Vascular surgeons in Pakistan confront challenging work conditions that can lead to a high incidence of burnout, a state of physical, emotional, and mental exhaustion caused by prolonged and intense stress. With the specialty still emerging in Pakistan. Objective: This study sought to quantify the prevalence of stress levels and burnout among these surgeons. Methods: Conducted by the Department of Vascular and Endovascular Surgery, Shaheed Mohtarma Benazir Bhutto Institute of Trauma, Karachi, this cross-sectional electronic survey included all practicing vascular surgeons. Non-probability convenience sampling was employed, and data were collected over two weeks using Google Forms. The Maslach Burnout Inventory—Human Services Survey for Medical Personnel was incorporated to measure burnout. Results: The survey found a significant presence of high-level burnout symptoms among vascular surgeons, particularly in emotional exhaustion and personal achievement domains, with lesser but still notable levels among orthopedic and general surgeons. A substantial number reported low job satisfaction and experienced family conflicts. Conclusion: The study highlights the critical levels of burnout among vascular surgeons in Pakistan, emphasizing the need for interventions to mitigate stress and improve job satisfaction.