Mapping Of Arrhythmias Research Articles

Transseptal approach versus retrograde aortic approach in mapping and ablation of ventricular arrhythmias from anterolateral papillary muscles.

The anterior and lateral position of the anterolateral papillary muscle (ALPM) has found to be reached with better catheter stability and less mechanical bumping via the transseptal (TS) compared to the retrograde aortic (RA) approach. The aim of this study is to compare the TS and RA approaches on mapping and ablation of ventricular arrhythmias (VAs) arising from ALPMs. Thirty-two patients with ALPM-VAs undergoing mapping and ablation via the TS approach were included and compared with 31 patients via the RA approach within the same period. Acute success was compared, as well as other outcomes including misinterpreted mapping results due to bumping, radiofrequency (RF) attempts, procedural time and success rate at 12-month follow-up. Acute success was achieved in more cases in the TS group (96.4% vs. 72.0%, p = .020). During activation mapping, bump-provoked premature ventricular complexes (PVCs) misinterpreted as clinical PVCs were more common in the RA group (30.0% vs. 58.3%, p = .036), leading to more RF attempts (3.5 ± 2.7 vs. 7.2 ± 6.8, p = .006). Suppression of VAs were finally achieved in the unsuccessful cases by changing to the alternative approach, but the procedural time was significantly less in the TS group (90.0 ± 33.0 vs. 113.7 ± 41.1 min, p = .027) with less need to change the approach, although follow-up success rates were similar (75.0% vs. 71.0%, p = .718). A TS rather than RA approach as the initial approach appears to facilitate mapping and ablation of ALPM-VAs, specifically by decreasing the possibility of misleading mapping results caused by bump-provoked PVC, and increase the acute success rate thereby.

Phantom study of augmented reality framework to assist epicardial punctures.

The objective of this study is to evaluate the accuracy of an augmented reality (AR) system in improving guidance, accuracy, and visualization during the subxiphoidal approach for epicardial ablation. An AR application was developed to project real-time needle trajectories and patient-specific 3D organs using the Hololens 2. Additionally, needle tracking was implemented to offer real-time feedback to the operator, facilitating needle navigation. The AR application was evaluated through three different experiments: examining overlay accuracy, assessing puncture accuracy, and performing pre-clinical evaluations on a phantom. The results of the overlay accuracy assessment for the AR system yielded . Additionally, the puncture accuracy utilizing the AR system yielded . During the pre-clinical evaluation on the phantom, needle puncture with AR guidance showed , whereas needle puncture without AR guidance showed . Overall, the AR platform has the potential to enhance the accuracy of percutaneous epicardial access for mapping and ablation of cardiac arrhythmias, thereby reducing complications and improving patient outcomes. The significance of this study lies in the potential of AR guidance to enhance the accuracy and safety of percutaneous epicardial access.

Atrial pace mapping using intracardiac pattern matching: feasibility and accuracy

Abstract Introduction Pace mapping of atrial arrhythmia is a method to localize the origin of usually focal arrhythmias that are unstable or not persisting during EP-study and, therefore not eligible for LAT-Mapping. The technique applies pattern matching of p-waves from surface-electrocardiogram (sEKG) as well as intracardiac signals during atrial tachycardia and pacing from the site of suspected origin. The CARTO® 3 system Version 7.2 applies an automated algorithm for intracardiac pace mapping (ICPM) using the unipolar signal of the reference electrode, usually located in the coronary sinus. Methods We examined 12 consecutive patients undergoing RF pulmonary vein isolation (PVI). We performed local pacing at the anterior and posterior wall of the left atrium (LA) and the posterior and lateral wall of the right atrium (RA). The first pacing point was defined as the reference pacing site (RPS). The ICPM algorithm was applied to calculate the similarity of the IC pattern of the RPS to the IC pattern across various distances. The maps, including mesh, point locations and IC pattern similarity of each point, were exported for further analysis in the Python environment. The areas were calculated for the 5% similarity strata. Results The study assessed areas with a 95% or higher pattern similarity in different atrial regions, revealing notable differences in pattern similarity. The median area of pattern similarity was 1.48 cm² (IQR: 0.76 - 2.01 cm²) in the LA posterior, 0.62 cm² (IQR: 0.15 - 1.06 cm²) in the LA anterior, 0.60 cm² (IQR: 0.38 - 1.19 cm²) in the RA posterior, and 5.68 cm² (IQR: 2.89 - 11.1 cm²) in the RA lateral wall. Significant differences were found between the posterior and anterior walls of the LA and the RA lateral wall, as well as between the RA posterior and RA lateral wall, indicating variability in intracardiac pattern matching accuracy. Patterns below 2 cm² are acceptable for catheter ablation. An outlier was noted in the RA posterior region. Conclusion The intracardiac pattern matching for atrial arrhythmias employing the CARTO-ICPM algorithm is feasible with acceptable accuracy except for the lateral regions of the right atrium. This might be explained by the larger distance to the referent catheter in the coronary sinus and the preferred conduction direction in the crista terminalis. Enhancing localization accuracy may necessitate the adjunctive use of surface ECG-pace mapping or the deployment of an additional multipolar intracardiac reference catheter in the lateral RA.A: IC Pattern, B: Box plots similarity

A VENTRICULAR TACHYCARDIA CASE NOT TREATABLE WITH TRANSCATHETER ABLATION DUE TO APICAL THROMBOSIS OF THE LEFT VENTRICLE RESOLVED WITH RADIOTHERAPY BASED ON THE NON–INVASIVE MAPPING SYSTE

Abstract The clinical case focuses on a 52–year–old man smoker, heavy alcohol consumer. In 2017 he began with sustained ventricular tachycardia (VT) effectively treated with DC–shock. The following ECG showed signs of anterior necrosis. Severe left ventricular (LV) dilatation, apical thrombosis and severe impairment of LV function were found on echocardiogram. Angiography was performed and LAD occlusion was found. Since of 68% necrosis of the LV at myocardial scintigraphy, no revascularization was performed. He underwent to a dual chamber ICD implantation and started oral anticoagulation therapy. In the following years recurrence of arrhythmic episodes, despite the optimization of antiarrhythmic therapy, led the patient to numerous hospitalizations. Unfortunately the persistence of the apical thrombosis, made transcatheter ablation NOT possible. The only chance for the patient remained stereotactic arrhythmia radioablation. But which area of the LV to highlight as responsible for the arrhythmia and how to program the radiotherapy treatment plan was a challenging problem. We proposed in March 2023 non–invasive mapping of arrhythmia using Cardioinsight. The patient performed heart high–resolution computed tomography (CT) for the anatomical reconstruction with precise spatial resolution of all LV aereas and surrounding structures. A 252–electrode vest is applied to the patient’s torso and connected to the system Cardioinsight. A programmed ventricular stimulation was performed using ICD inducing two VT morphologies. Through electroanatomical mapping we identified the mid LV antero–septal and infero–septal sites as target areas. Thanks to multidisciplinary team a personalized treatment plan was created to deliver an effective lesion in the target area and minimize exposure to nearby organs at risk. The treatment was generated, optimized and delivered by TrueBeam, lasted 3 minutes and no complications arose. The patient was quickly discharged in good clinical condition. After 3 months of clinical well–being he was hospitalized for a single episode of VT. Up to now no hospitalizations occurred. This treatment may represent a "bail–out" choice in patients with advanced heart failure with arrhythmic storm who have exhausted all other therapeutic options.

Ablation of the epicardial substrate in patients with long-QT syndrome at risk of sudden death.

Sudden cardiac death remains a critical public health concern globally, affecting millions annually. Recent advances in cardiac arrhythmia mapping have demonstrated that the ventricular epicardial region has a critical arrhythmogenic role in some inherited cardiogenetic diseases. Among these, long-QT syndrome (LQTS) exposes patients to the risk of life-threatening arrhythmic events. Despite advancements, there is a need for more effective therapeutic strategies. A recent study has uncovered a noteworthy connection between LQTS and epicardial structural abnormalities, challenging the traditional view of LQTS as purely an electrical disorder. High-density mapping revealed electroanatomic abnormalities in the right ventricular epicardium, presenting a potential target for catheter ablation, to finally suppress ventricular fibrillation recurrences in high-risk LQTS patients.

Impact of artificial intelligence arrhythmia mapping on time to first ablation, procedure duration, and fluoroscopy use.

Artificial intelligence (AI) ECG arrhythmia mapping provides arrhythmia source localization using 12-lead ECG data; whether this information impacts procedural efficiency is unknown. We performed a retrospective, case-control study to evaluate the hypothesis that AI ECG mapping may reduce time to ablation, procedural duration, and fluoroscopy. Cases in which system output was used were retrospectively enrolled according to IRB-approved protocols at each site. Matched control cases were enrolled in reverse chronological order beginning on the last day for which the technology was unavailable. Controls were matched based upon physician, institution, arrhythmia, and a predetermined complexity rating. Procedural metrics, fluoroscopy data, and clinical outcomes were assessed from time-stamped medical records. The study group consisted of 28 patients (age 65 ± 11 years, 46% female, left atrialdimension 4.1 ± 0.9 cm, LVEF 50 ± 18%) and was similar to 28 controls. The most common arrhythmia types were atrial fibrillation (n = 10), premature ventricular complexes (n = 8), and ventricular tachycardia (n = 6). Use of the system was associated with a 19.0% reduction in time to ablation (133 ± 48 vs. 165 ± 49 min, p = 0.02), a 22.6% reduction in procedure duration (233 ± 51 vs. 301 ± 83 min, p < 0.001), and a 43.7% reduction in fluoroscopy (18.7 ± 13.3 vs. 33.2 ± 18.0 min, p < 0.001) versus controls. At 6 months follow-up, arrhythmia-free survival was 73.5% in the study group and 63.3% in the control group (p = 0.56). Use of forward-solution AI ECG mapping is associated with reductions in time to first ablation, procedure duration, and fluoroscopy without an adverse impact on procedure outcomes or complications.

Mapping and ablation of ventricular arrhythmias arising from the left ventricular summit.

The left ventricular summit (LVS) refers to the highest portion of the left ventricular outflow tract (LVOT). It is an epicardially delimited triangular area by the left coronary arteries and the coronary venous circulation. Its deep myocardium correlates closely with the left coronary cusp, aortic-mitral continuity, and right ventricular outflow tract (RVOT), complicating the anatomical relationship. Ventricular arrhythmias (VAs) originating from this area are common, accounting for 14.5% of all VAs origin from left ventricle. Specific electrocardiogram (ECG) characteristics may assist in locating LVS-VAs pre-procedure and facilitate procedure planning. However, catheter ablation of LVS-VAs remains challenging because of anatomical constraints. This paper reviews the recent understanding of LVS anatomy, concludes ECG characteristics, and summarizes current mapping and ablation methods for LVS-VAs.

Effects of parameters on radiofrequency guidewire ablation: In vitro and in vivo experiments.

A novel ablation technique with guidewire has emerged as a promising approach for mapping and ablation of arrhythmias originating from left ventricular summit. However, its biophysical characteristics have not been fully clarified. In the in vitro experiment, guidewire ablation (GA) was performed in vessel models of 1.17 and 2.24 mm to determine the maximum safety power. Then with the maximum safety power, the predictive value of generator impedance (GI) drop on lesion radius was explored. In the in vivo experiment, the feasibility of the maximum safety power and lesion formation was verified in the living swine. It was found that in both groups, the incidence of steam pops increased along with the raise of ablation power, and the maximum safety power was 10 W for the 1.17-mm group and 15 W for the 2.24-mm group. There was a strong linear correlation between GI drop and maximum lesion radius (in 1.17 mm-10-W group: r = .961; in 2.24 mm-15-W group: r = .918). In the in vivo experiment, besides ventricular fibrillation happened once, no other complications were observed, and lesions were found at both 48-h and 8-week groups. The safety power of GA should be adjusted according to the diameter of the vessel. Besides, the GI drop can predict the lesion radius during GA.

Electrocardiographic imaging to guide ablation of ventricular arrhythmias and agreement between two different systems.

A recent study using an epicardial-only electrocardiographic imaging (ECGI), suggests that the agreement of ECGI activation mapping and that of the contact mapping for ventricular arrhythmias (VA) is poor. The aim of this study was to assess the diagnostic value of two endo-epicardial ECGI systems using different cardiac sources and the agreement between them. We performed 69 ECGI procedures in 52 patients referred for ablation of VA at our center. One system based on the extracellular potentials was used in 26 patients, the other based on the equivalent double layer model in 9, and both in 17 patients. The first uses up to 224 leads and the second just the 12‑lead ECG. The localization of the VA was done using a segmental model of the ventricles. A perfect match (PM) was defined as a predicted location within the same anatomic segment, whereas a near match (NM) as a predicted location within the same segment or a contiguous one. 44 patients underwent ablation, corresponding to 58 ECGI procedures (37 with the first and 21 with the second system). The percentage of PMs and NMs was not significantly different between the two systems, respectively 76% and 95%, p=0.077, and 97% and 100%, p=1.000. In 14 patients that underwent ablation and had the ECGI performed with both systems, raw agreement for PMs was 79%, p=0.250 for disagreement. ECGI systems were useful to identify the origin of the VAs, and the results were reproducible regardless the cardiac source.

Subxiphoid epicardial access facilitated by saline infusion or carbon dioxide insufflation through a right atrial appendage controlled exit

Abstract Funding Acknowledgements Type of funding sources: None. Background Subxiphoid percutaneous access to the pericardial space for mapping and ablation of atrial and ventricular arrhythmia carries the potential risk of cardiac perforation and coronary artery laceration. Widening the pericardial space with saline solution or carbon dioxide (CO2) insufflation by intentional coronary vein exit prior to subxiphoid puncture reduces the risk of organ lesion. However, cannulation of a coronary branch is often difficult and adds complexity to the ablation procedure. Purpose To determine the feasibility and the safety of subxiphoid epicardial access facilitated by controlled pericardial saline infusion or neumopericardium through a right atrial appendage exit. Methods The right atrial appendage was transvenously cannulated using a steerable sheath following anatomical characterization of the right atrium on an electroanatomical navigation system. A 0.014" angioplasty guide was introduced with the proximal rigid end placed distally and progressed until the appendage was perforated and the guide-wire placed into the pericardial space. A double lumen microcatheter was then progressed over the wire. Saline solution (100-400 mL) or CO2 (100-500 cc) were infused through the microcatheter to achieve sufficient pericardial space widening or hemodynamic deterioration. Finally, pericardial access was obtained using the conventional subxiphoid approach. Results 17 consecutive patients (62±10 years, 15 male) with left atrial flutter (LAF n=11) or ventricular tachycardia (VT n=6) refractory to endocardial ablation were prospectively included. All patients with atrial flutter (uninterrupted oral anticoagulation plus heparin for ACT &amp;gt;300 sec) and ventricular tachycardia (heparin for ACT &amp;gt;300 sec) were fully anticoagulated at the time of the procedure. It was not possible to access epicardium in 4 patients due to adhesions (VT=3 LFA=1). The first 4 patients with successful access had saline infused and the remaining 9 patients had CO2 insufflated. Epicardial tachycardia ablation was successfully achieved in 8 patients (5 AFLs and 3 VTs) and partially successful in 1 patient (1AFL). A pericardial drainage was left in 6 patients before leaving the EP laboratory and removed in the remaining. There was no apparent right ventricular puncture, coronary artery laceration or other major complications. One patient had cardiac tamponade during the procedure and 2 other patients presented tamponade after the procedure following discharge from the interventional lab. One patient presented neumomediastinum and other patient presented subcutaneous emphysema, which resolved uneventful in 24 hours. Conclusions Saline infusion or carbon dioxide insufflation through a right atrial appendage controlled exit facilitates subxiphoid epicardial access for ablation of refractory atrial and ventricular arrhythmias. This approach can be performed in the majority the patients and appears to be safe.

PO-04-141 PRECISE LOCALIZATION OF ORIGINS IN VENTRICULAR ARRHYTHMIAS FROM PULMONARY SINUS CUSPS: INSIGHTS INTO DISCRETE POTENTIAL AT ANATOMIC VENTRICULO-ARTERIAL JUNCTION

The sharp high-frequency discrete potentials recorded during mapping of ventricular arrhythmias from pulmonary sinus cusps (PSCs) often indicate site of origin and target for ablation, which can be located beyond or below pulmonary sinuses. To understand the site of origin by investigating the relationship between the discrete potentials and local anatomic structures in PSC arrhythmias. Patients undergoing ablation for idiopathic ventricular arrhythmias from PSC using 3-D mapping system and intracardiac echocardiography were enrolled. The end of ventricular myocardial extension (VME) at anatomical ventriculo-arterial junction was mapped during sinus rhythm, with its distance to pulmonary valve attachment at each sinus bottom and junction measured. When discrete potentials were observed beyond pulmonary cusps, initial radiofrequency was delivered using supravalvular approach mapping of ventricular arrythmias, while conventional approach was used for targeting the potentials at interleaflet triangles. The anatomical relationship between sites of discrete potentials, valve attachment and VME was studied. From 21 patients with ventricular arrhythmias from PSCs, all had ventricular myocardium extending beyond the level of each sinus bottom and junction as well, with different VME length over 3 cusps (P<0.01). The longest VME was seen in left pulmonary cusp which was 13.3±4.7mm over the valve attachment, while the shortest was found in anterior cusp (Panel A). Typical near-field discrete potentials preceding local electrograms during ventricular beats were found in 17 patients with timing of 36.5±7.3mm before QRS onset, all proven as effective targets for ablation (Panel B). The potentials could be found beyond pulmonary cusps in 12 patients (8 in the left cusp, panel C) while at the interleaflet triangles in 7 cases. In 2 patients, they can be recorded from both above and below the valve. The sites of origin were close to VME with a mean distance of 2.3±2.8mm. Acute success were achieved in all patients with a success rate of 88.2% after a 6-month follow up period. In the cases of idiopathic ventricular arrhythmias from PSCs, ventricular myocardial extends beyond all pulmonary cusps with different length over each sinus. The sites of origin have close anatomical relationship with VME, which can be close to or distant from pulmonary valves. It is reasonable to select proper approach based on the location of discrete potentials.

How to Perform a Completely Fluoroless Ablation.

Radiation exposure related to electrophysiology catheter ablation procedures carries small but non-negligible stochastic and deterministic effects on health. Lead aprons can also place considerable pressure on the spinal column, resulting in potentially detrimental consequences. Fortunately, however, advancements in tools used for arrhythmia mapping and ablation have made it feasible to reduce or essentially eliminate the need for fluoroscopy, with no impact on the efficacy or safety of such procedures, as demonstrated by several long-term outcome studies. In this review, we describe our stepwise approach to safely and efficiently perform a completely fluoroless ablation.

Ablation of ventricular arrhythmias in cardiogenetic diseases.

Sudden cardiac death is a leading cause of mortality, claiming millions of lives every year. Recent advances in cardiac arrhythmia mapping have demonstrated that the ventricular epicardial region has a critical arrhythmogenic role in some inherited cardiogenetic diseases. Historically, electroanatomic abnormalities have been identified in the ventricular epicardium of patients with arrhythmogenic right ventricular cardiomyopathy. More recently, epicardial pathological substrates have been identified also in electrical disease (Brugada syndrome, early repolarization syndrome) and currently in long QT syndrome. In light of these findings, the epicardial area has emerged as an important determinant in sudden cardiac death-related cardiomyopathies.

Ups and downs in the mapping of macro-reentry arrhythmias. A revelation in a spark of light

Ups and downs in the mapping of macro-reentry arrhythmias. A revelation in a spark of light

First clinical experience using a novel automated mapping algorithm for mapping of ventricular arrhythmias

A new automated vector-based mapping algorithm (AMA) for 3-dimensional (3D) mapping has been introduced. The aim of this study was to present our experience using AMA to recognize additional catheter ablation targets in patients with ventricular arrhythmias (VA). A total of 16 patients (ICM; ischemic cardiomyopathy, n = 6; NICM; non-ischemic cardiomyopathy n = 10) suffering from VA underwent catheter ablation. Following bipolar voltage mapping, AMA was utilized to reveal zones of decelerated conduction velocity vectors (CVV) and this information was superimposed onto the 3D reconstructions and compared with the presence of scar. Mapping time was 28.1 ± 10 min for the endocardial reconstruction of the left ventricle (LV) and 17 ± 5.4 min for the epicardium (n = 6 patients). The mean area of LV low voltage was 13.9 ± 15% (endocardial) and 11.9 ± 5.7% (epicardial). Decelerating CVV zones were revealed in all patients (mean conduction velocity threshold of 39.3 ± 13%). Sustained VA have been terminated through ablation and substrate modification was performed in all patients. Correlation between the presence of CVV deceleration zones and areas of abnormal low voltage from bipolar mapping was revealed in only 37.5% of patients, but there was good correlation between scar from unipolar voltage mapping and the presence of CCV deceleration zones (94%; p = 0.008). The novel AMA may improve the understanding of individual VA substrates due to the visualization of decelerated CVV zones and their correlation with abnormal low voltage predominantly from unipolar mapping.

Study of coronary sinus anatomy during levophase of coronary angiography.

BACKGROUNDCoronary sinus (CS) imaging has recently gained importance due to increasing need for mapping and ablation of electrophysiological arrhythmias and left ventricular (LV) pacing during cardiac resynchronization therapy (CRT). Retrograde venogram is the current standard for imaging CS and its tributaries. AIMTo evaluate CS anatomy during levophase of routine coronary angiography to aid LV lead implantation during CRT.METHODSIn this prospective observational study, 164 patients undergoing routine coronary angiography for various indications (Chronic stable angina-44.5%, acute coronary syndrome- 39.5%, Dilated cardiomyopathy-11%, atypical chest pain-5%) were included. Venous phase (levophase) of left coronary injection was recorded in left anterior oblique - cranial and right anterior oblique -cranial views. Visibility of coronary veins, width and shape of CS ostium, angulations of proximal CS with body of CS were noted. Presence, size, take-off angle and tortuosity of posterolateral vein (PLV), anterior interventricular veins (AIV) and middle cardiac vein (MCV) were also noted.RESULTSDuring levophase, visibility grade (Muhlenbruch grade) for coronary veins was 3 in 74% and 2 in 26% of cases. Visibility of CS did not correlate with body mass index. The diameter of CS ostium was < 10 mm, 10-15 mm and > 15 mm in 48%, 42% and 10% of patients respectively. Proximal CS was tubular in 136 (83%) patients and funnel-shaped in 28 (17%) patients. Sharp take-off angulation between ostium and body of CS was seen in 16 (10%) patients. Two or more PLV were present in 8 patients while PLV was absent in 52 (32%) patients. Angle of take-off of PLV with body of CS was favourable (0°-45°) in 65 (40%) patients. The angle was 45°-90° in 36 patients and difficult take-off angle (> 90°) was seen in 8 patients. Length of PLV reached distal third of myocardium in 84 cases and middle third in 11 cases. There was no tortuosity in 79 cases, a single bend in 29 cases and more than 2 bends in 4 cases. Thirty nine (24%) patients had other veins supplying posterior/Lateral wall of LV. There was a single vein supplying lateral/posterior wall in 31 (19%) patients. Diameter of MCV and AIV was significantly larger in patients with absent PLV as compared to patients with a PLV. CONCLUSIONLevophase study of left coronary injection is effective in visualization of the CS in almost all patients undergoing coronary angiography and may be an effective alternative to retrograde venogram in patients with LV dysfunction or LBBB.

A novel dipole charge density mapping system integrated in robotics offers advantages for ablation of atrial tachycardias: first-in-human experience

Abstract Funding Acknowledgements Type of funding sources: None. Background Catheter ablation (CA) for atrial tachycardia (AT) and atrial flutter (AFL) offers favorable acute and long-term outcomes. Until recently, mapping of AT/AFL was only possible with sequential mapping methods using manually controlled catheters. Even by implementing multielectrode mapping, some limitations exist during mapping of short-lived arrhythmias and ATs with unstable CL. Remote magnetic navigation (RMN) with its atraumatic catheter design has superior safety profile and excellent accuracy. Recently, a novel high-resolution mapping system (AcQMap) can be used in combination with RMN (AcQMap-RMN). Purpose To assess the feasibility, safety and efficacy of AcQMap-RMN guided ablation in the management of complex ATs. Methods All patients undergoing CA for AT/AFL using AcQMap-RMN were included. The AcQMap system utilizes two different types of mapping: Single Position Map (SMP) and SuperMap, allowing mapping of both non-sustained and sustained ATs. Procedural efficiency was characterized by procedure time, total ablation time and radiation doses. Acute success was defined by arrhythmia source elimination. Efficacy data are based on 12-month follow up and number of redo procedures. Procedural safety was evaluated by intra- and post-procedural complications. Results A total number of 76 patients were referred for CA with AT/AFL (mean age 59.0±13.2), including 3 patients with inappropriate sinus tachycardia and 73 patients with AT/AFL. Out of 73 patients, 8 had perinodal AT. From the remaining 65 patients, 38 had de novo, 22 had post-PVI, and 5 patients had post-MAZE AT/AFL. Twenty-nine patients had short-lived ATs and were mapped exclusively by SPM. The mean procedure time was 175.9±61.4 min, mean ablation time 964.0 (IQR 422.0-1693.0) s, and mean radiation dose was 152.0(IQR 86.7-294.0) mGy. Acute success was documented in 70 procedures (92.1%). From de novo AT/AF patients 4 (10.5%), from post-PVI and post-MAZE AT/AFL patients 3 had recurrence at the end of the follow-up period (11.1%). Four patients had redo procedure. Three patients had post-procedural complications including 2 patients with groin hematoma and 1 patient with transient ischemic attack. Conclusion AcQMap-RMN integration offers improved efficiency, high success and low complication rates in complex AT ablation.

Performance and acute procedural outcomes of the EnSite Precision™ cardiac mapping system for electrophysiology mapping and ablation procedures: results from the EnSite Precision™ observational study

BackgroundThe EnSite Precision™ cardiac mapping system (Abbott) is a catheter navigation and mapping system capable of displaying the three-dimensional (3D) position of conventional and sensor-enabled electrophysiology catheters, as well as displaying cardiac electrical activity as waveform traces and dynamic 3D maps of cardiac chambers. The EnSite Precision™ Observational Study (NCT-03260244) was designed to quantify and characterize the use of the EnSite Precision™ cardiac mapping system for mapping and ablation of cardiac arrhythmias in a real-world environment and evaluate procedural outcomes.MethodsA total of 1065 patients were enrolled at 38 centers in the USA and Canada between 2017 and 2018 and were followed for 12 months post procedure for arrhythmia recurrence, medication use, and quality-of-life changes. Eligible subjects were adults undergoing a cardiac electrophysiology mapping and radiofrequency ablation procedure using the EnSite Precision™ System.ResultsA final cohort of 925 patients (64.3 years of age, 30.2% female) were analyzed. The primary procedural indication was atrial flutter in 48.1% (445/925), atrial fibrillation in 46.5% (430/925), and other arrhythmias in 5% (50/925). Electroanatomic mapping was performed in 81.5% (754/925) of patients. Mapping was stable throughout 79.8% (738/925) of procedures with initial mapping time of 8.6 min (IQR 4.7–15.0). Average mapping efficiency created with AutoMap or TurboMap was 164.9 ± 365.7 used points per minute. Median number of mapping points collected and used was 1752.5 and 811.0, respectively. Only 335/925 (36.2%) required editing and 66.0% (221/335) of these patients required editing of less than 10 points. Fluoroscopy was utilized in most cases (n = 811/925, 87.4%) with fluoroscopy time of 11.0 min (IQR 6.0–18.0). Overall median procedure time was 101.0 min (IQR 59.0–152.0). Acute procedural success was high for both atrial fibrillation (n = 422/430, 98.1%) and atrial flutter (n = 434/445, 97.5%).ConclusionIn a real-world study analysis, use of the EnSite Precision™ mapping system was associated with high procedural stability, short mapping times, high point density requiring infrequent editing, low fluoroscopy time, and high prevalence of acute procedural success.

PO-666-05 A NOVEL DIPOLE CHARGE DENSITY MAPPING SYSTEM INTEGRATED IN ROBOTICS OFFERS ADVANTAGES FOR ABLATION OF ATRIAL TACHYCARDIAS: FIRST-IN-HUMAN EXPERIENCE

Catheter ablation (CA) for atrial tachycardia (AT) and atrial flutter (AFL) offers favorable acute and long-term outcomes. Until recently, mapping of AT/AFL was only possible with sequential mapping methods using manually controlled catheters. Even by implementing multielectrode mapping, some limitations exist during mapping of short-lived arrhythmias and ATs with unstable CL. Remote magnetic navigation (RMN) with its atraumatic catheter design has superior safety profile and excellent accuracy.

Coronary Ostia Mapping with Remote Magnetic Navigation can Facilitate Safe Mapping and Ablation of Outflow Tract Ventricular Arrhythmias

Coronary Ostia Mapping with Remote Magnetic Navigation can Facilitate Safe Mapping and Ablation of Outflow Tract Ventricular Arrhythmias