Abstract The beginning of the article defines current issues in manufacturing production lines which are classified into three categories. The next part is dedicated to the solution of these problems via core characteristics of reconfigurability and their application to particular problems of designing and optimization of manufacturing configuration. Based on these characteristics was created an algorithm for the design of the reconfigurable manufacturing line configuration. The suggested reconfigurable line configurations with multiagent logistic system are verified through simulation models. The simulation results are compared with the classic design of the dedicated manufacturing line for each part of the product family. The article concludes with recommendations for an application of these systems for improvement of flexibility and adaptability of current manufacturing systems.