Here we report continuous and chronologically well-constrained records of stable oxygen (δ18O) and carbon (δ13C) isotope compositions of carbonate nodules (nodular calcretes), and δ13C of sediment organic matters (δ13CSOM) in samples from two (~48 m deep) drill-sediment cores, collected from a paleo-Yamuna channel in the NW Indo-Gangetic Plain in north Haryana. The results were used to reconstruct Indian summer monsoon (ISM) precipitation variability and paleovegetation pattern during the past ~75 ka and present a longer record of ISM variability in the Indo-Gangetic Plain. The δ18O of carbonate nodules (−7.80‰ to −4.04‰, average −6.01‰) shows a good negative covariation with variability in the model-derived intensity of ISM precipitation, indicating it to be a good proxy for ISM variability. We infer intense ISM precipitation during late marine isotope stage (MIS) 5, early and late MIS 3, and early MIS 1 periods, marked by relatively lower δ18O of carbonates. These changes in the ISM intensity are in-phase with the precession-induced changes in the Northern Hemisphere summer insolation. The δ13CSOM (−27.4‰ to −22.3‰, average −25.3‰) indicates C3-dominated vegetation in the Himalayan catchment with a noticeable increase in δ13CSOM during late MIS 4 to early MIS 3, late MIS 3, and early MIS 1 periods, which are characterized by the intense ISM (warm and moist condition). This suggests an increased abundance of C4 plants during the periods of intensified ISM precipitation. The δ13C of carbonate nodules varies from −3.63‰ to 1.56‰ (average −1.55‰). The enrichment in 13C of the carbonates is most likely due to the influence of dissolved inorganic carbon derived from the Himalayan source and/or atmospheric CO2 on the carbonate nodules. Therefore, we suggest that the δ13C of carbonate nodules from the Indo-Gangetic Plain requires a careful evaluation.