Abstract Background The surge in drug use and lack of awareness about drug-related dangers among young adults have become major public health concerns in South Korea. According to the Theory of Planned Behavior, understanding attitudes towards drugs is crucial, as permissive attitudes may lead to drug use. Thus, the study aims to identify latent classes of drug use attitudes among Korean young adults and evaluate how their well-being influences each class. Methods A total of 301 college students in Seoul, South Korea, participated in the study. Latent class analysis (LCA) was employed to identify unique patterns of attitudes towards drug use. Subsequently, we examined the relationships between auxiliary variables (i.e., well-being, including life satisfaction, self-control, quality of life, depression, generalized anxiety disorder, childhood trauma, self-esteem, stress, family strengths, perceived social support, and stigmatization) and latent classes (i.e., attitudes towards drug use subgroups) by conducting multivariate logistic regression analyses. Results LCA categorized attitudes towards drug use into three groups: Class 1 (Permissive Drug Attitude Group), Class 2 (Moderate Drug Attitude Group), and Class 3 (Critical Drug Attitude Group). Class 2 showed a particularly permissive view on marijuana legalization. In multivariate logistic regression, higher stigmatization (β = .900, p < .05) was associated with membership in Class 1 compared to Class 3. Furthermore, being male (β = 2.272, p < .001) and having higher self-esteem (β = .989, p < .05) were linked to membership in Class 2 compared to Class 3. Conclusions The study enhances understanding of the complex relationship between Korean young adults’ well-being and their drug use attitudes. Effective interventions by frontline social workers aimed at preventing drug use should continuously monitor and address social stigmatization and self-esteem while providing accurate information and education regarding drug use. Key messages • Latent Class Analysis sorted drug attitudes into three groups: ‘Permissive,’ ‘Moderate,’ and ‘Critical’ Attitude Groups. • Individuals experiencing social stigmatization had a higher risk of permissive attitudes, while higher self-esteem increased the likelihood of being in the moderate group over the critical group.