Search Criteria Research Articles

Stem cells and platelet-rich plasma for the treatment of naturally occurring equine tendon and ligament injuries: a systematic review and meta-analysis.

Platelet-rich plasma (PRP) and mesenchymal stromal or stem cells (MSCs) have been investigated as treatments for equine tendon and ligament injuries, but little consensus exists on the efficacy of these treatments. The study sought to evaluate the efficacy of PRP and MSC treatments by systematic review and meta-analysis. A systematic review was performed using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Inclusion criteria required an original, peer-reviewed study where horses were administered MSCs or PRP (or both), and a comparator group was described. Studies were assessed for risk of bias and study quality. Random effects meta-analysis with inverse variance weighting was used to calculate pooled estimates of the ORs for the primary outcomes of return to performance and reinjury. The search criteria identified 764 unique studies, and 21 studies met the inclusion criteria for the systematic review. Seventeen studies were further assessed for the primary outcomes of return to performance and reinjury rate within a meta-analysis. Meta-analyses revealed no increase in the likelihood of a return to performance with any of the biologic treatments. However, MSCs and MSCs administered concurrently with PRP provide a reduced risk of reinjury. The current study identified a decrease in reinjury rate in horses administered MSCs or a combination of MSCs and PRP for tendinopathy and desmopathy. However, results should be interpreted with consideration of the heterogeneity of findings, poor study quality, and high risk of bias in the majority of studies.

MyPharmaceutical: an interactive proof of concept

With the rise of health awareness, pharmaceutical and cosmetic products should be verified to protect ourselves from health risks. MyPharmaceutical is a proof-of-concept proposed to provide a mobile application for users to carry out product verification and reporting and a web application for administrative purposes. The data on the registered pharmaceutical and cosmetic products were extracted from national pharmaceutical regulatory agency (NPRA) website. MyPharmaceutical mobile application provides functionalities such as searching the registered product, bookmarking products, reporting products, and tracking report status. The mobile application also implemented a barcode scanner feature to provide ease of product verification. A named entity recognition algorithm is applied with the NLP.js library to provide an improved product search feature for the users, where products can be searched with multiple search criteria in a single input. The web application is proposed to support the mobile application, where the NPRA data admins and officers can manage reported products, publish announcements, verify product data, and utilize the analytic dashboard. The system proposed is expected to provide ease of product verification and reporting to assist the public in choosing safe registered products and a platform for NPRA to manage data and deliver information to the users.

Perancangan Aplikasi Input Surat Berbasis VBA (Visual Basic for Application) di Kantor Sekretariat Daerah Kabupaten Gunung Mas

Electronic archiving can be easily stored in digital storage, accessed from various locations using devices connected to the internet, and available search features that make it faster and more effective. in this study, a VBA-based letter input information system design was carried out to facilitate Regional Secretariat Office specially at the people’s welfare section in archiving incoming and outgoing letters. So that it is expected to be one of the solutions so that it can be implemented and realized by the relevant agencies. The research method used is qualitative with a case study approach. The results of the research are that the correspondence administration system no longer uses manual methods and make it easier to collect data, search and make reports on correspondence with relevant agencies.

The Efficacy of Acupuncture Therapy in the Management of Dyspnea and Other Symptoms Associated with Heart Failure: A Consolidated Review of Trial Data.

Acupuncture has been used for pain management for thousands of years. However, it is largely unclear whether this therapeutic approach can effectively reduce heart failure-associated symptoms, including dyspnea. The hypothesis posited in this study was that acupuncture does indeed aid in the management of such symptoms and was motivated by the following statistics that establish a requisite need for efficient management of dyspnea to improve patient outcomes with heart failure. In 2020, an estimated 6.2 million adults in the USA had a heart failure diagnosis; in 2018, 379,800 death certificates reported heart failure; and the national cost of heart failure in 2012 was approximately USD 30.7 billion. The methodology employed to conduct this study involved review of trial data extracted from review of papers pertaining to acupuncture, symptoms of heart failure, and dyspnea, from academic and clinical data repositories subject to various inclusion and exclusion criteria. Of the initial set of 293 studies identified, the resulting inclusion set comprised 30 studies. The analysis conducted revealed that the highest frequency of combined acupuncture points prescribed for the foregoing search criteria were as follows: BL13, BL23, LU9, LU5, Dingchuan, LI4, PC6, and HT7. A meta-analysis of combined pooled p values for the studies revealed that acupuncture does aid in the management of symptoms of dyspnea and heart failure, subject to various limitations including but not limited to heterogeneity inherent between the studies in the inclusion set that were analyzed. Such limitations underscore the need to restrict generalizations from the conclusions of this study. The impact and novelty of this research study is its attempt to target the apparent paucity of literature that focuses on the management of dyspnea specifically in the context of heart failure with acupuncture and to bridge the gap of the application of acupuncture research on dyspnea to the cardiovascular context of heart failure. Notwithstanding the meta-analysis undertaken under this review study, further statistical analysis and a pilot study are warranted to consolidate or nullify the results of the research.

The reception of post-Soviet Russian fiction through the peritexts of Finnish translations

ABSTRACT This article is based on research addressing the reception of post-Soviet Russian fiction in the twenty-first century (2000–2023) through Finnish translations and the notions of Russia and Russian literature mediated through them. The investigation of translated fiction draws on imagology, i.e. the study of images and cross-national perceptions in literary representations. Focusing on the peritexts, a subcategory of paratexts coined by Genette (1987/1997), the article investigates book cover texts and publishers’ descriptions of the translated works to find out how the translations are received and introduced to readers of the target culture. The translations comprise 101 books, first translated during 2000–2023. The peritexts were retrieved directly from the printed books or using the search service Finna.fi and publisher websites. The analysis was conducted with help of a computer-assisted qualitative data analysis tool, designed to support inductive, data-driven qualitative analysis. As a result of the analysis, three thematic groups emerging from the peritexts were identified: 1) the portrayal of the (Soviet) Russian past and post-Soviet society as grim, insane and tragic, 2) the emphasis on realism and truthfulness of the image of Russia conveyed by the translations, and 3) praise of the authors’ literary skills.

An application of Rumor Propagation In Google trends

Daley and Kendle’s pioneering mathematical basis for modelling rumor propagation around 1965 has paved a strong platform for researchers to come up with new generalizations for practical scenarios of rumor spreading in social networks. In this study, we use a generalization of original DK model, Ignorant-Spreader-Stifler (ISS) model to analyze the cricket related searches in Sri Lanka on Google.The secondary data used for the study were obtained from Google trends for a five-year period from 2012 to 2017, targeting the three t20 matches held during the period. We introduce two algorithms on Maple mathematical software to estimate the parameters of the ISS model numerically. We observe that the way people search on web about cricket is roughly analogous to spreading a rumour and forecasting is better when modelling with most recent data than considering more data back in time and we also find that the predicting accuracy is significantly equal of the two models built considering the data in 2012 and 2014.

Impacts of Artificial Intelligence on Student Learning: A Systematic Literature Review

This research presents a systematic literature review on the impact of artificial intelligence (AI) on student learning outcomes. While previous studies have explored various aspects of AI in education, there has been a lack of comprehensive analysis specifically examining its effect on learning outcomes. The objective of this study is to provide a detailed review of the literature on the effects of AI on student learning outcomes from 2013 to 2023, employing the PRISMA methodology. From an initial pool of 1068 papers identified in the Scopus database using defined search criteria, 39 articles were selected for the final analysis. Descriptive data reveal that most of the research focuses on higher education students and aims to enhance cognitive learning outcomes. Despite being grounded primarily in empirical research, the findings suggest that AI has significant potential to enhance educational processes in both schools and universities. This study aims to elucidate how AI can improve the learning experience, identify associated challenges and risks, and underscore the importance of integrating technology into the educational system to elevate the overall quality of learning.

What motivates the intention of seeking confirmed cases' activity trajectory information in public health emergencies? An information ecology theory analysis

PurposeIn public health emergencies, seeking confirmed cases’ activity trajectory information (CCATI) is crucial to the public’s efforts to combat the epidemic. The public can stabilize their sentiments and mitigate the risk of cross-infection by obtaining CCATI. We investigated the factors influencing users' intentions to seek CCATI to enhance the government’s risk communication capabilities and improve information platform services.Design/methodology/approachWe analyzed how information ecological factors affect the intention to seek CCATI through perceived value. Data was collected from 429 Chinese citizens during the fourth wave of the coronavirus disease 2019 (COVID-19) pandemic. We used the structural equation model technology and bootstrap mediation effect test to examine the model.FindingsInformation understandability, information relevance, perceived severity and perceived vulnerability directly and positively affect the intention of seeking CCATI. While, the above relationships are also partially mediated by emotional value and functional value. Social support directly and negatively affects the intention of seeking CCATI, while the relationship is also partially mediated by emotional value and functional value. Curiosity directly and positively affects the intention of seeking CCATI, while the relationship is also partially mediated by emotional value. The relationship between the quality of the search service and the intention of seeking CCATI is not significant, instead, it is fully mediated by functional value. The influence effect of information relevance on the intention of seeking CCATI is the greatest, followed by perceived vulnerability. The mediating effect of functional value is higher than emotional value.Practical implicationsThe findings may help governments enhance their risk communication capabilities and improve epidemic prevention and control measures, enhancing the appeal of information platforms.Originality/valueWe focused on CCATI, an area with limited scholarly attention. We analyzed CCATI-seeking factors using an information ecology theory, introducing perceived value as a mediator, thus offering novel perspectives and models.

Hesperidin, a Potential Antiviral Agent against SARS-CoV-2: The Influence of Citrus Consumption on COVID-19 Incidence and Severity in China.

This review examines hesperidin, a citrus bioflavonoid, as a potential antiviral agent against SARS-CoV-2. The COVID-19 pandemic has demanded an urgent need to search for effective antiviral compounds, including those of natural origin, such as hesperidin. The review provides a comprehensive analysis of the chemical properties, bioavailability and antiviral mechanisms of hesperidin, particularly its potential efficacy against SARS-CoV-2. A review of databases, including PubMedPico, Scopus and Web of Science, was conducted using specific keywords and search criteria in accordance with PRISMA (Re-porting Items for Systematic Reviews and Meta-Analysis) guidelines between 2020 and 2024. Of the 207 articles, 37 were selected for the review. A key aspect is the correlation of in vitro, in silico and clinical studies on the antiviral effects of hesperidin with epidemiological data on citrus consumption in China during 2020-2024. The importance of integrating laboratory findings with actual consumption patterns to better understand the role of hesperidin in mitigating COVID-19 was highlighted, and an attempt was made to analyze epidemiological studies to examine the association between citrus juice consumption as a source of hesperidin and the incidence and severity of COVID-19 using China as an example. The review identifies consistencies and discrepancies between experimental and epidemiological data, highlighting the need to correlate the two fields to better understand the potential of hesperidin as an agent against SARS-CoV-2. Challenges and limitations in interpreting the results and future research perspectives in this area are discussed. The aim of this comprehensive review is to bridge the gap between experimental studies and epidemiological evidence and to contribute to the understanding of their correlation.

ReactomeGSA: new features to simplify public data reuse.

ReactomeGSA is part of the Reactome knowledgebase and one of the leading multi-omics pathway analysis platforms. ReactomeGSA provides access to quantitative pathway analysis methods supporting different 'omics data types. Additionally, ReactomeGSA can process different datasets simultaneously, leading to a comparative pathway analysis that can also be performed across different species. We present a major update to the ReactomeGSA analysis platforms that greatly simplifies the reuse and direct integration of public data. In order to increase the number of available datasets, we developed the new grein_loader Python application that can directly fetch experiments from the GREIN resource. This enabled us to support both EMBL-EBI's Expression Atlas and GEO RNA-seq Experiments Interactive Navigator within ReactomeGSA. To further increase the visibility and simplify the reuse of public datasets, we integrated a novel search function into ReactomeGSA that enables users to search for public datasets across both supported resources. Finally, we completely re-developed ReactomeGSA's web-frontend and R/Bioconductor package to support the new search and loading features, and greatly simplify the use of ReactomeGSA. The new ReactomeGSA web frontend is available at https://www.reactome.org/gsa with an built-in, interactive tutorial. The ReactomeGSA R package (https://bioconductor.org/packages/release/bioc/html/ReactomeGSA.html) is available through Bioconductor and shipped with detailed documentation and vignettes. The grein_loader Python application is available through the Python Package Index (pypi). The complete source code for all applications is available on GitHub at https://github.com/grisslab/grein_loader and https://github.com/reactome.

Infrared Small Target Detection Based on Density Peak Search and Local Features

The detection of small infrared targets is still a challenging task and efficient and accurate detection plays a key role in modern infrared search and tracking military applications. However, small infrared targets are difficult to detect due to their weak brightness, small size and lack of shape, structure, texture, and other information elements. In this paper, we propose a target detection method. First, to address the problem that the proximity of targets to high-brightness clutter leads to missed detection of candidate targets, a Gaussian differential filtering preprocessed image is used to suppress high-brightness clutter. Second, a density-peaked global search method is used to determine the location of candidate targets in the preprocessed image. We then use local contrast to the candidate target points to enhance the gradient features and suppress background clutter. The Facet model is used to compute multidirectional gradient features at each point. A new efficient surrounding symmetric region partitioning scheme is constructed to capture the gradient characteristics of targets of different sizes in eight directions, followed by weighting the candidate target gradient characteristics using the standard deviation of the symmetric region difference. Finally, an adaptive threshold segmentation method is used to extract small targets. Experimental results show that the method proposed in this paper has better detection accuracy and robustness compared with other detection methods.

Pay-per-click (PPC) advertising and continuous banking service intentions

AbstractDespite the increasing popularity of pay-per-click (PPC) advertising and search engine optimization within the financial industry, there is a notable lack of research on the effectiveness of PPC on bank customers' continuous search intention and banking services intention. This study aims to fill this gap by investigating the use of PPC as a tool on customers' search intention and continuous services intention in a retail banking context. Utilizing a quantitative design, we collected data and employed maximum likelihood estimation (MLE) for path analysis to analyze the empirical data. Our findings reveal several substantial results. Firstly, continuous search intentions significantly influence continuous banking services intentions. Secondly, attitude toward PPC advertising significantly affects both continuous search and banking services intentions. Thirdly, satisfaction with PPC advertising is crucial in shaping attitudes toward PPC, continuous search intention, and continuous banking services intention. Fourthly, perceived usefulness directly influences attitudes toward PPC, satisfaction with PPC, and continuous search intention. Lastly, while PPC advertising's perceived ease of use and perceived confirmation are linked to perceived usefulness, they do not directly affect attitude toward PPC. By adopting a dual intentions approach, this study contributes to banking literature by highlighting the importance of understanding the distinct roles of PPC attributes in shaping short- and long-term customer behavioral intentions.

#1103 Delayed initiation or reduced initial dose of calcineurin-inhibitors for kidney transplant recipients: a systematic review and meta-analysis

Abstract Background and Aims Delayed graft function (DGF) is more common in donors after cardiac death, especially expanded criteria donors and those with longer cold ischaemia time, older or with an increased serum creatinine. There is no agreement on the optimal immunosuppressive approach in patients at increased risk of DGF, with strategies including a delayed introduction of calcineurin inhibitors (CNI) or initial low dose CNI. Our aim was to evaluate the benefits and harms of delayed initiation of CNI or reduced CNI dose as initial immunosuppression therapy for kidney transplant (KT) recipients at high risk of DGF. Method We searched the Cochrane Kidney and Transplant Register of Studies up to 07 March 2023 through contact with the Information Specialist using search terms relevant to this review. Studies in the Register are identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Register (ICTRP) Search Portal, and ClinicalTrials.gov. We included all randomized controlled trials (RCTs) and quasi-RCTs evaluating early vs delayed initiation of CNI or reduced vs standard initial dose of CNI in kidney transplant (KT) recipients at high risk of DGF. Three authors independently assessed study eligibility, and two assessed the risk of bias, certainty of evidence, extracted the data, and performed the analysis. Results were reported as risk ratios with 95% confidence intervals for dichotomous outcomes and as mean difference with 95% CI for continuous outcomes. Statistical analysis was performed using the random-effects model. Risk of bias was assessed with RoB2 and the certainty of the evidence according to GRADE methods. Results Thirteen studies were included (2386 randomized participants). Incidence of DGF (RR 1.09, 95% CI 0.89 to 1.32; I2 = 18%) and acute rejection (RR 0.98, 95% CI 0.72 to 1.33; I2 = 54%) were similar between early and delayed introduction of CNI, as well as between low vs standard dose of CNI (DGF: RR 1.16, 95% CI 0.90 to 1.50; I2 = 9%; acute rejection: RR 0.70, 95% CI 0.43 to 1.14; I2 = 58%). There were also no differences in secondary outcomes such as graft function, graft loss, risk of death, or infection. Conclusion In patients at high risk of DGF, the strategy of delaying CNI introduction or starting at a lower dose does not reduce the risk of DGF.

Enhancing Care Standard at Public Healthcare Facilities through Patient Satisfaction Assessment – A Review

This review paper provides a comprehensive analysis of research on enhancing care standard at public healthcare facilities through patient satisfaction assessment. By synthesizing findings from peer-reviewed studies, this review aims to identify trends, gaps, and best practices in this critical area of healthcare. Through rigorous search and selection criteria, a total of 15 relevant articles were identified and analyzed. The review explores various dimensions of patient satisfaction assessment, including factors influencing satisfaction, methods of assessment, and the impact on healthcare delivery. Key findings highlight the importance of effective communication, staff attitudes, waiting times, and facility cleanliness in shaping patient satisfaction. Additionally, the review examines the role of different assessment tools, such as surveys, interviews, and online platforms, in capturing patient experiences. Furthermore, it discusses the implications of patient satisfaction assessment on healthcare outcomes, provider-patient relationships, and organizational performance. The review also identifies challenges and opportunities for future research and practice, including the need for standardized assessment tools, resource allocation, and cultural sensitivity. Overall, this review paper contributes to the understanding of how patient satisfaction assessment can be leveraged to improve the care standard at public healthcare facilities.

In Search of Evidence: A Scoping Review of School Nurse Leadership Training Programs.

This scoping review explores leadership training opportunities for school nurses. The review was conducted to inform the development of a new leadership training program for school nurses in Massachusetts. A search conducted across four databases (PubMed, CINAHL, ERIC, and Web of Science) yielded four articles meeting the search criteria published between 1993 and 2007, and no articles meeting the criteria after 2007. The four articles that were found discussed the approaches and evaluation methods of school nurse leadership training programs. They revealed varying training structures and evaluation approaches and covered a wide range of leadership competencies. Importantly, all of the programs reported enhancements in participants' leadership knowledge and practice upon completion of the training program. This review highlights the necessity of documenting and disseminating program outcomes in peer-reviewed literature to guide the development of new initiatives and recommends adopting standardized evaluation frameworks.

Interventions for preventing haemodialysis dysequilibrium syndrome.

Dialysis dysequilibrium syndrome (DDS) refers to neurological symptoms usually seen during or after new initiation or following reinitiation of haemodialysis (HD) after missing multiple sessions. DDS is associated with death and morbidity. We studied interventions aimed at preventing DDS. To evaluate the benefits and harms of different types of interventions for preventing DDS. We contacted the information specialist and searched the Cochrane Kidney and Transplant Register of Studies up to 8 May 2024 using search terms relevant to this review. Studies in the Register were identified through searches of CENTRAL, MEDLINE, and EMBASE, conference proceedings, the International Clinical Trials Registry Platform (ICTRP) Search Portal, and ClinicalTrials.gov. We included randomised controlled trials (RCTs) that compared any intervention against standard care, including individuals initiated on HD, regardless of age. Two authors independently determined study eligibility, assessed quality and extracted data. Data were collected on methods, interventions, participants, and outcomes (DDS incidence, severe DDS, death, adverse events). Risk ratios (RR) and confidence intervals (CI) were calculated. Study quality was assessed using the Cochrane Risk of Bias 2 (ROB2) tool. Confidence in the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. We included two RCTs, enrolling 32 adult participants. Interventions included were slow dialysis, sodium modelling, standard sodium dialysate, and high sodium dialysate. The risk of bias was of some concern to high risk of bias in both studies. Slow dialysis compared to sodium modelling (1 study, 15 participants) may result in little to no difference in DDS, severe DDS, and death (low certainty evidence) and has uncertain effects on adverse events (RR 1.33, 95% CI 0.15 to 11.64; very low certainty evidence). Standard sodium dialysate compared to high sodium dialysate (1 study, 17 participants) has uncertain effects on the incidence of DDS (RR 0.07, 95% CI 0.00 to 1.12), severe DDS (RR 0.47, 95% CI 0.02 to 10.32), and adverse events (RR 0.29, 95% CI 0.08 to 1.02) (very low certainty evidence). In HD patients, sodium modelling, compared to slow dialysis, may result in little to no difference in DDS and death (low certainty evidence) and has uncertain effects on adverse events (very low certainty evidence). The evidence is very uncertain for the effect of high-sodium dialysate and standard sodium dialysate on DDS, death and adverse events (very low certainty evidence).

Effects of dynamic wrist-hand splints for patients with rheumatoid arthritis: A systematic review.

Rheumatoid arthritis (RA) results structural changes on wrist-hand joints, which can have negative impact on daily activities. Splints are commonly used to reduce pain and improve function of people with RA. The research shows that usage of dynamic splints improves wrist-hand function of people with other conditions. This systematic review aims to understand impact of dynamic wrist-hand splints on daily activity functioning of people with RA. A systematic review. Search criteria were applied to PubMed, Web of Science, MEDLINE, CINAHL, Cochrane Library, Physiotherapy Evidence Database, and Scopus electronic databases. Only papers, January 1980 to January 2024, conducted use of dynamic wrist-hand splint for people with RA were included. Quality assessment was completed using the Jovell and Navarro-Rubio classification. Five papers that evaluated the use of dynamic wrist-hand splint for people with RA were included. All the papers showed that use of dynamic wrist-hand splints have positive effect on people with RA, but further research is required to show effect of them on daily activity functioning. Use of dynamic wrist-hand splints improves function and preferred to be used more commonly by the people with RA; however, there is not enough research to show its effect on daily activities as most of the research conducted had limitations. Therefore, further research is required to show the impact of dynamic wrist-hand splint of daily activities for people with RA.

Exploring the relationship between e-health literacy and online health information-seeking behaviour among pharmacy students in Indonesia

Background: Digital transformation has changed the health service system and how people search for health information. Digital health literacy provides basic knowledge that the prospective pharmacy workforce must have to provide comprehensive pharmacy service. Objective: This study aims to explore pharmacy students' eHealth literacy level and relate to their behaviour in accessing health information online. Methods: A cross-sectional survey was conducted on 314 pharmacy students at two pharmacy diploma schools in Jakarta and Bandung, Indonesia. A semi-structured questionnaire was administered to identify online health information-seeking behaviour and e-health literacy scores. Results: Out of 314 students, most were women (86.3%) and sophomores (43.3%). More than half have health applications installed on their smartphone and access health information online more than twice a week. There was a significant relationship between e-health literacy scores and student entry year (p = 0.000), the frequency of online health information-seeking practice (p = 0.001), and installed health apps on smartphones (p = 0.002). Conclusion: A future altered curriculum and the appropriate study materials on digital health must be implemented to equip pharmacy students with adequate skills before graduation.

Optimising personal continuity for older patients in general practice: a cluster randomised stepped wedge pragmatic trial

AimTo evaluate the effectiveness, feasibility and acceptability of a multicomponent intervention for improving personal continuity for older patients in general practice.DesignA cluster randomised three-wedged, pragmatic trial during 18 months.Setting32 general...

Management of a patient at very high cardiovascular risk with myositis during high-intensity statin therapy

The main purpose of this article is to translate the existing experience of successful optimization of lipid-lowering treatment in a patient with a very high cardiovascular risk and a long history of dyslipidemia, cerebral atherosclerosis and myositis, which developed on a high-intensity statin therapy regimen. Using the example of a 56-year-old patient observed in the lipid center of the city of Kemerovo, it was shown that the combination of pitavastatin in the maximum tolerated dose of 2 mg and the cholesterol absorption inhibitor ezetimibe 10 mg can not only be effective in achieving target values of low-density lipoprotein cholesterol (1.4 mmol/l) after undergoing carotid revascularization, but also safe for registered muscle symptoms that arose during a high-intensity statin therapy regimen. It was demonstrated that, against the background of high adherence to the selected treatment and low-cholesterol diet, and maintenance of regular physical activity, the patient completely disappeared both muscle pain and muscle weakness, and there was no clinical or instrumental progression of cerebral stenosis. The article provides current data on the prevalence of muscle symptoms when taking statins in real practice and in randomized clinical trials, discusses existing predisposing factors and potential mechanisms of occurrence, describes variants of clinical manifestations and tentative diagnostic search criteria. In addition, recommendations on the tactics of managing patients with their development at various cardiovascular risks have been systematized. An expert classification system for statin-associated muscle symptoms is demonstrated. Also presented is the routing of patients with side effects developing during statin therapy, adopted in the city of Kemerovo.