Quality Of Manuscripts Research Articles

STORAGE EFFECT ON THE GC-MS PROFILING AND ANTIOXIDANT ACTIVITIES OF ESSENTIAL OILS FROM LEAVES OF ANNONA SQUAMOSA L.

Aim and objective: Medicinal plants, their biological activities, and their phytochemical contents are important for finding safe and potent new compounds for therapeutic use. In order to investigate the chemical contents and to evaluate the storage effect on the antioxidant activity of Lebanese Annona squamosa (AS) leaf essential oil, the current study was undertaken. Methods: Shade-dried leaves of AS were taken from Batroun (Lebanon), and the essential oil (EO) was extracted by hydrodistillation. The gas chromatography-mass spectrometry (GC-MS) technique was used to analyze the composition of the EO. Concerning the antioxidant activity, two different methods namely radical scavenging activity (DPPH test) and ferric reducing antioxidant power (FRAP) were used. Results: A total of 21 compounds were identified. The majority of the identified compounds belong to sesquiterpenoids. β-elemene (11.39 -14.14 %) and β-carophyllene (10.15 – 15.56 %) were the most abundant components. On the other hand, the storage of the plant materials containing the EOs or the EOs themselves leads to a loss in the volatile compounds, which is reflected in the bioactivity as shown in the results of the antioxidants assays. The EOs demonstrated antioxidant activities with IC50 lower than 9 μg.mL-1. DPPH test and FRAP test exhibited a strong positive correlation (r=0.99). Conclusion: The obtained results suggest that EO extracts from AS have an antioxidant to protect people. Thus, the EO of fresh samples of AS can have interesting applications in versatile areas such as the pharmaceutical and food industries. Peer Review History: Received: 27 April 2022; Revised: 11 June; Accepted: 29 June, Available online: 15 July 2022 Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com Similar Articles: GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS

MAXILLARY SINUS SEPTA: PREVALENCE AND ASSOCIATION WITH GENDER AND LOCATION IN THE MAXILLA AMONG ADULTS IN SANA'A CITY, YEMEN

Background and aims: Maxillary sinus septa are partitions of cortical bone dividing the sinus into multiple compartments. Their presence and dimension are of relevance to periodontitis, oral and maxillofacial surgeons as well as otolaryngologists. The aim of this study was to determine the prevalence and association of maxillary sinus septum with gender and location in maxilla among adults in Sana’a city, Yemen.
 Methods: This is a retrospective study carried out on 633 patient orthopantomograms (OPGs) which had visible maxillary sinus without pathological or developmental changes from the first of March 2021 to the end of February 2022 at the Department of Oral and Maxillo-Facial Surgery, Faculty of Dentistry, Sana’a University and private clinics in Sana’a city. Descriptive statistics of the continuous variable (age) was summarized as mean and standard deviation while the categorical variables were summarized as frequencies and percentages and presented as tables. Bivariate analysis was performed to test for association between the dependent variables (maxillary sinus septum presence, presentation and position) and independent variables (gender and location).
 Results: The mean age of the patients was 29.59 years, range from 16 -56 years, and females 380 (60.0%). Of 259 (40.9%) maxillary sinus septum identified, 206 (79.5 %%) were from females. Majority 180 (69.5%) were unilateral, while 79 (30.5%) were bilateral. Occurrence of unilateral maxillary sinus septum was higher in males 104 (41.1%) with OR=2.8, 95% CI=1.9-3.98, p<0.0001; than females (20%), while bilateral septum occurs roughly in equal rates in both gender (11.86 VS 12.89%). 
 Conclusion: This study has shown a significant proportion of maxillary sinus septum among patients with visible orthopantomogram without pathology in Sana’a, Yemen, with the highest proportion being females. There is therefore the need for the occurrence and presentation of maxillary sinus septum in this study to serve as a baseline data in the treatment of dental implant and surgical procedures in Sana’a, Yemen.
 
 Peer Review History: 
 Received: 2 May 2022; Revised: 18 June; Accepted: 29 June, Available online: 15 July 2022
 Academic Editor: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 6.0/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Dr. Bountain Welcome Tebeda,Chemical Pathology Department, Federal Medical Centre, Yenagoa, Nigeria. bountaintebeda@yahoo.com
 Dr. Rima Benatoui, Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, BP12 E L Hadjar–Algeria, benattouiryma@gmail.com
 Dr. Esther Marguerite Chase DJANGA, Faculty of Medicine and Biomedical Sciences. Department of Public Health. University of Yaoundé I, Cameroon. e.djanga@yahoo.com

IN-VITRO ANTICOAGULANT EFFECT OF AERIAL PARTS EXTRACTS OF YEMENI FAGONIA SCHWEINFURTHII HADIDI

Background: Blood coagulation is a quick and effective process that results in the creation of clots, which demands to monitor. Many illness disorders include an abnormality in blood coagulation. This study examined the in vitro effects of methanol, ethyl acetate, and n-hexane extracts from aerial parts of Fagonia schweinfurthii Hadidi on healthy human volunteers' blood coagulation. 
 Methods: The Secondary metabolites were extracted from dried and crushed F. schweinfurthii aerial parts using n-hexane, ethyl acetate, and methanol, respectively. Additionally, the extracts were tested in vitro at different concentrations (10-100 µg/ml) on the blood coagulation profile, prothrombin time (PT), and activated partial thromboplastin time (a PTT) of apparently healthy human volunteers.
 Results: Methanol, ethyl acetate, and n-hexane extracts of F. schweinfurthii aerial parts significantly (p˃0.05) prolonged PT and PTT in the blood of healthy human volunteers with Ethyl acetate and methanol extracts recorded the largest prolongation of PT and PTT correspondingly. The highest PT and PTT prolongation was achieved at 100µg/ml, and the least prolongation time was obtained at 10µg/ml.
 Conclusion: These findings displayed that F. schweinfurthii aerial parts contain phytochemical constituents with anticoagulant characteristics and could be used to treat blood clotting disorders.
 
 Peer Review History: 
 Received: 26 April 2022; Revised: 12 June; Accepted: 30 June, Available online: 15 July 2022
 Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 5.5/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com 
 Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com
 Prof. Dr. Hüsniye Kayalar, Ege University, Turkey, husniyekayalar@gmail.com
 Similar Articles: 
 GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS

SEROPREVALENCE OF THE VIRAL MARKERS OF HEPATITIS B, HEPATITIS C, AND HIV AMONG MEDICAL WASTE HANDLERS IN SOME HOSPITALS IN SANA'A CITY- YEMEN

Background and Objective: Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are highly contagious pathogens that threaten medical waste handlers who are highly exposed to these viruses due to the nature of their work. To date, little data is available on the prevalence of viral markers (HBV, HCV, and HIV) among medical waste handlers in Sana'a city, Yemen. Hence, this work was conducted to enhance knowledge of the prevalence of viral markers among medical waste handlers working in some hospitals in the capital, Sana'a.
 Methods: A cross-sectional prospective study was conducted on 120 randomly selected medical waste handlers from January to June 2022. A pretested and designed questionnaire was used to collect the required data. Total 5mL of venous blood was collected. Then blood was tested for hepatitis B surface antigen and anti-HCV, as well as HIV antibody, were detected using a qualitative by rapid test cassette and positive results were confirmed by ELIZA technique.
 Results: The overall positive rates for HBsAg, anti-HCV, and HIV were 9.17%, 5.0%, and 0.0%, respectively, based on the rapid test. No significant differences were detected between socio-demographic characteristics and hepatitis B and HCV infection. High rates of hepatitis B and C infection were found in the age group ≥41 years (9.17%) and 21-30 years (8.77%), respectively. These two viruses have also been detected among married people with a history of acute infection between 7-9 times. There was a significant correlation between HBsAg positivity and history of blood transfusion as well as between HBsAg and anti-HCV positivity and history of hepatitis B vaccination. ELISA confirmed that the rate of HBsAg was 4.17% and anti-HCV was 2.5%.
 Conclusion: Appropriate training, immunization against HBV, and regular motivation of medical waste handlers on the practices of universal standard precautions are recommended to reduce transmission of hepatitis B virus, hepatitis C virus, and HIV among medical waste handlers.
 
 Peer Review History: 
 Received: 4 May 2022; Revised: 14 June; Accepted: 27 June, Available online: 15 July 2022
 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 6.0/10
 Average Peer review marks at publication stage: 7.5/10
 Reviewers:
 Rusmir Baljic, Clinic for infectious diseases, Clinical center University of Sarajevo, Bosnia and Herzegovina. rusmir.baljic@gmail.com
 Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
 Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
 Dr. Jucimary Vieira dos Santos, Hemonorte Dalton Barbosa Cunha, Brazil, jucimaryvieira@yahoo.com.br 
 Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
 Similar Articles: 
 PREVALENCE OF HEPATITIS A VIRUS, HEPATITIS B VIRUS, AND HEPATITIS C VIRUS, AMONG PATIENTS WITH HEPATIC JAUNDICE IN SANA’A CITY, YEMEN: A HOSPITAL BASED STUDY 
 SERO-EPIDEMIOLOGICAL STUDY OF HEPATITIS B, C, HIV AND TREPONEMA PALLIDUM AMONG BLOOD DONORS IN HODEIDA CITY- YEMEN 
 EXPLOSION OF HEPATITIS B AND C VIRUSES AMONG HEMODIALYSIS PATIENTS AS A RESULT OF HEMODIALYSIS CRISIS IN YEMEN

Segmentasi Baris Lontar Dengan Metode A * Path Planning

Historical documents in the form of ancient manuscripts are one form of the Indonesian nation's cultural heritage that deserves to be important, one of which is Lontar. Currently not many people can read the writings in palm leaves, therefore, ancient manuscript collectors have made efforts to digitize ancient manuscripts. The digitization of ancient manuscripts aims to improve the image quality of ancient manuscripts with the help of computers. Digitization requires an image quality improvement process by performing noise reduction and edge detection and line segmentation on digital images of ancient manuscripts. In this study, the noise reduction process uses the Mean Filter method, edge detection uses the Sobel operator, and line segmentation in this study uses the A * Path Planning Algorithm. Based on research conducted on 24 lontar images, line segmentation process obtained an accuracy of 95%.

PHARMACOGENOMIC CONSIDERATIONS FOR PRESCRIBING THE ANTIDEPRESSANT FLUOXETINE: A REVIEW IN PERSONALIZED MEDICINE

The worthwhile intellectual synthesis proposing that nothing makes sense except in light of context has also revolutionized pharmaceutical science putting patients’ genomic context at the center of attention in a rapidly developing area known as pharmacogenomics. As a result, an alternative approach to medicine referred to as personalized medicine was born considering the individual-specific genomic context the hardcore of any diagnostic, prognostic, and therapeutic intervention. Therefore, a considerable need has been created to address questions based on the underlying genotypic characteristics of patients. Depressive spectrum disorders are a cluster of closely-linked psychiatric disorders with a growing incidence rate across the world. Although there are multiple therapeutic approaches to treating depressive spectrum disorders, pharmacotherapy is still considered one of the most effective strategies. Among the therapeutic antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs) are most widely prescribed. Fluoxetine (FLX) is a highly valued SSRI which is broadly ordered by psychiatric practitioners to treat miscellaneous psychological disorders, including depressive spectrum disorders, anxiety spectrum disorders, and obsessive-compulsive disorder. Although FLX therapy can bring about a positive therapeutic effect on a considerable proportion of depressed patients, it does not elicit a favorable response in 30-40% of patients owing to the presence of genomic variations negatively affecting the pharmacokinetic and pharmacodynamic characteristics of this medication. This challenging fact has led us to conduct current research on how genotypic variations at the inter-individual level can heavily affect the response to FLX therapy.
 
 Peer Review History: 
 Received: 2 May 2022; Revised: 9 June; Accepted: 28 June, Available online: 15 July 2022
 Academic Editor: Dr. Amany Mohamed Alboghdadly, Princess Nourah bint abdulrahman university, Riyadh, amalbgadley@pnu.edu.sa
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. 
 Received file: Reviewer's Comments:
 Average Peer review marks at initial stage: 5.5/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewers:
 Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye
 Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
 Similar Articles: 
 PREVALENCE AND SEVERITY OF DEPRESSION AMONG PEOPLE LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS IN YENAGOA, SOUTHERN NIGERIA

SURGICAL SITE INFECTIONS: PREVALENCE, ASSOCIATED FACTORS AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF THE BACTERIAL ISOLATES AMONG POSTOPERATIVE PATIENTS IN SANA’A, YEMEN

Background: Surgical site infections (SSIs) are infections that occur one month after a surgical operation or one year after implant surgery and a surgical procedure, either at the injury site or near the injury site. Despite SSIs are still a major problem causing increased morbidity and mortality globally, especially in developing countries, there is a dearth of information in Yemen. Objective: This study was aimed to assess the prevalence of SSIs, associated factors and antimicrobial susceptibility patterns of the bacterial isolates among post-operative patients in public and private hospitals in Sana’a, Yemen. Methods: This is a cross-sectional study carried out on 309 postoperative patients, aged one year and over that underwent surgery in selected public and private hospitals between January 2019 and January 2020 in Sana’a. Patients’ demographic and clinical information were assessed using an interviewer-administered, pretested, structured questionnaire. Wound swabs and aspirates were collected, placed in Stuart transport media and transferred to the Bacteriology Department of the National Center for Public Health Laboratories in Sana’a for bacterial isolation, identification and antimicrobial susceptibility testing.. Results: The mean age of postoperative patients was 34.0±18.3 (SD) years, age group 25-34 years was 93 (30.1%), and females were 105 (33.8%). Total 309 postoperative patients, 98 (31.7%) presented with SSI. Having postoperative antibiotics (OR=7.0, 95%CI: 4.1-12.0), dirty surgical wound (OR=10.5, 95%CI: 5.0-21.9), emergency surgery (OR=3.1, 95%CI: 1.8-5.1), amputation (OR=2.5, 95%CI: 1.1-5.7), excision (OR=2.2, 95%CI: 1.2-4.0), hospital stay > two weeks (OR=5.2, 95%CI: 2.3-11.1) and having diabetes mellitus (OR=2.2, 95%CI: 1.1-4.7) were factors significantly associated with SSIs. Conclusion: This study shows a significant proportion of SSIs among patients in Sana’a, Yemen. Being a female, having a dirty surgical wound, amputation, excision, long hospital stays, diabetes mellitus, and emergency surgery appears to be the major factors associated with SSIs. The most common SSI bacterial etiology is S. aureus, sensitive to vancomycin and rifampicin. Peer Review History: Received: 10 May 2022; Revised: 12 June; Accepted: 30 June, Available online: 15 July 2022 Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Bountain Welcome Tebeda,Chemical Pathology Department, Federal Medical Centre, Yenagoa, Nigeria. bountaintebeda@yahoo.com Dr. Esther Marguerite Chase DJANGA, Faculty of Medicine and Biomedical Sciences. Department of Public Health. University of Yaoundé I, Cameroon. e.djanga@yahoo.com Similar Articles: EFFECT OF MOST COMMON ANTIBIOTICS AGAINST BACTERIA ISOLATED FROM SURGICAL WOUNDS IN ADEN GOVERNORATE HOSPITALS, YEMEN PREVALENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AT A PRIVATE HOSPITAL IN SANA'A, YEMEN

Preface: 3rd International Conference on Humanities, Arts, and Social Sciences (HASS 2022)

3rd International Conference on Humanities, Arts, and Social Sciences (HASS 2022) was held from June 28-29, 2022 in New York, United States. The conference is co-organized by Guangzhou College of Commerce and Asian Union of Information Technology. This HASS welcomes the sociologists, artists, designers, humanists, educators, teachers, policy makers, scholars, and graduate students, etc. from different cultural backgrounds to present and discuss research, developments and innovations in all fields of Humanities, Arts, and Social Sciences.
 The aim of HASS 2022 is to provide a platform for sociologists, artists, designers, humanists, educators, teachers, policy makers, scholars, and graduate students, etc. from different cultural backgrounds to present and discuss research, developments and innovations in all fields of Humanities, Arts, and Social Sciences. It provides opportunities for the delegates to exchange new ideas and application experiences, to establish business or research relations and to find global partners for future collaboration.
 HASS 2022 received 227 manuscripts. And 84 submissions had been accepted by our reviewers. All papers were reviewed using a double-blind review process: authors declared their names and affiliations in the manuscript for the reviewers to see, but reviewers did not know each other’s identities, nor did the authors receive information about who had reviewed their manuscript. Many thanks go as well to all of the reviewers who helped us maintain the high quality of manuscripts. Lastly, sincere thanks to the members of the conference committees and organizing team for their hard work.
 HASS 2022 Organizing Committee

Evaluation of the quality and subsequent performance of manuscripts rejected by Clinical Rheumatology: a research report

To assess the quality and performance of manuscripts previously rejected by a rheumatology-focused journal. This was a cross-sectional, audit-type, exploratory study of manuscripts submitted to Clinical Rheumatology (CLRH) and rejected by one associate editor in 2019. We used a 36-item quality assessment instrument (5-point ordinal scale, 1 being worst). Performance variables included whether a rejected manuscript was published in another PubMed-listed journal, impact factor of the publishing journal (Scimago), number of citations (Web of Science), and social media attention (Altmetrics). Exploratory variables included authors' past publications, use of reporting guidelines, and text structure. Exploratory variables were assessed using non-parametric tests. In total, 165 manuscripts were rejected. Reporting guidelines were used in only five (4%) manuscripts. The mean overall quality rating was 2.48 ± 0.73, with 54% of manuscripts rated 2; 40-80% were rated < 3 on crucial items. Over a 26-month follow-up, 79 (48%) rejected manuscripts were published in other journals, mostly with lower impact factors; 70% of these had at least one citation, compared with 90.5% for manuscripts published in CLRH. Altmetrics was significantly lower for manuscripts published elsewhere than for those published in CLRH. As for text structure, the methods and results sections were shorter and the discussion longer than suggested. The corresponding authors' past experience and text structure were not associated with quality or acceptance. Research report quality is an area for improvement, mainly for items critical to explaining the research and findings. The use of reporting guidelines should be encouraged by journals. Key Points • The quality of research reports (in rejected manuscripts) is insufficient. • Guidelines for reporting are seldom used in rejected manuscripts. • A manuscript rejected by Clinical Rheumatology may subsequently be published in another journal with a lower impact factor and have fewer citations and less social media attention than accepted manuscripts.

Editorial Policy

Editorial Policy

European Neuroendocrine Tumor Society (ENETS) 2022 Guidance Paper for Carcinoid Syndrome and Carcinoid Heart Disease

European Neuroendocrine Tumor Society (<scp>ENETS</scp>) 2022 Guidance Paper for Carcinoid Syndrome and Carcinoid Heart Disease

DIAGNOSIS OF THYROID MALIGNANCY USING TRACE ELEMENTS OF NODULAR TISSUE DETERMINED BY X-RAY FLUORESCENCE ANALYSIS

Background: Benign (TBN) and malignant (TMN) thyroid nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of this study is to evaluate the possibilities of using differences in trace element contents (TEs) in nodular tissue to diagnose thyroid malignancies and to determine the sensitivity, specificity, and accuracy for most informative TEs in the diagnosis of TMN. Methods: Contents of TEs such as bromine (Br), copper (Cu), iron (Fe), iodine (I), rubidium (Rb), strontium (Sr), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using energy-dispersive X-ray fluorescent analysis. Results: It was observed that in TMN tissue the mean mass fractions of I and Zn were lower while the mean mass fraction of Rb was higher than in NT and TBN tissue. It was demonstrated that the I contents is nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue (87±5%, 96±2% and 94±2% respectively) were significantly higher than that made using ultrasound screening and cytological test of fine needle aspiration biopsy. Conclusions: It was concluded that determination the I level in a needle biopsy of TNs using energy-dispersive X-ray fluorescent analysis, is a fast, reliable, and informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification. Peer Review History: Received: 11 March 2022; Revised: 9 April; Accepted: 28 April, Available online: 15 May 2022 Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics &amp; Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. U. S. Mahadeva Rao, Universiti Sultan Zainal Abidin, Terengganu Malaysia, raousm@gmail.com

SEROPREVALENCE AND RISK FACTORS FOR HELICOBACTER PYLORI INFECTION AMONG SCHOOL STUDENTS IN SANA'A CITY, YEMEN

Background and Objectives: Helicobacter pylori is the most common bacterial infection affecting more than 50% of the population globally, especially in developing countries, while data on its prevalence in Yemen is still limited. Therefore, the current study aimed to estimate the seroprevalence and risk factors of H. pylori among school students in Sana'a city, Yemen.&#x0D; Methods: A cross-sectional study was conducted in primary and secondary schools in Sana'a during the period from October to December 2021 in which two hundred and ninety-three (293) school students aged 11-21 years were enrolled in this study and tested for H. pylori in blood specimens by using a cassette Rapid antibody test. Associated risk factors were collected through a designed questionnaire.&#x0D; Result: Overall, H. pylori antibody was positive in 82/293(27.99%) students. The higher rate of seroprevalence of H. pylori antibodies was reported among male students (29.25%; P˃0.05), age group of 16-21 years (33.69%; P ˂0.05), and secondary students in schools (31.66%; P ˂0.05). Also, the highest rate of H. pylori infection was positive among students who drank untreated water (32.61%), consuming of unwashed vegetables (28.71%) and fruits (30.51%), not been infected previously (28.45%), one of their family infected (28.98%), sometimes eating out of home (32.47%), and non-use antibiotics (29.12%) and there was non-statistical significant difference (P ˃0.05). In addition, there were no significant relationships between seropositivity of H. pylori and clinical signs and symptoms as well as antibiotic use. Finally, most of the students with blood group (O) had H. pylori antibodies (P ˃0.05).&#x0D; Conclusion: It can be concluded that the increasing rate of H. pylori among school students will become a real serious health problem if it is not monitored. Therefore, an effective educational health program is important for the prevention and control of H. pylori infection among school students.&#x0D; &#x0D; Peer Review History: &#x0D; Received: 26 February 2022; Revised: 18 March; Accepted: 22 April, Available online: 15 May 2022&#x0D; Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics &amp; Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com&#x0D; UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. &#x0D; Received file: Reviewer's Comments:&#x0D; Average Peer review marks at initial stage: 5.5/10&#x0D; Average Peer review marks at publication stage: 7.0/10&#x0D; Reviewers:&#x0D; Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye&#x0D; Dr. Nkechi Obiofu Ezenobi, University of Port Harcourt, Nigeria, nkechi.ezenobi@uniport.edu.ng&#x0D; Similar Articles: &#x0D; SEROPOSITIVITY OF HELICOBACTER PYLORI AND ASSOCIATED RISK FACTORS AMONG DYSPEPETIC PATIENTS&#x0D; PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN

BACTERIOLOGICAL CHARACTERISTICS OF DIABETIC FOOT INFECTION AND SUSCEPTIBILITY OF MULTIRESISTANT ISOLATES TO HYDRAULIC EXTRACTS FROM ALLIUM SATIVA, ALLIUM CEPA AND CANNABIS SATIVA

Background and objective : Diabetic foot infection is one of the most serious complications of diabetes and its persistence is the result of the ineffectiveness of antibiotic therapy due to the exponentially increasing of antibiotic resistant bacteria. The study aimed at investigating the antibacterial effect of the aqueous extract of some plants on the antibiotic resistant bacteria isolated from diabetic foot wound infections. Methods : A 6-months cross-sectional study from July 2021 to January 2022 at the Yaoundé Central Hospital, was undertaken with diabetic foot wound patients. All samples were appraised to determine presence of infectious agents using standard methods for isolation and identification of bacteria. Subsequently, Antibiotic resistance was done using Kirby-Bauer disc diffusion methods. Finally, extracts of Cannabis sativa leaves, Allium cepa and Allium sativum bulbs were obtained with water and their antibacterial activities were evaluated by the microdillution method on liquid medium. Results : 20 patients whom 14 men were included, with a sex ratio of 2.33, and their mean age was 52.5±9.6 years. 60% of these patients presented wounds in grade III and were of several types : purulent (48.57%), moist (31.43%) and dry (20%). 35 strains were isolated. The predominant GPB were S. aureus (34.29%) followed by Coagulase-negative Staphylococcus (14.29%), and Bacillus Spp (2.86%). Among the GNB, Pseudomonas aeruginosa (11.46%), Serratia Spp. (8.56%), Escherichia coli (8.56%), Enterobacter Spp. (5.71%), Proteus Spp. (5.71%), Klebsiella Spp., Yersinia Spp. and Salmonella Spp. in proportions of 2.86% each. A high rate of antibiotic resistance was recorded for Oxacillin (100%), Vancomycin (83.34%) and Augmentin (55.56%). Sensitivity tests on liquid medium showed that MIC ranged between 3.12-25.00 mg/mL, 6.25-25.00 mg/mL and 1.86-25.00 mg/mL respectivelly for A. sativa, A. cepa and C. sativa. Alliums were much more active on GNB. Although these results are low, they could be an alternative for the diabetic foot infection treatment. Conclusion : Alliums were much more active on GNB Although these results are low, they could be an alternative for the diabetic foot infection treatment. Peer Review History: Received: 28 February 2022; Revised: 15 April; Accepted: 24 April, Available online: 15 May 2022 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: THE SCOPING REVIEW OF CHINESE AND WESTERN MEDICINE TREATMENT OF DIABETIC FOOT IN ASIA A SURVEY ABOUT THE CURRENT SCENARIO OF DIABETES IN CHATTOGRAM AREA BY DETERMINING PRACTICE OF THE SELF-CARE ACTIVITIES AMONGST PEOPLE WITH DIABETES

PREVALENCE OF VISCERAL LEISHMANIASIS AMONG ADULTS IN SANA’A CITY-YEMEN

Background and Aims: Visceral leishmaniasis (VL) is a zoonotic and human disease caused by species of Leishmania. Parasites are transmitted to the vertebrate host by the bite of a sand fly female (Phlebotomus longipalpis), where the infected promastigotes transform into amastigotes; and this is deadly if left untreated. The purposes of the current research were to reveal the prevalence and potential risk factors for VL in adults in Sana’a city, Yemen. Subjects and methods: This cross-sectional study was performed during the period from January 2020 to November 2020. Individuals who come for a regular medical examination at Al-Zahrawi Medical Center, Althobhani Specialist Laboratories, Police Hospital, and University of Science and Technology Hospital. A target sample size of 300 was selected, and serum samples were collected from all subjects to determine the prevalence of anti-VL antibodies in human by immune-chromatographic assay using K39 recombinant antigen. Results: The ages of the participants' ranged from 18-65 years, with a mean of 29.8±8.2 years. The positive rate of antibodies against Leishmania species by immune-chromatographic dipstick strip (rK39) was 6.0%. There was statistically important association linking male gender and contracting VL (8.8%, OR=4.1, CI=1.2-14.4, P=0.01). There was a significant association (&lt;0.001) between the presence of dogs, rats, and goats in or around live houses and positive VL antibodies with an OR equal to 8.8.7.3 and 8.4, respectively. There were significant risk factors for garbage around the living house, there was also a significant association between displacement and the incidence of VL (P&lt;0.001) (OR=8.6, CI=2.8–27.2). Conclusion: Visceral leishmaniasis was highly prevalent in Sana'a city, and potential risk factors for VL were present with displacement, dogs, rats, goats, garbage, sleeping outside enclosed rooms, and sand flies in living houses. Further studies of human VL need to be conducted to clarify this issue in Yemen, to track and confirm potential reservoirs among canines and other animals, as well as to study vectors. Keywords: adults, immune-chromatographic assay, prevalence, potential risk factors, recombinant antigen K39, Sana’a city, visceral leishmaniasis, Yemen. Peer Review History: Received: 9 March 2022; Revised: 14 April; Accepted: 29 April, Available online: 15 May 2022 Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg Dr. Nicola Micale, University of Messina, Italy, nmicale@unime.it Dr. Rawaa Souhil Al-Kayali, Aleppo University, Syria, rawah67@hotmail.com Similar Articles: PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN

ANATOMICAL INVESTIGATIONS ON HAPLOPHYLLUM CAPPADOCICUM SPACH

Aim and objective: The aim of this work is to put forward the anatomical features of Haplophyllum cappadocicum, an endemic plant for Turkey. Methods: Plant materials were fixed in 70 % ethyl alcohol. The anatomical studies include transverse sections of roots, stems, leaves, fruits and seeds with illustrations. The investigations were made under microscope and photographs were taken by microphotography apparatus. Conclusion: Haplophyllum genus with potential pharmaceutical interest are worthy of investigation not only for chemical content but also anatomically. This is the first report on anatomical features of Haplophyllum cappadocicum collected from Malatya, Türkiye. Peer Review History: Received: 1 March 2022; Revised: 19 April; Accepted: 1 May, Available online: 15 May 2022 Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: ETHNOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGY OF OCHNA SCHWEINFURTHIANA: A REVIEW A STUDY ON DIFFERENT PLANTS OF APOCYNACEAE FAMILY AND THEIR MEDICINAL USES A REVIEW ON CONSTITUENTS, PHARMACOLOGICAL ACTIVITIES AND MEDICINAL USES OF GLYCYRRHIZA GLABRA

PATTERNS OF UVEITIS AT A TERTIARY REFERRAL CENTER IN YEMEN: ONE CENTRAL RETROSPECTIVE STUDY

Background: Uveitis is described as a disorder of the eye so as to leads to the iris, ciliary body, choroid, and adjacent parts of the eye inflammation. The disturbances may produce impermanent or continuing visual impairment or sightlessness. Purpose: The main purpose of the study was to reveal the causes of uveitis in a referral center in Sana'a city, Yemen. Sequentially the study was conducted to assist in the development and design of preventive policies and diagnostic methods for uveitis in Yemen. Methods: This cross-sectional, retrospective analysis integrated 65 uveitis patients who were referred to the Eye Consulting Center clinic, from January 2021 to the end of December 2021. Data concerning patient gender, age and anatomical location of disease, clinical and pathological manifestations were collected then evaluated. Results: The mean patient age at onset of uveitis was 36.3 ± 13.4 (range: 9-75) years. The female to male ratio was 2.6: 1. Sixty-seven percent participated uveitis patients suffered from bilateral involvement. The predominant type was Pan-uveitis (46.2%), anterior acute uveitis (36.9%), intermediate acute uveitis (12.3%) while posterior acute uveitis was less common (4.6%). Considering medical conditions, 53.8% of patients had acute uveitis and 46.2% had chronic uveitis. Laterality, 38.5% had unilateral uveitis while most patients had bilateral uveitis. Also, 53.8% of patients developed complications. Given the possible causes, the most common diagnoses were 'idiopathic' (32.3%), HLA-B27-positive (21.5%), Behçet‘s syndrome (13.8%), and granulomatous uveitis (TB) (9.2%)., seronegative spondyloarthropathy (6.2%), Fuch’s uveitis (6.2%), followed by less common Vogt Koyanagi Harada (4.6%), herpetic uveitis (3.1%), and toxoplasmosis (3.1%). Conclusion: On the contrary to most uveitis epidemiologic studies the uveitis etiologic and clinical patterns were diverse in a tertiary referral center in Sana’a city, Yemen. Pan-uveitis and anterior acute uveitis were the most frequent clinical pattern in this study, and the most common related causes were HLA-B27 positive and Behçet's syndrome. Peer Review History: Received: 12 March 2022; Revised: 17 April; Accepted: 30 April, Available online: 15 May 2022 Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Jucimary Vieira dos Santos, Hemonorte Dalton Barbosa Cunha, Brazil, jucimaryvieira@yahoo.com.br Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com Similar Articles: PREVALENCE OF CNS TUMORS AND HISTOLOGICAL RECOGNITION IN THE OPERATED PATIENTS: 10 YEARS EXPERIENCE IN YEMEN

INTEGRATING GENOMIC DISCOVERIES INTO FORENSICS: A MINI REVIEW

The justification that behavioral genetic evidence provides in criminality remains a wonder. Scientific evidence suggests that a decreased activity of the enzyme monoamine oxidase (MAOA-L) dubbed the warrior gene surges the possibility for aggressive, antisocial behavior and increased criminality. Ever since the human genome project was completed, breakthrough in genetics and biotechnology are now advancing at a speedy rate. Advancement in genetics and biotechnology has opened a frontier to carry out investigation on the influence of genetics on human behavior at the molecular-genetic level. The interplay between genes and susceptibility to diseases has extensively been accepted, but, the similar link between genes and predisposition to criminal behavior is yet to gain a wide acceptance. Notwithstanding this cynicism, biological studies have revealed that relatives of convicted criminals have higher chances of criminality, suggesting a genetic association to certain criminal behavioral tendencies. Emerging data and evidence indicates that without recourse to genetics, there would be a limited opportunity in elucidating the mechanism and reason for criminal, aggressive and antisocial behavior of some individuals. In this light, reports from some scientific finding revealed that monoamine oxidase A (MAOA) provides the strongest association between genetic variation and aggressive behavior particularly low gene variant monoamine oxidase A (MAOA-L) which has been introduced by experts as evidence for criminal behavior. Beside a satisfaction of scientific curiosity, genetic research portends the potential to contribute to preventive measures and investigation into the genetic etiological correlation of criminal behavior may result to the opening of a new frontier for treatment and intervention. Peer Review History: Received: 27 February 2022; Revised: 22 March; Accepted: 28 April, Available online: 15 May 2022 Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. amaechitoexcel@yahoo.com Idoko Alexander, Caritas University, Enugu, Nigeria, idokoalexander1@gmail.com Similar Articles: IN SILICO ANTIMALARIAL TARGET SELECTION CONSERVED IN FOUR PLASMODIUM SPECIES

A NOVEL QUATERNARY ALKALOID N-METHYLCORYXIMINE FROM HYPECOUM PENDULUM L.

Objective: In this study, the isolation and chemical structure elucidation of a new alkaloid from Hypecoum pendulum L is provided. Material and Methods: Column and ascending preparative thin layer chromatographic methods were utilized for the purification of the novel compound. The structure elucidation was determined based on spectroscopic methods including infrared (IR), nuclear magnetic resonance (NMR), and Mass (MS) spectroscopy. Results: N-methylcoryximine, a quaternary alkaloid from secoberbine subgroup of isoquinoline alkaloids, was isolated and the structure of this compound was elucidated. Conclusion: The natural occurrence and spectral data of N-methylcoryximine is reported for the first time. Peer Review History: Received: 7 March 2022; Revised: 12 April; Accepted: 29 April, Available online: 15 May 2022 Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics &amp; Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com Similar Articles: PURIFICATION AND BIOLOGICAL ACTIVITIES OF COMBINATION OF HEMI-SYNTHESIZED THIOSEMICARBAZONES OF MITRACARPUS SCABER ZUCC

UTILIZATION OF HEALTH MANAGEMENT INFORMATION SYSTEM AND ASSOCIATED FACTORS IN HEALTH INSTITUTIONS OF KEMBATA TEMBARO ZONE, SOUTHERN ETHIOPIA

Background: Health Management Information System (HMIS) is one of the six building blocks of a health system designed to provide important data for continuous quality improvement at all levels of health care administration. It is a major source of information for monitoring and adjusting policy implementation and resources use. Some studies have been conducted in health data collection and ways to improve data quality, but little is known about utilization of HMIS in health services organization. Therefore, this study aimed to assess the utilization of HMIS and associated factors in the study area.&#x0D; Methods: A facility-based cross-sectional study conducted in public health institutions of Kembata Tembaro zone from March 1 to March 30, 2018. The sample size was calculated using single population proportion formula,and a total of 317 heads of units/departments of district health offices and health facilities were included. Both quantitative and qualitative data were collected using structured questionnaires, observational check-lists and interview guide by trained data collectors. Multivariable logistic regressions were performed using Enter method to identify factors independently associated with dependent variable. Statistical significant variables were declared at P-value less than 0.05 and Odds ratio with 95% confidence interval were used for data interpretation.&#x0D; Result: In this study, overall data utilization was 131(41.59%) with 95% CI of 38.9-46.1%. The data utilization was found to be 98(38.73%) and 33(53.23%) in the health facilities and health administrative units respectively. Training for HMIS [AOR (95% CI)=3.06(2.15-6.75)], availability of procedure manuals [AOR (95% CI)=3.67(1.78-9.01)], and Supportive supervision[AOR (95% CI)=5.30(3.05-11.53)] were found to be significant with HMIS utilization.&#x0D; Conclusion: Utilization of HMIS in public health institution was lower compared to previous studies. HMIS training, supportive supervision and availability of procedure manuals were positively associated with utilization of HMIS. Health facilities and offices should avail HMIS manuals and capacity building of health workers through training and supportive supervision was recommended.&#x0D; &#x0D; Peer Review History: &#x0D; Received: 7 March 2022; Revised: 11 April; Accepted: 27 April, Available online: 15 May 2022&#x0D; Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com&#x0D; UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. &#x0D; Received file: Reviewer's Comments:&#x0D; Average Peer review marks at initial stage: 6.0/10&#x0D; Average Peer review marks at publication stage: 7.0/10&#x0D; Reviewers:&#x0D; Dr. Awofisayo, O Abosede, University of Uyo, Nigeria, shalomgirl08@yahoo.com&#x0D; Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com&#x0D; Similar Articles: &#x0D; INVESTIGATING THE OBSTACLES OF IMPLEMENTING HEALTH INFORMATION SYSTEMS FROM VIEWPOINT OF PERSONNEL OF MEHRIZ HEALTHCARE SYSTEM IN 2017