Fire has become a major disturbing factor in boreal forests, and giant forest disturbances play a vital role in regulating the climate under global warming. Therefore, it is essential to investigate the spatiotemporal patterns and main drivers of post-fire vegetation recovery for forest ecological research and post-fire recovery management. However, previous studies have focused on the post-fire forest change within the entire fire perimeter, lacking separate analysis and comparison of the burned zone (BZ) and unburned zone (UNBZ). Here, we propose the utilization of Moderate Resolution Imaging Spectroradiometer land cover type and vegetation index data to monitor vegetation dynamics and explore its drivers after the most serious forest fire in the history of P.R. China in the Greater Hinggan Mountains (GHM). The temporal and spatial patterns of vegetation recovery in the BZ/UNBZ in the GHM were analyzed using the Sen & Mann-Kendall method, Hurst index and coefficient of variation, and their driving mechanisms were explored using GeoDetector and geographically weighted regression. The results showed that there were significant differences in the spatial distribution and fluctuation of vegetation between the BZ and UNBZ, and that the BZ exhibited higher productivity and vigor. Vegetation recovery was influenced by different dominant factors and changed over time, in which land surface temperature and precipitation dominated all the time, whereas topographic relief and elevation had a more significant contribution to vegetation recovery in the BZ and UNBZ, respectively. This study provides a scientific basis for the protection and management of vegetation in disturbed forested areas, particularly after fires.