Manipulation Devices Research Articles

Biomimetic artificial cilia with three-dimensional motion driven by magnetic fields

Abstract Inspired by natural cilia, we developed magnetically actuated artificial cilia capable of controlled three-dimensional motion. The key innovation lies in concentrating hard magnetic particles at the tip of a silicon pillar, enabling asymmetric effective and recovery strokes under a constant rotational magnetic field. By magnetizing the pillar at 45° to the ground, we achieved complex three-dimensional movements that closely mimic biological ciliary motion. Our developed simulation system reproduced individual pillar trajectories in static conditions, showing consistency with experimental results in the range without snapping, a phenomenon characterized by the sudden release of twist-induced stress. Furthermore, we demonstrated metachronal wave-like motion in pillar arrays. These arrays exhibited both transport capabilities, successfully moving a 10 mg object, and locomotion functions. The combination of precise motion control, predictive modeling, and demonstrated functionality suggests promising applications in microfluidic manipulation and biomedical devices.

A Hybrid Vacuum Flange RF Oscillator for Low-Cost Mass Spectrometry.

In this communication we report the construction of a printed circuit board which mounts directly to the vacuum chamber of a mass spectrometer and produces the RF waveforms needed by many nonmass-selective devices such as ion guides and ion funnels. Our device is designed to replace a standard KF40 flange, can maintain vacuum chamber pressures of less than 10-6 Torr, and contains the circuitry of the open-source Wisconsin Oscillator RF power supply to generate RF waveforms of 1-4 MHz and up to 200 Vp-p. In this iteration of the Wisconsin Oscillator, we also introduce a variable resistor to control the output RF amplitude and show that its ion transmission capabilities are identical to those provided by commercial RF power supplies. With this new implementation we have greatly reduced the space and monetary requirements for driving nonmass-selective ion manipulation devices, which we expect to be advantageous to those developing low-cost and/or portable mass spectrometry systems.

Tri-Prism Origami Enabled Soft Modular Actuator for Reconfigurable Robots.

Soft actuators hold great potential for applications in surgical operations, robotic manipulation, and prosthetic devices. However, they are limited by their structures, materials, and actuation methods, resulting in disadvantages in output force and dynamic response. This article introduces a soft pneumatic actuator capable of bending based on triangular prism origami. The origami creases are crafted by utilizing fabrics to gain swift response and fatigue-resistant properties. By connecting two actuators in series, combined motions including extension and diversified compound bending can be achieved, facilitating control in complex scenarios. After modularizing the soft actuator via mortise and tenon structures, several actuators can be programmed to execute a variety of intricate tasks by adjusting the timing sequences of their contraction and expansion. We showcase its applications in reconfigurable robots, and the results confirm that such a design is adequate for flexibly performing tasks such as soft gripping, navigational movement, and obstacle avoidance. These findings highlight the significance of our actuator in developing soft robots for versatile tasks.

Concept of a device for universal manipulation of charging processes of electric vehicles to increase distribution system hosting capacity

Concept of a device for universal manipulation of charging processes of electric vehicles to increase distribution system hosting capacity

Utilization of Electric Fields to Modulate Molecular Activities on the Nanoscale: From Physical Properties to Chemical Reactions.

As a primary energy source, electricity drives broad fields from everyday electronic circuits to industrial chemical catalysis. From a chemistry viewpoint, studying electric field effects on chemical reactivity is highly important for revealing the intrinsic mechanisms of molecular behaviors and mastering chemical reactions. Recently, manipulating the molecular activity using electric fields has emerged as a new research field. In addition, because integration of molecules into electronic devices has the natural complementary metal-oxide-semiconductor compatibility, electric field-driven molecular devices meet the requirements for both electronic device miniaturization and precise regulation of chemical reactions. This Review provides a timely and comprehensive overview of recent state-of-the-art advances, including theoretical models and prototype devices for electric field-based manipulation of molecular activities. First, we summarize the main approaches to providing electric fields for molecules. Then, we introduce several methods to measure their strengths in different systems quantitatively. Subsequently, we provide detailed discussions of electric field-regulated photophysics, electron transport, molecular movements, and chemical reactions. This review intends to provide a technical manual for precise molecular control in devices via electric fields. This could lead to development of new optoelectronic functions, more efficient logic processing units, more precise bond-selective control, new catalytic paradigms, and new chemical reactions.

Droplet Helical Motion on Twisted Fibers.

We investigate herein the impact of helical structures on the motion of asymmetrical droplets along vertically twisted fibers. The droplet adopts helical motion around the bundle driven by gravity. This complex motion can be manipulated by varying the twists turns of the fibers. When the droplet size is smaller than the characteristic length of the helix (pitch), the droplet adopts a predominant helical motion correlated to the groove of the twisted fibers. When the droplet size exceeds the pitch length, a mixed motion of intermittent vertical sliding and helical movement emerges. A model describes rotational and linear speeds as a function of the number of fiber twist turns. This research highlights the profound role of substructures in droplet dynamics, offering fresh insight into droplet manipulation or fiber-based devices.

Design and experimental demonstration of functional devices for energy manipulation in new analog acoustic computers

The development of new analog computers based on analog signals of electromagnetic or elastic waves has become a hot research topic in recent years. In this Letter, based on the concept of quantum state transfer, we study the process of energy transfer between acoustic cavities. Through the transformation from the temporal domain to the spatial domain, we further study the process of energy transfer between acoustic waveguides, and then we realize the applications of energy distributors and limiters in the acoustic system, which are the functional devices of wireless communication technology in new analog acoustic computers. We both simulationlly and experimentally demonstrate the effectiveness of the two applications. The energy distributor and limiter we proposed have the advantages of a relatively wide operating frequency range and adjustability. Our work shows the transfer mechanism of acoustic energy between different structures, which increases its potential application value in new analog acoustic computers.

A multimodal rotational acoustic manipulation device for hydrophilic/hydrophobic floating and submerged particles

Rotational acoustic manipulation technology offers precise control of particle motion, making it advantageous for applications in microfluidics, biomedicine, materials research, and so on. Current advanced techniques that use acoustic waves to rotate particles include microstructure vibration, microbubble oscillation, and acoustic holography. Although these methods have achieved some success in rotational acoustic manipulation, they face challenges such as limited types of particles, complex device fabrication, and single-mode manipulation. To address these issues, this study proposes a novel rotational acoustic manipulation device based on traveling wave acoustic fields. The traveling wave acoustic field is achieved by planning the vibration modes of the vibrational source. In this study, a ring-shaped piezoelectric ceramic with four-quadrant dual polarization is designed to excite two orthogonal B11 bending vibration modes of the vibrator. By adjusting the phase difference of the excitation signals, these two B11 bending vibration modes can be coupled into either clockwise or counterclockwise traveling wave vibration modes, thereby establishing unidirectional rotating traveling waves in the water within the PDMS ring. The PDMS ring features an open structure, meeting the requirements for manipulating both floating and submerged particles. The performance of the proposed acoustic manipulation device is validated and analyzed through experiments with hollow glass particles, hollow polystyrene particles, and solid polystyrene particles. The results demonstrate that the proposed acoustic manipulation device can achieve precise fixed-point self-rotation and regional revolution manipulation of particles, regardless of their floating, submerged, hydrophilic, or hydrophobic properties. This indicates the high universality and robustness of the device, making it applicable for the manipulation of various types of particles. Overall, this study introduces a novel acoustic manipulation method for particle rotation, providing strong support for the development and application of acoustic manipulation devices in diverse fields.

DC voltage switching-based octuple-electrode microdevice for cell rotation and area-specific membrane capacitance measurement

Single-cell electrorotation plays an important role in the field of single-cell imaging and electric parameter measurement. However, reported cell rotation technology often adopts a quadruple-electrode structure and is excited by an AC signal. The distribution of electric field strength in the enclosed area is not uniform, and the rotation speed of the cells is related to the location in the area, so it is difficult to achieve uniformity of electric field distribution and the stationarity of rotation. This work proposes a DC voltage switching-based octuple-electrode microdevice for cell rotation and area-specific membrane capacitance measurements. This design can switch the DC voltages on each electrode periodically to produce a uniformly distributed rotating electric field. The rotation direction of the electric field can be realized by simply controlling the switching order of the analog switches. According to the theoretical single-cell model, the area-specific membrane capacitance of cells are determined through rotation movements. Simultaneously, based on simulation results, the rotation area is normalized to enhance the accuracy of the measuring electrical parameters. This study demonstrates the potential application of the proposed octuple-electrode DC voltage-based electro-rotation device for rapid, convenient, and cost-effective manipulation and electrical parameter measurement of single cells.

Water drop transportation on wettability switchable surface via anisotropic molecules

Active control of the transportation of liquid drops on a horizontal surface is achieved using surfaces with switchable wettability via remote stimuli. However, the mechanism how the dynamic wettability influences drop dynamics is rarely reported. In this paper, we demonstrate that a surface with switchable wettability induces depinning of the contact line through re-orientation of anisotropic molecules. We investigated the dynamics of contact lines and contact angles during the initiation of drop movement by the advancing and receding angles of the surface. We found that imbalance between advancing and receding angles with respect to the dynamic contact angle provides the force needed to overcome the energy barrier due to contact angle hysteresis on the surface. We discovered that the driving energy is accumulated with oscillations in contact angle until it breaks the pinning energy barrier. Understanding the role of dynamic contact angles in drop movement on switchable surfaces paves the way for designing effective fluid manipulation devices, such as water harvesters, biosensors, and oil–water separators.

Rotational manipulation of paramecium using a semi-capsule-shaped bubble with an adjustable volume actuated by acoustic waves

Acoustically actuated bubbles provide a versatile and non-invasive approach for manipulating microorganisms in fluid. However, the susceptibility of the bubble volume to environment and the complex intersecting vortices of the oscillation of hemispherical bubbles reduce the stability of micromanipulation of ellipsoid-like organisms. This study involves an on-chip rotational manipulation device for rotating ellipsoid-like organisms, which utilizes parallel microstreaming vortices that are generated with acoustically actuated semi-capsule-shaped bubbles. In addition, a relatively stable volume of the semi-capsule-shaped bubble with tolerances about 5 % is realized by adjusting the gas diffusion between the bubble and the gas channel. Characterized experiments using polystyrene particles of 10 μm demonstrate that two pairs of significant out-of-plane parallel microstreaming vortices can be generated near the short or long side of a semi-capsule-shaped bubble at acoustic driving frequencies of 11.23 kHz and 13.97 kHz, respectively. The vortices effectively induce rotation both for the spherical particles and the ellipsoid-like paramecia in fluid. Compared to oscillating hemispherical bubbles, acoustically actuated semi-capsule-shaped bubbles offer a more stable attitude of the rotation axis and even rotation velocity for paramecia. The acoustically actuated semi-capsule-shaped bubbles offer a label-free method for rotational manipulation of ellipsoid-like organisms, characterized by good stability, adaptability, and biocompatibility.

Particle manipulation based on curved, slanted-finger interdigital transducer

Abstract In this paper, an acoustic particle manipulation device is proposed to realize multi-function particle operation in a droplet. A curved slanted-finger interdigital transducer is designed to excite surface acoustic wave (SAW) in different resonance frequency. Diversity acoustic pressure field can be formed by turning the excitation frequency of the transducer. Moreover, through switching the excitation combination of the interdigital transducers, different acoustic field distributions can be aotained and diversity acoustic stream can be formed in the droplet. A finite element model is setup to study the acoustic field distribution and acoustic stream. Simulation results show that when a single frequency SAW is excited, acoustic streaming can be formed in the fluid and the particles can be rotated in the droplet. By switching the excitation frequency of the interdigital transducer, the direction of acoustic stream can be changed. In addition, the interdigital transducer can simultaneously excite multiple surface acoustic waves of different frequencies, which can manipulate the particles move in different tragectory. The study provides an effectively device to multi-function particle manipulation.

Full-space metasurfaces for independent manipulation of transmission and reflection.

In recent years, beam manipulation using metasurfaces has evolved from being limited to either a transmission or reflection space to encompassing a full space. However, existing methods still inevitably require complex systems and are unable to achieve continuous and arbitrary phase manipulation. Here, one type of a bilayer metasurface is proposed to simultaneously manipulate reflection and transmission phases continuously and independently, which also makes the optical system more compact without requiring any analyzers and enhances the degree of freedom for full-space beam manipulation. As a proof-of-concept demonstration, one device is designed to show different holograms in transmission and reflection spaces. Additionally, the Dammann grating designed in the reflection hologram increases the information capacity. The proposed method may pave the way toward achieving a variety of applications such as multi-channel beam manipulation and multifunctional optical devices.

Selection of functional sperm by using hyaluronic acid modified magnetic microbeads and an electromagnetic manipulation system.

In recent years, the incidence of infertility has increased year by year. Assisted reproductive technology (ART) is one of the effective strategies to treat infertility. In the process of ART, commonly used methods for sperm separation have shortcomings and there is still room for improvement. In this study, a functional sperm selection strategy was established based on hyaluronic acid (HA) modified magnetic microbeads (MBs) and a supporting two-dimensional electromagnetic manipulation device system. Due to the modification of HA on the surface of MBs, the HA-MBs have the ability to target and bind to specific receptors on the sperm membrane to form a sperm-MB complex. A disulfide linker was introduced to connect HA and MBs. After modifying HA and connecting it with the disulfide linker, the sperm of sperm-MBs can be released under the combined effect of hyaluronidase and reduced GSH with the disulfide bond broken and HA degraded. A two-dimensional electromagnetic manipulation system was introduced to generate a magnetic field and control the directional movement of the sperm-MB complex under the guidance of an inverted microscope. The free MBs can also be removed after the sperm is released. Furthermore, the mouse sperm selected through this strategy can achieve normal insemination via ICSI and the obtained blastocysts have normal morphology and developmental milestones. This strategy has potential to be developed into an automated screening solution for the screening of functional sperm for assisted reproductive technology.

Analytical realization of complex thermal meta-devices

Fourier’s law dictates that heat flows from warm to cold. Nevertheless, devices can be tailored to cloak obstacles or even reverse the heat flow. Mathematical transformation yields closed-form equations for graded, highly anisotropic thermal metamaterial distributions needed for obtaining such functionalities. For simple geometries, devices can be realized by regular conductor distributions; however, for complex geometries, physical realizations have so far been challenging, and sub-optimal solutions have been obtained by expensive numerical approaches. Here we suggest a straightforward and highly efficient analytical de-homogenization approach that uses optimal multi-rank laminates to provide closed-form solutions for any imaginable thermal manipulation device. We create thermal cloaks, rotators, and concentrators in complex domains with close-to-optimal performance and esthetic elegance. The devices are fabricated using metal 3D printing, and their omnidirectional thermal functionalities are investigated numerically and validated experimentally. The analytical approach enables next-generation free-form thermal meta-devices with efficient synthesis, near-optimal performance, and concise patterns.

Injury to Anatomic Structures Due to Fixation Device in Management of Mandibular Fracture.

ORIF is the gold standard for the management of mandibular fractures. The chances of postoperative complications are due to infection, damage of the inferior alveolar nerve canal, or tooth root during the fixation of the fracture fragments. Fixation hardware placed in the vicinity of the vital structures may encroach on the anatomic structures, leading to postoperative complications. The aim of this study is to evaluate the injury to the anatomic structures in the proximity of the fracture line due to the fixation device. This retrospective study was conducted in a tertiary care teaching hospital from July 2021 to June 2023. The cases of maxillofacial trauma reported and referred from peripheral centers were considered duly, applying the inclusion and exclusion criteria. Patients having mandibular fractures from one mandibular foramen to another with or without associated other facial fractures were treated by ORIF under general anesthesia. The patient was followed up at 1 week, 1 month, 3 months, and 6 months. The cases of postoperative complications were further investigated by CBCT. There were 67 patients (56 males and 11 females) with 86 fracture lines in the age group of 18-55 years with an average age of 35.2 years. Postoperatively 7 patients presented with unilateral paresthesia of the lower lip and chin region. CBCT revealed that the mean distance of the screw from the inferior alveolar nerve canal was 3.02mm. None of these cases had injury to the nerve canal or roots of teeth. All the patients recovered from paresthesia within 6 months. Complications like injury to the inferior alveolar nerve (IAN) with sensory disturbances to the lower lip and chin, as well as tooth/tooth root fractures, may occur due to mandibular fracture, surgical manipulation, and fixation devices. The anatomic structures in the vicinity of the fracture line can be damaged during the fixation of the fracture fragments by the bone plates and screws. In the present study, it was found that 7 out of 67 patients presented with unilateral paresthesia of the lower lip and chin. CBCT analysis showed a considerable distance of 3.02mm from the inferior alveolar nerve canal to the screws. There was no evidence of hardware encroachment on the IAN or tooth roots. Selection and placement of appropriate fixation devices, particularly the length of the bone screws, are crucial to avoid injury to the anatomic structures.

Controllable optical tweezer and spanner in evanescent fields via a single plasmonic metasurface

A dual-functional plasmonic metasurface is proposed to realize trapping and rotation of microparticles in evanescent fields by simply changing the polarization of incident light. The metasurface is constituted with subwavelength rectangular nanoslit that is perforated in an Au film on the glass substrate. Simulated near-field intensity distributions show that surface plasmon vortex with designed topological charge and focused point with enhanced intensity can be controllably generated in the center region of the designed metasurface by different circularly polarized lights. Calculated optical force and optical potential on a polystyrene sphere further demonstrate the good performances of rotating and trapping a microparticle with the generated vortex and focused surface plasmon polaritons. Moreover, two examples designed with different topological charges demonstrate the flexibility of these metasurfaces in tuning the rotation radius of microparticles. The advantages of the proposed metasurface in design flexibility, multifunctionality, and small size may provide new possibilities for applications of integrated optical manipulation devices and systems.

Influence of triangular obstacles on droplet breakup dynamics in microfluidic systems

Microfluidic devices with complex geometries and obstacles have attracted considerable interest in biomedical engineering and chemical analysis. Understanding droplet breakup behavior within these systems is crucial for optimizing their design and performance. This study investigates the influence of triangular obstacles on droplet breakup processes in microchannels. Two distinct types of triangular obstructions, positioned at the bifurcation (case I) and aligned with the flow (case II), are analyzed to evaluate their impact on droplet behavior. The investigation considers various parameters, including the Capillary number (Ca), non-dimensional droplet length (L*), non-dimensional height (A*), and non-dimensional base length (B*) of the triangle. Utilizing numerical simulations with COMSOL software, the study reveals that the presence of triangular obstacles significantly alters droplet breakup dynamics. Importantly, the shape and location of the obstacle emerge as key factors governing breakup characteristics. Results indicate faster breakup of the initial droplet when the obstacle is positioned in the center of the microchannel for case I. For case II, the study aims to identify conditions under which droplets either break up into unequal-sized entities or remain intact, depending on various flow conditions. The findings identify five distinct regimes: no breakup, breakup without a tunnel, breakup with a tunnel, droplet fragmentation into unequal-sized parts, and sorting. These regimes depend on the presence or absence of triangular obstacles and the specific flow conditions. This investigation enhances our understanding of droplet behavior within intricate microfluidic systems and provides valuable insights for optimizing the design and functionality of droplet manipulation and separation devices. Notably, the results emphasize the significant role played by triangular obstacles in droplet breakup dynamics, with the obstacle’s shape and position being critical determinants of breakup characteristics.

Ultrasonic manipulation of particles and cell aggregates with simultaneous acoustic visualization

Acoustical tweezers can manipulate inanimate particles as well as living cells in liquid in 2D using surface acoustic waves and in 3D using bulk acoustic waves. Here, we demonstrate a MHz twin-trap device for underwater manipulation of particles and cell aggregates and show that it operates effectively within a Petri dish and a plastic tube. We also describe a method to visualize in real time the acoustic field using a contained layer of small, high-density particles, which allows the trap to be seen in the same image as the manipulated particle. The device used was made with simple components, integrated onto a printed circuit board, and requires a single electrical channel for excitation. As a result, this device has the potential to be widely implemented in applications such as micro-organism manipulation, in vivo manipulation, and drug delivery.

Capillary-based, multifunctional manipulation of particles and fluids via focused surface acoustic waves

Surface acoustic wave (SAW)-enabled acoustofluidic technologies have recently attracted increasing attention for applications in biology, chemistry, biophysics, and medicine. Most SAW acoustofluidic devices generate acoustic energy which is then transmitted into custom microfabricated polymer-based channels. There are limited studies on delivering this acoustic energy into convenient commercially-available glass tubes for manipulating particles and fluids. Herein, we have constructed a capillary-based SAW acoustofluidic device for multifunctional fluidic and particle manipulation. This device integrates a converging interdigitated transducer to generate focused SAWs on a piezoelectric chip, as well as a glass capillary that transports particles and fluids. To understand the actuation mechanisms underlying this device, we performed finite element simulations by considering piezoelectric, solid mechanic, and pressure acoustic physics. This experimental study shows that the capillary-based SAW acoustofluidic device can perform multiple functions including enriching particles, patterning particles, transporting particles and fluids, as well as generating droplets with controlled sizes. Given the usefulness of these functions, we expect that this acoustofluidic device can be useful in applications such as pharmaceutical manufacturing, biofabrication, and bioanalysis.