Abstract
Introduction: The dedo de moça pepper is spicy due to capsaicin, which activates receptors in sensory neurons, generating a burning sensation. Studies suggest that capsaicin-sensitive neurons, by releasing neuropeptides, may affect uterine contraction. Objective: To evaluate the effect of chronic administration of capsaicin extract (Cps) during pregnancy in Wistar rats and their fetuses. Methodology: Pregnant female Wistar rats were divided into 4 groups (n = 5/group): Group I – Negative Control; Group II – Positive Control; Group III – Cps 1 – 0.25 mL; Group IV – Cps 2 – 0.5 mL. Exposure was initiated after embryo implantation (3rd day of pregnancy) until full term (20th day of pregnancy), with gavage performed three times per week. Results: On the 20th day, pregnant rats were euthanized, and outcomes evaluated included weight gain, placental morphology, reproductive capacity, and embryonic/fetal development. Ingestion of capsaicin extract resulted in negative impacts on fetal intrauterine growth parameters and placental alterations, with deposition of atypical hyaline material for gestational age and changes in vascular structures. Conclusion: The results indicate that capsaicin extract interfered with placental exchange, leading to intrauterine growth restriction of the fetuses.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
