Mapping Studies Research Articles

Comparing Apples and Oranges: Advances in Disease Resistance Breeding of Woody Perennial Fruit Crops.

Apple and citrus are perennial tree fruit crops that are vital for nutritional security and agricultural economy and to achieve the Sustainable Development Goals of the United Nations. Apple scab and fire blight, along with Huanglongbing, canker, and tristeza virus, stand out as their most notorious diseases and annually destabilize fruit supply. An environmentally sound approach to managing these diseases is improving tree resistance through breeding and biotechnology. Perennial fruit tree germplasm collections are distributed globally and offer untapped potential as sources of resistance. However, long juvenility, specific pollination and flowering habits, and extensive outcrossing hinder apple and citrus breeding. Advances in breeding approaches include trans- and cis-genesis, genome editing, and rapid-cycle breeding, which, in addition to conventional crossbreeding, can all facilitate accelerated integration of resistance into elite germplasm. In addition, the global pool of available sources of resistance can be characterized by the existing genetic mapping and gene expression studies for accurate discovery of associated loci, genes, and markers to efficiently include these sources in breeding efforts. We discuss and propose a multitude of approaches to overcome the challenges of breeding for resistance in woody perennials and outline a technical path to reduce the time required for the ultimate deployment of disease-resistant cultivars.

Size and Topography of the Brain’s Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder

BackgroundExisting functional connectivity studies of psychosis use population-averaged functional network maps, despite highly variable topographies of these networks across the brain surface. We aimed to define the functional network areas and topographies in the general population and the changes associated with psychotic experiences (PEs) and disorders. MethodsMaps of 8 functional networks were generated using an individual-specific template-matching procedure for each participant from the Human Connectome Project Young Adult cohort (n = 1003) and from a matched case cohort (schizophrenia [SCZ], n = 27; bipolar disorder, n = 35) scanned identically with the same Connectom scanner. In the Human Connectome Project Young Adult cohort, PEs were estimated based on scores from the Achenbach Self-Report Scale. The relationship of symptoms to the probability of network representation at each cortical vertex was assessed using logistic regression. ResultsIn Human Connectome Project Young Adult participants, PE severity on the Achenbach thought problems scale was predicted by increased language network (LAN) and dorsal attention network (DAN) areas and decreased cingulo-opercular network area (r < 0.12). Significant effects were found in SCZ, with a larger DAN and LAN and a smaller frontoparietal network. Network pattern analysis in SCZ showed an increased probability of LAN in the posterior region of the left superior temporal gyrus and of the visual network in the left insula. Regression analyses in SCZ found that mood dysregulation was related to increased DAN surface area. ConclusionsThose with PEs and SCZ showed abnormal functional network cortical topographies, particularly involving DAN and LAN. Network findings may predict psychosis progression and guide earlier intervention.

Cortical and subcortical substrates of working memory in the right hemisphere: A connectome-based lesion-symptom mapping study

Working Memory (WM) is a cognitive system whose crucial role is to temporarily hold and manipulate information. Early studies suggest that verbal WM is typically associated with left hemisphere (LH) brain regions, while the processing of visuospatial information in WM more specifically depends on the right hemisphere (RH). However, recent evidence suggests a more complex network involving both hemispheres' prefrontal and posterior parietal cortices in these processes. Unfortunately, previous lesion studies often examined only one modality (either verbal, or visuospatial) or one hemisphere, which limits the possible conclusions regarding non-lateralized hemispheric involvement. Using connectome-based lesion-symptom mapping on a large sample of patients with left (LBD) and right (RBD) focal brain damage, we examined whether gray matter damage and white matter disconnections predict deficits of WM updating in an N-back task. Patients were examined with two WM tasks that differed regarding modality (verbal, spatial) and cognitive load (1-back, 2-back). Behavioral outcomes indicated that RBD patients showed significant deficits in WM updating, regardless of task modality or load. This observation was supported by whole-brain voxel-based analysis, revealing associations between WM deficits and gray matter clusters in the RH. Specifically, damage to the right lateral frontal cortex including the brain region homologous to Broca's area was associated with verbal WM deficits, while damage to the right inferior parietal lobe and posterior temporal cortex predicted spatial WM deficits. Additionally, white matter analyses identified severely impacted tracts in the RH, predicting deficits in both verbal and spatial WM. Our findings suggest that the mental manipulation of both verbal and visuospatial information in WM updating relies on the integrity of the RH, irrespective of the specific type of information held in mind.

Identification of quantitative trait loci of pod dehiscence in a collection of soybean grown in the southeast of Kazakhstan.

Soybean [Glycine max (L.) Merr.] is one of the important crops that are constantly increasing their cultivation area in Kazakhstan. It is particularly significant in the southeastern regions of the country, which are currently predominant areas for cultivating this crop. One negative trait reducing yield in these dry areas is pod dehiscence (PD). Therefore, it is essential to understand the genetic control of PD to breed new cultivars with high yield potential. In this study, we evaluated 273 soybean accessions from different regions of the world for PD resistance in the conditions of southeastern regions of Kazakhstan in 2019 and 2021. The field data for PD suggested that 12 accessions were susceptible to PD in both studied years, and 32 accessions, in one of the two studied years. The genotyping of the collection using a DNA marker for the Pdh1 gene, a major gene for PD, revealed that 244 accessions had the homozygous R (resistant) allele, 14 had the homozygous S (susceptible) allele, and 15 accessions showed heterozygosity. To identify additional quantitative trait loci (QTLs), we applied an association mapping study using a 6K SNP Illumina iSelect array. The results suggested that in addition to major QTL on chromosome 16, linked to the physical location of Pdh1, two minor QTLs were identified on chromosomes 10 and 13. Both minor QTLs for PD were associated with calmodulin-binding protein, which presumably plays an important role in regulating PD in dry areas. Thus, the current study provided additional insight into PD regulation in soybean. The identified QTLs for PD can be efficiently employed in breeding for high-yield soybean cultivars.

Architecture and anatomy of executive processes: evidence from verbal fluency and Trail Making Test in 2009 stroke patients.

The few voxel-wise lesion-symptom mapping (VLSM) studies aimed at identifying the anatomy of executive function are limited by the absence of a model and by small populations. Using Trail Making Test (TMT) and verbal fluency and a model of their architectures, our objective was to identify the key structures underlying two major executive processes, set-shifting and strategic word search. We applied a validated VLSM analysis to harmonized cognitive and imaging data from 2009 ischemic stroke patients as a part of the Meta VCI Map consortium. All contrast analyses used an adjusted threshold with 2000 Freedman-Lane permutations (p ≤ 0.05). The TMT parts A and B were associated with structures involved in visual-spatial processing, the motor system, the frontal lobes, and their subcortical connections. Set-shifting depended on the left dorsomedial frontal region. Both semantic and phonemic fluency tests depended on verbal output abilities and processing speed with similar slopes in different languages. The strategic search process depended on Broca's area, F2 and related tracts, temporal and deep regions. Lastly, the lesion map of set-shifting did not overlap with those of strategic word search processes. Our results identify the anatomical substrates of two main executive processes, revealing that they represent only a specific subpart of previously reported structures. Finally, our results indicate that executive functions depend on several specific, anatomically separable executive processes mainly operating in various parts of the frontal lobes.

The HAPPY concept mapping study: “to prevent injuries in young handball players it's important to…” – perceptions among stakeholders

Objective: This study aimed to identify facilitators for implementing injury prevention initiatives in youth handball, and to assess stakeholders' perceptions of their importance and feasibility. Method: Four stakeholder groups — coaches, administrators, health staff and players — participated in this mixed-method concept mapping study. Participants (n = 224; 19 % coaches, 22 % health staff, 63 % players, 18 % administrators) first provided statements about facilitators for implementing injury prevention initiatives in youth handball, then thematically grouped them (n = 47), before rating them (n = 57) for importance and feasibility (5-point Likert scales). Stakeholder-specific cluster maps and Go-Zone scatter plots were created. Statements rated above average for both importance and feasibility were considered as prioritized (Go-Zone 1). Results: 87 unique statements were generated during brainstorming. Multidimensional scaling and hierarchical cluster analysis resulted in similar sorting data clustering patterns for coaches, health staff, and administrators, which included federation strategies, club strategies, and coach and athlete education/knowledge. All clusters were rated >3 on average ratings of importance by all stakeholder groups. Six statements were in Go-Zone 1 for all stakeholder groups, including three statements about coach knowledge and education. Players' importance and feasibility ratings had limited overlap with other stakeholder groups' Go-Zone 1 statements. Players' Go-Zone 1 statements mainly addressed individual load management and practical training setup. Conclusion: Coach knowledge and education, alongside collaboration among stakeholder groups, are essential when implementing injury prevention initiatives in youth handball. Stakeholder groups have varying perspectives, underscoring the importance of understanding and addressing these diverse viewpoints when implementing injury prevention initiatives in youth handball.

A Concept Mapping Study on the Challenges of University Life Adjustment for Military Discharged Students

A Concept Mapping Study on the Challenges of University Life Adjustment for Military Discharged Students

Genetic, molecular and physiological crosstalk during drought tolerance in maize (Zea mays): pathways to resilient agriculture.

This review comprehensively elucidates maize drought tolerance mechanisms, vital for global food security. It highlights genetic networks, key genes, CRISPR-Cas applications, and physiological responses, guiding resilient variety development. Maize, a globally significant crop, confronts the pervasive challenge of drought stress, impacting its growth and yield significantly. Drought, an important abiotic stress, triggers a spectrum of alterations encompassing maize's morphological, biochemical, and physiological dimensions. Unraveling and understanding these mechanisms assumes paramount importance for ensuring global food security. Approaches like developing drought-tolerant varieties and harnessing genomic and molecular applications emerge as effective measures to mitigate the negative effects of drought. The multifaceted nature of drought tolerance in maize has been unfolded through complex genetic networks. Additionally, quantitative trait loci mapping and genome-wide association studies pinpoint key genes associated with drought tolerance, influencing morphophysiological traits and yield. Furthermore, transcription factors like ZmHsf28, ZmNAC20, and ZmNF-YA1 play pivotal roles in drought response through hormone signaling, stomatal regulation, and gene expression. Genes, such as ZmSAG39, ZmRAFS, and ZmBSK1, have been reported to be pivotal in enhancing drought tolerance through diverse mechanisms. Integration of CRISPR-Cas9 technology, targeting genes like gl2 and ZmHDT103, emerges as crucial for precise genetic enhancement, highlighting its role in safeguarding global food security amid pervasive drought challenges. Thus, decoding the genetic and molecular underpinnings of drought tolerance in maize sheds light on its resilience and paves the way for cultivating robust and climate-smart varieties, thus safeguarding global food security amid climate challenges. This comprehensive review covers quantitative trait loci mapping, genome-wide association studies, key genes and functions, CRISPR-Cas applications, transcription factors, physiological responses, signaling pathways, offering a nuanced understanding of intricate mechanisms involved in maize drought tolerance.

A debris flow susceptibility mapping study considering sample heterogeneity

A debris flow susceptibility mapping study considering sample heterogeneity

Pengembangan Keuangan Mikro Islam untuk Mengatasi Kemiskinan dan Mencapai Tujuan SDGs: Pendekatan Bibliometrik

This study tries to review research on sustainable microfinance development in Scopus indexed journals. This analysis uses descriptive statistical analysis based on 319 selected papers related to microfinance sustainable development from both national and international journals. All samples of published journals have been published for 27 years from 1996 to 2022. The data is then processed and analyzed using the VOSviewer application program to find out the bibliometric visualization map for sustainable development of microfinance research. The results of this bibliometric mapping study show a map of the development of research in the field of microfinance sustainable development. This study also found a close relationship between microfinance sustainable development and the main goal of the SDGs, namely eradicating poverty to promote prosperity for all people of all ages around the world. This research finds new and interesting keywords for further research.

Identifying and prioritizing recommendations to optimize transitions across the care journey for hip fractures: Results from a mixed-methods concept mapping study.

Individuals who experience a hip fracture have numerous care transitions. Improving the transition process is important for ensuring quality care; however, little is known about the priorities of different key interest groups. Our aim was to gather recommendations from these groups regarding care transitions for hip fracture. We conducted a concept mapping study, inviting persons with lived experience (PWLE) who had a hip fracture, care partners, healthcare providers, and decision-makers to share their thoughts about 'what is needed to improve care transitions for hip fracture'. Individuals were subsequently asked to sort the generated statements into conceptual piles, and then rate by importance and priority using a five-point scale. Participants decided on the final map, rearranged statements, and assigned a name to each conceptual cluster. A total of 35 participants took part in this concept mapping study, with some individuals participating in multiple steps. Participants included 22 healthcare providers, 7 care partners, 4 decision-makers, and 2 PWLE. The final map selected by participants was an 8-cluster map, with the following cluster labels: (1) access to inpatient services and supports across the care continuum (13 statements); (2) informed and collaborative discharge planning (13 statements); (3) access to transitional and outpatient services (3 statements); (4) communication, education and knowledge acquisition (9 statements); (5) support for care partners (2 statements); (6) person-centred care (13 statements); (7) physical, social, and cognitive activities and supports (13 statements); and (8) provider knowledge, skills, roles and behaviours (8 statements). Our study findings highlight the importance of person-centred care, with active involvement of PWLE and their care partners throughout the care journey. Many participant statements included specific ideas related to continuity of care, and clinical knowledge and skills. This study provides insights for future interventions and quality improvement initiatives for enhancing transitions in care among hip fracture populations.

Frictional stability of pumice-reinforced lightweight magnesium composite in ambient and elevated temperature environments

Lightweight materials with better resistance to sliding wear are prominent candidates for automobile brake drums, clutch pads and cylinder block applications to facilitate fuel economy. This attempt is reserved to cater to materials with higher tribological quality needs. Less dense foamy pumice stone particles were involved in three different percentages (5, 10, and 15 wt%) to reinforce lightweight AZ31 Mg alloy. A stir-assisted squeeze casting technique was pursued to process the composite and refine the grain structure. A phase detection, elemental mapping and microstructure study were done through X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), and scanning electron microscopy (SEM), respectively. An experimental dry sliding wear scrutiny was administered using a pin-on-disc apparatus by considering: (i) ambient and elevated temperature environments and (ii) three different levels of loads. The results reveal a significant drop in wear loss and a frictional coefficient for 15% pumice-loaded composite than the base alloy. Post-wear examination acknowledges the fact that the ambient temperature wear is governed by adhesive-abrasive wear and high temperature is by abrasive wear mechanisms. Worn-out scrutiny authenticates the presence of oxide layers and their role in lubrication. A comparative study with previous works upholds the novel magnesium composite is the right candidate for the mentioned automobile applications.

False Discovery Rate Control for Lesion-Symptom Mapping With Heterogeneous Data via Weighted p-Values.

Lesion-symptom mapping studies provide insight into what areas of the brain are involved in different aspects of cognition. This is commonly done via behavioral testing in patients with a naturally occurring brain injury or lesions (e.g., strokes or brain tumors). This results in high-dimensional observational data where lesion status (present/absent) is nonuniformly distributed, with some voxels having lesions in very few (or no) subjects. In this situation, mass univariate hypothesis tests have severe power heterogeneity where many tests are known a priori to have little to no power. Recent advancements in multiple testing methodologies allow researchers to weigh hypotheses according to side information (e.g., information on power heterogeneity). In this paper, we propose the use of p-value weighting for voxel-based lesion-symptom mapping studies. The weights are created using the distribution of lesion status and spatial information to estimate different non-null prior probabilities for each hypothesis test through some common approaches. We provide a monotone minimum weight criterion, which requires minimum a priori power information. Our methods are demonstrated on dependent simulated data and an aphasia study investigating which regions of the brain are associated with the severity of language impairment among stroke survivors. The results demonstrate that the proposed methods have robust error control and can increase power. Further, we showcase how weights can be used to identify regions that are inconclusive due to lack ofpower.

An engineered NKp46 antibody for construction of multi-specific NK cell engagers.

Recent developments in cancer immunotherapy have highlighted the potential of harnessing natural killer (NK) cells in the treatment of neoplastic malignancies. Of these, bispecific antibodies, and NK cell engager (NKCE) protein therapeutics in particular, have been of interest. Here, we used phage display and yeast surface display to engineer RLN131, a unique cross-reactive antibody that binds to human, mouse, and cynomolgus NKp46, an activating receptor found on NK cells. RLN131 induced proliferation and activation of primary NK cells, and was used to create bispecific NKCE constructs of varying configurations and valency. All NKCEs were able to promote greater NK cell cytotoxicity against tumor cells than an unmodified anti-CD20 monoclonal antibody, and activity was observed irrespective of whether the constructs contained a functional Fc domain. Competition binding and fine epitope mapping studies were used to demonstrate that RLN131 binds to a conserved epitope on NKp46, underlying its species cross-reactivity.

On the Pre-Perception of Gamification and Game-Based Learning in Higher Education Students: A Systematic Mapping Study

Background The fields of gamification and game-based learning are growing and changing quickly, with researchers investigating the use of gamification in education using various methods and in numerous case studies, however, no research investigates the significance pre-perception of higher education students has in gamification, game-based learning, and serious games studies. Objective We perform a systematic mapping to identify the gaps in our understanding on the effects of pre-perception in gamification, focusing on the under-researched area of gamification and game-based learning applications for higher education. Results We present three main findings: (1) Current research on the effects of higher education’s students' pre-perception of gamification and game-based learning are limited. (2) The limited available research indicates perception towards gamification and game-based learning in participants may impact on the effectiveness of game-based solutions, but more research is required to better understand the relationship. (3) A significant body of new research work is required to examine how student perception can affect the effectiveness of gamification and game-based learning solutions in higher education. Conclusion Our understanding of the effect pre-perception may have on the results reported by research on gamification applications for higher education is limited. We encourage more, non-empirical research, to be conducted around pre-perception, and more research that considers gamification and game-based learning applications for higher education.

A Systematic Mapping Study about Technologies for Hedonic Aspects Evaluation in Text-based Chatbots

A Systematic Mapping Study about Technologies for Hedonic Aspects Evaluation in Text-based Chatbots

Identification of geological units in Alborz Mountain in Iran using Landsat-9 image

In the present study, the suitability of principal components analysis (PCA) based techniques was evaluated for identification of geological units from Landsat-9 satellite imagery. In this respect, a scene of Landsat-9 operational land imager 2 (OLI–2) data of the year 2023 was acquired and a geological map scale 1:100000 of the study area was used as the reference. The results indicated suitability of the PCA based techniques for discrimination of geological units from Landsat-9 image, especially the PCA of decorrelation stretch (DS) approach. The PCA-DS approach, which considered the advantages of both PCA and DS techniques, successfully identified all the geological units in the study area, including the Basalt, Sandstone, Dolomite, and Conglomerate. However, the performance of the PCA and DS techniques was also reasonable for this purpose. On the other hand, the study revealed weak performance of the minimum noise fraction (MNF) and PCA-MNF techniques for geological mapping using Landsat-9 imagery. In conclusion, the study demonstrated the advantage of the PCA-DS approach for geological mapping using Landsat-9 imagery; therefore, it may be useful in futures studies for geological mapping along the whole Alborz Mountain with similar lithological and geomorphological conditions.

Exploring the Legacy of Tibetan Mapmaking

At the 2019 International Conference on the History of Cartography (ICHC) in Amsterdam, the map historian Peter Barber stated in his ground-breaking keynote speech that ‘with a few exceptions, the emphasis in the traditional history of cartography [before 1980s] was on European mapping. In the age of European empires, it was assumed that, on grounds of technological skill as well as cultural superiority, European map making set the standard and that indigenous mapping in other parts of the world, with the partial exceptions of the medieval Arab world and China, was ipso facto inferior and hardly worth consideration.’ In recent decades the approach to the study of maps has changed and the field has been transformed. Researchers from different academic backgrounds have discovered the relevance of maps to their disciplines, and the primacy of the essentially European concepts of scale and accuracy as the sole criteria for assessing the quality of maps has been questioned. Finally, non-European indigenous mapping has been brought into the field. This paper makes a significant contribution to this development by presenting an important collection of Tibetan maps, namely those of the Harrer Collection held at the Ethnographic Museum at the University of Zurich, probably the largest corpus of Tibetan geographic regional maps outside of Tibet. For the first time, we show the entire set of maps and describe their cartographic characteristics. We also provide the Tibetan spelling, transliteration and translations for the numerous Tibetan inscriptions and explanations. We have endeavoured to study the maps using a comprehensive approach, and we discuss what we can learn from them in various respects: the human and geographic landscapes they show; their makers; the role they might have played within the historical context and the society in which they were produced; their circulation; and their role as historical sources.

Behavior Mapping Study of The Layout of Drug Service Room in Outpatient Pharmacy of X Hospital

The quality of pharmaceutical services is related to patient satisfaction and the short waiting times for their accomplished drug in pharmacy installation. This research was conducted to describe the prescription service process in the outpatient pharmacy at X Hospital by observing the flow of drug dispensing and officer movement along with the time required for the process, with the environment behavior study and value stream mapping as the observation method. This action research was conducted by collecting qualitative and quantitative data. Data collection was carried out by observation (time allocation, time for drug service activities), interviews, focus group discussion (FGD), and Behavior Mapping. The results of value stream mapping showed that non-value added was greater than value-added, 78.5% versus 21.5%. Behavior mapping showed a physical trace in a stack of prescription files in all POSs during the service process. The longest process time occurred at post 4, which is during drug preparation, while the longest interval time was interval time 4, which is waiting for the re-check process. Other factors cause the waiting time for drug services to be lengthened. The spatial structure of pharmacy depot block A was less effective. The waiting time was still long. The researchers suggest that the space be regulated again and continued to the next action research cycle, up to the effective drug services, so that the waiting times can be short.

The impact of breastfeeding on the preterm infant's microbiome and metabolome: a pilot study.

Human milk is unquestionably beneficial for preterm infants. We investigated how the transition from tube to oral/breastfeeding impacts the preterm infants' oral and gut microbiome and metabolome. We analyzed stool, saliva, and milk samples collected from a cohort of preterm infants enrolled in the MAP Study, a prospective observational trial. The microbiome and metabolome of the samples were analyzed from 4 longitudinal sample time points, 2 during tube feeds only and 2 after the initiation of oral/breastfeeding. We enrolled 11 mother-infant dyads (gestational age = 27.9 (23.4-32.2)) and analyzed a total of 39 stool, 44 saliva, and 43 milk samples over 4 timepoints. In saliva samples, there was a shift towards increased Streptococcus and decreased Staphylococcus after oral feeding/breastfeeding initiation (p < 0.05). Milk sample metabolites were strongly influenced by the route of feeding and milk type (p < 0.05) and represented the pathways of Vitamin E metabolism, Vitamin B12 metabolism, and Tryptophan metabolism. Our analysis demonstrated that the milk and preterm infant's saliva microbiome and metabolome changed over the course of the first four to 5 months of life, coinciding with the initiation of oral/breastfeeds. The microbiome and metabolome is altered in the infant's saliva but not their stool, and in mother's milk when feeds are transitioned from tube to oral/breastfeeding. We assessed the relationship between the gut and oral microbiome/metabolome with the milk microbiome/metabolome over a longitudinal period of time in preterm babies. Metabolites that changed in the infants saliva after the initiation of oral feeds have the potential to be used as biomarkers for disease risk.