ABSTRACT Domain adaptation can effectively enhance a model’s performance on target domain data with limited data. However, when some target domain labels are obtainable, training the model with both source and target domain data simultaneously can lead to worse performance due to the lower density of target domain data. If a large amount of target domain data is labeled without discrimination, it will necessitate a considerable expenditure of human resources. To address this issue, this paper proposes a human-in-one-loop active domain adaptation framework based on Target Domain Feature Generation to solve the problems. The oracle participates in only one iteration of data labeling, and a target domain classifier will take over the subsequent rest iterations. An image generator based on multiple CycleGANs forms an iterative co-training mechanism, which can continuously generate more high-quality labeled fake target domain data in iterations to improve the performance of the target domain classifier. The Top-N labeled data selection method with high confidence is devised to select the most accurately predicted data for labeling, reducing manual labeling workload. This framework can achieve an average accuracy of 0.8869 on six domain pairs, doubling the classical domain adaptation method DSN, requiring only a small amount of manual labeling.