Mass Components Research Articles

Tumoroid-On-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic Screening.

Employing three-dimensional (3D) in vitro models, including tumor organoids and spheroids, stands pivotal in enhancing cancer therapy. These models bridge the gap between two-dimensional (2D) cell cultures and complex in vivo environments and offer versatile tools for comprehensive studies into cancer progression, drug responses, and tailored therapies. This study introduces the Tumoroid-on-a-Plate (ToP) device, an innovative ope-surface microfluidic platform designed to create predictive 3D models of solid tumors. The ToP device combines tumor mass, stromal cells, and extracellular matrix (ECM) components, to closely replicate the microenvironment of glioblastoma (GBM) and pancreatic adenocarcinoma (PDAC). Using the advanced ToP model and testing various GBM ECM compositions such as collagen and Rreelin within the model, we can assess how specific elements affect GBM invasiveness. The ToP in vitro model also enables screening chemotherapeutics such as temozolomide and iron-chelators in a single and binary treatment setting on the complex ECM-embedded tumoroids to evaluate their toxicity on GBM and PDAC models viability and apoptosis. Furthermore, co-culturing PDAC tumoroids with human-derived fibroblasts reveals the pro-invasive influence of stromal elements on tumor growth and drug response. This research underscores the value of advanced 3D models like ToP in advancing the understanding of cancer complexity and therapy responses.

Origin of the black hole spin in lower-mass-gap black hole-neutron star binaries

During the fourth observing run, the LIGO-Virgo-KAGRA Collaboration reported the detection of a coalescing compact binary (GW230529$_ $181500) with component masses estimated at $2.5-4.5\, M_ and $1.2-2.0\, M_ with 90<!PCT!> credibility. Given the current constraints on the maximum neutron star (NS) mass, this event is most likely a lower-mass-gap (LMG) black hole-neutron star (BHNS) binary. The spin magnitude of the BH, especially when aligned with the orbital angular momentum, is critical in determining whether the NS is tidally disrupted. An LMG BHNS merger with a rapidly spinning BH is an ideal candidate for producing electromagnetic counterparts. However, no such signals have been detected. In this study, we employ a detailed binary evolution model that incorporates new dynamical tide implementations to explore the origin of BH spin in an LMG BHNS binary. If the NS forms first, the BH progenitor (He-rich star) must begin in orbit shorter than 0.35 days to spin up efficiently, potentially achieving a spin magnitude of $ BH > 0.3$. Alternatively, if a nonspinning BH (e.g., $M_ BH = 3.6\, M_ forms first, it can accrete up to $ 0.2\, M_ via case BA mass transfer (MT), reaching a spin magnitude of $ BH 0.18$ under Eddington-limited accretion. With a higher Eddington accretion limit (i.e., 10.0 $ M Edd $), the BH can attain a significantly higher spin magnitude of $ BH by accreting approximately $1.0\, M_ during case BA MT phase.

Numerical Simulation of Autoresonant Ion Oscillations in an Anharmonic Electrostatic Trap.

This work presents the results of modeling the ion dynamics in the ART-MS (Autoresonant Trap Mass Spectrometry) device in the quasi-static approximation. This instrument utilizes an anharmonic, purely electrostatic trap for ion confinement and a radio frequency (RF) voltage source with decrementally varying frequency for selective ion extraction. The autoresonant interaction between the oscillatory motion of the ion and the RF voltage increases the amplitude of some confined ions, allowing their selective extraction. Numerical modeling shows that the extraction of ions with a given mass occurs not only at the fundamental frequency but also at its harmonics. This effect reduces the selective properties of devices of this type because along with the main mass component for a given frequency, it is possible to enter the detector channel of ions with another mass, for which this frequency corresponds to the second or higher harmonics, even a superposition of some of these harmonics of different ions.

Scaling relations between mass components and rotational velocity in disk galaxies

Abstract In this study, we re-evaluate the baryonic Tully–Fisher relation (BTFR) by analyzing the correlations between maximum rotational velocity and various mass components, including stellar mass, atomic hydrogen (H i) mass, baryonic mass, and dark matter mass in a sample of 141 disk galaxies from the SPARC (Spitzer Photometry and Accurate Rotation Curves) database, augmented by recent data on stellar and dark matter masses. We apply multiple statistical methods, including Monte Carlo orthogonal distance regression (MCODR), Monte Carlo least-squares (MCLS), and traditional least-squares (LS), to assess the impact of different fitting techniques on the derived scaling relations between the mass components (stellar, H i, and dark matter) and maximum rotational velocities of these galaxies. We find that the selection of statistical methods significantly influences the derived slopes and intercepts the relation between maximum rotational velocity and mass components. The MCODR method that accounts for errors in both variables consistently produces steeper slopes, suggesting a stronger correlation between stellar mass and rotational dynamics compared to other methods. In contrast, the MCLS method tends to yield flatter slopes, highlighting the sensitivity of this approach to outliers. Despite the variations in slope and intercept across different methods, the fundamental relation between baryonic mass and rotational velocity remains robust. We have also compared dark matter mass derived from different halo models [NFW (Navarro–Frenk–White) versus combined NFW + Dekel–Zhao profiles] and noted that the slope from the NFW profile is slightly steeper than that from the combined profile, highlighting the sensitivity of scaling relations to the selection of halo model. Overall, this study reinforces the robustness of the BTFR across different mass components in disk galaxies while emphasizing the critical role of statistical methods and dark matter profiles in analyzing galactic dynamics.

No Evidence for a Dip in the Binary Black Hole Mass Spectrum

Stellar models indicate that the core compactness of a star, which is a common proxy for its explodability in a supernova, does not increase monotonically with the star’s mass. Rather, the core compactness dips sharply over a range of carbon–oxygen core masses; this range may be somewhat sensitive to the star’s metallicity and evolutionary history. Stars in this compactness dip are expected to experience supernovae leaving behind neutron stars, whereas stars on either side of this range are expected to form black holes. This results in a hypothetical mass range in which black holes should seldom form. Quantitatively, when applied to binary stripped stars, these models predict a dearth of binary black holes with component masses ≈10M ⊙–15M ⊙. The population of gravitational-wave signals indicates potential evidence for a dip in the distribution of chirp masses of merging binary black holes near ≈10M ⊙–12M ⊙. This feature could be linked to the hypothetical component mass gap described above, but this interpretation depends on what assumptions are made of the binaries’ mass ratios. Here, we directly probe the distribution of binary black hole component masses to look for evidence of a gap. We find no evidence for this feature using data from the third gravitational-wave transient catalog. If this gap does exist in nature, we find that it is unlikely to be resolvable by the end of the current (fourth) LIGO–Virgo–KAGRA observing run.

Mass modeling and kinematics of galaxy clusters in modified gravity

The chameleon screening mechanism has been constrained many a time using dynamic and kinematic galaxy cluster observables. Current constraints are, however, insensitive to different mass components within galaxy clusters and have been mainly focused on a single mass density profile, the Navarro-Frenk-White mass density model. In this work, we extend the study of the Chameleon screening mechanism in galaxy clusters by considering a series of mass density models, namely: generalized-Navarro-Frenk-While, b-Navarro-Frenk-While, Burket, Isothermal and Einasto. The coupling strength (β) and asymptotic value of the chameleon field (ϕ ∞) are constrained by using kinematics analyses of simulated galaxy clusters, generated both assuming General Relativity and a strong chameleon scenario. By implementing a Bayesian analysis we comprehensively show that the biases introduced due to an incorrect assumption of the mass model are minimal. Similarly, we also demonstrate that a spurious detection of evidence for modifications to gravity is highly unlikely when utilizing the kinematics of galaxy clusters.

Quantitative analysis of imaging characteristics in lung adenocarcinoma in situ using artificial intelligence.

With the rising incidence of pulmonary nodules (PNs), lung adenocarcinoma in situ (AIS) is a critical early stage of lung cancer, necessitating accurate diagnosis for early intervention. This study applies artificial intelligence (AI) for quantitative imaging analysis to differentiate AIS from atypical adenomatous hyperplasia (AAH) and minimally invasive adenocarcinoma (MIA), aiming to enhance clinical diagnosis and prevent misdiagnosis. The study analyzed 1215 PNs with confirmed AAH, AIS, and MIA from six centers using the Shukun AI diagnostic module. Parameters evaluated included demographic data and various CT imaging metrics to identify indicators for clinical application, focusing on the mean CT value's predictive value. Significant differences were found in several parameters between AAH and AIS, with nodule mass showing the highest predictive value. When comparing AIS to MIA, total nodule volume was the best predictor, followed by the maximum CT value. The mean CT value has limited discriminative power for AIS diagnosis. Instead, the maximum CT value and maximum 3D diameter are recommended for clinical differentiation. Nodule mass and volume of solid components are strong indicators for differentiating AIS from AAH and MIA, respectively.

Comprehensive Analysis of the Association Between Sex Hormones and Body Mass Components Among Men Adults: Results From a Large Population-Based Study.

As the human body ages, adverse body composition status such as sarcopenia and obesity become obvious phenotypes which can cause numerous health problems. We aimed to comprehensively investigate the association of sex hormones and body mass components in adult men of various age groups. We analysed national representative population data from the US National Health and Nutrition Examination Survey. Generalized linear model regression analyses were used to evaluate the association between sex hormones (total testosterone [TT], bio-available testosterone [BT], sex hormone-binding globulin [SHBG], estradiol [E2] and testosterone to estradiol ratio [T/E ratio]) and body mass components (weight, body mass index (BMI), total lean mass, appendicular lean mass, bone mineral content, total fat and trunk fat). The collection and testing time of blood samples were not fixed and there was no strict fasting, but in subsequent analysis we used statistical methods to minimize the impact of random testing. After screening for inclusion and exclusion, 3759 male participants aged 20-85 years old were included in this study. Higher levels of TT, SHBG, BT and T/E ratios were significantly associated with higher total lean mass, appendicular lean mass and bone mineral content, while lower weight, BMI, total fat and trunk fat. For E2 levels in men, we found an opposite trend, with higher E2 levels significantly associated with lower total lean mass and appendicular lean mass, and higher weight, BMI, total fat and trunk fat. Notably, in subgroup analysis, the results showed that there were significant interaction effects of age and smoking history in the association between sex hormones and body mass components. Higher TT levels, BT levels, SHBG levels and T/E ratios are associated with lower body weight and improved body composition in young adult men (characterized by higher lean body mass, higher bone density and lower fat mass). The relationship is especially pronounced among relatively young, nonsmoking men.

Application of X-Ray Computed Tomography to Identify Defects in Lost Wax Ceramic Moulds for Precision Casting of Turbine Blades.

This article presents the results of testing the suitability of X-ray computed tomography for the quality control of the casting moulds used for producing turbine blades. The research was focused on the analysis of cross-sectional images, spatial models and the porosity of moulds using a Phoenix L 450 microtomograph. The research material consisted of samples from three mixtures of ceramic materials and binders intended for producing casting moulds using the lost wax method. Various configurations of filling materials (Molochite and quartz flours) and binder (Remasol, Ludox PX 30 and hydrolysed ethyl silicate) mixtures were considered. X-ray computed tomography enabled the detection of a number of defects in the ceramic mass related to the distribution of mass components, porosity concentration and defects resulting from the specificity of the mould production. It was found that casting mould quality control on cross-sectional tomographic images is faster and as accurate as the analysis of three-dimensional models and allows for the detection of a whole range of ceramic defects, but the usefulness of the images is greatest only when the cross-sections are taken at an appropriate angle relative to the object being examined.

Quality Improvement Assessment of Massive Transfusion Protocol (MTP) Utilization and Blood Component Return to Blood Bank in a Level 1 Trauma Center

Abstract Introduction/Objective The goal of MTP in management of patients with hemorrhage is to restore coagulation factors, oxygen carrying capacity, and platelets by transfusing equal amount of plasma, RBC, and platelets. Upon activation of MTP, blood components are released in rounds until deactivation. This quality improvement study was initiated to assess blood products transfused versus returned during MTP activation at our Level1 Trauma Medical Center. Methods/Case Report Upon MTP activation, the Blood Bank (BB) prepares first round of cooler with components at 5:5:1 ratio of plasma, RBC, apheresis platelets. We reviewed retrospective MTP data of eleven-month, from 10/2022- 08/2023. We analyzed patterns of blood component usage by service line, number of MTP rounds issued, and number of units transfused versus returned. Results (if a Case Study enter NA) MTP data was reviewed for 195 patients. MTP activation by service line included emergency department 58.5%, medical ICU (MICU) 14.4%, and surgical ICU (SICU) 11.8%. In many MTP activations, only one round of components was released. Overall, an average of 1.5 rounds were issued. Data of units transfused and returned by component type showed more RBC (43.1%) units were transfused than plasma (39.4%) suggesting MTP transfusion did not follow 1:1:1 ratio. Out of all issued blood units 58% were returned. The high fraction of returned blood components suggests MTP activation may not always truly indicate massive hemorrhage. This finding, and the notable frequency of MTP activation for MICU and SICU patients suggests that individual component order on an emergency-release basis may have been the appropriate option. Conclusion In general, the data suggests implementation of a quality improvement initiative focused on increasing awareness of criteria for MTP activation, and training of staff surrounding MTP is essential. We recently implemented an electronic emergency transfusion order set that allows providers to order individual components for non-massively bleeding patients.

Iron bed accelerator for discharging cylindrical NCA battery in salt solution

This study examines the iron bed accelerator for discharging cylindrical NCA batteries in salt solution. The use of Li-ion batteries has increased due to the rise of e-mobility in computers, cell phones, and electric vehicles. Recycling Li-ion batteries for raw material in lithium-ion battery production is increasingly important as the revolution unfolds. When disposing of, transporting, and recycling the battery, it is important to crush it to separate the black mass, plastic, and metal components. However, there is a potential explosion risk due to the remaining voltage in the battery. In recycling, the discharge step is significant. The research aimed to test a new method for discharging cylinder batteries using saltwater and an iron bed. Higher NaCl content increases pH and lowers electrochemical potential for water electrolysis. This unique combination enables the battery to discharge at a high rate. In 6 hours, the battery discharged in a 20 wt.% salt solution with 99.6% efficiency. The battery discharge efficiency decreased when exposed to 25 wt% and 30 wt% salt solutions, attributed to reduced water electrolysis intensity. According to the results of various experiments, it has been observed that as the temperature of the salt solution rises, there is a slight increase in the rate of battery discharge; however, no significant difference has been observed. This article talks about how batteries are discharged. It shows the electrochemical reaction using the Eh-pH diagram for Fe-Na-Cl. It also has a schematic diagram that shows the process and a chemical analysis of the precipitate that forms during the discharge test.

Fat deposition and body mass components of Mongolian urban children and adolescents living in various social conditions

Introduction. The purpose of the study is to characterize and to compare the indicators of fat deposition and body composition in groups of urban children and adolescents of the Republic of Mongolia in various living conditions. Materials and methods. The material for this study was the results of a comprehensive survey of 5 612 Mongolian children and adolescents aged 9-17 years (born and permanently residing in the capital city of Ulaanbaatar). In accordance with the objectives of the study, the body circumferences, the skinfolds, as well as the body mass components evaluated by bioimpedance technique were analyzed. Results. Based on the obtained statistical parameters of the studied features, as well as on the results of their comparison in the studied groups, it can be concluded that the value of most of the considered indicators in children and adolescents living in apartments is higher than in their peers living in yurts. Discussion. The increase in body weight in boys living in the apartments, recorded according to the results of our previous work, is associated with an increase in active cell mass, and, as a result, – lean body mass. To a lesser extent, judging by the existing differences, its value is influenced by the fat component. While the parameters of fat deposition show a small number of significant differences, unlike circumferences, it can also be concluded that the variability of the girths is more associated with the development of the muscular component. Similar patterns were obtained for girls. However, in this case they are less pronounced, but also correspond to the previously obtained results. Conclusion. The general increase in the welfare of the population of Ulaanbaatar and significant improvement in the living conditions of the younger generation, has a positive effect on the youth physical development, primarily due to a more pronounced increase in the metabolically active components of body weight. This may be considered as an important reflection of the socio-political processes taking place in the country. © 2024. This work is licensed under a CC BY 4.0 license

The Bering Strait Throughflow Component of the Global Mass, Heat and Freshwater Transport

AbstractAs the only oceanic connection between the Pacific and Arctic‐Atlantic Oceans, Bering Strait throughflow carries a climatological northward transport of about 1 Sv, contributing to the Atlantic Meridional Overturning Circulation (AMOC). Here, Lagrangian analysis quantifies the global distributions of volume transport, transit‐times, thermohaline properties, diapycnal transformation, heat and freshwater transports associated with Bering Strait throughflow. Virtual Lagrangian parcels, released at Bering Strait, are advected by the velocity of Estimating the Circulation and Climate of the Ocean, backward and forward in time. Backward trajectories reveal that Bering Strait throughflow enters the Pacific basin on the southeast side, as part of fresh Antarctic Intermediate Water, then follows the wind‐driven circulation to Bering Strait. Median transit time from S in Indo‐Pacific to Bering Strait is 175 years. Sixty‐four percent of Bering Strait throughflow enters the North Atlantic through the Labrador Sea. The remaining 36% flows through the Greenland Sea, warmed and salinified by the northward flowing Atlantic waters. Deep water formation of water flowing through Bering Strait occurs predominantly in the Labrador Sea. Subsequently, this water joins the lower branch of AMOC, flowing southward in the deep western boundary current as North Atlantic Deep Water. Median transit time from Bering Strait to S in South Atlantic is 160 years. The net heat transport of Bering Strait throughflow is northward everywhere, and net freshwater transport by Bering Strait throughflow is mostly northward. The freshwater transport is largest in the subpolar region of basin sectors: northward in the Pacific and Arctic and southward in the Atlantic.

Determination of the Abundance of Mercury from the Hg ii Line at 5677.10 Å in Late B-type Stars. VII. HD 141556 (χ Lupi)

The weak line of Hg ii located at 5677.10 Å is used to measure the mercury abundance in the most massive component of the double-lined spectroscopic binary HgMn star HD 141556 (χ Lupi). This line is detected at 3σ above the noise in the adjacent continuum. The synthesis of this line confirms a large overabundance of mercury, about +5.30 dex, which is about twice the excess derived from the 3983.93 Å line in earlier studies. Spectrum synthesis yields estimates of the abundance deficiencies/excesses for fourteen other elements which agree well with previous measurements.

LP349-25AB: Application of Magneto-convection Model to an M Dwarf Binary Where Radio and Astrometric Data have Yielded Masses with 0.7% Precision

Reliable (±(1–2)%) estimates of stellar masses have typically been obtained from eclipsing binaries. In such cases, derived values of radii and T eff are in many cases discrepant relative to standard models, especially in active stars. These discrepancies led to the development of magneto-convection theory. Recently, an independent technique has emerged for determining precise masses of radio-emitting binary components: interferometric observations at multiple points around the orbit. S. Curiel et al. have used this technique to determine the masses of both components of an M8+M9 binary (LP349-25AB) with remarkably high precision: ±0.7%. However, applying standard models suggests that the components are not co-eval, differing in age by ∼30%. But LP349-25 is such a close binary (with a separation of 1.2 au) that non-coevality seems unrealistic. Here, we report on magneto-convective modeling which resolves the apparent non-coevality while simultaneously explaining why the primary component is variable, but the secondary component is not.

The effect of stellar rotation on black hole mass and spin

Abstract The gravitational wave signature of a binary black hole (BBH) merger is dependent on its component mass and spin. If such black holes originate from rapidly rotating progenitors, the large angular momentum reserve in the star could drive a collapsar-like supernova explosion, hence substantially impacting these characteristics of the black holes in the binary. To examine the effect of stellar rotation on the resulting black hole mass and spin, we conduct a 1D general relativistic study of the end phase of the stellar collapse. We find that the resulting black hole mass at times differs significantly from the previously assumed values. We quantify the dependence of the black hole spin magnitude on the hydrodynamics of the accretion flow, providing analytical relations for calculating the mass and spin based on the progenitor’s pre-collapse properties. Depending on the nature of the accretion flow, our findings have implications for the black hole upper mass gap resulting from pair-instability supernovae, the maximum mass of a maximally rotating stellar black hole, and the maximum effective spin of a BBH formed in a tidally locked helium star - black hole binary.

Analysis of KIC 7023917: Spotted Low-mass Ratio Eclipsing Binary with δ Scuti Pulsations

Times of minima of eclipsing binary KIC 7023917 show quasiperiodic anti-symmetric deviations from the calculated one with an amplitude of up to 10 minutes and a period of 200–300 days. These changes correlate with the observed variations of the light-curve maxima (amplitude and phase separation). We used photometric data obtained by Kepler and TESS missions to analyze the times of minima and determine system parameters. The phases and amplitudes of the maxima were measured to study the O’Connell effect. As an additional source of information, we performed ground-based multicolor photometric observation and determined the radial velocities of the system from our spectroscopic measurements. We could explain long-term variations of the light-curve shape and times of the eclipses using the cold star spot located on the secondary component and the modification of its size. Based on our modelling, the system consists of a primary main-sequence star of spectral type A7 and an evolved, oversized secondary component with a mass ratio of only 0.1 due to past mass transfer. Calculation of absolute parameters gives us the mass of the primary component about 1.8 M ☉ and 0.2 M ☉ for the secondary one, and radii of 2.2 R ☉ of the primary star and 0.9 R ☉ of secondary one, respectively. The studied low-mass ratio eclipsing binary is probably a progenitor of the variable star of EL CVn type. A multiple-period photometric variability was disclosed in the TESS data ranging from half to two hours due to δ Scuti-type pulsations of the primary component.

A lie group PMP approach for optimal stabilization and tracking control of autonomous underwater vehicles

AbstractIn this research, we explore a finite horizon optimal stabilization and tracking control scheme for the dynamical model of a 6‐DOF Autonomous Underwater Vehicle (AUV). Dynamical equations of the AUV are represented in a Lie group () framework, encompassing both translational and rotational motions. Utilizing a left Lie group action on , we define error function for velocities via a right transport map to effectively address optimal trajectory tracking. The optimal control objective is formulated as a trade‐off problem, aiming to minimize both errors and control effort simultaneously. Left action on yields the left trivialized Hamiltonian function from which the concomitant state and costate dynamical equations are derived using Pontryagin's Minimum Principle (PMP). Consequently, the resulting two‐point boundary value problem is solved to obtain optimal trajectories. We demonstrate the optimality of the resulting solution obtained from the derived control law. For ensuring boundedness in the presence of small disturbances, this study incorporates the effects of internal parametric uncertainties associated with added mass and inertia components, along with the influence of external disturbances induced by ocean currents. Through simulation validations, we confirm the alignment of our results with the theoretical developments, demonstrating that the proposed control law effectively mitigates both parametric uncertainties and ocean current disturbances.

Stability constants of mixed-ligand cobalt(II) complexes with pyridinedicarboxylic acids and small bioligands studied by potentiometric measurements

In this work, we have studied the stability constants of ternary cobalt(II) complexes with the primary ligands: pyridine-2,3-dicarboxylic acid (H22,3-Dipic, H2L) and pyridine-3,4-dicarboxylic acid (H23,4-Dipic, H2L) and secondary ligands representing low molecular mass components of blood serum: lactic acid (HLac), oxalic acid (H2Ox), citric acid (H3Cit), and phosphoric acid (H3PO4). Potentiometric data were analyzed using the least squares computational program LETAGROP. Ionic strength and temperature were both kept constant using 1.0 mol dm−3 NaNO3 as ionic medium at 25 °C. Species distribution diagrams were generated to determine the speciation variations with respect to pH.

Higher Flower Hydraulic Safety, Drought Tolerance and Structural Resource Allocation Provide Drought Adaptation to Low Mean Annual Precipitation in Caragana Species.

Determining the differences in flower hydraulic traits and structural resource allocation among closely related species adapted to low mean annual precipitation (MAP) can provide insight into plant adaptation to arid environments. Here, we measured the maximum flower hydraulic conductance (Kmax-flower), water potential at induction 50% loss of Kmax-flower (P50-flower), flower pressure-volume parameters, dry mass of individual flowers and structural components (vexillum, wings, keels, stamens and sepals) of six Caragana species growing in regions ranging from 110 to 1400 mm MAP. Compared with species from high-MAP environments, those from low-MAP environments presented lower Kmax-flower, more negative P50-flower, osmotic potential at full turgor (πo) and turgor loss points (πtlp), and a greater bulk modulus of elasticity (ε). Consequently, a negative correlation between Kmax-flower (hydraulic efficiency) and P50-flower (hydraulic safety) was observed across Caragana species. Furthermore, the dry masses of individual flowers and structural components (vexillum, wings, keels, stamens and sepals) were greater in the species from the low-MAP environment than in those from the high-MAP environment. These findings suggest that greater flower hydraulic safety and drought tolerance combined with greater structural resource allocation promote drought adaptation in Caragana species to low-MAP environments.