in the public health systems in Porto Alegre, Brazil. The Parental Bonding Instrument and the Edinburgh Postpartum Depression Scale were assessed. Exclusive and prolonged breastfeeding were analyzed by questionnaires. Data were analyzed by one-way ANOVA with Tukey’s post-hoc test, Kruskal-Wallis with Dunn’s post-hoc test, or Pearson’s chi-squared test. The significance was set at 5%. Results: 209 mother-infant pairs were investigated. Among those who did not practice breastfeeding, a lower perception of care, a higher perception of maternal protection, and a higher score of postpartum depression were observed (p=0.022, p=0.038, and p&lt;0.001, respectively), when compared to peers who practiced. The control group had a significantly higher perception of care when compared to thediabetes mellitus group (p=0.006), and the perception of maternal protection and postpartum depression had no differences between the intrauterine groups (p&gt;0.05). Conclusions: the perception of care and maternalprotection and the postpartum depressive symptomatology influenced breastfeeding at three months. It is possible to assume a transgenerational effect on breastfeeding, suggesting the existence of a complex model related to mental health in a sample of women who had different backgrounds of gestational clinical conditions

The influence of perception of care and maternal protection on breastfeeding practices on the infants’ third month of life

Resumo Objetivos: avaliar a influência da percepção do cuidado e da proteção materna sobre as práticas de aleitamento materno em lactentes no terceiro mês de vida. Métodos: estudo longitudinal, com pares mães-lactentes distribuídos em cinco grupos de diferentes condições clínicas gestacionais. O recrutamento ocorreu no período de 2011 a 2016 em três hospitais da rede pública de saúde de Porto Alegre, Brasil. Foram utilizados o Parental Bonding Instrument e o Edinburgh Postpartun Depression Scale. O aleitamento materno exclusivo e continuado foi analisado por questionários. Na análise de dados foram utilizados os testes de ANOVA com post-hoc de Tukey, Kruskal-Wallis com post-hoc de Dunn e Qui-quadrado. Resultados: foram investigados 209 pares mães-lactentes. Entre aqueles que não praticaram o aleitamento materno foi observadouma menor percepção de cuidado materno, uma maior percepção de proteção materna e ummaior escore de depressão pós-parto (p=0,022, p=0,038 e p&lt;0,001, respectivamente) quandocomparados aos pares mães-lactentes que praticaram. O grupo controle teve significativamente maior percepção do cuidado materno quando comparado ao grupo com diabetes mellitus (p=0,006) enquanto a percepção de proteção materna e a depressão pós-parto não apresentaram diferenças entre os cinco grupos intrauterinos (p&gt;0,05). Conclusões: a percepção de cuidado e proteção materna e asintomatologia depressiva pós-parto influenciaram o aleitamento materno aos três meses. É possível assumir um efeito transgeracional no aleitamento materno, sugerindo a existência de um modelo complexo relacionado à saúde mental numa amostra de mulheres que tinham diferentes antecedentes de condições clínicas gestacionais.

Community-Based Diagnosis for the Improvement of Maternal and Child Protection in the ASACOSEKASI Health Area in the Urban Area of Bamako (Mali)

Community-Based Diagnosis for the Improvement of Maternal and Child Protection in the ASACOSEKASI Health Area in the Urban Area of Bamako (Mali)

Whites Only: Race and Mobility in Kym Ragusa's The Skin Between Us: A Memoir of Race, Beauty, and Belonging and Claudia Rankine's Citizen: An American Lyric

Whites Only: Race and Mobility in Kym Ragusa's <i>The Skin Between Us: A Memoir of Race, Beauty, and Belonging</i> and Claudia Rankine's <i>Citizen: An American Lyric</i>

Accompagnement à la parentalité en Protection maternelle et infantile : co-construction de la logique d’intervention PERL

In the Greater Eastern region of France, a primary prevention intervention in perinatal care has shown promising results on child development. In order to make this intervention transferable and sustainable outside a research context, it was adapted into a universal family health program. The PERL (Petite Enfance Recherche-action en Lorraine: early childhood research-action in Lorraine) research-action aimed to evaluate the effects of this new intervention. The objective of the article was to present the intervention logic of the PERL program, based on the evaluation of processes and mechanisms (2018-2019). The method was based on 18 semi-structured interviews with actors involved in the construction and implementation of PERL, and a consultation process. Supported by the Maternal and Child Protection services (PMI), PERL is a program based on home visits by nurses, analysis of practices and supervision. In contrast to a standardized or an injunctive perspective, the approach recognizes and supports the parent as an expert of his or her own child. The importance of supervision in facilitating the adoption of an unconditional benevolent posture and the professional development of nurses confronted with complex situations is one of the cornerstones of the system. PERL is a structured and non-standardized parenting support program, based on strong health promotion concepts. This evaluation underlines the importance and challenges of having a shared vision of the intervention logic. In the perspective of the deployment and transfer of PERL, it will be necessary to adapt the system to the contexts and territories. In this perspective, an implementation guide has been produced.