Geographical Information Systems are used in solving many regional development related problems, around the world. Starting from some national programs to famous international ones, such as INSPIRE program, each such initiative uses geospatial data as well in the process of building regional development strategies. This paper presents the main technical components of a geographical information system, meaning the spatial database, the web mapping server and the APIs used to embed the maps into web applications. The development steps for a pre-alpha version of a web GIS application dedicated to the regional development in Romania are also shown. The software tools which were integrated in order to develop the online application were Oracle Spatial, geospatial data was stored, GeoServer, an open source web mapping server used to generate the map out of the data from Oracle Spatial's tables and ASP.NET as a web framework for building the website.Keywords: Regional Development, GIS, Spatial Database, Web Mapping Server(ProQuest: ... denotes formulae omitted.)IntroductionI n the new knowledge based economy, the information systems for data handling, and for knowledge discovery became a must for making decisions and elaborate development strategies in both public and private sectors.Among the classical data types, the geospatial data became very interesting for the governmental decision factors, especially after the launch of the INSPIRE (Infrastructure for Spatial Information in the European Community) directive of the European Parliament in 2007. This kind of data shows where certain objects are placed on the surface of the Earth, from the pipes of a city to the best possible location to open a new business.The Geographical Information Systems (GIS) have the technical capacity of storing, manipulating and visualizing the geospatial data, together with the descriptive/economic data. GIS is used for example in urban and regional development by creating different planning maps [1], in utilities management (electricity, gas, water) [2], when choosing the best locations for a certain investment ([3], [4]), in the environment studies [5], in assuring national health programs ([6], [7], [8]). The essential role of geospatial information in pressing issues such as: land cover, access to water, food production and distribution, biodiversity, is the main topic in many conferences in this field such as AGIT symposium Geoinformation for Development (gi4dev) held in 2006 in Austria.This paper discusses the use of GIS tools in regional development and details the GIS architecture by analyzing its main software components: spatial databases, web mapping servers and the application programming interfaces (APIs) used to embed maps in web applications. In the last chapter we propose system architecture for building an online GIS for regional development in Romania. The application will offer the possibility of maintaining both spatial data and economical/statistical data regarding different variables of interest in different counties and to visualize statistical thematic maps which could be the basis of the decision making process.2 Regional Development and GISRegional development's aim is to offer assistance and to modernize regions which are less economically developed than others, at international or domestic level. In order to comply with EU regional policy, in Romania there were identified eight regions which are administrated by the nongovernmental, nonprofit organizations called Regional Development Agencies (ADR) which are functioning in compliance to the Law no. 315/2004 on the regional development of Romania. The purposes of the Regional Development Agencies are detailed in paper [9] but all the tasks could be included into the main one and that is the creation of regional development plans.A regional development plan starts with an analysis of the existing situation in a certain region by investigating the natural resources, infrastructure, physical capital, human capital, knowledge capital and the productive capital of the region. …