Deposition Of Material Research Articles

Evaluating myocardial involvement in patients with multiple myeloma at different stages a cardiac MR T1 mapping study

Abstract Background At present, the International criteria for diagnosis multiple myeloma（MM） do not specifically highlight the use of cardiac magnetic resonance (CMR) to detect abnormal myocardial infiltration in patients at different clinical stages of MM. Extracellular volume fraction (ECV) based on CMR T1 mapping indicates expansion of the extracellular space or deposition of material in infiltrative heart diseases. Purpose To detect whether myocardial involvement in patients with MM at different clinical stages based on CMR T1 mapping. Methods A cohort consisting of 20 patients with diagnosed MM and 15 sex- and age-matched controls (Cs) were recruited for this study. All participants underwent CMR examination to obtain native T1 and ECV. The patients with MM were stratified into three groups based on the International Staging System (ISS): Stage I (n=5), Stage II (n=7), and Stage III (n=8). Cardiac amyloidosis (CA) is diagnosed based on the patient's clinical presentation and tissue biopsy. The baseline biochemical indices were collected before CMR examination. Result Among patients with MM, there were a total of 9 patients diagnosed with CA, comprising 3 patients in stage II and 6 patients in stage III. The ECV in stage III patients (45.13±11.89%) was significantly higher compared to that in stage I (26.65±4.22%), stage II (34.09±8.90%), and controls (25.40±2.52%) (p < 0.05). Furthermore, the ECV in stage II patients (34.09±8.90%) was higher compared to controls (25.40±2.52%), though not significantly different from stage I patients (26.65±4.22%). Correlation analysis revealed a positive correlation between brain natriuretic peptide (BNP) levels and ECV (r=0.606, p=0.013). Receiver operating characteristic (ROC) curve analysis demonstrated that ECV had good predictive value for CA, with an area under the curve (AUC) of 0.898 (p < 0.01), and the optimal cutoff value for ECV was determined to be 33.7%. Conclusions ECV derived from CRM T1 mapping holds promise for identifying amyloid accumulation, which deteriorates progressively with the advancement of disease stages in patients with MM. It is recommended that patients diagnosed with Stage II and Stage III MM should undergo CMR to facilitate the early detection of myocardial infiltrative damage.

An Analysis Management by Mike 21 Modelling at Rolak 70 Retention Pool in Jombang Regency, East Java Province, Indonesia

Some areas in Indonesia have high level of sedimentation problems that able to cause flooding, and one apparent solution is to build a retention pool. Sedimentation is deposition of material into the reservoir or dam due to environmental damage or erosion occurs in the river basin area. Sedimentation becomes the main factor in constructing the Rolak 70 Retention Pool, as an important component in controlling floods on the Konto River when the water discharge exceeds the maximum limit. From geography perspective, the modelling location is in waters located between 112° 11′ 22.85″ South Latitude and 7° 38′ 42.23″ East Longitude. The model area has northern boundary at the tip of Rolak 70 pool, while western boundary at the outlet of Rolak 70 pool. The lowest water depth value is located in upstream area of Konto River at coordinates of 112°11’27.81″ South Latitude and 7°38’49.27″ East longitude. Weight of soil sample taken from the research site was ± 1000 grams at each point, and the result of sediment sample test performed at the Soil Mechanics Laboratory of Civil Engineering Department, Sultan Agung University, Semarang showed that the research area is dominated by sand, followed by mud and gravel. There were several tests conducted include grain size analysis, hydrometer analysis, and specific gravity analysis to determine the D50 of the sediment. In the study area, several sampling points were taken, started from upstream area of the river in front of Rolak 70 building to the Rolak 70 Retention Pool. For this purpose, a MIKE 21 software modelling was used to determine distribution and lines of sedimentation in the study area. As visible from changes found in bed level morphology that occurred in Rolak 70 Retention Pool by cross section extraction, it can be seen that the largest change occurred in analysis for line 1 and the smallest bed level changes occurred in the analysis for line 6. Then, the result revealed that sedimentation tends to occur at large locations in upstream area of Rolak 70 Retention Pool, while the smallest sedimentation potential will happen at the downstream area of Rolak 70 Retention Pool. These results can be caused by changes of speed from the river flow which tends to decrease towards the end of Rolak 70 Retention Pool. So, the river flow has no more energy to carry heavy amount of sediments originating from the upstream area of the Konto River. By the existence of this retention pool, the need for rice field irrigation will not be disturbed by sediment deposits. In addition, the Rolak 70 Retention Pool can be used as temporary storage for material from Mount Kelud eruption where these materials can be utilized as building material or other useful purposes.

Histopathological Analysis of Pseudoexfoliation Material in Ocular Surgeries: Clinical Implications

Background: Pseudoexfoliation syndrome (PEX) is a common age-related ocular condition characterized by the accumulation of a fibrillar, pseudoexfoliative material on the anterior segment of the eye. This study aims to investigate the histopathological characteristics of pseudoexfoliative material within different ocular structures, including the eyelid, conjunctiva, and anterior lens capsule. Methods: A total of 32 anterior lens capsules, 3 eyelid fragments, and 12 conjunctival specimens were obtained from patients clinically diagnosed with PEX during ocular surgeries at the Onioptic Hospital of Ophthalmology. The tissue specimens were subsequently processed using the classical histological technique of paraffin embedding. This process enabled the production of serial sections with a thickness of 4 microns, facilitating the microscopic examination of fine details. The sections were stained with the hematoxylin-eosin (HE) method for the observation of microscopic structures. Results: This study’s findings reveal that PEX material, characterized by its fibrillar and amorphous components, is consistently present across multiple ocular structures, including the anterior lens capsule, eyelid, and conjunctiva. When stained with H&E, the PEX material typically appears as amorphous, eosinophilic deposits. Under higher magnification, these deposits exhibit a fibrillar structure, often appearing as irregular, granular, or filamentous aggregates. Conclusions: The deposit of fibrillar material in the eyelid and conjunctiva, though less commonly emphasized compared to other structures, is a significant finding that sheds light on the systemic nature of the syndrome. The consistent identification of fibrillar eosinophilic deposits across these structures highlights the systemic distribution of PEX material, reinforcing the notion that PEX syndrome is not confined to the anterior segment of the eye.

Back-Side Stress to Ease p-MOSFET Degradation on e-MRAM Chips

Abstract Magnetoresistive random access memory process makes great contribution to threshold voltage deterioration of metal-oxide-silicon field-effect transistors, especially on p-type devices. Herein, a method was proposed to reduce threshold voltage degradation by utilizing back-side stress. Through the deposition of tensile material on the back side, positive charges generated by silicon-hydrogen bond breakage were inhibited, resulting in a potential reduction of threshold voltage shift by up to 20%. In addition, it was found that the method could only relieve silicon-hydrogen bond breakage physically, failing to provide a complete cure. However, it holds significant potential for applications where additional thermal budget is undesired. Furthermore, it was also concluded that the method used in this work was irreversible, with its effect sustained to the chip package phase, and it ensures competitive reliability of the resulting magnetic tunnel junction devices.

Genesis of Devonian volcanic-associated Lahn-Dill-type iron ores – part II: trace element fractionation evidences diffuse fluid venting

The iron (Fe)-oxide deposits of the Lahn-Dill-type are composed of haematite-quartz and rare siderite-haematite ores. These ores formed as marine chemical sediments on top of volcaniclastic rocks near the Middle to Late Devonian boundary (∼ 380 Ma). As such, their trace element fractionation patterns provide key information on venting style, ocean chemistry, particle-solution interaction, and depositional environment at the time of ore formation. This study combines WDXRF and ICP-MS/OES whole-rock geochemistry with complementary in-situ LA-ICP-MS analysis, and TEM element mapping of ore samples from the Fortuna Mine (Rhenish Massif, Germany). In-situ measurments were conducted on quartz-haematite, haematite, and siderite-haematite microdomains. Bulk major element contents of the ores indicate (volcani)clastic contamination and post-depositional hydrothermal alteration. Microdomain trace element distributions reveal four different trace element signatures, which are related to: (1) syngenetic apatite formation due to sorption of P and REY from seawater; (2) Fe-(oxyhydr)oxide-specific trace element scavenging and fractionation within the seawater column; (3) diagenetic Fe(III) reduction and trace element mobilisation in pore water; and (4) simultaneous deposition of (volcani)clastic material and Fe-(oxyhydr)oxides. These results show that Lahn-Dill-type iron ore formation resulted from mixing of a low-temperature vent fluid with ambient seawater at high seawater to vent fluid ratios. This likely was related to an environment in which diffuse venting dominated over focused venting, and in which quick Fe-particle precipitation led to formation of haematite-quartz ores. Local diagenetic Fe(III) reduction resulted in post-depositional siderite-haematite ore formation during which trace elements were partially remobilised in pore water.

Soil carbon stocks and nutrient stratification in a volcanically active coffee-dominated landscape in south-central Guatemala

The volcanoclastic mountains of Central America offer elevations ideal for coffee production. Both vulcanism and land use can have significant impacts on soil formation and properties. We evaluated how the interactive impacts of soil formation and coffee-dominated land use modulate soil storage and vertical distribution of organic carbon and nutrient elements in a volcanically active landscape dominated by coffee agriculture in south-central Guatemala. Thirty-seven pedons under coffee production (n = 29), forest cover (n = 5) and pasture (n = 3) were characterized and classified, and concentrations and stocks of organic carbon and macronutrient and micronutrient elements were quantified across genetic horizons. Additionally, soil organic carbon (SOC) stock values calculated using the fixed depth (FD) and equivalent soil mass (ESM) methodologies were compared. The active stratovolcano in the region had a strong effect on the development of andic properties and soil horizon burial, with thirty-one pedons classified as Andisols, three as Inceptisols and three as Entisols. Land use management practices and soil horizon burial by deposition of volcanic material were partly reflected in the vertical distribution of SOC concentrations and stocks. The vertical distribution of macronutrients was generally more sensitive to land use than the vertical distribution micronutrients, which could potentially reflect differences in inputs via fertilizers and vegetation cover and in outputs with biomass harvest. Soil organic carbon stocks were similar when calculated by FD and ESM, reflecting relatively consistent depth-wise bulk density. These results demonstrate that in volcanically active landscapes, land use should be considered in concert with soil-forming factors to comprehensively understand organic carbon and nutrient element storage in soils.

Altered kidney distribution and loss of ACE2 into the urine in acute kidney injury.

There are diverse pathophysiological mechanisms involved in acute kidney injury (AKI). Among them, overactivity of the renin-angiotensin system (RAS) has been described. Angiotensin-converting enzyme 2 (ACE2) is a tissue RAS enzyme expressed in the apical border of proximal tubules. Given the important role of ACE2 in the metabolism of angiotensin II, this study aimed to characterize kidney and urinary ACE2 in a mouse model of AKI. Ischemia-reperfusion injury (IRI) was induced in C57BL/6 mice by clamping of the left renal artery followed by removal of the right kidney. In kidneys harvested 48 h after IRI, immunostaining revealed a striking maldistribution of ACE2 including spillage into the tubular lumen and the presence of ACE2-positive luminal casts in the medulla. In cortical membranes, ACE2 protein and enzymatic activity were both markedly reduced (37 ± 4 vs. 100 ± 6 ACE2/β-actin, P = 0.0004, and 96 ± 14 vs. 152 ± 6 RFU/μg protein/h, P = 0.006). In urine, full-length membrane-bound ACE2 protein (100 kDa) was markedly increased (1,120 ± 405 vs. 100 ± 46 ACE2/µg creatinine, P = 0.04), and casts stained for ACE2 were recovered in the urine sediment. In conclusion, in AKI caused by IRI, there is a marked loss of ACE2 from the apical tubular border with deposition of ACE2-positive material in the medulla and increased urinary excretion of full-length membrane-bound ACE2 protein. The deficiency of tubular ACE2 in AKI suggests that provision of this enzyme could have therapeutic applications and that its excretion in the urine may also serve as a diagnostic marker of severe proximal tubular injury.NEW & NOTEWORTHY This study provides novel insights into the distribution of kidney ACE2 in a model of AKI by IRI showing a striking detachment of apical ACE2 from proximal tubules and its loss in urine and urine sediment. The observed deficiency of kidney ACE2 protein and enzymatic activity in severe AKI suggests that administration of forms of this enzyme may mitigate AKI and that urinary ACE2 may serve as a potential biomarker for tubular injury.

CHARACTERISTICS OF YALIMO PAPUA KINANG JINGKION POWDER AS FILLER IN HRS-WC MIXTURE

<span lang="EN-US">Kinang Jingkion is the name of a region in Yalimo Regency, Papua, which has unique material deposits with specifications that make it suitable for use as aggregate in road pavement, including as filler in powder form. Jan Ukago, one of the first researchers on this aggregate, named the material after the region or location, so the material from the Kinang Jingkion region is now called Kinang Jingkion material. The high construction costs in the Yalimo region and generally in the Papua Mountains are caused by logistics, where materials such as cement and asphalt are mobilized using airplanes. With the alternative of using local filler material, it will eliminate long and expensive mobilization. The testing method was carried out according to the 2018 General Specifications Revision 2, Directorate General of Highways and Indonesian National Standard (SNI) for each test, including asphalt, coarse and fine aggregates, and Kinang Jingkion material. The Optimum Asphalt Content (OAC) obtained from Kinang Jingkion Filler was 6.85%. The Marshall characteristic test results for Kinang Jingkion Filler at OAC of 6.85% showed a stability value of 1194.40 Kg, MQ of 460.2 Kg/mm, VIM of 2.68%, and VFB of 80.16</span>

Neurobiological Effects of Lipoid Proteinosis: A Study on Phosphorylated Tau, S100B, NSE, NEFL, and GFAP

Background: Lipoid Proteinosis (LP), also termed Urbach-Wiethe disease, is an enigmatic genodermato-sis marked by the systemic deposition of hyaline material. With its etiology rooted in ECM1 mutations, LP’s neuropathological spectrum has been hypothesized to involve an array of neurodegenerative biomarkers, underscoring a potential for substantial neurobiological implications. This study endeav-ored to elucidate the serum concentrations of neurodegenerative biomarkers—phosphorylated Tau (pMAPT), S100B, Neuron-Specific Enolase (NSE), Neurofilament Light Chain (NEFL), and Glial Fibrillary Acidic Protein (GFAP)—in LP patients, seeking to establish their diagnostic utility for the condition. Materials and Methods: Fifteen LP patients and 15 matched healthy controls were enrolled. Serum levels of the biomarkers were quantified using ELISA, and their predictive power was assessed through binary logistic regression and Receiver Operating Characteristic (ROC) analysis. Results: Elevated serum levels of NSE, NEFL, and GFAP were observed in LP subjects relative to healthy counterparts, reaching statistical significance (p<0.05). In contrast, pMAPT and S100B levels did not differ appreciably. GFAP is considered a predictive marker for LP with an area under the curve (AUC) value of 0.813 and a 95% confidence interval (CI) of 0.658-0.968 (p=0.003). Conclusions: The study underscores a distinctive neurodegenerative profile in LP, with NSE, NEFL, and GFAP concentrations significantly amplified. These biomarkers, particularly GFAP, may represent novel indicators for LP, offering prospective biomarker-based diagnostic strategies. The insights garnered herein pave the way for advanced understanding and clinical management of LP, delineating a novel avenue for future high-impact research.

Utilization of boron particulate wall conditioning in the full tungsten environment of WEST

Over a series of experiments performed on the WEST device we have demonstrated the ability to perform controlled impurity injections and improve overall wall conditions. Positive changes to overall machine conditions are evidenced by reduced native impurity content after injection as well as decreases in radiated power and reductions in recycling. These results are consistent with the formation of a gettering layer which provides a particle sink and a reduction of source terms. We also observe a reduction in overall Zeff at the conclusion of the powder injection period consistent with a reduced impurity burden within the plasma. Finally, we have demonstrated a minimal injection quantity required to affect a positive change in wall conditions. These results confirm that plasma assisted deposition of conditioning material through particulate injection shows substantial promise as a supplemental wall conditioning technique.

Surface Analysis of Orthodontic Mini-Implants after Their Clinical Use.

Temporary anchorage devices (TADs) are orthodontic mini-implants with remarkable characteristics that, once inserted, present mechanical retention (primary stability) without the process of bone osseointegration. However, interaction with the biological environment may cause changes in the morphology of the external surface of dental TADs. In this study, we used 17 TADs made of aluminum-vanadium titanium alloy, produced by two companies, which were analyzed through optical microscopy after being removed from the patients during orthodontic treatment. We evaluated the changes that appeared on the TADs' surfaces after their use in the biological environment, depending on the morphological area in which they were inserted. In our study, we found changes in the morphology of the implant surface, and especially deposits of biological material in all study groups. On all samples examined after clinical use, regardless of the period of use, corrosion surfaces in different locations were observed. Our obtained results support the idea that the biological environment is aggressive for mini-implant structures, always producing changes to their surface during their clinical use.

Geomorphological Compartmentation of Pereiro Massif and its surroundings, in Northern Northeast of Brazil

The Pereiro Massif (PM), located between the states of Ceará, Rio Grande do Norte and Paraíba, is a granitoid body that occupies an area of ​​approximately 2,200 km2, and and has maximum altitudes of 861 meters. This work aimed to elaborate and discuss the geomorphological compartmentalization of the Pereiro Massif and its surroundings. To this end, the following procedures were followed: 1) bibliographic and cartographic review on the geology and relief of the study area; 2) creation of the geomorphological map in a GIS environment, through SRTM image processing; 3) field activities for mapping conference, obtaining information to characterize the shapes and photographic survey. Fifteen units were mapped and grouped into three dimensions that consider the resulting processes and forms: accumulation, flattening and erosion surfaces. The compartments are classified recognizing processes associated with continental denudation with erosion, transport and deposition of material, based on structural geomorphology. The mapping carried out enhances the scientific notoriety of the PM and is expected to serve for environmental planning actions, such as the creation of protected areas and environmental licensing procedures.

The northernmost Polish Eemian palaeolake near Łęczyce − Stratigraphic and palaeoecological implications for a MIS 6a − MIS 5d sediment record

We report the results of high-resolution multi-proxy studies of a 10 m thick sedimentary profile from Łęczyce, Poland. It reveals a continuous lacustrine succession from the Eemian Interglacial. On this basis, we have distinguished seven sedimentary units (U7a-U7f) and ten local palynological zones (LPAZ Lec 1 − Lec 10), revealing the evolution of the lake from the moment of dead-ice melting, through the continuous filling of the lake basin with organic mud, to the final stage of shallowing and transformation into a peat bog. This northernmost known Eemian site was investigated for the first time, therefore, the reconstructed changes in local conditions were correlated with global changes from the final phase of the penultimate glaciation through the Eemian Interglacial to the beginning of the last glaciation. The results show that the melting of dead ice blocks at this site was delayed compared to central Poland, with lacustrine processes starting as glaciolimnic sedimentation. Furthermore, the delayed start of vegetation development around the lake resulted in the absence of a Pinus-Betula-Ulmus E2 level. During the Eemian, local conditions were generally stable, and sedimentation took place in a relatively deep basin with well-defined epilimnion and hypolimnion zones. Climatic instability at the end of the Eemian resulted in reduced vegetation cover. During the first climatic deterioration in the Weichselian (presumably the Herning Stadial), lacustrine sedimentation was reduced and the deposition of fine-grained mineral material predominated. This was followed by the complete drying out of the lake and the development of soil formation. The subsequent climatic warming (Brørup Interstadial?) recorded in the uppermost part of the profile (U7f) was characterised by the plant community Lec 10 (Carpinus-Corylus-Picea) and was presumably warmer than commonly assumed. Multi-proxy studies show that the development of the lake was more similar to that of southern Scandinavia than to that of Poland.

Phenotypes Associated with NOTCH3 Cysteine-Sparing Mutations in Patients with Clinical Suspicion of CADASIL: A Systematic Review.

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is caused by NOTCH3 mutations affecting the number of cysteines. The pathogenic role of cysteine-sparing NOTCH3 mutations with typical clinical CADASIL syndrome is still debated. This review aimed to characterize NOTCH3 cysteine-sparing mutations in patients with clinical suspicion of CADASIL. Articles on NOTCH3 cysteine-sparing mutations with clinical suspicion of CADASIL were reviewed. Clinical and radiological cerebral phenotypes data were extracted and characterized across regions and compared with phenotypes of typical CADASIL patients. We screened 298 NOTCH3 cysteine-sparing mutation individuals from 20 publications, and mutations in exon 3 were the most frequently reported (21.46%). Gait impairment (76.47%), cognitive impairment (67.47%), and stroke (62.37%) were the three most common clinical phenotypes; the most frequent radiological cerebral phenotypes were lacunes (74.29%) and cerebral microbleeds (72.73%). Compared with CADASIL patients, cognitive impairment and cerebral microbleed frequencies were significantly higher in patients with NOTCH3 cysteine-sparing mutations, while the white matter hyperintensities in anterior temporal polar and external capsule were rarely observed. Compared with Western patients, radiological phenotypes were more common than clinical phenotypes in cysteine-sparing Asian patients. More than half of cysteine-sparing patients had positive granular osmiophilic material deposits. NOTCH3 cysteine-sparing mutations in patients with clinical suspicion of CADASIL mainly manifested with gait and cognitive impairment but rare white matter hyperintensities in anterior temporal pole and external capsule. Further studies are warranted to pay attention to atypical NOTCH3 variants, which could guide specific diagnosis and help unravel underlying mechanisms.

Design and Preparation of One-Dimensional Cathode By Electrophoretic Deposition Method for Flexible Knitted Batteries

Rechargeable batteries are highly promising energy storage systems that can convert and store electrical energy. Effective energy storage systems should have high energy density, high power, safety, environmentally friendliness, and long cycle life. To meet the aforementioned objectives, researchers have attempted to use different morphologies of nanomaterials as electrodes to improve the electrochemical performance of batteries. Among the materials available, one-dimensional structures have unique properties over traditional ones and extensive applications in wearable devices due to their flexibility [1]. Flexible batteries have several advantages such as mechanical flexibility, good energy storage capabilities, affordability, and environmental safety [2]. They knitted or sewed into textiles, folded into random forms, and wrapped around body parts like the neck or wrist [3]. However, there is little research that covers Li-ion batteries that have a one-dimensional flexible structure.Achieving simultaneous high electronic/ionic conductivity and electrochemical stability is difficult in a homogeneous single-component electrode material. Consequently, the development of precisely defined functional one-dimensional (1D) hetero-nanostructures that effectively integrate the advantages and address the limitations of various electrochemically active materials becomes critical [1].The proposed methodology involves the electrophoretic deposition of lithium iron phosphate on conductive nickel wire, providing a one-dimensional cathode structure. As an anode, nickel-tin is deposited on nickel wire by electrochemical deposition. The deposition method allows greater precision and control over the deposition of active material on the current collector and also has possible applications on different structures such as 1D and 3D. Also, the electrolyte was obtained by layer-by-layer method, by dipping the cathode and anode, separately, in polymers to coat the cathode material as an electrolyte-separator film. The full cell was assembled and the better results will be presented in the meeting. Acknowledgments This research was funded by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan (Grant No. АР19679855).

All Organic Quinone Solid State Batteries for Environmentally Friendly and Chemical Robust Alternatives Beyond Lithium-Ion Batteries

Introduction: Organic solid-state quinone batteries have unparalleled properties that can meet the most urgent challenges the industry faces. It can create an energy system that is environmentally friendly and electrochemically robust, while being cost efficient enough for industry to adopt and invest in. The inspiration for fully organic solid-state batteries came from extended studies on our all-organic aqueous redox flow batteries, where much of the science of organic redox coupling molecules were understood. Like redox flow batteries, organic solid state quinone batteries utilizes the breaking and reforming of bonds to generate electrical energy. However, it doesn’t require the constant flow of charge carrier solution like the flow batteries. Consequently, this avoids the cost of an extra pumping system and significantly reduce the size of the batteries compared to flow battery systems. Furthermore, the downsized battery system allows for the cell to be implemented into applications such as EV and portable devices. The redox species are directly deposited onto the electrodes. This deposition of active material on carbon paper enables higher surface area for charge transfer, which increases the capacity for fast charge and discharge compared to flow batteries. Additionally, the active materials are of organic quinone nature providing great robustness that other battery systems like lithium-ion batteries don’t allow. The redox chemistry of these quinones still happens in aqueous system, which allows us to use very small amount of aqueous electrolyte instead of the combustible organic solvent used in lithium batteries. Results and discussion: The appropriate quinone species for this solid-state battery must be electrochemically stable and dissolution free in the aqueous system. Various quinones with different substituents were tested. One of the promising redox couples discovered is 2-methylanthraquinone (MAQ) and duroquinone (DQ). The couple displayed a cell voltage of 400 mV (0.4 V) as shown in Figure 1. This value was found to correspond to the redox potential difference between DQ and MAQ. New methods of deposition of active materials onto the electrodes were developed. High conductivity was achieved by introducing CNT with appropriate binder, which resulted in improvements to the cell’s charge and discharge performance (Figure 2). Figure 1. Cyclic voltammetry study of 10 mM 2-Methylanthraquinone (MAQ) and 10 mM Duroquinone (DQ) in 1 M sulfuric acid with 20% ethanol, MSE reference electrode, glassy carbon, 50 mV/s. (Refer to image file) Figure 2: Charge and discharge of solid-state batteries of 2-Methylanthraquinone (MAQ) and Duroquinone (DQ) at 10 mA. (Refer to image file)For the positive side, 0.164 g of duroquinone was deposited on 25 cm2 carbon paper with 0.05 g of CNT. Correspondingly, 0.222 g of 2-Methylantroquinone was deposited for the negative side. The cell was assembled with Nafion 117 as separator and small amount of 1 M sulfuric acid as the supporting electrolyte. The initial charge and discharge curve of this cell showed 97% columbic efficiency. Long-term cycling to test the stability was performed and other redox couples also showed higher cell voltage with high efficiency.The next step for this study is to explore different redox couples that might have better compatibility and higher cell voltage compared to the current redox couple. This will be done through studying the large library of organic compounds including quinones and other redox active organic compounds. Figure 1

Effect of the Saccharin Concentration on Electrodeposition of the Fe-Ni Alloy

The FMM (Fine Metal Mask) used in the OLED display manufacturing process is a metal sheet with holes formed to allow the deposition of diode material only in the sub-pixel area. To prevent deformation and misalignment of the FMM (Fine Metal Mask) caused by heat during the RGB organic deposition process, an Invar plate with a thermal expansion coefficient (CTE) close to 0 is used. The Invar sheet applied to the current FMM is manufactured through a metallurgical process, and its final thickness after rolling is 20 micron. However, due to limitations in reducing thickness with the rolling process, for manufacturing FMM with a thickness of under 10 micron for next-generation high-resolution (UHD-level) displays, the bottom-up electroplating process is suitable. However, to maintain the shape of the electroplated Invar sheet while ensuring commercial-grade low CTE, heat treatment at temperatures exceeding 600℃ for an extended period is required, utilizing thermo-mechanical processing methods. If uniformity in the microstructure composed of nano-grains is ensured in the electroplated Invar alloy in the As-deposited, it is possible to increase the efficiency of the process by reducing the heat-treatment processing cost.Therefore, in this study, we investigated the microstructural evolution in the Invar alloy by controlling the surface stress of the electroplated layer during pre-plating. We controlled the key additive, saccharin, in the Fe-Ni alloy electrolyte to assist the diffusion of iron and nickel ions. By examining the relation between microstructural uniformity, determined by the plated layer, and CTE, we propose optimized process conditions for the pre-plated Invar sheet.

Effects of 'dedo de moça' pepper extract administration on wistar rat pregnancy and fetal development

Introduction: The dedo de moça pepper is spicy due to capsaicin, which activates receptors in sensory neurons, generating a burning sensation. Studies suggest that capsaicin-sensitive neurons, by releasing neuropeptides, may affect uterine contraction. Objective: To evaluate the effect of chronic administration of capsaicin extract (Cps) during pregnancy in Wistar rats and their fetuses. Methodology: Pregnant female Wistar rats were divided into 4 groups (n = 5/group): Group I – Negative Control; Group II – Positive Control; Group III – Cps 1 – 0.25 mL; Group IV – Cps 2 – 0.5 mL. Exposure was initiated after embryo implantation (3rd day of pregnancy) until full term (20th day of pregnancy), with gavage performed three times per week. Results: On the 20th day, pregnant rats were euthanized, and outcomes evaluated included weight gain, placental morphology, reproductive capacity, and embryonic/fetal development. Ingestion of capsaicin extract resulted in negative impacts on fetal intrauterine growth parameters and placental alterations, with deposition of atypical hyaline material for gestational age and changes in vascular structures. Conclusion: The results indicate that capsaicin extract interfered with placental exchange, leading to intrauterine growth restriction of the fetuses.

Survival and Growth of Asellus aquaticus on Different Food Sources from Drinking Water Distribution Systems

Invertebrates, including Asellidae, are part of the natural ecosystem of the drinking water distribution system (DWDS) and are known to cause a nuisance to consumers. In addition, recently, the potential role of the species Asellus aquaticus (L. 1758) in the regrowth of Aeromonas bacteria was published. Aeromonas is included in the Dutch drinking water guidelines as a process parameter, and the guideline values are regularly exceeded. Although neither A. aquaticus nor Aeromonas is associated with health risks, the Evides drinking water utility shows a strong interest in the possible reasons for these exceedances and possible control measures. In surface waters, Asellidae feed mainly on decaying leaves that are abundantly present. These food sources are not present in the DWDS. Therefore, we determined suitable food sources for A. aquaticus in the DWDS. Laboratory experiments show that A. aquaticus individuals survive on biofilm on pipe wall material and loose deposits (sediments) collected from DWDS. Growth and survival rates on these loose deposits were even higher than on the positive control (decaying leaves). As the basis of these loose deposits is inorganic (iron deposits, sand, and pipe particles), the organic matter (living and decaying bacteria, protozoans, fungi, and invertebrates) must be their substrate. These experiments validate hypotheses that Asellidae can grow and survive on organic matter in deposits in DWDS.

Lanthanum deposition of the gastric mucosa in a dialysis patient.

A 49-year-old man presented for a screening esophagogastroduodenoscopy (EGD) as part of his registration for a donated kidney transplant. He had been on hemodialysis for 4 years for end-stage renal disease (ESRD) due to diabetic nephropathy. He was taking lanthanum carbonate (LaC) for hyperphosphatemia. A plain abdominal radiograph and CT showed the radiopaque appearance of LaC. EGD disclosed whitish spots resembling xanthomas in the stomach. Biopsies showed deposition of granular crystalline-like material and phagocytosis of these by multinucleated giant cells on HE staining. These histiocytes were positive for CD68. La deposition was suspected because of the long-term oral administration of LaC. LaC is commonly used to treat hyperphosphatemia in patients with ESRD. La deposition on the gastric mucosa presents with various endoscopic findings, including whitish spots, annular whitish mucosa, and diffuse whitish mucosa. The gastric endoscopic findings of La deposition reflect the infiltrated histiocytes and not the LC deposition itself. Our case highlights the importance of recognizing the rare but characteristic imaging findings of gastrointestinal La deposition in hemodialysis patients who are taking LaC.