Background: Prevalence of alcohol dependence in men has been increasing worldwide, particularly in India. Alcohol dependence syndrome appears to be associated with psychiatric problems specially among spouses. Understanding and addressing the effects of such psychiatric problems becomes necessary. Aim: The aim of this study was to assess the pattern of psychiatric morbidity and marital satisfaction in spouses of patients with alcohol dependence syndrome. Materials and Methods: 246 men with alcohol dependence syndrome and their spouses were evaluated. Marital satisfaction was assessed using the ENRICH marital satisfaction scale. Mini International Neuropsychiatric Interviews (MINI) was used to screen for the possible presence of psychiatric morbidity among spouses. Severity of alcohol dependence in the husbands and consequences of drinking was assessed using Short Alcohol Dependence Data (SADD) and drinkers inventory of consequences (DrInC) respectively. Results: More than half of the spouses (57.72%) had a psychiatric disorder. Primarily mood and anxiety disorder were present. Major depressive disorder was present in 33.33%. Psychiatric morbidity among spouses was significantly associated with SADD. Significant association was found between age, education status, occupation, religion and psychiatric morbidity of spouses. Marital satisfaction score was low and conflicts between the couple was significantly associated with psychiatric morbidity of spouses. Conclusion: Psychiatric morbidity in spouses of alcohol dependent men is high, with marital satisfaction being low. Addressing these issues in spouses can improve their quality of life as they play an important role in the treatment of alcohol dependence syndrome.