This paper takes the industrial development of 33618 modern manufacturing clusters in Chongqing Municipality as the actual background as the basis. The purpose of this paper is to study the adaptability of the construction of higher education institutions and the development of "33618" modern manufacturing cluster system, analyze the degree of match between the current higher education institutions' professional settings and the development needs of the manufacturing industry, and put forward corresponding optimization proposals. Through this research, we can more deeply understand the development status and future trends of the city's manufacturing industry, to further promote the high-quality development of the manufacturing industry to provide strong support. The study firstly elaborates the development overview of modern manufacturing industry in Chongqing, combines the development of 33618 modern manufacturing cluster system, and constructs the development model of professional construction applicable to the current economic background. Secondly, through questionnaire survey, interviews and policy text analysis, multi-source data including teachers, students, enterprises and relevant government document statements were collected to ensure the comprehensiveness and accuracy of the research results. The study found that: educational institutions with high technology acceptance are more capable of attracting and cultivating students with innovative spirit and practical ability; effective allocation of resources directly affects the quality of teaching and the enhancement of students' ability; the implementation of teaching reforms can significantly enhance the responsiveness of education and the level of market orientation; and the in-depth promotion of the integration of industry and education is conducive to the accumulation of students' practical experience and the enhancement of their employment competition. In summary, the construction of e-commerce in colleges and universities should comply with the general trend of digital transformation, innovative educational concepts and teaching models, and strengthen cooperation with the industry in order to better adapt to and lead the needs of future e-commerce development. The research results of this paper expand the theoretical vision of 33168 modern manufacturing cluster system development research, and provide experience exploration and practical guidance for the construction of modern manufacturing industry in Chongqing and even the whole country, the new requirements for university professional construction and talent training, collaborate with industry information technology, education, science and technology, human resources and other relevant departments to promote the innovation of manufacturing high-quality development of talent training system, and promote the integration of "industry chain, innovation chain, talent chain, capital chain" depth.