Feasible, smooth, and time-jerk optimal trajectory is essential for manipulators utilized in manufacturing process. A novel technique to generate trajectories in the joint space for robotic manipulators based on quintic B-spline and constrained multi-objective student psychology based optimization (CMOSPBO) is proposed in this paper. In order to obtain the optimal trajectories, two objective functions including the total travelling time and the integral of the squared jerk along the whole trajectories are considered. The whole trajectories are interpolated by quintic B-spline and then optimized by CMOSPBO, while taking into account kinematic constraints of velocity, acceleration, and jerk. CMOSPBO mainly includes improved student psychology based optimization, archive management, and an adaptive ε-constraint handling method. Lévy flights and differential mutation are adopted to enhance the global exploration capacity of the improved SPBO. The ε value is varied with iterations and feasible solutions to prevent the premature convergence of CMOSPBO. Solution density estimation corresponding to the solution distribution in decision space and objective space is proposed to increase the diversity of solutions. The experimental results show that CMOSPBO outperforms than SQP, and NSGA-II in terms of the motion efficiency and jerk. The comparison results demonstrate the effectiveness of the proposed method to generate time-jerk optimal and jerk-continuous trajectories for manipulators.