The α + β dual phase titanium alloys are key structural materials in aviation and aerospace industries, and the complicated flow behavior of these titanium alloys during hot deformation requires to establish a constitutive model incorporating physical mechanism for optimizing processing parameters and designing forming tools. This work aims to establish a constitutive model incorporating physical mechanism for hot deformation of TC18 in α + β phase region. Firstly, the flow behavior and microstructure evolution for hot deformation of TC18 in α + β phase region are characterized. The TC18 shows significant strain hardening rate and negative strain hardening exponent around and after peak flow stress, respectively. After peak flow stress, Dynamic Recovery (DRV) mechanism dominates the evolution of α and β phases according to the results of substructure evolution. Then, the internal state variables method is applied to establish a constitutive model incorporating physical mechanism for hot deformation of dual phase titanium alloys. The variation of dislocation density during the hot deformation of titanium alloys is modeled by considering the accumulation of dislocation due to the impediment to dislocation movement by substructure obstacles and the annihilation of dislocation due to the dynamic restoration effect. The interaction between dislocations, the subgrain boundaries and the grain/phase boundaries obstruct the dislocation movement in the α phase, and the first two obstructs the dislocation movement in the β phase during the hot deformation of TC18. The dislocation annihilation process in the α and β phases during the hot deformation of TC18 is dominated by DRV. Finally, the substructure evolution in the two phases based constitutive model for hot deformation of TC18 in α + β phase region is presented. This model is well applied to predict the flow stress and quantitively analyze the role of DRV effect in the evolution of α and β phases during the hot deformation of TC18.