Introduction.Brachytherapy is a localized radiotherapy technique that uses the movement of a radioactive source near the tumor to treat it. Conventional solutions for delivering this type of treatment are the use of non-personalized applicators or the creation of personalized molded applicators, the source being guided into these applicators by catheters. The manual manufacturing process is long, tedious, with a precise positioning of the catheters in the applicator that can become a real challenge. The objective of this work is to improve and extend the possibilities by creating custom applicators by 3D printing. In order to guarantee quality treatment, these applicators must be positioned precisely, reproducibly and individually to the patient’s anatomy. We present the technical implementation of this method.