This article presents an experimental study on cyclic testing of full-scale reinforced concrete (RC) frames designed for modern codes with three different masonry infills: burnt clay brick, fly ash brick, and autoclaved aerated concrete (AAC) block masonry. A digital image correlation (DIC) system was used to study, in detail, the failure pattern and the complex interaction between the infill and the surrounding frame. The experimental results were compared with the pre-existing analytical models for strength and stiffness to determine the best-fit model. The experimental results indicated that the masonry-infilled frames had higher strength, stiffness, and energy dissipation capacity compared to the bare frame, and brittle modes of failure were avoided due to the design for modern codes. The masonry infill altered the RC frame’s deformation pattern by constraining the end portions of the columns from moving laterally, resulting in widespread flexure cracks throughout the column’s height, unlike the bare frame, where cracking was limited to the end portions. The modification was minimal in the case of AAC block masonry infill. The AAC block infilled frame reached different damage states at lower drifts than the other two infill types. The strength and stiffness, separately, were found to be in good agreement with some of the existing models; however, none of the considered models could predict both stiffness and strength accurately.