Manifestations Of Fever Research Articles

Coinfection of leptospirosis and coronavirus disease 2019: A retrospective case series from a coastal region in South India.

During the monsoon season of 2020, the coastal areas of South India were endemic to both leptospirosis and coronavirus disease 2019 (COVID‐19). This study aimed to investigate the clinical features and outcomes of patients infected with both infections. A retrospective review of charts of all patients with COVID‐19 who were also diagnosed with leptospirosis by immunoglobulin M enzyme‐linked immunosorbent assay was undertaken. The clinical features, laboratory report, treatment details, and outcomes of all the included patients were recorded. The collected data were summarized as the frequency with percentage for categorical data and the mean or median for continuous data. Twenty‐four cases of coinfections were admitted between July and November 2020. Most of these patients were categorized as severe COVID‐19 (n = 15, 62.5%). Acute kidney injury was seen in 79.2% (n = 19) patients, while raised bilirubin was present in 79.2% (n = 19) of the patients. All patients had raised C‐reactive protein, while all but one had raised procalcitonin. Thrombocytopenia, leucocytosis, and leukocytopenia were seen in 91.7% (n = 22), 45.8% (n = 11), and 12.5% (n = 3) of the patients. The median duration of hospital stay was 11 (8.25–15) days. A total of 79.2% (n = 19) of the patients improved and were discharged, while 20.8% (n = 5) died during the hospital stay. In conclusion, patients with fever and atypical manifestations such as hepatic dysfunction, renal dysfunction, and thrombocytopenia should be evaluated for leptospirosis even if they are COVID positive.

Can the treatment of polycystic ovary syndrome with spironolactone prevent severe COVID infection?

In a recent paper, Subramanian and collaborators reported a 52% increased risk of COVID-19 infection in women with polycystic ovary syndrome (PCOS) and an incidence nearly twice that of women without PCOS. The authors focused, as important factors of the increased prevalence of infection, both the inflammatory characteristic of PCOS and the increase in androgens that facilitate the entry of the virus into the cells of the target organs. We asked 200 consecutive, unvaccinated women with PCOS who had been followed with spironolactone for more than 4 months, about COVID-19 infection and found only four patients who were infected. None of the infected patients were hospitalized and only one had fever and other manifestations of the syndrome, but these symptoms resolved in a few days. The other three reported only mild or minimal symptoms. This observation needs confirmation with specific studies, considering the possibility that many other patients may have been infected by being asymptomatic and not swabbing for COVID-19. Spironolactone can increase the circulating angiotensin-converting enzyme 2 and antagonize the androgen receptor, preventing activation of transmembrane protease serine 2 in cells of the respiratory tract and other tissues. Drug also has potent anti-inflammatory and antithrombotic actions by antagonizing the mineralocorticoid receptor in target tissues and inflammatory cells. From Subramanian's study and reported observations, a proper evaluation of the use of spironolactone in COVID-19 in both PCOS and the general population is urged.

Changing Spectrum of Acute Encephalitis Syndrome in India and a Syndromic Approach.

Acute encephalitis syndrome (AES) refers to an acute onset of fever and clinical neurological manifestation that includes mental confusion, disorientation, delirium, or coma, which may occur because of infectious or non-infectious causes. Cerebrospinal fluid (CSF) pleocytosis generally favors infectious etiology, and a normal CSF favors an encephalopathy or non-infectious AES. Among the infectious AES, viral, bacterial, rickettsial, fungal, and parasitic causes are the commonest. Geographical and seasonal clustering and other epidemiological characteristics are important in clinical decision making. Clinical markers like eschar, skin rash, myalgia, hepatosplenomegaly, thrombocytopenia, liver and kidney dysfunction, elevated serum CK, fronto-temporal or thalamic involvement on MRI, and anterior horn cell involvement are invaluable clues for the etiological diagnosis. Categorizing the AES cases into neurologic [Herpes simplex encephalitis (HSE), Japanese encephalitis (JE), and West Nile encephalitis (WNE)] and systemic (scrub typhus, malaria, dengue, and Chikungunya) helps in rational utilization of diagnostic and management resources. In neurological AES, cranial CT/MRI revealing frontotemporal lesion is consistent with HSE, and thalamic and basal ganglia lesions are consistent with JE. Cerebrospinal fluid nucleic acid detection test or IgM antibody for JE and HSE are confirmatory. Presence of frontotemporal involvement on MRI indicates acyclovir treatment pending virological confirmation. In systemic AES, CT/MRI, PCR for HSE and JE, and acyclovir therapy may not be useful, rather treatable etiologies such as malaria, scrub typhus, and leptospirosis should be looked for. If smear or antigen for malaria is positive, should receive antimalarial, if negative doxycycline and ceftriaxone should be started pending serological confirmation of scrub typhus, leptospira, or dengue. A syndromic approach of AES based on the prevalent infection in a geographical region may be developed, which may be cost-effective.

Expanded Dengue Syndrome with Status Epilepticus in a nine months old boy: A Case Report

Dengue fever is a major global public health challenge in tropical and subtropical countries. The clinical spectrum of dengue infection ranges from mild illness to the life-threatening severe forms of the disease with plasma leakage, severe bleeding, or multi-organ failure, which may be fatal. The term expanded dengue syndrome is used for atypical manifestations of dengue fever. This study presented a case of expanded dengue syndrome with status epilepticus in a 9-month-old boy hospitalized with the chief complaint decreased of consciousness with fever and seizures. From the physical examination, there was a decrease in consciousness with GCS 9 accompanied by fever, ascites, and gastrointestinal bleeding. On laboratory examination, hyponatremia, increased transaminase enzymes, and hypoalbuminemia with positive dengue IgM were found. The patient had specific clinical features of expanded dengue syndrome with status epilepticus the appropriate anti-convulsion, vasopressor, and fluid management was given to the patient.
 In cases of dengue virus infection, it is important to prevent other potential complications such as expanded dengue syndrome with status epilepticus. Early diagnosis of expanded dengue syndrome simultaneously with adequate treatment will prevent the complications of the disease.

Laboratory Parameters of Dengue Infection in a Medical College Hospital

Introduction & objective: Dengue is an acute illness caused by Aedes mosquito, commonly caused by Aedes aegypti. It is an endemic disease in South East Asian countries especially in Bangladesh. In 2019 a outbreak occurred in Bangladesh. The objective of the study was to see the laboratory parameter and outcome of dengue fever in a tertiary medical college hospital. Early diagnosis and laboratory investigations is essential to prevent the mortality associated with this disease. Materials & Methods: This prospective study was conducted on dengue ward at Khulna medical college hospital from 1 July 2019 to 31 December 2019. The diagnosis of dengue infection was confirmed by serology. Sera were processed by dengue ELISA. Investigations like haemoglobin estimation, haematocrit, platelet count, total count; differential leukocyte count, peripheral smear, coagulation profile were performed. Results: Total number of cases was 98. Of them 62 (63.2%) was male and 36 (36.73%) was female. Fever was most common (100%) manifestation and duration of fever ranges from 5 to 8 days with a mean duration of 6.31 (± 0.95) days. Blood for NS1 was positive in 90 (91.83% ) cases; most cases 71 (72.44%) become positive between 2nd to 4th day. 90 (91.83%) cases developed thrombocytopenia and it starts at 5th day in 45 (45.91%) cases. Anti IgM was positive in 4 (4.08%) cases; 2 at 4th day and 2 at 5th day of illness. IgG was positive in case at 8th day of illness. Conclusion: These findings help physicians in early diagnosis of dengue by suspecting these features as of dengue and can prevent morbidity and mortality associated with dengue. Medicine Today 2022 Vol.34(1): 61-64

ГРИБКОВАЯ СЕНСИБИЛИЗАЦИЯ У ПАЦИЕНТОВ С ПОЛЛИНОЗОМ

Fungal sensitization makes a significant contribution to the development of allergopathology. Literature reviews, based on domestic and foreign literature data, present general characteristics of mold allergens. It reflects features and problems of diagnosis of mold allergy. The necessity of aeropalynological monitoring of mold allergens is considered in connection with the combined influence of pollen and mold on the development of clinical manifestations of hay fever.

Histopathological and Haematological Manifestations of Typhoid Fever in Pediatric Age Group

Background: Typhoid fever is an acute systemic infection caused by Salmonella Enterica Serovar Typhi. Organism is transmitted by fecal-oral route. Aim: To determine frequency of various histopathological & hematological manifestations of typhoid fever in pediatric age group. Study design: Cross-sectional survey. Methodology: Complete blood count, pro-thrombin time and activated partial thromboplastin time were performed on the patients (n=140) to find out various hematological manifestations. Histopathological findings of patients undergoing colonoscopy and biopsy due to gastrointestinal presentations were also noted. Results: Present study had 65% males with 35% females. Almost 65.7% cases presented with anemia. Around 50.7% patients had leucopenia while eosinopenia was 67.1%. Cases (39.3%) presented with prolonged activated partial thromboplastin time while 32.1% cases had prolonged pro-thrombin time. Among histopathological manifestation, 3(2.14%) presented with Typhoid colitis/enteritis, 2(1.43%) with gastrointestinal bleeding due to ulcers and only 1(0.71%) with peritonitis. Conclusion: It was concluded that most common haematological manifestation in typhoid fever was eosinopenia which was most frequently found in coexistence with thrombocytopenia. However, histopathological abdominal complications were quite rare but could be dreadful and should be kept in mind. Keywords: Typhoid Fever, Hematological, Histopathological Manifestations, Abdominal complications and Children.

Gastrointestinal manifestations of food allergy in children: oral allergic syndrome

Oral allergic syndrome is a manifestation of an acute allergic reaction from the mucous membrane of the oropharynx in the form, itching and tingling on the oral mucosa, dysphonia, itching in the auricles, some patients may experience classic manifestations of hay fever in the form of rhinoconjunctival syndrome. Diagnostics of this disease includes collection of allergic anamnesis, allergy examination. The only pathogenetic method of therapy is carrying out specific immunotherapy with causally significant allergens.

Serum metabolic profile analysis of syndrome of Qi-yin deficiency and Yang deficiency in diabetic coronary heart disease by UPLC-Q/TOF MS

AimsQi-yin deficiency (QYD) and Yang-deficiency (YD) syndrome are two common syndromes with contrasting clinical manifestations of low fever and cold phobia. Different syndrome phenotypes must have distinct biological underpinnings in vivo. Based on serum metabolomics, this study aims to reveal the biological characteristics of the two diabetic coronary heart disease syndromes mentioned above. MethodsA total of 33 diabetic coronary heart disease (DCHD) patients were included in the study, with 13 cases of QYD, 11 cases of YD syndrome, and 9 cases of Pinghe constitution (PH). Based on UPLC-Q/TOF MS, metabolomics was used to detect and analyze serum samples from the three groups mentioned above. To find differentiating metabolites, PLS-DA (Partial least squares discrimination analysis) and database searching were used. Meanwhile, the metabolic pathways of various metabolites were investigated. ResultsThere were 17 different metabolites between QYD syndrome and YD syndrome of DCHD. Cyclic GMP, LysoPE (20:3), proline, isoleucine, N-lactoyl-tyrosine, 3-oxohexadecanoyl-CoA, and oxalosuccinic acid were lower in the (YD) group than those in the PH group, while galactitol, N-lactoyl-tyrosine, and oxalosuccinic acid were higher in the QYD group than in the PH group. The 17 differential metabolites mentioned above were linked to a variety of pathways, including amino acid metabolism, purine metabolism, fatty acid elongation in mitochondria, the tricarboxylic acid cycle, lipid metabolism, energy metabolism, etc. ConclusionDifferent DCHD syndromes, such as liver-kidney Yin deficiency and YD syndrome, have different biological bases for the same disease. To some extent, the findings of this study provide a scientific foundation for different approaches to treating the same disease in Traditional Chinese Medicine. It is also important for guiding the clinical use of herbal medicine.

Anosmia en pacientes jóvenes con COVID-19: Revisión Narrativa

COVID-19 is the disease classified as a pandemic and that currently affects our reality. Its clinical manifestations are varied among themselves and its most serious expression can be fatal. Anosmia, on the other hand, is one of the less serious symptoms in the patient's health, but one that can nevertheless directly affect their quality of life. This symptom generally appears in cases of mild intensity, associated with the most typical manifestations such as headache, fever, general malaise and upper respiratory manifestations. Young adult patients have had a higher proportion of mild COVID-19 cases, and thus the clinical manifestation of anosmia has also been reported. Despite the aforementioned, and that this particular manifestation becomes more frequent among those affected, the mechanism, the approach and finally the prognosis that can be offered to the patient are still not clear. Due to the aforementioned, the research team set out to carry out a narrative review in order to collect the most relevant data or the most promising theories regarding anosmia in young patients affected by COVID-19.

Cutaneous manifestations of Rickettsial fever in paediatric age group

<p class="abstract"><strong>Background: </strong>Rickettsial fever is well known to have various cutaneous manifestations that can help in the probable clinical diagnosis especially in the context of non availability of resources and aid in prompt administration of treatment, hence reducing mortalitiy and morbidity. The main objective of this study was to estimate the prevalence of cutaneous manifestations in patients with a positive Weil-Felix and also to study the plethora of cutaneous manifestations seen in Rickettsial fever.</p><p class="abstract"><strong>Methods:</strong> All the consenting patients admitted in in the Department of Paediatrics below 18 years and with a positive Weil-Felix test were thoroughly screened for cutaneous manifestations.</p><p class="abstract"><strong>Results: </strong>Of the 114 patients screened, 29 children (21.05%) had cutaneous manifestations. The various cutaneous manifestations encountered in the study are erythematous rash, maculopapular rash, petechial rash and cutaneous necrosis.</p><p class="abstract"><strong>Conclusions:</strong> Though cutaneous manifestations was seen in only 21% of the patients with fever, when present it could help in suspecting rickettsial fever in a case of pyrexia of unknown origin.</p>

Sulfasalazine induced atypical drug reaction with eosinophilia and systemic symptoms syndrome: a case report

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a type IV b hypersensitivity reaction characterized by cutaneous manifestations, fever, lymphadenopathy, hematologic abnormalities, and multiple organ manifestations. We report a case of sulfasalazine induced DRESS syndrome who was admitted with a complaint of morbilliform rash all over the body, a fever of 100oF, and severe abdominal pain. Initially the patient did not mention about intake of sulfasalazine while taking the drug history as he could not remember the past medication. The laboratory investigations revealed elevated eosinophils, WBC, and liver function tests. The patient was treated with antibiotics assuming tropical infection, but the patient’s condition was not improving. Later while taking proper drug history from a patient representative over the telephone revealed that the patient was in 4th week of tablet sulfasalazine 500 mg treatment for polyarthritis. Further, the J-SCAR scale was used to diagnose it as Sulfasalazine induced atypical DRESS syndrome. The patient was treated with topical and intravenous corticosteroids and antihistamine; the patient exhibited surprising symptomatic improvement. The patient was given a tapering dose of oral corticosteroid tablet prednisolone 20 mg for three weeks and topical corticosteroid mometasone lotion for two weeks upon discharge.

Dynamic disequilibrium-based pathogenicity model in mutated pyrin’s B30.2 domain—Casp1/p20 complex

BackgroundThe B30.2 variants lead to most relevant severity forms of familial Mediterranean fever (FMF) manifestations. The B30.2 domain plays a key role in protein-protein interaction (PPI) of pyrin with other apoptosis proteins and in regulation the cascade of inflammatory reactions. Pyrin-casp1 interaction is mainly responsible for the dysregulation of the inflammatory responses in FMF. Lower binding affinity was observed between the mutant B30.2 pyrin and casp1 without the release of the complete pathogenicity mechanism. The aim of this study was to identify the possible effects of the interface pocked residues in B30.2/SPRY-Casp1/p20 complex using molecular mechanics simulation and in silico analysis. ResultsIt was found that Lys671Met, Ser703Ile, and Ala744Ser variants led mainly to shift of the binding affinity (∆G), dissociation constant (Kd), and root mean square deviation (RMSD) in B30.2/SPRY-Casp1/p20 complex leading to dynamic disequilibrium of the p20-B30.2/SPRY complex toward its complex form. The current pathogenicity model and its predicted implementation in the relevant colchicine dosage were delineated. ConclusionThe molecular mechanics analysis of B30.2/SPRY-p20 complex harboring Lys671Met, Ser703Ile, and Ala744Ser variants showed dynamic disequilibrium of B30.2/SPRY-casp1/p20complex in context of the studied variants that could be a new computational model for FMF pathogenicity. This study also highlighted the specific biochemical markers that could be useful to adjust the colchicine dose in FMF patients.

Sex-Based Variations in the Clinical Manifestations, Comorbidities, and Outcomes of Patients With COVID-19 in Baghdad, Iraq, 2020

Background A higher incidence of COVID-19 in males has been widely reported. However, whether clinical manifestations, comorbidities, severity, and outcomes differ between males and females remains an area of active investigation. Objective We aimed to compare the clinical features, comorbidities, severity, and outcomes between male and female patients with COVID-19 from Baghdad, Iraq, in 2020. Methods We performed a records-based cross-sectional study by extracting sociodemographic, clinical manifestation, severity, and outcome data from the records of patients with COVID-19 admitted to 2 COVID-19 hospitals in Baghdad, Iraq, between June and August 2020. Results We reviewed a total of 2111 patient records with a history of COVID-19, and 1175 (55.7%) patients were males. We found that respiratory symptoms, sore throat, and gastrointestinal manifestations were significantly more common among females. In contrast, males had significantly more “other” manifestations. No significant difference was noted for fever, nasal congestion, conjunctival congestion, headache, and musculoskeletal manifestations. Generally, female patients had a significantly higher proportion of comorbidities than males (42.7% vs 36%; P=.002). The proportion of severe and critical cases was not different between males and females. The mean time from diagnosis to the outcome was significantly longer in females (P=.03), but the duration of the hospital stay was not significantly different between males and females. Finally, the case fatality ratio was higher in males (16.1%) than in females (13.2%). Conclusions Sex affects the clinical course and outcomes of patients with COVID-19. Male patients may need more attention, considering the higher case fatality ratio.

Analysis of clinical characteristics of 35 inflammasomopathies cases

Objective: To summarize the clinical characteristics of inflammasomopathies, enhance the recognition of those diseases, and help to establish the early diagnosis. Methods: The clinical manifestations including fever, rash, systems involvement as well as laboratory results and genotypic characteristics of 35 children with inflammasomopathies diagnosed by the Department of Pediatrics, Peking Union Medical College Hospital, from January 1, 2008 to December 31, 2020 were analyzed retrospectively. Results: A total of 35 cases of inflammasomopathies were diagnosed, and 20 of them were boys while 15 were girls. Inflammasomopathies patients have early onset, the age of onset as well as diagnostic age were 1 (0,7) and 7 (3,12), respectively. Among those patients, 10 had familial mediterranean fever, 3 had mevalonate kinase deficiency, 15 cases had NLRP3 gene associated autoinflammatory disease, 4 cases had NLRP12-associated autoinflammatory disease, 2 cases had familial cold autoinflammatory syndrome 3, and 1 case had familial cold autoinflammatory syndrome 4. A total of 34 cases (97%) showed recurrent fever, 27 cases (77%) had skin rashes, while 11 cases (31%), 10 cases (29%), and 8 cases (23%) were presented with lymphadenopathy, hepatosplenomegaly and growth retardation, respectively. In terms of systemic involvement, there were 18 cases (51%), 12 cases (34%), 8 cases (23%), and 5 cases (14%) with skeletal, neurological, auditory, and renal involvement, respectively. Central nervous system involvement was seen only in NLRP3 gene associtated autoinflammatory diseases (12 cases), sensorineural deafness was seen in NLRP3 gene associtated autoinflammatory diseases (6 cases) and NLRP12 gene associated autoinflammatory diseases (2 cases), and abdominal pain was observed in familial Mediterranean fever (5 cases), mevalonate kinase deficiency (1 case) and NLRP12 gene related autoinflammatory diseases (1 case). In the acute inflammatory phase, the acute phase reactants (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) of 35 cases (100%) were significantly increased. There were 21 cases received ferritin examination, and only 4 cases (19%) showed an increase of it. In terms of autoantibodies, among all 35 patients, 4 cases (11%) were positive for antinuclear antibodies (ANA). Conclusions: Fever, skin rash, and skeletal manifestations are the most common clinical features, accompanied with increased CRP and ESR, and negative results of autoantibodies such as ANA. The clinical manifestations of those diseases are complex and diverse, and it is prone to delayed diagnosis and treatment.

Aspek Klinis dan Pemeriksaan Laboratorium untuk Diagnosis Demam Berdarah Dengue

Dengue infection is a viral infection through arthropods that is found throughout the world. This disease is caused by dengue virus which consists of four serotypes and each of these serotypes can cause disease. The pathogenesis of dengue infection, especially the mechanism of dengue hemorrhagic fever (DHF) manifestations is still not clearly understood. The results of laboratory tests on dengue hemorrhagic fever found thrombocytopenia (≤ 100,000/mm3), a 20% increase in hematocrit and a positive Rumple Leed test. Five basic serological tests used to detect antibodies in diagnosing dengue infection are haemagglutination-inhibition (HI), complement fixation (CF), neutralization test (NT), IgM capture enzyme-linked immunosorbent assay (MAC-ELISA), and indirect IgG. ELISA. RT-PCR examination in a number of studies was reported to have successfully detected the dengue virus. This examination has better specificity and sensitivity compared to virus isolation with a fast turn around timeLaboratory tests on dengue infection include hematological, serological and nucleic acid tests that play a role in supporting the rapid and accurate diagnosis of dengue hemorrhagic fever.

Clinical Presentations of Lassa Fever in Non-Endemic Parts of the World: A Systematic Review

Background: Lassa fever cases outside Africa are seen as imported cases of Lassa fever. Timely diagnosis of imported Lassa fever is important for timely intervention necessary to reduce the morbidity and mortality associated with Lassa fever, and this requires the knowledge of the clinical manifestations of Lassa fever. Purpose: This review was done to see how clinical diagnosis of imported Lassa fever can be facilitated based on the clinical presentations of imported cases of Lassa fever in Lassa fever non-endemic region. Methods: The relevant articles for the review were obtained from the databases of PubMed and Google Scholar. Results: The clinical presentations of the imported Lassa fever cases consisted of multisystem involvement and were similar to those of Lassa fever patients who were treated in the Lassa fever endemic region. Conclusions: History of recent travel to, or residence in, Lassa fever endemic region is an important clue for clinical diagnosis of Lassa fever. The 2011 CDC surveillance case definition and the modified Khan case definition for Lassa fever may aid clinical diagnosis of Lassa fever. Any clinically suspected case of Lassa fever should have a laboratory confirmation.

Bilateral internuclear ophthalmoplegia developing as a manifestation of dengue fever and treatment by modified Nishida procedure

Typical causes of internuclear ophthalmoplegia (INO) include demyelinating conditions, with inflammation, infection, and trauma being less common causes. Diplopia associated with INO severely impacts the patient's quality of life. Orthoptic treatment usually fails; therefore, appropriate surgical treatment should be considered. We report the unique case of a 25-year man with bilateral INO developing as a manifestation of dengue fever-related encephalitis and its successful treatment by modified Nishida procedure.

Clinical Course and Characteristics of Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterized by episodes of widespread sterile macroscopic pustules, with or without systemic inflammation and/or plaque psoriasis. Multiple GPP subtypes have been described, from acute GPP of von Zumbusch to milder, annular pustular psoriasis. Generalized pustular psoriasis mainly affects adults, with a female preponderance, but juvenile GPP also occurs. Flares are a hallmark of GPP and may occur de novo or be provoked by triggers, including withdrawal of systemic corticosteroids, infections, stress, pregnancy, and menstruation. Severity of flares varies widely between patients, and between flares in an individual patient. Significant flares are often accompanied by systemic symptoms, notably fever, general malaise, and extracutaneous manifestations such as arthritis, uveitis, and neutrophilic cholangitis. Common laboratory abnormalities include neutrophilia, elevated C-reactive protein levels, hypocalcemia, and abnormal liver function tests. The clinical course of GPP is highly variable; it can be a relapsing disease with recurrent flares and no pustulation between flares or a persistent disease with perpetual mild pustulation punctuated with flares of greater severity. Patients may have multiple flares per year or a flare every few years. Most flares last 2–5 weeks and approximately 50% require hospitalization. Life-threatening complications include sepsis and renal, hepatic, respiratory, and heart failure. Reported mortality rates are 2–16%.

Risk factors for sporadic listeriosis in Beijing, China: A matched case-control study.

Abstract Listeriosis is a rare but serious foodborne disease caused by Listeria monocytogenes. This matched case–control study (1:1 ratio) aimed to identify the risk factors associated with food consumption and food-handling habits for the occurrence of sporadic listeriosis in Beijing, China. Cases were defined as patients from whom Listeria was isolated, in addition to the presence of symptoms, including fever, bacteraemia, sepsis and other clinical manifestations corresponding to listeriosis, which were reported via the Beijing Foodborne Disease Surveillance System. Basic patient information and possible risk factors associated with food consumption and food-handling habits were collected through face-to-face interviews. One hundred and six cases were enrolled from 1 January 2018 to 31 December 2020, including 52 perinatal cases and 54 non-perinatal cases. In the non-perinatal group, the consumption of Chinese cold dishes increased the risk of infection by 3.43-fold (95% confidence interval 1.27–9.25, χ2 = 5.92, P = 0.02). In the perinatal group, the risk of infection reduced by 95.2% when raw and cooked foods were well-separated (χ2 = 5.11, P = 0.02). These findings provide important scientific evidence for preventing infection by L. monocytogenes and improving the dissemination of advice regarding food safety for vulnerable populations.