Large-scale earthquakes and huge landslide surges may cause the failure of cascade reservoirs, resulting in massive downstream flooding. The flood risk zoning of cascade reservoir dam breaks is crucial for local governments to formulate emergency plans and for individuals to garner their awareness of the flood risks. This paper presents a flood risk zoning approach based on a one-dimensional and two-dimensional coupled hydrodynamic model. The flooding area simulated by the coupled hydrodynamic model was divided into a Deadly Zone (D-zone) and an Escape Zone based on whether there is sufficient time for the public to evacuate the danger area under a specific evacuation generation time (EGT). A case study was conducted on the Jinsha-Yalong River (JYR), a confluence river located in Panzhihua City, to map the risk zones. This study considered a dam-break flood in Yalong River encountering two river flood scenarios in Jinsha River (scenario A: the annual average flow; scenario B: a 1000-year return period flood). Two evacuation scenarios (EGT of 30 and 60 min) were also considered; thereafter, four combined evacuation scenarios (A-EGT30, A-EGT60, B-EGT30, and B-EGT60) were simulated. The coupled hydrodynamic model is demonstrated to be effective through the analysis of water balance and hydrographs of special section discharge. The results show that: (1) in comparison to scenario A, scenario B reached its maximum flood extent approximately 5 min earlier, signifying that flood spread speed increases with the increase in flood magnitude; (2) the D-zone area was 127.7 % larger in scenario A-EGT60 compared to A-EGT30 and 120.8 % larger in scenario B-EGT60 compared to B-EGT30. These findings underscore the importance of flood scenarios and EGT on flood risk zones. The proposed risk zoning method can help government agencies in the JYR and major river regions worldwide with flood management and emergency strategy development.