This study examines whether and how stock exchange self-regulation affects stock market liquidity and corporate transparency. Using a large sample of firms from 46 stock exchanges from 2001 to 2015, we find significant and robust evidence that firms listed in self-regulated stock exchange are associated with fewer zero-return days, lower daily stock price variation, higher stock trading volume, smaller analyst forecast errors, lower discretionary accruals and less earnings management. These findings are more pronounced when the stock exchange has a strong self-regulation model rather than a limited self-regulation model. Also, our results are robust in different-in-difference tests based on the Australian Securities Exchange’s change from strong self-regulation model to a government regulation model. Further, when a firm from a country with a government-regulated stock exchange is cross-listed in a self-regulated stock exchange, the firm has higher liquidity and transparency than the matched firms. In addition, we find that self-regulated exchanges set more detailed insider trading and disclosure rules and are more transparent with their rules and rule enforcement. Overall, our study suggests that stock exchange self-regulation improves the efficiency of stock market regulation.