The impact of laser-spectroscopy techniques on the study of hyperfine interactions is illustrated by chosen examples. A brief survey of the theory of hyperfine interactions is given as well as an overview of the available experimental techniques. Results from alkali atoms, alkaline-earth elements and Group III atoms are given with special emphasis on the studies of electronic properties in sequences of Rydberg states and the investigation of nuclear properties for long chains of isotopes of the same element. Recent developments on the theoretical side, particularly what regards the many-body perturbation approach, are also discussed.