Abstract The U.S. sheep industry has experienced many changes over the last 50 years, the most prominent being a 75% reduction in the national breeding ewe inventory. Wool now accounts for ~10% of enterprise returns compared to ~80% from the sale of market lambs. Most breeding objective work indicates greatest emphasis should be placed on traits associated with ewe reproductive efficiency [e.g., number of lambs born/weaned (NLB/NLW), lamb survival]. Still, average NLB across the U.S. (1.07 lambs/ewe) and within geographic regions (East = 1.13, Midwest = 1.25, West = 1.09, Southwest = 0.79 lambs/ewe) remains low. Several genetic technologies are available to improve reproductive performance. Introgression of large effect gene variants, such as those within BMPR-1B, have increased NLB by ~1.0 and ~1.5 lambs in heterozygous and homozygous ewes, respectively. However, without joint improvement in maternal ability and/or husbandry, advantages in NLW are less pronounced and few U.S. producers utilize such variants in practice. Reproductive efficiency traits present challenges in selection programs as they are lowly heritable (< 0.15) and sex-limited. Previous single-trait selection experiments had modest improvement in NLB (0.01 – 0.02 lambs/yr). Selection accuracy is greatly improved by including pedigree and/or genomic relationships when deriving estimated breeding values (EBV). Since 2000, NLW EBV have increased by 0.01 lambs/yr with concurrent improvement in direct (0.02 kg/yr) and maternal (0.04 kg/yr) weaning weight for Polypay flocks enrolled in the National Sheep Improvement Program (NSIP). Still, NSIP flocks represent < 1% of production-oriented U.S. flocks so considerable expansion is needed to realize within-breed genetic improvement at a national level. Perhaps most importantly, large differences in reproductive efficiency traits exist across breeds and should be utilized to a greater extent in strategic crossbreeding systems. Optimizing reproductive performance for specific production environments is essential for the sustainability of the U.S. sheep industry.