Manifestation Of Crohn's Disease Research Articles

Crohn disease: perirectal and perianal findings at CT.

The computed tomographic scans of 200 consecutive patients with Crohn disease were studied to determine the frequency and patterns of perirectal and perianal involvement. In 163 patients (82%) abnormalities in the perirectal-perianal region were demonstrated; findings included inflammation of fat planes (73%), bowel wall thickening (30%), fistulas or sinus tracts (22%), and abscesses (14%). Fistulas or sinus tracts occurred with equal frequency above or below the level of the anterior symphysis pubis. Abscesses, rectal thickening, and inflammatory infiltration of fat occurred more than twice as often above the symphysis pubis. However, 37% of patients had manifestations of Crohn disease below the symphysis pubis, emphasizing the importance of extending scanning sequences to the perineum.

Crohn's Disease

The protean clinical manifestations of Crohn disease require that all physicians have a rather intimate familiarity with it in order that such things as anemia, weight loss, fever, or vaguely described gastrointestinal complaints not be ascribed to other disease processes or, particularly, emotional states. Because of this broad presentation, a book detailing many of the current etiological, clinical, and therapeutic considerations has been most desired. As is indicated in the foreword by Dr. Burrill B. Crohn, the information thus far available has only been fractional and this book may be the most comprehensive thus far at hand. Fortunately, the author, a surgeon from Aberdeen, Scotland, has discussed the subject in an admirable and succinct fashion. He has obviously drawn on his own clinical experience, well documented with many of his own personal publications, and has augmented this experience with a comprehensive review of data from numerous other investigators. The extensive

Oesophageal stricture associated with Crohn's disease.

Regional enteritis wasoriginally described asa disease oftheterminal ileum (Crohn, Ginzburg, and Oppenheimer, 1932). Thisconcept ofthecondition hasgradually beenbroadened anditisnowrealized thatsimilar histopathological lesions mayinvolve anypartofthealimentary tract fromstomach to anus(Crohn andYunich, 1941; Lockhart-Mummery andMorson,1960;WolfandMarshak, 1962; Pryse-Davies, 1964). Manyauthors alsomention thatCrohn's disease mayoccasionally involve the oesophagus (Crohn andYarnis, 1958), butthere are veryfewcasereports intheliterature andother authorities doubtwhether suchlesions arereally manifestations ofCrohn's disease (Cooke, 1955). We report twopatients withCrohn's disease in whomradiological andendoscopic abnormalities of theloweroesophagus werefound. Inoneofthese patients surgical resection was performed thus providing full-thickness sections ofthewallfor histological examination. CASEREPORTS