Marc De Research Articles

Braindance

Neuromarketing is the use of imaging technology to ascertain information about brain states during the viewing of advertising and products. It is an area of increasing interest for the purposes of both neuroscience brain research and marketing. At present, there remains significant disagreement about value of knowledge claims made by neuromarketing and its efficacy in both understanding and predicting consumer behavior. This paper outlines an approach to epistemic conception of neuromarketing by applying and broadening the categories of technological knowledge produced by Walter Vincenti and Marc de Vries. Categories of technological knowledge capture several important elements of epistemology and knowledge generation, though more work in areas such as business judgment and knowledge translation remains to be done. The framework provided herein presents new epistemological considerations for the analysis of marketing practice related consumer behavior and brain activity.

Book Review: Gender Quotas for Company Boards, edited by Marc De Vos and Philippe Culliford. (Cambridge: Intersentia, 2014)

Book Review: <i>Gender Quotas for Company Boards</i>, edited by Marc De Vos and Philippe Culliford. (Cambridge: Intersentia, 2014)

Automated Dictionary-based Indexing of Electron Channeling Patterns

Journal Article Automated Dictionary-based Indexing of Electron Channeling Patterns Get access Saransh Singh, Saransh Singh Dept. of Materials Science and Engineering, Carnegie Mellon Univ., Pittsburgh PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar Marc De Graef Marc De Graef Dept. of Materials Science and Engineering, Carnegie Mellon Univ., Pittsburgh PA 15213, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 21, Issue S3, 1 August 2015, Pages 2041–2042, https://doi.org/10.1017/S1431927615010983 Published: 23 September 2015

CLINICAL NUTRITION WEEK 2015: Long Beach, CA February 14–17, 2015

CLINICAL NUTRITION WEEK 2015: Long Beach, CA February 14–17, 2015

Pharmacophore modeling: advances, limitations, and current utility in drug discovery

Pharmacophore modeling: advances, limitations, and current utility in drug discovery Xiaoyu Qing,1,* Xiao Yin Lee,2,* Joren De Raeymaeker,1 Jeremy RH Tame,3 Kam YJ Zhang,2 Marc De Maeyer,1 Arnout RD Voet1,2&nbsp;1Laboratory for Biomolecular Modelling, Department of Chemistry, Katholieke Universiteit Leuven, Heverlee, Belgium; 2Structural Bioinformatics Team, Center for Life Science Technologies, RIKEN, Yokohama, Kanagawa, Japan; 3Drug Design Laboratory, Yokohama City University, Yokohama, Kanagawa, Japan *These authors contributed equally to this work Abstract: Pharmacophore modeling is a successful yet very diverse subfield of computer-aided drug design. The concept of the pharmacophore has been widely applied to the rational design of novel drugs. In this paper, we review the computational implementation of this concept and its common usage in the drug discovery process. Pharmacophores can be used to represent and identify molecules on a 2D or 3D level by schematically depicting the key elements of molecular recognition. The most common application of pharmacophores is virtual screening, and different strategies are possible depending on the prior knowledge. However, the pharmacophore concept is also useful for ADME-tox modeling, side effect, and off-target prediction as well as target identification. Furthermore, pharmacophores are often combined with molecular docking simulations to improve virtual screening. We conclude this review by summarizing the new areas where significant progress may be expected through the application of pharmacophore modeling; these include protein&ndash;protein interaction inhibitors and protein design. Keywords: ADME-tox, computer-aided drug design, pharmacophore fingerprint, protein design, virtual screening&nbsp

English

BACKGROUND: Cystic lesions of the mesentery are uncommon lesions which are infrequently diagnosed prior to surgery. They may be located anywhere in gastrointestinal tract, although they are most often found in small bowel mesentery. Mesenteric and omental cysts are unique for their diverse clinical presentation, etiology, radiological features and pathological characteristics. AIMS AND OBJECTIVES: To present a series of patients with mesenteric and omental cysts, their clinical presentation, gross & histopathology with special emphasis on new updated classification proposed by Marc de Perrot in 2000. MATERIAL AND METHODS: A total of 5376 surgical specimens in Paediatric Referral Hospital , Hyderabad from June 2003 to May 2012 of which 55 children presented with mesenteric and omental cysts, which were prospectively and retrospectively evaluated. Gross, radiologic images and histopathological sections were reviewed to categorize and classify, to determine their relationship to mesentery and intestines. RESULTS: The study group comprised of 39 boys and 16 girls with an age range of 3 days to 7 years. There was male predominance with M: F=2.4:1. CONCLUSION: Mesenteric and omental cysts in children are a rare benign lesions but present with huge masses and acute symptoms very early in their lives. Preoperative diagnosis and localization are very difficult. Histopathological classification of mesenteric and omental cysts has an advantage of identifying epithelial lining and distinguishing malignant masses that possess a cystic appearance and aid in post-operative chemotherapy or radiotherapy.

Transgenic plants: from first successes to future applications

This dialogue was held between the Guest Editors of the Special Issue on "Plant Transgenesis" of the Int. J. Dev. Biol. and Marc De Block. He was one of the first scientists worldwide to obtain transgenic plants transformed with the chimeric selectable marker genes encoding neomycin phosphotransferase and bialaphos that confer resistance against the antibiotic kanamycin and the herbicide Basta®/glufosinate, respectively at the Department of Genetics of Ghent University and, later on, at the spin-off company, Plant Genetic Systems. Today, these two genes are still the most frequently utilized markers in transgene technology. Marc De Block chose to work on the improvement of crops in an industrial environment to help realize the production of superior seeds or products. He was part of the team that developed the male sterility/restorer system in canola (Brassica napus var. napus) that led to the first hybrid lines to be commercialized as successful products of transgene technology. In more than 30 years of research, he developed transformation procedures for numerous crops, designed histochemical, biochemical and physiological assays to monitor plant performance, and made original and innovative contributions to plant biology. Presently, he considers transgenic research part of the toolbox for plant improvement and essential for basic plant research.

Senescene associated cells in human CD8+ T-lymphocytes and their homing characteristics

Event Abstract Back to Event Senescene associated cells in human CD8+ T-lymphocytes and their homing characteristics Oscar O. Onyema1*, Rose Njemini1, Louis N. Forti1, Ivan Bautmans1, Joeri L. Aerts2, Marc De Waele3 and Tony Mets1, 4 1 Vrije Universiteit Brussel, Gerontology Department, Belgium 2 Vrije Universiteit Brussel, Immunology and Physiology Department, Belgium 3 Universitair Ziekenhuis Brussel, Hematology Department, Belgium 4 Universitair Ziekenhuis Brussel, Geriatrics Department, Belgium The expression of CD57 and the absence of CD28 on T-lymphocytes have been used as "senescence" markers. The association of these markers with characteristics of senescence that emerge during in vitro cellular aging is, however, not clear. Using flow cytometry, CD8+ T-cells were analyzed in old and young human subjects for their expression of CD57 and CD28. The subpopulations were tested for various markers of cellular senescence, apoptosis, homing and differentiation, and for their proliferation capacity. Significantly higher proportions of CD28+CD57+ and CD28-CD57+ cells were found in old subjects. CD28+CD57+ cells lacked proliferation. They also had the highest intensity of expression of the senescence markers: p16 and p21, the pro-survival protein: Bcl-2, and the apoptosis and survival regulator: CD95, and the highest frequency of Bcl-2 and CD95 expressing cells, favouring a likely role of these proteins in promoting senescence in CD28+CD57+ cells despite their significantly higher proportion of cells positive for the apoptosis indicator, Annexin-V, compared with other subpopulations. The frequency of CD45RO and CCR5 expressing cells was also highest in CD28+CD57+ cells. CD45RO, CCR5 and CD95 are highly expressed by cell populations believed to be dominated by senescent cells. CD28-CD57+ cells also showed appreciable senescence behaviour; however, their heterogeneity emphasized in this study, and our observation of a subpopulation of CXCR2+ cells among them indicates the possibility of a subpopulation of CD28-CD57+ cells that might represent a more pronounced senescent phenotype. Although there are evidences from our study that different cell phenotypes might represent senescent cells from different T cell homing environments shown by their level of expression of CD62L and CCR7, we conclude that among CD8+ T-lymphocytes, characteristics that correspond to a senescent cell type are most prominent in CD28+CD57+ cells, thus providing further evidence for the existence of senescent cells in vivo and their possible importance in aging. Acknowledgements The study was supported by a scientific grant from the "Wetenschappelijk Fonds Willy Gepts" from the Universitair Ziekenhuis Brussel.

In Memoriam: Mikhail Konstantinovich Ivanov, 1945–2012

The guest editors Marc De Batist and Oleg Khlystov dedicate this special double issue of Geo-Marine Letters, presenting contributions from the 10th International Conference on Gas in Marine Sediments (September 2010, Lake Baikal, Russia), to the memory of Mikhail Konstantinovich Ivanov. The author of this In Memoriam is Alexei Suzyumov, former staff member of UNESCO responsible for the TTR program.

Plus Ça Change: Along the Rue de Caumartin [Doing No Harm

Plus Ça Change: Along the Rue de Caumartin [Doing No Harm

Statistics re-analysed: From complexity to simplicity and utility

[first paragraph of article] ‘‘ Everything should be made as simple as possible, but not one bit simpler ’’ (Einstein) There is no shadow of doubt that statistics are an essential part of science and clinical practice, and therefore should be readily available to all concerned, in a comprehensible manner. In recent years, statistics have tended to deviate from this intention, with their perception of being complex and user-unfriendly. This misconception requires an urgent re-evaluation of statistics, with the aim of restoring their original image of simplicity, elegance and application. In this issue of the Journal, the two excellent articles by Marc de Leval & Ben Bridgewater and Sir Bruce Keogh serve the purposes of clarifying several aspects relating to the philosophy and applications of statistics. We strongly endorse their message, and attempt in this Editorial to present a simplified road map of the applications of statistics including the origins and utility of commonly used methodologies.

Physical activity participation, functional exercise capacity and self-esteem in patients with schizophrenia

Davy Vancampfort, Marc De Hert, Katrien Maurissen, Kim Sweers, Jan Knapen, Julie Raepsaet, Michel Probst Aims: This article describes a study comparing level of physical activity functional exercise capacity and body image and self-esteem variables between patients with schizophrenia with high and low perceived sports competence and perceived physical fitness (HPSCPF and LPSCPF). Methods: A cross-sectional study with 67 schizophrenia patients was undertaken. The final sample included 19 patients with HPSCPF and 19 with LPSCPF The Baecke Physical Activity questionnaire, the 6-minute walk test, the Physical Self-Perception Proflie (PSPP) and the B-WISE® were used. Body mass index (BMI) was incorporated as a covariate. Findings: In LPSCPF-patients, sport (p = 0.008) and leisure time physical activity (p = 0.004) participation was poorer and the distance walked 20.4% shorter (p &lt; 0.001) compared with HPSCPF-patients. Also all other PSPP scores (p &lt; 0.001) and the B-WISE® total score (p &lt; 0.001) were lower in LPSCPF-patients compared to HPSCPF-patients. Conclusions: In order to motivate patients with schizophrenia to become more physically active, physical therapists should be aware of the detrimental effects of a LPSCPF.

A New State of MIIND

Event Abstract Back to Event A New State of MIIND Dave Harrison1* and Marc De Kamps1 1 University of Leeds, United Kingdom Multiple Interacting Instantiations of Neuronal Dynamics (MIIND) [1] is a software suite for the simulation of neuronal circuits and large-scale networks. MIIND models at the level of the population. It is very easy to model circuits of populations and visualize the dynamics. Whole circuits can now be embedded in large hierarchical structures so that networks of circuits with considerable spatial complexity can be created. The activation of the networks can be visualized in 2D and 3D. Although MIIND is a C++ framework, with the associated performance benefits, much of its functionality can be accessed in Python. Uniquely, MIIND offers the possibility to simulate neural populations with population density techniques. Conventional population simulation techniques require a large number of neurons to be simulated and then to calculate relevant population statistics by spike counting and averaging. With population density techniques these averages are simulated directly, bypassing the simulation of individual neurons. This leads to remarkably efficient simulations. MIIND is the only publicly available repository of population density algorithms. Recently, we have managed to include networks of leaky-integrate-and-fire neurons with balanced excitation-inhibition. In the diffusion approximation this entails the solution of Fokker-Planck equations, but importantly, our algorithms are also applicable outside of the diffusion regime. At present MIIND is a powerful tool for the simulation of large networks of spiking neuron populations and the presentation of their results. MIIND is an open source framework for computational and cognitive neuroscience, which exposes application programming interfaces for the creation of neural models of cognition through design patterns. This allows rapid application development through reuse of contributed components to create complex neural models. We will demonstrate a number of applications developed with MIIND to show coupled systems of Wilson-Cowan and Fokker-Planck equations. The demonstrations are shown from within a graphical interface to a dynamical model of visual attention. The software allows the time-course of neural activity to be visualised as a complete model, as cortical circuits, and as individual neurons or neural populations.

Alister Jones and Marc de Vries (eds): International handbook of research and development in technology education

Alister Jones and Marc de Vries (eds): International handbook of research and development in technology education

Should We Expand the Pharyngitis Paradigm for Adolescents and Young Adults?

Letters6 April 2010Should We Expand the Pharyngitis Paradigm for Adolescents and Young Adults?Em. Marc De Meyere, MD and Jan Matthys, MDEm. Marc De Meyere, MDFrom University of Ghent, Belgium, 9000 Ghent, Belgium.Search for more papers by this author and Jan Matthys, MDFrom University of Ghent, Belgium, 9000 Ghent, Belgium.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-7-201004060-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Centor (1) presented an interesting article about management of pharyngitis in adolescents and young adults. The data on the Lemierre syndrome oblige us to be vigilant, but we disagree with the author's conclusions, especially as formulated in the second key summary point (“Use a penicillin or a cephalosporin for empirical treatment of rapid streptococcus-negative pharyngitis in adolescents and young adults”). Centor mentions that we do not have data on the clinical presentation of Fusobacterium necrophorum pharyngitis. Whether antibiotic therapy affects the duration and severity of pharyngitis symptoms or contagion is unknown, so these considerations cannot be included ...

A Companion to the works of Walter Benjamin

Walter Benjamin (1892-1940) has emerged as one of the leading cultural critics of the twentieth century. His work encompasses aesthetics, metaphysical language and narrative theories, German literary history, philosophies of history, the intersection of Marxism and Messianic thought, urban topography, and the development of photography and film. Benjamin defined the task of the critic as one that blasts endangered moments of the past out of the continuum of history so that they attain new significance. This volume of new essays employs this principle of actualization as its methodological program in offering a new advanced introduction to Benjamin's own work. The essays analyze Benjamin's central texts, themes, terminologies, and genres in their original contexts while simultaneously situating them in new parameters, such as contemporary media, memory culture, constructions of gender, postcoloniality, and theories of urban topographies. The Companion brings together an international group of established and emerging scholars to explicate Benjamin's actuality from a multidisciplinary perspective. Designed for audiences interested in literary criticism, cultural studies, and neighboring disciplines, the volume serves as a stimulus for new debates about Benjamin's intellectual legacy today. Contributors: Dominik Finkelde, Wolfgang Bock, Bernd Witte, Lutz Koepnick, Eric Jarosinski, Karl Ivan Solibakke, Marc de Wilde, Vivian Liska, Willi Bolle, Dianne Chisholm, Adrian Daub. Rolf J. Goebel is Professor of German at the University of Alabama in Huntsville.

Pulmonary Hypertension and Lung Transplantation

A discussion on current practice, challenges, and emerging opportunities in lung transplantation for pulmonary hypertension patients was led by guest editor Deborah Jo Levine, MD, of the University of Texas Health Science Center at San Antonio. Joining her were Marc de Perrot, MD, a thoracic surgeon at Toronto General Hospital, Toronto, Ontario, Canada; Reda Girgis, MD, Associate Professor of Medicine, Johns Hopkins Hospital, Baltimore, Maryland; and Myung Park, MD, Assistant Professor of Medicine, University of Maryland School of Medicine, Baltimore.

Editorial [Hot Topic: Novel Peptides and Proteins in Diabetes Mellitus (Guest Editors: Po Sing Leung and Marc de Gasparo)

Editorial [Hot Topic: Novel Peptides and Proteins in Diabetes Mellitus (Guest Editors: Po Sing Leung and Marc de Gasparo)

Marc de Vries, Rod Custer, John Dakers and Gene Martin (eds): Analyzing Best Practices in Technology Education

Marc de Vries, Rod Custer, John Dakers and Gene Martin (eds): Analyzing Best Practices in Technology Education

Notification (Reference C/NL/06/01) for the placing on the market of the genetically modified carnation Moonaqua 123.8.12 with a modified colour, for import of cut flowers for ornamental use, under Part C of Directive 2001/18/EC from Florigene ‐ Scientific Opinion of the Panel on Genetically Modified Organisms

Notification (Reference C/NL/06/01) for the placing on the market of the genetically modified carnation Moonaqua 123.8.12 with a modified colour, for import of cut flowers for ornamental use, under Part C of Directive 2001/18/EC from Florigene ‐ Scientific Opinion of the Panel on Genetically Modified Organisms