Marker-based optical motion capture (mocap) systems are increasingly utilized for acquiring 3D human motion, offering advantages in capturing the subtle nuances of human movement, style consistency, and ease of obtaining desired motion. Motion data acquisition via mocap typically requires laborious marker labeling and motion reconstruction, recent deep-learning solutions have aimed to automate the process. However, such solutions generally presuppose a fixed marker configuration to reduce learning complexity, thereby limiting flexibility. To overcome the limitation, we introduce DAMO, an end-to-end deep solver, proficiently inferring arbitrary marker configurations and optimizing pose reconstruction. DAMO outperforms state-of-the-art like SOMA and MoCap-Solver in scenarios with significant noise and unknown marker configurations. We expect that DAMO will meet various practical demands such as facilitating dynamic marker configuration adjustments during capture sessions, processing marker clouds irrespective of whether they employ mixed or entirely unknown marker configurations, and allowing custom marker configurations to suit distinct capture scenarios. DAMO code and pretrained models are available at https://github.com/CritBear/damo
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