There are concerns over the impact of the congested international match calendar on professional footballers' physical and mental well-being, and injury susceptibility. This study aimed to determine whether there were differences in match workload and international travel between injured and non-injured male football players over two elite competition seasons. An observational, retrospective, case-control study was conducted using data from the 2021/2022 and 2022/2023 seasons of five top-tier European men's football leagues. Student t-tests were used to compare cumulative match workload and international travel data over a 28-day period preceding 1270 injuries and 2540 controls. There were significant differences in match workload and international travel variables between the injured groups (all injuries and hamstring injuries) and the control group. Match workload variables were higher (p < 0.01), recovery variables lower (p < 0.01), and international travel variables higher (p < 0.01). An overload of match workload and international travel contribute to increased injury susceptibility in professional men's football. This emphasizes the need to address international match calendar concerns, including the number of games per season, the frequency of back-to-back games, and international travel requirements. Additionally, the findings highlight the importance of monitoring player match workloads, and implementing squad rotations and tailored training programs to mitigate injury risks.
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