Mat Group Research Articles

Substance use disorder risk assessment: positive emotional experiences with first time use and substance use disorder risk.

Substance Use Disorder (SUD) screening tools used in current practice are designed to identify SUD once patients have begun regular dangerous drug use. While these screening tools are valuable, prevention and avoidance of SUD would save countless lives. The climbing number of deaths due to drug overdose make screening for and prevention of SUD imperative. This study addresses this care gap. The aim was to develop a simple screening tool for patients who may be prone to develop Alcohol Use Disorder (AUD) and/or SUD prior to addiction. It was hypothesized that participants with initially positive emotional experiences would be correlated with a future SUD diagnosis. The study involved a self-administered survey using a cross-sectional design and was carried out over one-month in the spring of 2021. Those patients who presented to the MAT clinic (SUD group) were seen in a separate area than the patients presenting for urgent care (Comparison group). Participants (N=259) were voluntarily recruited from MAT and Urgent care: Patients receiving acute care were assigned to the Comparison (N = 126, 50.8% female, 5.7% non-white, 27.2% age < 34) and those receiving treatment for SUD were assigned to the MAT group (N =133, 40.8% female, 4.8% non-white, 36.8% ≤34). The survey questioned demographics (4 items), risk factors for AUD/SUD (6items), information about first alcohol/opioid experiences (16 items), and factors for seeking AUD/SUD treatment and recovery (2 items). Feelings were categorized as positive (e.g., euphoria, happiness, self-confident), neutral (e.g., nothing, normal), or negative (e.g., depressed, sad, sick). The MAT group felt more positive feelings with first usage of alcohol and opioids compared to the comparison group (p<.001). With first usage of opioids specifically, MAT (0.13 ± 0.04) and comparison (0.29 ± 0.07) groups differed (p <.001). Over half (55.3%), of the MAT participants reported feeling self-confident with first use of alcohol while only 29.7% of the comparison reported this (p<.001). Over three-fifths (63.7%) of the MAT group reported feeling of euphoria with the first usage of opioids compared to one-tenth (9.8%) in the comparison group (p<.001). This retrospective cross-sectional report shows the first affective responses to substances may predict risk for future SUD and could be a prevention screening tool. Asking patients about positive feelings with first usage of alcohol/opioids could be a simple screening tool employed for prevention.

Clinical comparison of aspiration to stentriever-mediated aspiration thrombectomy for M2 occlusions

ObjectiveWhile revascularization for M2 occlusions is generally recommended and considered beneficial, the optimal approach (aspiration vs stentriever/combined) is less well defined in the literature. We sought to compare outcomes after thrombectomy with manual aspiration thrombectomy alone (MAT) or stentriever-mediated aspiration thrombectomy (SMAT) Materials and MethodsTo circumvent inter-operator technical variability, patients underwent thrombectomy for M2 occlusions by a single operator and were stratified by first pass approach: manual aspiration thrombectomy (MAT/aspiration alone) and stentriever-mediated manual aspiration thrombectomy (SMAT/combination). Efficacy outcomes included good reperfusion (mTICI score ≥2b) and a favorable 90-day functional outcome (mRS score of ≤2). Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage. ResultsOne hundred three patients were identified: 57 underwent MAT whereas 46 underwent SMAT. Good reperfusion (TICI 2b or greater) was comparable between groups (93.5 % vs. 87.7 %, P=0.33). The intracranial hemorrhage rate was higher with SMAT compared to MAT (13 % vs. 1.8 %, P=0.04). Puncture-to-recanalization time was longer in SMAT (34.4 vs. 19.9 minutes, P<0.001). In multivariable analysis, complete or good reperfusion was associated with shorter puncture-recanalization time (adjusted odds ratio [aOR], 0.85) or less total passes (aOR, 0.58), respectively. In a propensity score matched analysis of 66 patients with comparable baseline and technical efficiency, the safety outcomes were not different between SMAT and MAT groups. ConclusionsSMAT compared with MAT did not result in an improved revascularization rate or functional outcome, while it was related to more hemorrhagic complications and mortality. Given cost and time savings with manual aspiration alone, this approach may be optimal as first line for M2 occlusions.

Ultra-high density mapping and ablation of localized microreentrant tachycardias: insight from the CHARISMA registry

Abstract Background The optimal criteria for distinguishing microreentrant atrial tachycardias (mAT) from macroreentrant atrial arrhythmias (MAT) in clinical practice have not been definitively established. Recent advancements in ultra-high-density mapping featuring automated functionalities, has enhanced our understanding of mAT circuits and the precise localization of foci. Purpose Our intent was to observe the diagnostic support provided by high density mapping and Lumipoint algorithm in mAT as well as the ablation outcomes. Methods Consecutive patients eligible for atrial tachycardia (AT) ablation in 22 Italian centres were prospectively enrolled. all ATs were comprehensively mapped in either the left or right atrium utilizing the Rhythmia mapping system and the 64-pole Orion basket catheter. A mAT was defined as an AT characterized by slow, continuous, low fragmented potentials covering a minimum of 50% of the tachycardia cycle length (CL) within a confined area (defined as a circuit within &amp;lt; 1 cm2), enclosed by a couple of closed splines of the Orion catheter, and exhibiting a centrifugal activation pattern to the rest of the atria. The Lumipoint tool was systematically employed to confirm electrogram fragmentation within this defined area. Results Among 159 ATs analysed, 97 (61.0%) were identified as MAT, 50 (31.4%) as focal atrial tachycardias and 12 (7.5%) as mAT. Of these latter, 6 patients (50%) had a previous history of atrial ablation procedure. Concerning the mAT group, the predominant origin site was the left atrium (10 mAT, 83,3%); the targeted activity was localized in the anterior wall in 4 cases (33.3%), in proximity to PVs in 3 cases (25%), along the left ridge in 2 cases (16.6%) and at the roof in 1 case (8,3%). In the remaining right mAT, the foci were found in the free wall and along the CTI in 1 case (8.3% each). The electrical activity spanning the whole CL was detected by 2.7±1.8 pairs of close bipoles of the Orion catheter, was confined to a region of 0.36±0.3cm2 with the longest component of fractionated EGM per spline equal to 64.7±17% of the CL. Low voltage areas (&amp;lt;0.1 mV) were detected in all mAT cases and colocalized with the origin site. Voltage level was 0.2±0.1mV at the site of longest duration of the fragmented potential. A single shot RF delivery terminated each arrhythmia at targeted location. Consolidative RF ablations were then delivered in the adjacent area. Over a median of 288 [248-349] days of follow-up, 5 (3.1%) patients suffered from an AT/AF arrhythmia recurrence and of these, 3 (3.1%) were in the MAT group, 1 (2%) in the focal AT and 1 (8.3%) in the mAT group. No complications were observed. Conclusions A novel automated algorithm for microreentrant atrial tachycardia identification, coupled with the identification of matched areas of electrogram fractionation by the Orion catheter, may restrict the extent of required ablation and result in a low arrhythmia recurrence.

THE EFFECT OF TRADITIONAL MAT EXERCISES VERSUS REFORMER PILATES AND HAMMOCK YOGA ON PAIN, ENDURANCE, BALANCE, DISABILITY, AND QUALITY OF LIFE IN INDIVIDUALS WHO HAD CHRONIC BACK PAIN

Objective: The aim of this study to examine the effects of traditional mat exercises, Reformer Pilates (RP) and Hammock Yoga (HY) approaches on pain, endurance, balance, disability, and quality of life of individuals who had Chronic low back pain (LBP). Method: 60 individuals who had Chronic LBP were participated and randomly attended into 3 groups as RP group (n=20, mean age:31.85±8.89 years), HY group (n=20, mean age:29.90±6.70 years), and mat group (n=20, mean age:30.40±8.21 years). All exercise training was applied twice a week for 4 weeks (45 minutes). The pain was evaluated with VAS and McGill, endurance was evaluated with plank tests and single leg hip bridge test, static balance was assessed with standing on single leg, and dynamic balance was assesed with the Star Excursion Balance Test. The Oswestry Disability Questionnaire and World Health Organization Quality of Life (WHOQOL-Bref) were used for disability and quality of life measurements, respectively. Results: Improvements were observed on a group basis in all evaluated parameters (p

Effects of Nesting Material Provision and High-Dose Vitamin C Supplementation during the Peripartum Period on Prepartum Nest-Building Behavior, Farrowing Process, Oxidative Stress Status, Cortisol Levels, and Preovulatory Follicle Development in Hyperprolific Sows.

Hyperprolific sows often experience increased oxidative stress during late gestation and lactation periods, which can adversely affect the farrowing process and overall lactation performance. This study examines the influence of providing a coconut coir mat (CCM; 1 × 1 m) as nesting material, supplementing high-dose vit-C (HVC; 20% vit-C, 10 g/kg feed) as an antioxidant, or both on maternal behavior, the farrowing process, oxidative status, cortisol levels, and preovulatory follicle developments in sows with large litters. In total, 35 sows (Landrace × Yorkshire; litter size 15.43 ± 0.27) were allocated to the following four treatment groups: control (n = 9, basal diet), vit-C (n = 8, basal diet + HVC), mat (n = 10, basal diet + CCM), and mat + vit-C (n = 8, basal diet + HVC + CCM). A post-hoc analysis showed that compared with sows that were not provided CCM, mat and mat + vit-C groups demonstrated increased durations of nest-building behavior during the period from 24 h to 12 h before parturition (p < 0.05 for both), reduced farrowing durations, and decreased intervals from birth to first udder contact (p < 0.01 for both). The mat group exhibited lower advanced oxidation protein product (AOPP) levels during late gestation and lactation periods than the control group (p < 0.05). Sows with HVC supplementation showed longer farrowing durations than those without HVC supplementation (p < 0.0001). The vit-C group had higher salivary cortisol levels on day 1 after farrowing than the other treatment groups (p < 0.05). Furthermore, the follicle diameters on day 3 after weaning in the vit-C group tended to be smaller than those in the control group (p = 0.077). HVC supplementation prolonged farrowing and increased the physiological stress on postpartum, and no advantageous effects on maternal behavior and developmental progression of preovulatory follicles were observed. Hence, alternative solutions beyond nutritional approaches are required to address increased oxidative stress in hyperprolific sows and secure their welfare and reproductive performance. The present results substantiated the positive impact of providing CCM as nesting material for sows with large litters on nest-building behavior and the farrowing process, which could mitigate the deleterious consequences induced by peripartum physiological and oxidative stress.

Effects of flooring types on teat end bacteria counts, milk quality, hygiene and behaviour of dairy cows housed in tie-stall closed barn.

This study aimed to investigate environmental mastitis causing bacteria counts in the teat end, somatic cell counts (SCC) of milk samples, cleanliness scores and behavior of cows kept on concrete and rubber mat floorings. For this purpose, 19 Holstein-Friesian dairy cows were allocated into concrete and rubber mat groups. Swab samples were taken from the teat ends to determine the bacterial counts causing environmental mastitis. Milk samples were collected from a composite of all four quarters to determine the SCC. Instantaneous sampling method was utilized to observe the behavioral activities of cows. Cows were visually evaluated to determine the udder cleanliness score. Independent samples t-test was utilized in the statistical analysis of the obtained data. Coliform (P<0.05), Escherichia coli, and Klebsiella spp. (P<0.01) counts of the swab samples taken from the cows housed on concrete flooring were significantly higher than rubber mat group. However, no statistically significant differences were found between groups in terms of total bacteria, Streptococcus spp., and Enterobacteriaceae counts. The SCC on samples taken from cows kept on concrete surface were significantly higher (P<0,05) than that of animals housed on rubber mat. Furthermore, cows in the rubber mat group were determined to be significantly cleaner (P<0.05) than those in concrete group. It was also determined that the cows housed on rubber mat spent significantly longer time for lying behavior (P<0.05), which is a significant indicator of animal comfort. The time spent for standing without eating was considerably higher (P<0.01) in concrete group. In addition, the times spent for eating was significantly lower (P<0.01) in the concrete group. It was concluded that, using rubber mat instead of concrete for flooring in tie-stall barns decreases the contamination of environmental mastitis pathogens, increases milk quality and cow cleanliness score as well as animal comfort and welfare.

The effects of aligned poly(lactic-co-glycolic acid) nanofibrous mat containing gold nanoparticles after planting onto an injured spinal cord

Transplanted cells rarely survive because of the inflammatory cytokines after spinal cord injury. To increase the survival, we synthesized a hydrophilic and aligned nanofibrous mat. We electrospun thiolate (SH)/aligned (A) poly(lactic-co-glycolic acid) (PLGA) nanofibrous mats. The PLGA-SH (A) nanofibrous mats were conjugated with gold nanoparticles (GNPs) to increase the hydrophilicity. The contact angle is decreased from 105.3° ± 5.2 (for randomly directional PLGA mats) to 28.1° ± 2.8 (for PLGA-GNP (A) mats). Green fluorescent protein (GFP)-expressing neural progenitor cells (NPCs) were dissociated from the embryonic spinal cords of Fisher 344 rats. We embedded the embryonic spinal-cord-derived NPCs in glycol chitosan (gC)-oxidized hyaluronate (oHA) hydrogels (=NPC graft). The NPC graft was transplanted into spinal-cord-injured Sprague-Dawley rats. Afterwards, the aligned PLGA-GNP nanofibrous mat was positioned onto the NPC-grafted region (=Injury + NPC graft + PLGA-GNP (A) nanofibrous mat (INP) group). We also added Injury (=I) and Injury + NPC graft (=IN) groups as control groups. The survival outcomes of transplanted NPCs were noticeably increased in the INP group compared to those in the IN group. We suggest a separate implanting therapy of NPCs and a hydrophilic PLGA-GNP (A) nanofibrous mat for spinal cord injuries.

The submucosal approach influences long-term outcomes of refractory obstructive rhinitis: A prospective study and a STROBE analysis

ObjectiveThe surgical approach to refractory hypertrophy of the inferior turbinates is the main therapeutic choice in the management of its symptoms. Although submucosal approaches have demonstrated efficacy, long-term results are debated in the literature and show variable stability. Therefore, we compared the long-term outcomes of three submucosal turbinoplasty methods with regard to the efficacy and stability managing the respiratory disorders. DesignMulticenter prospective controlled study. A computer-generated table was used to allocate participants to the treatment. SettingTwo teaching and university medical centers. MethodsWe used the EQUATOR network for guidelines describing design, conduct, and reporting of studies and searched the references of these guidelines to identify further relevant publications reporting adequate study protocols.Patients with persistent bilateral nasal obstruction due to lower turbinate hypertrophy were prospectively recruited from our ENT units. Participants were randomly assigned to each treatment and then underwent symptom assessment by visual analog scales, endoscopic assessment at baseline and 12, 24 and 36 months after treatment. ResultsOf the 189 patients with bilateral persistent nasal obstruction initially assessed, 105 met the study requirements; 35 were located in the MAT group, 35 in the CAT group and 35 in the RAT group. Nasal discomfort was significantly reduced after 12 months with all the methods. The MAT group presented better outcomes for all VAS scores at the 1-year follow-up, greater stability at the 3-year follow-up for VAS results (p < 0.001 in all cases) and lower disease recurrence (5/35; 14.28 %). At the 3-year follow-up intergroup analysis, a statistically significant difference was confirmed except for RAA scores (H = 2.88; p = 0.236). Rhinorrhea (r = −0.400; p < 0.001) was demonstrated as a predictive factor of 3-year recurrence, while sneezing (r = −0.25; p = 0.011), and operative time needed (r = −0.23; p = 0.016) did not reach statistical significance. ConclusionsLong-term symptomatic stability varies depending on the turbinoplasty method used. MAT demonstrated greater efficacy in controlling nasal symptoms, presenting better stability in reducing turbinate size and nasal symptoms. In contrast, radiofrequency techniques presented a higher rate of disease recurrence both symptomatically and endoscopically.

The Effect of Earthing Mat on Stress-Induced Anxiety-like Behavior and Neuroendocrine Changes in the Rat.

Grounding is a therapeutic technique that involves doing activities that "ground" or electrically reconnect us to the earth. The physiological effects of grounding have been reported from a variety of perspectives such as sleep or pain. However, its anti-stress efficacy is relatively unknown. The present study investigated the stress-related behavioral effects of earthing mat and its neurohormonal mechanisms in the Sprague-Dawley male rat. Rats were randomly divided into four groups: the naïve normal (Normal), the 21 days immobilization stressed (Control), the 21 days stressed + earthing mat for 7 days (A7) or 21 days (A21) group. The depressive-and anxiety like behaviors were measured by forced swimming test (FST), tail suspension test (TST) and elevated plus maze (EPM). Using immunohistochemistry, the expression of corticotrophin-releasing factor (CRF) and c-Fos immunoreactivity were analyzed in the brain. In the EPM, time spent in the open arm of the earthing mat groups was significantly increased compared to the Control group (p &lt; 0.001), even though there were without effects among groups in the FST and TST. The expression of CRF immunoreactive neurons in the earthing mat group was markedly decreased compared to the Control group. Overall, the earthing mat reduced stress-induced behavioral changes and expression of c-Fos and CRF immunoreactivity in the brain. These results suggest that the earthing mat may have the potential to improve stress-related responses via the regulation of the corticotrophinergic system.

Comparison of Conventional Surgical Turbinoplasty Versus Microdebrider Assisted Turbinoplasty in Cases of Inferior Turbinate Hypertrophy

Objective: To compare the conventional surgical turbinoplasty versus microdebrider assisted turbinoplasty in cases of inferior turbinate hypertrophy. Design of the Study: It was a cross-sectional survey. Place and Duration of Study: This study was carried at the Department of ENT Nishtar Medical University and Hospital, Multan from January 2022 to June 2022. Patients and Methods: Patients with hypertrophy of the inferior turbinates, the most common cause of nasal obstruction, were split into two groups of 30. The size of the inferior turbinates was classified as Grade I if they took up less than a third of the nasal cavity, Grade II if they took up more than a third but less than half, and Grade III if they took up more than half. Each group had either a standard partial inferior turbinectomy or a turbinoplasty with the help of a microdebrider. Visual evaluation was used to categorise blood loss during and after surgery. Patients were checked on at 1, 2, 4, and 6 months after surgery. Relief from symptoms and the occurrence of problems such crusting and synechiae formation were evaluated. Results of the Study: Both groups showed comparable significant improvements in nasal blockage. Most patients in the CPIT group experienced intraoperative blood loss of grade II (66.66%) or grade III (10%). When the packs were taken off, 60% of patients experienced grade I blood loss, 36.66% experienced grade II blood loss, and 3% experienced grade III blood loss after surgery. Most patients (46%) and surgeons (40%) in the MAT group experienced grade II or higher intraoperative blood loss. The majority of patients' postoperative blood loss was classified as grade I. Six months later, 6.66 percent of the CPIT group had acquired crusting, and 6.66 percent had developed synechiae. Those that received MAT did not have these problems. Practical implication: The choice of surgical procedure is up to the surgeon's attitude and experience due to the lack of agreement regarding their efficacy. That’s why we compared the effectiveness of these treatment methods for turbinate reduction in order to provide evidence to evaluate the results of the several surgical techniques in local population. Conclusion: According to the findings, both surgical approaches are effective in addressing nasal blockage. Complications are less likely to occur with microdebrider-assisted inferior turbinoplasty since the mucosa and nasal physiology are preserved. Keywords: Microdebrider assisted inferior turbinoplasty, Hypertrophied inferior turbinate, Conventional partial inferior turbinectomy,

A comparison of the effect of different forms of Graphene and Polyvinylpyrrolidone on physically strengthening PMMA

Aim: The aim of this study was to compare the effects of powder, mat, and sheet forms of graphene and polyvinylpyrrolidone (PVP) on the bending strength of polymethyl methacrylate (PMMA). Methodology: A total of 75 PMMA samples (64 x 13 x 3 mm) were obtained and separated into five groups of 15, one of which was the control group. No strengthening material was added to the control group samples. In the PMMA+Polyvinylpyrrolidone powder (PVPP) (Group B) and PMMA+Graphene powder (GP) groups (Group D), PVP (0.5%) and graphene (0.01%) powders, respectively were added to the PMMA. In the PMMA+Polyvinylpryrolidone fiber mat (PVPM) (Group C) and PMMA+Graphene sheet (GS) groups (Group E), a PVP mat and graphene sheet, respectively were placed in the center of a square PMMA resin mold. To measure the samples’ resistance to bending, the three-point bending test (ISO 1567) was applied. Fracture lines were examined under a scanning electron microscope (SEM), and bending strength was analyzed using one-way analysis of variance (ANOVA). Results: A statistically significant difference was determined between the GS (118.5093 ± 11.94859 Mpa) and PVPP (105.5267 ± 6.80595 Mpa) groups. The mean bending resistance values were numerically higher in the PVPM (115.8487 ± 17.15440), GS (118.5093 ± 11.94859), and GP (116.2680 ± 16.03207) groups compared to the control group (108.2407 ± 24.23104). The graphene sheets and PVP mats showed higher resistance to bending than the powder form of either material. Conclusion: In clinical dental prosthesis use, PVP mats and graphene sheets are preferable with respect to both PMMA strengthening and color. How to cite this article: Mutluay Ünal S. A comparison of the effect of different forms of Graphene and Polyvinylpyrrolidone on physically strengthening PMMA. Int Dent Res 2022;12(2):62-9. https://doi.org/10.5577/intdentres.2022.vol12.no2.4 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Emphasizing mindfulness training in acceptance relieves anxiety and depression during pregnancy

Mindfulness intervention, which trains participants to monitor momentary experiences with an accepting attitude, is effective for reducing maternal anxiety and depression. Monitoring and acceptance are two central components of mindfulness training. The aim of the study is to clarify whether adding acceptance component to monitoring training can help improve the mental health of pregnant people by comparing the effects between mindfulness training on monitoring with an emphasis on acceptance training and training on monitoring alone.Pregnant people with depressive or anxious symptoms (N = 149) were randomized to either a 4-week online intervention of (1) monitoring training (MT), (2) monitoring with an emphasis on acceptance training (MAT), or (3) emotional regulation course conditions as an active control group. All mindfulness training was based on the WeChat platform. We used the Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire (PHQ-9), Five Facets of Mindfulness Questionnaire (FFMQ), and Regulatory Emotional Self-Efficacy Scale (RESE) to evaluate symptoms of anxiety and depression, mindfulness monitoring and acceptance skills, and the self-efficacy of emotional regulation pre-and postintervention. Of the 149 people enrolled in this study, 10 in the MT training group, 9 in the MAT group, and 15 in the control group did not complete the intervention. Monitoring with an emphasis on acceptance training significantly reduced symptoms of anxiety and depression and improved perceived self-efficacy in managing depression/distress compared with the monitoring training alone and the control group. In addition, participants in the monitoring group showed a downward trend in GAD-7 scores and an upward trend in scores of perceived self-efficacy in managing anger/irritation. This study not only shows that the 4-week online mindfulness training could be a promising technique to help people improve mental health; moreover, it provides evidence that emphasizing acceptance skills on mindfulness training may play a critical role because of its positive effects. We suggest that the online mindfulness intervention should be added as part of psychological care and recommend emphasizing acceptance training during pregnancy.

Diagnostic Value of Artificial Intelligence Based on CT Image in Benign and Malignant Pulmonary Nodules.

Objective To evaluate the diagnostic value of artificial intelligence-assisted CT imaging in benign and malignant pulmonary nodules. Methods The CT scan screening of pulmonary nodules from November 2018 to November 2020 was retrospectively collected. The diagnosis of pulmonary nodules and surgical treatment were performed. A total of 194 nodules in 152 patients with clear pathological results were observed. All patients underwent CT examination to analyze the consistency of the results of artificial intelligence, physician reading according to imaging features, multidisciplinary team work (MDT) diagnosis, and postoperative pathological results; the diagnostic efficacy of different diagnostic methods for solitary pulmonary nodules and the differences of ROC curve and AUC were analyzed. The accuracy, specificity, sensitivity, positive predictive value, negative predictive value, false negative rate, and false positive rate of different diagnostic methods for pulmonary nodules were calculated, and the ROC curves of different diagnostic methods were plotted. Results The accuracy, sensitivity, specificity, and Youden index of artificial intelligence (AI) were 89.69%, 92.98%, 65.22%, and 58.20%; the accuracy, sensitivity, specificity, and Youden index of physician reading were 85.57%, 88.30%, 65.22%, and 53.52%; the accuracy, sensitivity, specificity, and Youden index of MDT were 96.91%, 98.25%, 86.96%, and 85.21%, respectively. The kappa values of artificial intelligence, physician reading, and MDT were 0.541, 0.437, and 0.852, and the AUC was 0.768, 0.791, and 0.926, respectively (P < 0.001). The average detection time of pulmonary nodules in the AI group, manual reading group, and MAT group was (145 ± 97) s, (534 ± 297) s, and (421 ± 128) s (P < 0.001). Conclusion Artificial intelligence pulmonary nodule detection system can improve the coincidence rate and accuracy of early diagnosis of lung cancer, shorten the average detection time, and provide more accurate information for clinical decision-making.

Investıgatıon of the effect of Pilates Exercıses on the Functıonal Parameters of Middle Age Sedantery Women

This study aimed to investigate the effects of 8-week mat and reformer pilates exercises on functional movement skills, flexibility of adult healthy sedentary women. 58 [reformer exercise group (n: 20), mat exercise group (n: 21) and control group (n: 17)] volunteer women participated in the study. Functional Movement Screen test (FMS), sit and reach test, Trunk lateral flexion test, Quadriceps Femoris and M.Iliopsoas flexibility test were applied to the participants. Two-way repeated measures ANOVA was used in the analysis of the obtained data. Additionally, Bonferroni test, one of the multiple comparison tests, was used to determine the source of the difference between groups. Moreover, the percentage changes of eight-week exercises on FMS scores, flexibility and strength parameters of adult women were determined by using the formula %Δ= [(Post-test - Pre-test) / Pre-test*100]. According to the results of the study, it was determined that there was a statistically significant difference in the total FMS mean scores and flexibility test results of the exercise group and the control group. There was a higher increase in FMS scores and lower extremity flexibility values of the reformer group compared to the mat group, on the other hand, upper extremity flexibility levels of the mat group were found to be higher than the reformer group. As a result, it was determined that 8-week mat and reformer pilates exercises had a positive effects on some functional movement skills and flexibility parameters in adult healthy sedentary women. Keywords: Mat pilates, Reformer pilates, Functional movement screen

Medication-assisted treatment and self-help group participation among military veterans with opioid or alcohol use disorder

IntroductionMedication-assisted treatment (MAT) is a combination of behavioural therapy and medications to assist with recovery and has been administered to individuals with alcohol and opioid withdrawal symptoms. Military veterans seeking...

Evaluation of Polyacrylonitrile Nonwoven Mats and Silver-Gold Bimetallic Nanoparticle-Decorated Nonwoven Mats for Potential Promotion of Wound Healing In Vitro and In Vivo and Bone Growth In Vitro.

We prepared polyacrylonitrile (PAN) and urchin-like Ag–Au bimetallic or Ag nanoparticle-decorated PAN nonwoven mats using electrospinning and evaluated them in vitro and in vivo for wound healing, antibacterial effects on skin tissue, and promotion of bone ingrowth in vitro. A facile, green, low-temperature protocol was developed to obtain these nonwoven mats. The sterilization rate of urchin-like Ag–Au bimetallic and Ag nanoparticle-decorated PAN nonwoven mats against Staphylococcus aureus was 96.81 ± 2.81% and 51.90 ± 9.07%, respectively, after 5 h treatment. In an in vitro cell model, these two mats did not show significant toxicity; cell viability of >80% was obtained within 5 h of treatment. In vivo animal model preclinical assessment showed that the urchin-like Ag–Au bimetallic nonwoven mat group showed significant wound recovery because of sebaceous gland, hair follicle, and fat formation during skin tissue regeneration; increased neovascularization and compact collagen fibers were observed in the dermal layer, comparable to the findings for the control group. The mother substrate of the urchin-like Ag–Au bimetallic nanoparticle-decorated PAN nonwoven mats, that is, pure PAN nonwoven mats, was found to be a potential scaffold for bone tissue engineering as osteoblast ingrowth from the top to the bottom of the membrane and proliferation inside the membrane were observed. The key genetic factor Cbfa1 was identified as a key osteoblast differentiation regulator in vitro. Thus, electrospun membrane materials show potential for use as dual-functional biomaterials for bone regeneration and infection control and composite grafts for infectious bone and soft tissue defects.

Microdebrider-Assisted Turbinoplasty and Submucosal Diathermy for Inferior Turbinate Hypertrophy: A Randomized Clinical Trial

ABSTRACT &#x0D; Background: Nasal obstruction is a common presenting problem which can lead to symptoms like sleep disturbances, mouth breathing, oral cavity dryness. Hypertrophied inferior turbinate is a common cause of nasal obstruction. Microdebrider assisted turbinoplasty and submucosal diathermy are widely used methods for patients who fail to respond to medical therapy to relieve obstruction. The aim of the study was to compare two methods in terms of relief of nasal obstruction, reduction in sneezing and post-operative complications.&#x0D; Material &amp; Methods: This randomized clinical trial was conducted at ENT Department, Benazir Bhutto Hospital Rawalpindi, Pakistan for one year from 01-03-2018 to 28-02-2019. One hundred and twenty patients were randomized to into either MAT and SMD groups each with 60 patients. Nasal obstruction symptom evaluation score system (NOSE) was used to access relieve from obstruction and sneezing. SPSS 22, online chai square and fisher exact test calculators were used to analyze the data.&#x0D; Results:&#x0D; Two groups were comparable for age and gender. After 3 months of treatment, all patients in MAT group and 51 patients in SMD group were completely relieved from obstruction. At two weeks follow up 37(61.57%) patients in MAT group had grade 0 obstruction compared with 14 (23.33%) in SMD group and this difference was significant (p value .000). at one month follow up 55 (91.67%) patients in MAT while 46 (76.67%) had completely relieved obstruction and this difference was significant ( p value .024). Not all patients showed reduction in sneezing in both groups. 37 patients in MAT and 25 patients in SMD group had completely relieved from sneezing at third month follow up with MAT group showing significantly more patients with sneezing reduced at one month follow up. Crust formation was most seen complication in both groups, more with SMD group at two weeks follow up which responded to treatment alkaline nasal douches and crust removal.&#x0D; &#x0D; Conclusion:&#x0D; MAT gives better in terms of nasal obstruction relieved, reduction in sneezing and less complications than SMD procedure.&#x0D; KEYWORDS: Microdebrider; Diathermy; Turbinates; Nasal obstruction&#x0D;

Effect of mat vs. apparatus pilates training on the functional capacity of elderly women

IntroductionIt is well known that physical exercise improves functional capacity (FC), promoting healthy aging. The Pilates method (PM) is an example of well-accepted physical exercise by the elderly and has been reported in studies to be beneficial for this population. However, it is not yet known whether there is a difference between the practice of mat and apparatus PM. The goal of this study was to compare the effect of mat versus apparatus Pilates training on functional capacity in elderly women. Method: 48 active elderly women (65.15 ± 3.0 years old), independent or partially independent in Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL), who had never practiced Pilates, were separated into three groups in a random order through a draw: Mat Group (MG = 15), Apparatus Group (AG = 16) and Control Group (CG = 17). Pilates training sessions were applied to MG and AG for 8 weeks, with two weekly sessions of 50 min. The FC of the three groups was evaluated by the Senior Fitness Test (SFT) battery, pre and post intervention. Results: There were improvements in lower and upper limb strength, aerobic endurance, lower and upper limb flexibility, and agility after the intervention in both groups, showing no significant differences when compared to mat and apparatus Pilates training (<0,05). Conclusion: The mat and apparatus Pilates training provide significant and similar improvements in the functional capacity of elderly women.

Remedying Contact Dermatitis in Broiler Chickens with Novel Flooring Treatments.

Contact dermatitis (footpad dermatitis (FPD), hock burns, and breast dermatitis) is a welfare issue for broiler chickens, causing pain and behavioral restrictions. Once lesions develop, often nothing is done to remedy the issue for the affected flock. Our objective was to evaluate novel flooring treatments at the flock level by providing preventative and remedial treatments against contact dermatitis, plumage soiling, and gait impairment. Broilers (n = 546) were housed in 42 pens, with 13 birds/pen. The flooring treatments (four) included used litter (NEG), new pine shavings replaced regularly (POS), a mat filled with 1% povidone-iodine solution (MAT), and the iodine mat placed on a slatted floor (SLAT). Flooring treatments were provided from day one of age (preventative approach; PREV) or day 29 (remedial approach; REM). Contact dermatitis, soiling, gait, and weight were recorded weekly (seven birds/pen). Results showed a treatment effect for all measures, dependent on bird age. Overall, the POS treatment resulted in the best welfare outcomes (FPD, hock burns, and gait). The worst contact dermatitis was found in the MAT and SLAT groups. NEG birds showed little contact dermatitis, opposite to expectations. Weights were lower for PREV-POS in week seven only. The treatments with povidone-iodine were deemed ineffective against contact dermatitis. Access to clean litter prevented and remedied contact dermatitis, and a comparable approach may be commercially feasible.

The Phosphodiesterase Inhibitor, Isobutyl-1-Methylxanthine Prevents the Sudden Drop in Cyclic Adenosine Monophosphate Concentration and Modulates Glucose Metabolism of Equine Cumulus–Oocyte Complexes Matured in Vitro

Spontaneous nuclear maturation of mammalian oocytes can occur when physically removed from the ovarian follicle during in vitro oocyte maturation (IVM), largely because of a decrease in cyclic adenosine monophosphate (cAMP) concentration. Modulation of oocyte cAMP during IVM by using phosphodiesterase inhibitors has been shown to maintain elevated oocyte cAMP concentrations and control meiotic resumption of bovine and ovine oocytes. This study determined the effect of inclusion of isobutyl-1-methylxanthine (IBMX) during collection and the first 12 hours of incubation of equine oocytes on cAMP concentration and glucose metabolism of cumulus–oocyte complexes (COCs). Abattoir-derived COCs were collected in aspiration medium with (Asp-IBMX) or without (Asp) IBMX. Cumulus–oocyte complexes were then incubated for 12 hours in IVM medium with (Mat-IBMX) or without (Mat) IBMX, followed by additional 24 hours in Mat medium. The cAMP concentration, glucose consumption, lactate production, and metaphase II rates of the COCs were assessed. Cumulus–oocyte complexes aspirated into Asp-IBMX (62.2 ± 2.6 fmol per COC) medium had higher cAMP concentration than Asp (31.8 ± 2.8 fmol per COC) control group (P < .05). Likewise, at 12 hours of IVM, Mat-IBMX group (33.2 ± 2.1 fmol per COC) had higher cAMP concentration than the Mat group (7.68 ± 0.5 fmol per COC; P < .05). Glucose consumption and lactate production were lower during the first 12 hours of incubation in COCs cultured in Mat-IBMX (P < .05). Isobutyl-1-methylxanthine prevented the rapid drop in cAMP concentration and altered metabolism of glucose by the COC. Preventing the sudden drop in cAMP prevents the premature nuclear maturation of in vitro–matured oocytes causing poor developmental competence.