Purpose: The aims of present study was to evaluate the effect of aerobic exercise training on serum IgE and pulmonary functions in asthma children before and after exercise program. Subjects: 60 children with asthma participated in this study and divided randomly to exercise and control groups. Procedure: Fasting serum IgE and some markers indicative of respiratory functions (FEV1, FVC, and FEV1/FVC) were measured before and after the study in both groups. Statistical analysis was performed with the SPSS software version 15.0 using an independent paired t-test. Results: Compared to pre-training, serum IgE decreased significantly and pulmonary function markers increased significantly (≥0.05) after exercise program. All variables remained without change in control group (≥0.05). Conclusion: Aerobic exercise program was associated with a significant decrease in serum level of IgE and improvement of pulmonary functions in asthmatic children.