ABSTRACT Not counting domestic dwellings, it has been estimated that some tens of thousands of older masonry buildings and structures exist nationally and that many of these are potentially at risk of partial (or worse) collapse from falling or dislodged masonry. This has significant implications for building owners, managers, insurers, the local and national economies, and the urban environment. The problem is caused mainly by the slow deterioration of masonry under atmospheric and other environments and by the corrosion of so-called wall-ties, relatively thin pieces of steel that tie the outer leaf of masonry walls to the inner leaf. The problem is likely to be particularly severe for scenarios such as synoptic windstorms and earthquake events as this causes area-wide damage, and potential wide-spread loss of human life – losses that could be prevented by timely intervention. The present paper deals with the research framework and the methodology being employed in a long-term project to develop tools for cost-effective structural masonry assessment and for risk estimation under structural deterioration conditions. Some early findings with potential immediate practical implications are given. Because the effects of deterioration are long-term, the overall project outcomes will take some years to come to fruition. They will be reported in due course.