In the dynamic landscape of the 21st century, Generation "Z" and Millennials face unique challenges requiring skills beyond technical knowledge, known as Soft Skills. These skills emerge as catalysts to overcome previous paradigms and mitigate work-related mental disorders like burnout. Innovative approaches, including the development of socio-emotional skills from university, not only boost productivity but also enhance the quality of life and mental health of young individuals. The review followed five methodological steps to ensure rigor and reproducibility. This included the defining research question (PICO method) and keywords, a Boolean scheme for search, eligibility criteria for articles, a selection from portals like PubMed, Science Direct, Lilacs, and Google Scholar, and result analysis using spreadsheets for article discussion. The inquiry into the benefits of Soft Skills for Generation "Z" and Millennials guided the article search. Using the Boolean scheme "generation" AND "soft skills" AND "work" AND "quality of life," 16 articles were found, with four meeting the selection criteria. Additionally, five articles were included for theoretical supplementation. The discussion emphasizes the necessary adaptations of youth to the 4.0 economy era, marked by volatility, uncertainty, complexity, and ambiguity (VUCA). These changes affect entry into the workforce, causing insecurities, uncertainties, and impacts on quality of life and mental health. The need for interpersonal skills and soft Skills is highlighted, with studies identifying ten essential competencies for success in the Fourth Industrial Revolution and Society 5.0. Universities should integrate the teaching of these skills to prepare students, improving their adaptability and mental health. Academic and work programs should emphasize personality development and values to facilitate the transition of recent graduates. It is concluded that, given the complexity of the 4.0 economy, youth face challenges in the job market, affecting quality of life and mental health. Soft Skills are crucial for this adaptation. Universities should integrate them into the curriculum, and academic programs should emphasize personal development to ensure an effective transition.