This paper reviews the research status, existing problems and challenges, and future research directions of the location of fresh cold chain logistics distribution centers. The research background is based on factors such as the development of the fresh product market, the technological progress of cold chain logistics, the requirements of environmental protection and sustainable development, and the intensification of market competition. The significance of site selection includes improving transportation efficiency, reducing costs, improving customer satisfaction, optimizing supply chain networks, and achieving environmental sustainability.The former focuses on low-carbon, demand uncertainty, and competitive distribution center location, while the latter focuses on the new retail environment and cold chain distribution. The review of relevant literature points out that some progress has been made in the research, but there are challenges such as market demand uncertainty, incomplete data and limited model applicability.Future research directions include the location model of cold chain logistics distribution center based on big data, the location model considering sustainable development factors, and the location method of cold chain logistics distribution center integrating multi-index evaluation.In the conclusion, it is pointed out that in the past, the time window and the overall logistics network were rarely used as research evaluation indicators in the site selection problems, and the cost of reverse logistics and closed-loop supply chain was rarely considered. In the prospect part, it is proposed that in the future, we should pay attention to the problems of reverse logistics and closed-loop supply chain in the distribution of fresh agricultural products, consider the multi-objective optimization of low-carbon cold chain logistics network in different policies and fields, and combine full simulation technology and optimization technology to realize the system optimization research.