Earthquake nests are anomalous clusters of seismicity located far from active collisional systems in intraplate, locked suture zones, or the deep part of relic subducted slabs, challenging classic earthquake generation mechanism theories. The Vrancea Seismic Zone in Romania is such an upper-mantle seismic nest located in the SE Carpathians, releasing the largest strain in continental Europe. To better understand earthquake generation and the relationship with lithospheric deformation, we estimate earthquake source parameters in Vrancea and surrounding regions between 2014 and 2020, and determine the stress field via focal mechanism inversion and unsupervised machine learning. In the crustal domain, maximum horizontal stress is in agreement with surface fault kinematics and GPS-derived S-SE trending horizontal plate velocities relative to Eurasia, implying that tectonic stress is vertically coherent on a crustal scale. The stress regime changes from transpression beneath the orogen to transtension towards the foreland where movement is accommodated along major crustal faults, and tension further away from the epicentre, in the Moesian Platform and the North Dobrogea Orogen. Inside the seismogenic body vertical tension and an overall compressive regime dominates, implying that vertical elongation may be the driving mechanism for brittle failure and that stress is transmitted along the sinking slab to the surface. However, the retrieved stress ratios are low: ~0.2 for mantle earthquakes Mw>4 and ~0.4 for Mw<4, challenging the brittle failure assumption. Increased pore fluid pressure has been shown to lower stress ratios, implying that dehydration embrittlement may contribute to generating intermediate-depth seismicity in the Vrancea slab. Comparisons with seismic tomography and anisotropy studies show excellent correlations between maximum horizontal stress directions, possible slab strike orientation, and seismic anisotropy, especially below ~130km depth, suggesting ambient mantle flow may also promote in-slab stress build-up and seismic potential.
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