Mass Ratio Research Articles

Encapsulation of a 5FU-curcumin hybrid on bacterial nanocellulose for colorectal cancer treatment

The traditional treatment of colorectal cancer (CRC) involves a combination of chemotherapy and synthetic and natural drugs. In this study, a hybrid compound of 5-fluorouracil-curcumin encapsulated in bacterial nanocellulose (BNC) was evaluated for CRC treatment. Bacterial nanocellulose was produced using K. medellinensis and spray-dried. The encapsulation technique involved solvent evaporation. The interactions between cellulose and the hybrid were evaluated using adsorption isotherms and kinetics, and the system was morphologically and physiochemically characterized. The capsules were tested in vitro using Dukes' C and B CRC cells. The results indicated heterogeneous and incomplete adsorption of the hybrid onto the active sites of cellulose. Capsules with a BNC:hybrid mass ratio of 1:1 maintained the encapsulant properties while maximizing the drug load according to desorption in simulated stomach and colon fluids, where desorption in the colon was 1.79 times greater than that in the stomach. Finally, the cancer cell inhibition results indicated that the encapsulated hybrid performed better on Dukes' C-stage cells than on Duke's B-stage cells. In this study, a new system based on a hybrid cellulose compound was proposed for CRC treatment, specifically for metastatic CRC.

A Merger-driven Scenario for Clumpy Galaxy Formation in the Epoch of Reionization: Physical Properties of Clumps in the FirstLight Simulation

Recent JWST observations with superb angular resolution have revealed the existence of clumpy galaxies at high redshift through the detection of rest-frame optical emission lines. We use the FirstLight simulation to study the properties of (sub)galactic clumps that are bright in the [O III] λ5007 line with flux greater than ∼10−18 erg s−1 cm−2, to be detected by JWST. For 62 simulated galaxies that have stellar masses of (0.5–6) × 1010 M ⊙ at z = 5, we find clumps in 1828 snapshots in the redshift range z = 9.5–5.5. The clumps are identified by the surface density of the star formation rate (SFR). About one-tenth of the snapshots show the existence of clumpy systems with two or more components. Most of the clumps are formed by mergers and can be characterized by their ages: central clumps dominated by stellar populations older than 50 Myr, and off-centered clumps dominated by younger stellar populations with specific SFRs of ∼50 Gyr−1. The latter type of young clumps is formed from gas debris in the tidal tails of major mergers with baryonic mass ratios of 1 ≤ q < 4. The merger-induced clumps are short-lived and merge within a dynamical time of several tens of million years. The number density of the clumpy systems is estimated to be ∼10−5 cMpc−3, which is large enough to be detected in recent JWST surveys.

Preparation and characteristics of zein/ethyl cellulose composite coating applied in aqueous system

Zein and ethyl cellulose (EC) were used as raw materials to prepare a composite coating applied in aqueous systems with mechanical properties, water stability, water solubility (including room-temperature (RT)/high-temperature and neutral/acidic conditions), and oil resistance as evaluation index. Results showed the most suitable conditions were mass ratio of zein/EC at 1:9, 93 % (v/v) aqueous ethanol, oleic acid as the plasticizer with the amount of 0.3 g/g, and curing temperature at 70 °C. Under these conditions, the tensile strength of composite coating was 4.61 MPa and elongation at break was 21.60 % after 4 weeks of soaking in water. Oil seepage was not observed within 1 week. The water solubility of coating in neutral water was 5.13 % at RT for 24 h, and 3.79 % at 80 °C for 2 min; in acidic water (pH = 4) was 4.54 % at RT for 24 h, and 5.44 % at 80 °C for 2 min. SEM results showed swelling occurred in zein coating after soaking, presenting micropores in soaked zein coating; zein microparticles in composite coating partially broke down and fell off after soaking. Water contact angle results revealed surface hydrophobicity by the following order: EC coating > composite coating > zein coating. FTIR results showed composite coating was physically compounding by hydrophobic interactions and hydrogen bonds.

Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis

ObjectiveTo provide a curcumin-based vaginal gel combined with electroporation for the treatment of vulvovaginal candidiasis (VVC) caused by Candida albicans. MethodsTemperature-sensitive in situ gels (ISG) were prepared using poloxamers 407 and 188 as matrices. The mass ratio of poloxamer 407 and poloxamer 188 was 7:1 with a gelation temperature of approximately 29°C and gelation time of 2.5 min. ResultsElectroporation increased the transmucosal permeability of the model drug, doxorubicin and improved the antifungal effects of curcumin. In vitro antifungal experiments showed that the number of fungal colonies in curcumin ISG combined with electroporation was lower than that in pure curcumin ISG. In vivo pharmacodynamic experiments showed that, compared to the model group, curcumin ISG with electroporation inhibited the growth of Candida albicans, alleviated vaginal mucosal edema, and reduced the inflammatory response. ConclusionCurcumin ISG combined with electroporation has substantial potential for the efficient clinical treatment of VVC.

Photothermal-assisted S-scheme heterojunction of NiPS3 nanosheets modified ZnIn2S4 microspheres for promoting photocatalytic hydrogen evolution

Exploring high-efficiency photocatalysts for solar hydrogen (H2) generation through water splitting is of great significance for addressing both energy shortage and environmental contamination. In this work, a facile self-assembly strategy was developed to couple NiPS3 nanosheets (NPS NSs) with ZnIn2S4 (ZIS) microspheres to synthesize NPS NSs/ZIS (NPS/ZIS) composites, featuring a characteristic of S-scheme charge transfer mechanism. The NPS/ZIS composites possess broad-spectrum light absorption property, improved photothermal effect and efficient charge transfer, showcasing exceptional solar-to-chemical energy conversion capability for visible-light-driven photocatalytic hydrogen evolution (PHE). The photothermal effect derived from NPS NSs loading can facilitate charge carrier transfer across the interfaces and surface reaction kinetics. By carefully adjusting the mass ratio of NPS NSs, the optimized 4-NPS/ZIS exhibits excellent stability and significantly improved PHE activity (1827.6 μmol⋅g−1⋅h−1) in water, which is 18.4 times higher than that of bare ZIS (99.4 μmol⋅g−1⋅h−1). Furthermore, the 4-NPS/ZIS also shows the high PHE efficiency of 312.2 μmol⋅g−1⋅h−1 in seawater. Diverse characterization results reveal that the remarkably enhanced PHE performance primarily arises from the synergistic effect of S-scheme heterostructure, heightened light harvesting capacity, and enhanced photothermal effect. On the basis of density functional theory (DFT) simulations and experimental verifications, a possible PHE mechanism via the S-scheme heterojunction with photothermal assistance in NPS/ZIS is proposed. This study serves as inspiration for the development of novel photothermal-assisted S-scheme photocatalysts, paving the way for efficient and sustainable green energy production.

Preparation of PTFE-TIO2-GO/EP superhydrophobic costing and its performance study

For many years, the issue of microbial adhesion has presented difficulties in both daily life and business. In this paper, superhydrophobic coatings were produced by adding epoxy resin (EP), butyl acetate, titanium dioxide (TiO2) nanoparticles, polytetrafluoroethylene micropowder (PTFE), and graphene oxide (GO) sequentially into a mug and mixing well, and then modifying the microscopic particles by using perfluorooctyltriethoxysilane (POTS), and lastly producing the superhydrophobic coatings applied via spraying on the aluminum sheet surface. The micro morphology of the samples was analysed by SEM and EDS, the molecular makeup of the samples was analysed by FTIR and the molecular stability, mechanical stability and algae resistance were tested, and finally the the rust unwillingness of the coatings was investigated by using an electrochemical workstation (Tafel and EIS). The outcomes demonstrated that the best GO to nanoparticle mass ratio of 10% was chosen to achieve a contact angle of 167.5° and a sliding angle of 2.5°. The coating contact angle was still superior to 150° after 7 days of immersion in strong acids and bases as well as 3.5 wt% Nacl and after 8 hours of immersion in boiling water. After 800 abrasion tests the contact angle was still 150.6°. Algae resistance tests showed that the coatings had good resistance to algae adhesion.

Removal of bisphenol A (BPA) from aqueous solution by potassium carbonate modified wetland plant biochars

Bisphenol A (BPA) is a known endocrine disruptor that is acutely toxic to the living organisms. In this study, the wetland plants Phragmites australis and Typha orientalis were subjected to carbonize at 500℃ for different durations (4, 5, and 6h) and varying mass ratios of wetland plants to potassium carbonate (1:2, 1:1, and 2:1). The prepared modified biochars were used to treat BPA in solution to explore the effect of contact time and initial concentration of BPA on adsorption performance. Both adsorption kinetic models and isotherm models were also studied. The results demonstrated a gradual increase in the adsorption capacity of Phragmites australis and Typha orientalis biochars for BPA with prolonged contact time. Furthermore, an enhancement in the adsorption capacity was observed with increasing initial BPA concentration. The modified biochars significantly enhanced BPA removal and adsorption capacities for BPA compared to the unmodified biochars. L55C (Phragmites australis carbonized at 500℃ for 5h with a mass ratio of 2:1) and X54C (Phragmites australis carbonized at 500 ℃ for 4h with a mass ratio of 2:1) exhibited the largest total surface areas, total pore volumes, microporous surface areas and microporous volumes, and achieved maximum adsorption capacities of 8.547 and 8.117mg/g, respectively. The adsorption processes were fitted with pseudo-second-order adsorption kinetic models and Langmuir models. The adsorption processes were monolayer chemical adsorption.

MMP2 enzyme-responsive extracellular vesicles as dual-targeted carriers to promote the phagocytosis of macrophages

Combination therapy using inhibition of tumor cell escape and alteration of the tumor microenvironment offers a new strategy for cancer treatment. This study aimed to develop an extracellular vesicle (EV) carrier that regulates tumor cells and the tumor microenvironment to achieve efficient tumor immunotherapy. The ligand modified on carriers targets the immune checkpoint CD47 protein, blocking tumor cell escape. This ligand is cleaved by the MMP2 enzyme and assembles into nanofibers, extending the retention time in the tumor. The carriers target the CD206 protein, enabling efficient uptake by M2 macrophages. Carriers with a high density of ligands (anti-CD206) exhibit strong receptorligand interactions with tumor cells. Due to their high rigidity, these EVs have difficulty deforming during the transmembrane process, reducing resistance and resulting in low uptake efficiency by M2 cells. The optimal uptake efficiency by M2 macrophages is achieved when the mass ratio of ligand to EVs is 1:25. Crocin loaded in EVs facilitates the polarization of M2 macrophages into M1 cells, which can phagocytize tumor cells. This study reveals a potential strategy for using extracellular vesicles in tumor treatment.

First Detection of Molecular Gas in the Giant Low Surface Brightness Galaxy Malin 1

After over three decades of unsuccessful attempts, we report the first detection of molecular gas emission in Malin 1, the largest spiral galaxy observed to date, and one of the most iconic giant low surface brightness galaxies. Using Atacama Large Millimeter/submillimeter Array, we detect significant 12CO (J = 1–0) emission in the galaxy’s central region and tentatively identify CO emission across three regions on the disk. These observations allow for a better estimate of the H2 mass and molecular gas mass surface density, both of which are remarkably low given the galaxy’s scale. By integrating data on its H i mass, we derive a very low molecular-to-atomic gas mass ratio. Overall, our results highlight the minimal presence of molecular gas in Malin 1, contrasting sharply with its extensive, homogeneous atomic gas reservoir. For the first time, we position Malin 1 on the Kennicutt–Schmidt diagram, where it falls below the main sequence for normal spirals, consistent with previous upper limits but now with more accurate figures. These findings are crucial for constraining our understanding of star formation processes in environments characterized by extremely low molecular gas densities and for refining models of galaxy formation, thereby improving predictions concerning the formation, evolution, and distribution of these giant, elusive galaxies.

Influence of laminated porous cathode structure on the performance and mass transfer of Li[sbnd]O2 batteries

The porous cathode is a crucial component of LiO2 batteries, and its porous structure significantly impacts the battery's performance. In this study, a stacked porous cathode was fabricated via roller pressing. The influence of the cathode structure on the battery performance and mass transfer characteristics were examined using experimental and simulation methods. The structural characteristics, electrochemical properties, and overall battery performance of the stacked porous cathode were analyzed. Furthermore, the effects of the cathode structure on mass transfer within the cathode and battery performance were explored through numerical simulation. The results indicate that when the mass ratio of CNTs to ACET on the diaphragm side is 5:1, the cathode exhibits optimal structural parameters, with an average pore size of 24 nm and a maximum pore volume of 0.85564 cm3/g. Concurrently, the battery demonstrates an exceptionally high area specific capacity of 30.35 mAh/cm2. Integrating the simulation findings, it was observed that adjusting the structural parameters of the cathode enhances material transfer efficiency, thereby improving battery performance.

Capacitive deionization exploiting La-based LDH composite electrode toward energy efficient and selective removal of phosphate

Capacitive deionization (CDI) is a promising technology for removing phosphate from wastewater. Its practical implementation is however hindered by the constraints on the electrode materials. To boost the adsorption capacity, phosphate selectivity, and cost-effectiveness of the electrode, this study proposed a composite electrode blending Lanthanum-based layered double hydroxide (CaLa LDH) and activated carbon (AC). It capitalizes on the synergistic effects of electric double layer capacitance (EDLC) of AC and the diffusion-controlled charge storage (pseudocapacitive behavior) of CaLa LDH. By optimizing the mass ratios of the constituents and the electrode material loading capacities, the composite electrode AC/Ca-La LDH-5020 was developed, which contains 20 mg of 50 wt% CaLa LDH. This composition achieved a remarkable phosphate adsorption capacity of 34.8 mg P /g and a low energy consumption of 0.0051 kWh/g P in constant voltage (CV) mode. It represented a 241 % increase in adsorption capacity (mg P/g) and 71 % decrease in specific energy consumption (kWh/g P) compared to the electrode made solely of AC. Particularly the moderate inclusion of Lanthanum contributes to its cost-effectiveness. Moreover, further studies extensively examined the impacts of electrical driving force, including applied voltage in constant current (CC) mode and applied current in constant voltage (CV) mode, on the phosphate removal efficiency. The composite electrode remained stable performance with the presence of the high content of coexisting anions (e.g.，Cl−，SO42−, HCO3−, NO3−), obtaining high selectivity coefficient of phosphate over other anions. This study highlighted the practical potential of AC/Ca-La LDH composite electrode for advancing CDI technology for phosphate removal in an efficient, energy-saving and cost-effective manner.

High-efficiency co-liquefaction of brominated epoxy resin and low rank coal in supercritical water: Waste recycling and products upgrading

With the acceleration of upgrading electronic information products, a large amount of electronic waste was generated. Brominated epoxy resins (BERs) are the main nonmetallic components of e-waste. The recycling of BERs has attracted people's attention due to their potential environmental risks. Low rank coal is difficult to efficiently utilize due to its high moisture content, oxygen content and low calorific value. This study developed an efficient co-liquefaction strategy for BERs and low rank coal by supercritical water (SCW) process. Under optimized conditions (temperature of 425 ℃, reaction time of 60min, solid-to-liquid ratio of 1:10g/mL, and BERs-coal mass ratio of 1:4g/g), the total conversion efficiency of co-liquefaction reached 56.76%. When the temperature was 325 - 425 °C, there was a positive synergistic effect between BERs and low rank coal co-liquefaction, and the highest synergy efficiency of 11.13% was reached at 400 °C. The introduction of BERs could significantly reduce the oxygenated compounds and the heteroatomic compounds in the liquefied oil products, improving the quality of oil products. The co-liquefaction promoted the production of phenolic chemicals and inhibited the cross-linking reaction of the decomposition products from low rank coal, and realized the synchronous conversion of BERs and low rank coal. The C-Br bond in the residue was significantly weakened after co-liquefaction. The oil products did not contain brominated organic compounds, also demonstrating the potential of the co-liquefaction process for debromination of BERs.

The Ce-modified biochar for efficient removal of methylene blue dye: Kinetics, isotherms and reusability studies

Exploring modification methods for enhancing the adsorption performance of biochar-based adsorbents for effective removal of methylene blue (MB), biochar-loaded CeO2 nanoparticles (Ce/BC) were synthesized by pomelo peels through co-precipitation combined with the pyrolysis method. Ce/BC showed a higher specific surface area and disorder degree than that of BC. The 0.5Ce/BC (mass ratio of Ce(NO3)3·6H2O/BC=0.5/1) showed the best performance to adsorption of MB solution at different reaction conditions (MB concentration, Ce/BC composites dosage, and initial pH). Adsorption kinetics and equilibrium isotherms were well-described with a pseudo-first-order equation and Langmuir model, respectively. In addition, the maximum adsorption capacity of 0.5Ce/BC for MB was 105.68 mg·g−1 at 328 K. The strong adsorption was attributed to multi-interactions including pore filling, π-π interactions, electrostatic interaction, and hydrogen bonding between the composites and MB. This work demonstrated that the modified pomelo peels biochar, as a green promising material with cost-effectiveness, exhibited a great potential for broad application prospectively to dyeing-contaminated wastewater treatment.

Efficient removal of low concentrations of copper and lead ions in water using chitosan-condensed tannin composite microspheres

Condensed tannin was solidified onto chitosan microspheres to prepare chitosan-tannin (CT) composite microspheres with a simple preparation method to study its performance in adsorbing copper (Cu2+) and lead ions (Pb2+) in aqueous media. The study investigated the influence of the mass ratio of tannin and chitosan, pH value, adsorption time, and initial concentrations of Cu2+ and Pb2+ on the adsorption capacity of Cu2+ and Pb2+ ions. Additionally, the study examined the adsorption isotherms and kinetics of Cu2+ and Pb2+ on CT composite microspheres. The adsorption process aligns more closely with the fitting results of the Langmuir model. The maximum capacity for saturated monolayer adsorption of CT composite microspheres for Cu2+ and Pb2+ was 37.6 and 52.9 mg/g, respectively. The adsorption process of CT composite microspheres for Cu2+ and Pb2+ was primarily driven by single-layer chemical adsorption. In addition, metal ions adsorbed onto CT composite microspheres can be released by treating them with a dilute solution of strong acid. Furthermore, the CT composite microspheres exhibited impressive removal efficiencies of 82 % and 95 % for Cu2+ and Pb2+ respectively, even at low concentrations of 2 mg/L. The CT composite microspheres have the ability to easily separate the adsorbed Cu2+ and Pb2+ ions.

Synergistic enhancing low-rank coal flotation mechanisms using nanocarrier collector through pore sealing and surface hydrophobicity

Low-rank coal (LRC) is difficult to float using conventional oily collectors due to the rich oxygen-containing functional groups and abundant pores on its surface. In this study, an effective nanocarrier collector containing both nanoemulsion and nanoparticle with droplet size of 10–70 nm was developed, through diesel-beeswax mixture and AEO-7 using low-energy shearing and rapid cooling emulsification to enhance the LRC flotation. The surface morphology and elemental compositions of LRC were firstly characterized using SEM and EDS, identifying its difficult-to-float mechanisms. Then, the macroscopic appearance and microscopic size distribution of nanocarriers, and flotation tests were conducted to determine the optimum formula of nanocarrier collector for LRC. The results indicated that the recovery rate of combustibles was first increased and then decreased, by increasing the mass ratio of beeswax to diesel. When the mass ratio of diesel, beeswax, and AEO-7 was 2:3:5, the recovery rate of combustibles could be achieved to 92.98 %. Finally, the BET specific surface area, water adsorption, contact angle and wrap angle experiments were conducted to clarifying the synergistic enhancing LRC flotation mechanisms of nanocarriers collector. The nanocarriers could permeate into and seal the LRC surface pores, thereby reducing the both surface pore volumes and specific surface area. In addition, the mixtures of diesel and beeswax synergistically improved the surface hydrophobicity. Consequently, this research provides new insight into the development of effective collectors for LRC flotation.

Facile fabrication of BiOI/ZIF-67 Z-scheme heterojunction photocatalyst for visible-light-driven tetracycline degradation

In this paper, a novel Z-scheme BiOI/ZIF-67 photocatalyst (BOI/ZIF) was successfully prepared using an in-situ growth method, and its effectiveness in degrading tetracycline (TC) under visible light was assessed. Using a range of characterization techniques, the crystal structure, elemental composition, microstructure and optical characteristics of the composite catalyst were examined. Simultaneously, a 30% mass ratio catalyst (BOI/ZIF-30) could remove 91% of TC under visible light, which was 41% and 28% greater than the degradation rates of BiOI and ZIF-67, respectively. These results demonstrated that BOI/ZIF exhibited strong photocatalytic activity and excellent stability. The results of the radical quenching experiment and electron spin resonance revealed that h+ and •O2− were the principal chemical substances responsible for TC degradation, corresponding with the suggested charge transfer mechanism of Z-scheme heterojunction. The Z-scheme heterojunction created between BiOI and ZIF-67 improved the effective separation of photogenerated carriers and boosted the efficiency of TC degradation. This study offers a promising method for designing photocatalytic systems to break down antimicrobial contaminants.

Comparison of the Dynamic Characteristics of Tuned Liquid Column Dampers with Different Elbow Forms

This study aims to examine experimentally the damping performance of Tuned Liquid Column Dampers (TLCD) by considering different elbow forms. Experiments carried out within the scope of the study point out the dynamic characteristics of TLCD, which has 45 (open) and 90 (closed) degree-elbow forms with theoretical angular frequencies that are the same. Experiments consist of ±5 and ±10 mm harmonic excitation amplitude to observe the relationship between the damping ratio and head loss coefficient with the mass ratio of the TLCD. These experiments with an incremental mass ratio of 0.05% from 0.80% to 1.00% and with an incremental mass ratio of 0.10% from 1.00% to 1.20% had been carried out in detail. Mass and stiffness Modification Factors (MF) are suggested to minimize the difference between numerical and experimental results. Determined MFs are used to examine the earthquake performance of TLCD on a Single-Degree-of-Freedom (SDOF) system. It is shown that the open elbow has an advantage of approximately 25% over the close elbow under earthquake performance on the SDOF system.

Interfacial property optimization through the co-deployment of MOF-derived nickel phyllosilicate and DOPO: Effective reinforcement and flame retardancy of epoxy resin

Epoxy resin (EP) is a versatile material widely employed in diverse fields such as electronic encapsulation, coatings, and adhesives. The optimization of flame-retardant, mechanical and interfacial properties in composites through material modification and compounding represents a prominent research focus within the field of EP. This study presents a novel approach by synthesizing MOF-derived nickel phyllosilicate (K-NiPS) and compounding it with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) into the EP matrix. The incorporation of 5 wt% total K-NiPS and DOPO, with a mass ratio of 2:3, achieves a UL-94 V-0 rating and enhances the limiting oxygen index from 23.5 to 28.8%. This combination also reduced the peak heat release rate, peak smoke release rate, and total smoke release by 44.6%, 53.6%, and 37.8% respectively. Besides, the interface optimization effect of K-NiPS in collaboration with DOPO improved the tensile strength of EP/2K-NiPS/3DOPO from 77.5 MPa to 94.3 MPa, and the wear rate was only 1.25 × 10-5 mm3/(N·m), which is 82.2% lower than that of pure EP. This study will pave the way for the applied interface design of multi-functional EP.

Sugarcane bagasse and iron ore tailings thermochemical conversion towards sustainable iron recovery with biogenic carbon and hydrogen production

The recovery of valuable chemical elements from industrial waste is essential for production processes' economic and environmental sustainability. The interaction between the iron ore tailings and sugarcane bagasse, both wastes, has the potential to provide a secondary iron source for future iron and steelmaking processes. This study evaluated the use of volatiles from sugarcane bagasse (SCB) and iron ore tailings (IOT) to the synergistic promotion of carbon deposition, H2 production and conversion of weak magnetic iron oxides in strong magnetic iron phases. The experiments were carried out at 400, 600, 800, and 1000 ºC with different SCB/IOT ratios under an N2 atmosphere. In all tests, SCB and IOT were heated simultaneously in separate beds to prevent direct contact between the materials. The combination of 600 ºC and higher SCB/IOT ratio resulted in a product with 96.7% magnetite, 98% magnetic fraction recovery, and 3.5% deposited carbon. The use of lower SCB/IOT ratio provided an increase in H2 production. Regardless of the mass ratio, heating the IOT and SCB simultaneously up to 1000 ºC led to significant mineralogical transformations, reaching reduced phases such as wüstite, fayalite and metallic iron, which impaired magnetic separation efficiency. The results indicate an alternative for recovering iron from IOT using biomass waste as a renewable reducing agent for the steel industry.

Preparation and characterization of a novel active sediment capping material (geopolymer) for inhibiting phosphate releasing from sediment

In situ remediation of sediment can effectively control the release of phosphate in sediment and improve water eutrophication. The essential question of this remediation techniques lies in the development of stable, high-efficiency, low-cost and easily available active sediment capping materials. This study synthesised a novel sediment capping material using bulk solid waste, and phosphate inhibition mechanism of the materials was explored. Results indicated that GSCM was prepared under the conditions of NaOH concentration of 3M, hydrothermal temperature of 160℃, hydrothermal time of 36h and the mass ratio of 40wt.% SS to 60wt.% FA. The result of batch adsorption and compressive strength test suggested that phosphate adsorption capacity and compressive strength of GSCM were 2.15mg/g and 24.20MPa, respectively. The characterization result showed that GSCM was composed of sodium zeolite, riversideite, grossular and fayalite, exhibiting a uniformly distributed slit mesoporous structure. The in-situ inhibition efficiency of GSCM to P ranged from 76.65% to 86.72%, exceeding that of commercial zeolite. The in-situ inhibition mechanism was controlled by sodium zeolite and riversideite, and concluded by the following:1) Substitution between [SiO4] tetrahedra (within the sodium zeolite structure), -OH (on the surface of materials) and [PO4], 2) Coordination of [PO4] tetrahedra with Al active site within the sodium zeolite structure, 3) Precipitation reaction between phosphate and slow-release of Ca2+ from the riversideite.