Those who are addicted to substances face increased psychological emotional, social and economic problems which can potentially have negative impacts on marital satisfaction and sexual self-esteem and efficacy. Routine activities are often displaced by the need to satisfy the physiological urges. Within a marital union, this along with other variables can distract many from their expected marital responsibilities and daily activities. This study investigated quality of life, marital satisfaction, and sexual self-efficacy in couples who were both addicted to substances within an identified treatment period. The number of participants was 40 (N = 40). Participants were randomly assigned to two of four treatment conditions. Each group was comprised of 10 people undergoing treatment for addiction. All participants were couples entering treatment together who agreed to participate in a treatment program in Qazvin city. Instruments utilized in this investigation included the Enrich marital satisfaction questionnaire (short form) and the Reynolds’ sexual self-efficacy scale. Treatments consisted of eight sessions of training in the form of group therapy, which were conducted by trained clinicians. The control group consisted of those who were waiting for training. No treatment/ training was given. After intervention both groups were tested. Descriptive and inferential statistics were used to analyze data. The results indicated that training significantly improved marital satisfaction and sexual self-efficacy. Scores ob tained in the treatment and control group showed a significant difference ( p < 0.05). The conclusion of this study suggests that couples where both partners are addicted to substances can increase their levels of satisfaction and efficacy within the marital union. Quality of life therapy empowers people to actualize their knowledge, attitudes and values. These skills can enable partners to have increased motivation for starting healthy behaviors which will have significant impacts on their marital satisfaction and sexual function. Trainings designed to enhance communication and collaboration can improve the quality of the marital union despite the influence of substance and addiction within both marital partners.