The current study aimed to investigate the relationship between attitudes toward marital infidelity (ATMI) and family cohesion (FC) through the mediating role of the meaning in life (MIL) in Iranian married women. This was a correlational study of path analysis type. The statistical population included all married women living in Kermanshah, Iran in 2021, among whom 310 were selected using convenience sampling method. Participants were asked to fill out Watley's ATMI, Steger et al.'s MIL and Fischer et al.'s Family Organized Cohesion scales. Data were analyzed using path analysis in AMOS-26 and SPSS-26 software. The results indicated that there is a significant negative relationship between FC and ATMI. Moreover, the result of the path analysis revealed that hypothesized model of the study had a good fit in the participants of the current study. That is, there was a significant relationship between FC and ATMI through the mediating role of MIL.