Marine Sponge Haliclona Sp Research Articles

Haliclonacyclamines A and B, cytotoxic alkaloids from the tropical marine sponge Haliclona sp

The structures of haliclonacyclamines A ( 1) and B ( 2), and their methiodide salts ( 3) and ( 4), were investigated by 1D- and 2D-NMR experiments, notably DQFCOSY, HMBC, HMQC-HOHAHA, and HOHAHA. The relative stereochemistry and position of alkene substituents were determined by single crystal x-ray study at low temperature. The parent haliclonacyclamines show pronounced cytotoxic, antibacterial and antifungal activity.

Rottnestol, a new hemiketal from the sponge Haliclona sp.

Rottnestol, a new hemiketal, was isolated from an Australian collection of the marine sponge Haliclona sp. Its structure was deduced as 3 from 1 H, 13 C, COSY, HMQC, HMBC and nOe NMR studies. Hemiketal 3 was readily converted to its epimer, 4 , and the methyl ketal of 4 .

ChemInform Abstract: Novel Marine Sponge Alkaloids. Part 6. A Tetracyclic Diamine Alkaloid, Halicyclamine A (I), from the Marine Sponge Haliclona sp.

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Alkyl and Alkenyl Resorcinols From an Australian Marine Sponge, Haliclona Sp (Haplosclerida : Haliclonidae)

Eleven alkyl and alkenyl resorcinols have been isolated from the Australian marine sponge Haliclona sp. Three of these, (3), (5) and (10), have previously been described from Australian terrestrial and marine plant sources. The remaining eight, (13)-(20), are new natural products whose structures have been secured by a combination of spectroscopic analysis and chemical degradation. This report represents the first account of this structure class being isolated from a non-plant source.