Manganese Ferrite Nanoparticles Research Articles

Thermal behavior of MnFe2O4 and MnFe2O4/C nanocomposite synthesized by a solvothermal method

A new solvothermal method for MnFe2O4 nanoparticles and MnFe2O4/C nanocomposite synthesis is reported. Manganese ferrite nanoparticles thus sinthesized are not stable at thermal treatment in oxidizing atmosphere, due to Mn(II) oxidation to Mn(III), evidenced at 640°C by thermal analysis. The FTIR spectroscopy also confirmed the oxidation of Mn(II) to Mn(III). XRD analysis has revealed the complete decomposition of manganese ferrite around 700°C. The specific surface area of the composite with activated carbon was much higher (253m2g−1), in comparison with that of the naked ferrite (65m2g−1). Scanning electron microscopy and transmission electron microscopy images evidenced the obtaining of nearly spherical ferrite nanoparticles, with diameters within the range 10nm − 30nm, loaded on the surface of activated carbon in case of the composite. The magnetization of the synthesized composite (30emug−1) was below the one of naked manganese ferrite (40emug−1), but sufficient to insure a facile magnetic separation of the composite from aqueous solution, in case of its use as adsorbent for pollutant removal.

Effect of Zn doping on the structural, electrical and magnetic properties of MnFe2O4 nanoparticles

Zinc doped manganese ferrite nanoparticles having chemical formula Mn1−xZnxFe2O4 (x = 0, 0.1, 0.2, 0.3, 0.4, 0.5) were synthesized by co-precipitation method. The structural characterization of the prepared nanoparticles was done by X-ray diffraction and fourier transform infrared spectroscopy. It gave a confirmation of spinel phase formation. Electrical properties such as dielectric constant, dielectric loss tangent, dc-resistivity were studied. Substitution of zinc in manganese ferrite highly enhanced dielectric constant and at the same time it reduces the dielectric loss tangent. The magnetic characterization was carried out using a vibrating sample magnetometer and the parameters such as saturation magnetization, coercivity and retentivity of the synthesized samples were found out. It showed strong dependence on the zinc concentration. The observed behaviour of the structural, electrical and magnetic properties with varying zinc concentration was discussed.

Annealing temperature dependent structural and magnetic properties of MnFe2O4 nanoparticles grown by sol-gel auto-combustion method

Manganese ferrite (MnFe2O4) nanoparticles were synthesized by sol-gel auto-combustion method using manganese nitrate and ferric nitrate as precursors and citric acid as a fuel. Scanning electron micrographs show irregularly shaped morphology of the particles. The as-prepared samples were annealed at 400, 500, 600 and 800°C for 2h in air. The phase identification and structural characterizations were performed using powder X-ray diffraction technique along with Mössbauer spectroscopy. Magnetization loops and 57Fe Mössbauer spectra were measured at RT. After annealing the sample at or below ∼ 500°C, we observed two different spinel phases corresponding to two different lattice parameters. This is originating due to the partial oxidation of Mn2+ to Mn3+. At high annealing temperatures (∼ 600°C or above) the spinel MnFe2O4 phase decomposes into crystalline α-Mn2O3 and α-Fe2O3 phases, and amorphous FeO phase.

The Effect of Co0.2Mn0.8Fe2O4 Ferrite Nanoparticles on the C2 Canine Mastocytoma Cell Line and Adipose-Derived Mesenchymal Stromal Stem Cells (ASCs) Cultured Under a Static Magnetic Field: Possible Implications in the Treatment of Dog Mastocytoma

Cobalt manganese ferrite nanoparticles have application potential in the biomedical field, however there is limited information concerning the biological response. The aim of this work was to investigate the cytotoxic potential of cobalt-manganese ferrite nanoparticles in canine mastocytoma tumor cells (C2) and adipose-derived mesenchymal stromal stem cells (ASCs) cultured under a static magnetic field (MF). In this study, we investigated the viability and proliferation rate of ASC and C2 cells cultured with Co0.2Mn0.8Fe2O4 nanoparticles under 0.5T MF. We observed cells morphology and measured intracellular ROS generation. Thermal observations were used to characterize the thermotrophic cell behavior in different condition and RNA level of heat shock proteins and apoptotic genes was measured. Nanoparticles reduced cell viability, caused cell damage, i.e., through the formation of reactive oxygen species (ROS) and increased transcriptional level of apoptotic genes (Bcl-2, Bax, p53, p21). In addition, we have found that C2 mastocytoma cells cultured with metal oxide nanoparticles under MF exhibited unexpected biological responses, including thermotolerance and apoptotic response induced by the expression of heat shock proteins and ROS produced under a MF. Our results suggest that stimulation using MF and Co0.2Mn0.8Fe2O4 nanoparticles is involved in mechanisms associated with controlling cell proliferative potential signaling events. We can state that significant differences between normal and cancer cells in response to nanoparticles and MF are apparent. Our results show that nanoparticles and MF elevate the temperature in vitro in tumor cells, thereby increasing the expression of ROS as well as heat shock proteins.

Nickel-Salen supported paramagnetic nanoparticles for 6-His-target recombinant protein affinity purification

In this research, a simple, efficient, inexpensive, rapid and high yield method for the purification of 6×histidine-tagged recombinant protein was developed. For this purpose, manganese ferrite magnetic nanoparticles (MNPs) were synthesized through a co-precipitation method and then they were conveniently surface-modified with tetraethyl orthosilicate (TEOS) in order to prevent oxidation and form high density of hydroxyl groups. Next, the salen ligand was prepared from condensation reaction of salicylaldehyde and 3-aminopropyl (trimethoxy) silane (APTMS) in 1:1 molar ratio; followed by complexation with Ni(OAc)2.4H2O. Finally, the prepared Ni(II)-salen complex conjugated to silica coated MNPs and MnFe2O4@SiO2@Ni-Salen complex nanoparticles were obtained. The functionalized nanoparticles were spherical with an average diameter around 70nm. The obtained MNPs had a saturation magnetization about 54 emu/g and had super paramagnetic character. These MNPs were used efficiently to enrich recombinant histidine-tagged (His-tagged) protein-A from bacterial cell lysate. In about 45min, highly pure His-tagged recombinant protein was obtained, as judged by SDS-PAGE analysis and silver staining. The amount of target protein in flow through and washing fractions was minimal denoting the high efficiency of purification process. The average capacity of the matrix was found to be high and about 180±15mgg−1 (protein/MnFe2O4@SiO2@Ni-Salen complex). Collectively, purification process with MnFe2O4@SiO2@Ni-Salen complex nanoparticles is rapid, efficient, selective and whole purification can be carried out in only a single tube without the need for expensive systems.

Arsenic adsorption on cobalt and manganese ferrite nanoparticles

The adsorption of As(III) on cobalt and manganese ferrite nanoparticles (NPs) was studied. The ferrite NPs were synthesized using the Massart-assisted microwave hydrothermal treatment. All the NPs exhibited the spinel structure with a formula such as M x Fe3−x O4, where M = Co or Mn, and x runs from 0.21 to 1.14. The changes in the stoichiometry caused different effects on the physical properties as well on the As(III) adsorption capacity of the NPs. The adsorption data were fitted in very good agreement with the Freundlich model. It was concluded that As(III) was better attracted to ferrimagnetic cobalt ferrite NPs, given that the arsenic removal was significantly higher than that exhibited by superparamagnetic manganese-substituted ferrite NPs.

Estimation of Lattice Stress and Strain in Zinc and Manganese Ferrite Nanoparticles by Williamson–Hall and Size-Strain Plot Methods

The Williamson–Hall (W–H) analysis and size-strain plot method (SSP) were used to study the lattice stress, strain and crystalline size of zinc (ZnFe2O4) and manganese (MnFe2O4) ferrite nanoparticles. These nanoparticles were synthesized by chemical co-precipitation method and characterized by powder X-ray diffraction analysis (PXRD). The PXRD results revealed that the sample product was crystalline with mixed type spinel with cubic structure. The crystalline development in the ZnFe2O4 and MnFe2O4 was investigated by X-ray peak broadening. The physical parameters such as strain, stress and energy density values were calculated more precisely for all the reflection peaks of PXRD using the W–H plots and SSP method. The variation in particle size, lattice strain, stress and energy density calculated from W–H analysis and SSP method reveals a nonuniform strain in the particles. This nonuniform strain was increased when the particle sizes were increased.

Rational Design of Multilayer Ultrathin Nano‐Architecture by Coupling of Soft Conducting Nanocomposite with Ferrites and Porous Structures for Screening Electromagnetic Radiation

AbstractFabrication of multilayered thin polymer films by rational arrangement of tailor‐made nanocomposites was designed to absorb electromagnetic (EM) radiation. Mn (manganese) ferrite nanoparticles were incorporated in polyvinylidene fluoride (PVDF) matrix, along with conductive MWCNTs, treated as outer layers of the multilayer assembly. The higher permittivity, permeability and attenuation constant ensure the higher absorption ability of these resulting outer layers. Selectively etching of one of the phases of the inner layers, which consist of immiscible blends of polycarbonate (PC) and PVDF with conductive MWCNTs, porous structure can be designed to maximize the penetration of incoming EM radiation from outer layers. Further scattering of the penetrated EM wave between the interfacial walls of conducting nano fillers inside the porous matrix enhance the shielding efficiency. The resulting ultrathin (0.60 mm) multilayered architecture was able to block >99.999 % (ca. −50dB) of the incoming EM radiation. This new‐age EM radiation absorbing material, powered by multi‐functionality henceforth, offers amendable, cost‐effective replacement to the existing solutions.

Photochemical Decoration of Silver Nanocrystals on Magnetic MnFe2O4 Nanoparticles and Their Applications in Antibacterial Agents and SERS-Based Detection

In this study, multifunctional nanocomposites consisting of silver nanoparticles and manganese ferrite nanoparticles (Ag–MnFe2O4) were successfully synthesized using a two-step chemical process. The formation of Ag–MnFe2O4 nanocomposites were analyzed by transmission electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy measurements. Noticeable antibacterial activity of the Ag–MnFe2O4 nanocomposites was demonstrated against two Gram-negative bacteria, Salmonella enteritidis and Klebsiella pneumoniae. A direct-drop diffusion method can be an effective way to investigate the antibacterial effects of nanocomposite samples. Interestingly, we also demonstrated the use of Ag–MnFe2O4 nanocomposites as a surface-enhanced Raman scattering (SERS) platform to detect and quantify trace amounts of organic dye in water solutions. The combination of Ag and MnFe2O4 nanoparticles opens opportunities for creating advantages such as targeted bactericidal delivery, recyclable capability, and sensitive SERS-based detection for advanced biomedicine and environmental monitoring applications.

Development of manganese ferrite/graphene oxide nanocomposites for magnetorheological fluid with enhanced sedimentation stability

Abstract Novel nanocomposites consisting of manganese ferrite nanoparticles and graphene oxide nanosheets (MnFe2O4/GO) have been synthesized as a promising candidate for magnetorheological (MR) fluid. The morphology, microstructure, composition and magnetic properties of the obtained MnFe2O4/GO were studied in detail. It was found that the MnFe2O4 nanoparticles with diameter of 8–12 nm were densely decorated on the surface of GO nanosheets. The magnetization investigation revealed that as-prepared MnFe2O4/GO had superparamagnetic behavior with saturation magnetization of 36.2 emu/g. The MR fluid was prepared by the obtained MnFe2O4/GO and the corresponding MR properties were investigated using a Physica MCR301 rheometer fitted with a magneto-rheological module. The MnFe2O4/GO-based MR fluid exhibited typical MR effect with increasing shear stress, yield stress and dynamic shear modulus depending on magnetic fields. More importantly, the sedimentation stability of the prepared MR fluid was found to be improved due to the unique sheet-like structure and the reduced density mismatch between the dispersed particles and the carrier medium. The MnFe2O4/GO-based fluid with typical MR effect and excellent sedimentation stability would provide a feasible candidate for practical applications.

Copper doped manganese ferrites nanoparticles anchored on graphene nano-sheets for high performance energy storage applications

Graphene nanosheets fabricated with copper doped manganese ferrite nanoparticles and the resultant Mn1-xCuxFe2O4/rGO nanocomposite was investigated as electrode material for supercapacitors. Copper doped manganese ferrite nanoparticles chemically anchored on graphene nanosheets exhibited the enhanced capacitive performance as compared to individual components due to the synergistic effect of faradic behavior and electric double layer capacitance. It is observed that the electrical conductivity of manganese ferrites was enhanced by the doping of conducting metal copper ions. Two-probe (I-V) measurements, assured the increased conductivities of copper doped manganese ferrites and Mn1-xCuxFe2O4/rGO nanocomposite. Cyclic voltammetry experiments and electrochemical impedance spectroscopy confirmed the superior electrochemical activity of Mn1-xCuxFe2O4/rGO nanocomposite. The fascinating electrochemical activity of nanocomposite makes it a potential candidate for supercapacitor applications.

Pegylated and amphiphilic Chitosan coated manganese ferrite nanoparticles for pH-sensitive delivery of methotrexate: Synthesis and characterization

Magnetic nanoparticles (MNPs) are the major class of nanoparticles (NPs) with specific functional properties that make them good candidates for biomedical applications. Due to their response to the magnetic field, they can be used in targeted drug delivery systems. In current research, the MNPs were synthesized with the general formula of Fe1−xMnxFe2O4 by the co-precipitation technique. First, the effect of the Fe2+ ions in the system was investigated. Succinic anhydride was used as the first stabilizer to prepare surface for binding two types of polymer, including Polyethylene glycol (PEG) and palmitoylated Polyethylene glycol-grafted Chitosan (Cs-PEG-PA) were introduced as a polymeric shell. The composition, size, structure and magnetic properties of NPs were determined by the particle size analysis (PSA), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM). Determining the well-defined properties of MNPs, methotrexate (MTX), as a common anticancer drug, was encapsulated into the coated MNPs. The drug encapsulation efficiency was as high as 92.8% with the magnetization value of 19.7emu/g. The in-vitro release pattern was studied, showing only 6% of the drug release in pH=7.4 (as a model of the physiological environment) and 25% in pH=5.4 (as a model of the tumor tissue environment) after 72h. Based on these results, we may be able to introduce this specific system as a novel pH sensitive MNP system for MTX targeting to tumor tissues in cancer chemotherapy.

Synthesis and characterization of manganese ferrite nanoparticles obtained by electrochemical/chemical method

A combined electrochemical/chemical method was developed in order to synthesize manganese ferrite nanoparticles. The synthesis was carried out in an electrochemical cell containing iron as anode and cathode electrodes and an electrolyte solution of manganese chloride and tetrabutyl ammonium bromide. A usual XRD, STEM compositional mapping images and ICP analysis showed the formation of spinel structure and the presence of Mn, Fe and O in the nanoparticles (NPs) with a stoichiometry Mn0.5Fe2.5O4. The nanoparticle size, shape, and morphology were characterized using electron microscopy and X-Ray absorption spectroscopy, and SQUID measurements were carried out to determine the magnetic behavior. This sample was compared with a same composition manganese ferrite obtained by electrochemical synthesis.

The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5.

Diseases caused by bacterial and fungal pathogens are among the major health problems in the world. Newer antimicrobial therapies based on novel molecules urgently need to be developed, and this includes the antimicrobial peptides. In spite of the potential of antimicrobial peptides, very few of them were able to be successfully developed into therapeutics. The major problems they present are molecule stability, toxicity in host cells, and production costs. A novel strategy to overcome these obstacles is conjugation to nanomaterial preparations. The antimicrobial activity of different types of nanoparticles has been previously demonstrated. Specifically, magnetic nanoparticles have been widely studied in biomedicine due to their physicochemical properties. The citric acid-modified manganese ferrite nanoparticles used in this study were characterized by high-resolution transmission electron microscopy, which confirmed the formation of nanocrystals of approximately 5 nm diameter. These nanoparticles were able to inhibit Candida albicans growth in vitro. The minimal inhibitory concentration was 250 µg/mL. However, the nanoparticles were not capable of inhibiting Gram-negative bacteria (Escherichia coli) or Gram-positive bacteria (Staphylococcus aureus). Finally, an antifungal peptide (Cm-p5) from the sea animal Cenchritis muricatus (Gastropoda: Littorinidae) was conjugated to the modified manganese ferrite nanoparticles. The antifungal activity of the conjugated nanoparticles was higher than their bulk counterparts, showing a minimal inhibitory concentration of 100 µg/mL. This conjugate proved to be nontoxic to a macrophage cell line at concentrations that showed antimicrobial activity.

Targeting T1 and T2 dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles.

Tumor angiogenesis plays very important roles for tumorigenesis, tumor development, metastasis, and prognosis. Targeting T1/T2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and specificity, as well as helping to make an early diagnosis of tumor at the preclinical stage. In this study, a new T1 and T2 dual modality nanoprobe was successfully fabricated. The prepared nanoprobe comprise peptides CL 1555, poly(ε-caprolactone)-block-poly(ethylene glycol) amphiphilic copolymer shell, and dozens of manganese ferrite (MnFe2O4) nanoparticle core. The results showed that the hydrophobic MnFe2O4 nanoparticles were of uniform spheroidal appearance and narrow size distribution. Due to the self-assembled nanomicelles structure, the prepared probes were of high relaxivity of 281.7 mM−1 s−1, which was much higher than that of MnFe2O4 nanoparticles (67.5 mM 1 s−1). After being grafted with the targeted CD105 peptide CL 1555, the nanomicelles can combine TVECs specifically and make the labeled TVECs dark in T2-weighted MR imaging. With the passage on, the Mn2+ ions were released from MnFe2O4 and the size decreased gradually, making the signal intensity of the second and third passage of labeled TVECs increased in T1-weighted MR imaging. Our results demonstrate that CL-poly(ethylene glycol)-MnFe2O4 can conjugate TVECs and induce dark and bright contrast in MR imaging, and act as a novel molecular probe for T1- and T2-enhanced MR imaging of tumor angiogenesis.

Effect of bimetallic (Ni and Co) substitution on magnetic properties of MnFe2O4 nanoparticles

Nickel and cobalt substituted manganese ferrite nanoparticles (NPs) with the chemical composition NixCoxMn1–2xFe2O4 (0.0≤x≤0.5) NPs were synthesized by one-pot microwave combustion route. The effect of co-substitution (Ni, Co) on structural, morphological and magnetic properties of MnFe2O4 NPs was investigated using XRD, FT-IR, SEM, VSM and Mössbauer spectroscopic techniques. The cation distribution of all products were also calculated. Both XRD and FT-IR analyses confirmed the synthesis of single phase spinel cubic product for all the substitutions. Lattice constant decreases with the increase in concentration of both Co and Ni in the products. From 57Fe Mössbauer spectroscopy data, the variations in line width, isomer shift, quadrupole splitting and hyperfine magnetic field values with Mn2+, Ni2+ and Co2+ substitution have been determined. While the Mössbauer spectra collected at room temperature for the all samples are composed of magnetic sextets, the superparamagnetic doublet is also formed for MnFe2O4 and Ni0.2Co0.2Mn0.6Fe2O4 NPs. The magnetization and Mössbauer measurements verify that MnFe2O4 and Ni0.2Co0.2Mn0.6Fe2O4 NPs have superparamagnetic character. The saturation and remanence magnetizations, magnetic moment and coercive field were determined for all the samples. Room temperature VSM measurements reveals saturation magnetization value close to the bulk one. It has been observed that the saturation magnetization and coercive field increase with respect to the Ni and Co concentrations.

Synthesis and characterization of mixed phase manganese ferrite and hausmannite magnetic nanoparticle as potential adsorbent for methyl orange from aqueous media: Artificial neural network modeling

In this study, a novel magnetic nanoscale adsorbent of mixed phase manganese ferrite and hausmannite (MNF–HM) was synthesized by a simple chemical precipitation method and its adsorptive property towards a toxic anionic dye methyl orange (MO) was investigated. This new adsorbent was characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), point of zero charge (PZC), vibrating sample magnetometer (VSM) measurements and Brunauer–Emmett–Teller (BET) analysis. These crystalline mixed phase MNF–HM nanoparticles show high saturation magnetization (30.12emu/g) as well as high specific surface area (100.62m2/g) and pore volume, which makes it a magnetically separable efficient adsorbent with maximum adsorption capacity of 303.66mg/g for MO at room temperature. The solution pH becomes the most influencing parameter and maximum adsorption efficiency of 97.4% is observed within 45min at solution pH2.0 with initial MO concentration of 50mg/L and MNF–HM nanoparticle dose of 1.0g/L. An artificial neural network (ANN) model was developed for accurate prediction of MO removal (%) and optimal ANN structure (4–7–1) shows minimum mean squared error (MSE) of 0.00071 and high determination coefficient (R2) of 0.990. Isotherm modeling exhibited that Langmuir isotherm model is the most efficient one in explaining its adsorption behavior and the kinetic studies reveal that the adsorption process follows pseudo-second-order kinetic model with the involvement of intra-particle diffusion. Thermodynamic studies reveal that the adsorption process is feasible, spontaneous and exothermic in nature.

Molar spin-susceptibility measurement of Manganese ferrite nanoparticles using Electron Spin Resonance study

The Electron Spin Resonance (ESR) of Manganese ferrite nanoparticles was studied. Depending on the temperature, ESR spectrum was deconvoluted into two different signals. The temperature independent ESR signal intensity and its magnitude lead to the Pauli spin-susceptibility whereas temperature dependent ESR signal intensity and its magnitude lead the Curie spin-susceptibility. ESR linewidth of Pauli was weakly increases with increasing temperature but for Curie it is decreased. From Pauli and Curie spin-susceptibilities density of states of Manganese ferrite nanoparticles are calculated which is increased with increasing temperature. This rise in density of state is more reliable property which could be used in spintronics applications. Scanning Electron Microscope (SEM) of Manganese ferrite nanoparticles confirms the magnetic behaviour through grain sizes.

Effect of additives on the hydrothermal synthesis of manganese ferrite nanoparticles

Superparamagnetic iron oxide nanoparticles (Nps), composed of magnetite, <TEX>$Fe_3O_4$</TEX>, or maghemite, <TEX>${\gamma}-Fe_2O_3$</TEX>, core and biocompatible polymer shell, such as dextran or chitozan, have recently found wide applications in magnetic resonance imaging, contrast enhancement and hyperthermia therapy. For different diagnostic and therapeutic applications, current attempt is focusing on the synthesis and biomedical applications of various ferrite Nps, such as <TEX>$CoFe_2O_4$</TEX> and <TEX>$MnFe_2O_4$</TEX>, differing from iron oxide Nps in charge, surface chemistry and magnetic properties. This study is focused on the synthesis of manganese ferrite, <TEX>$MnFe_2O_4$</TEX>, Nps by most commonly used chemical way pursuing better control of their size, purity and magnetic properties. Co-precipitation syntheses were performed using aqueous alkaline solutions of Mn(II) and Fe(III) salts and NaOH within a wide pH range using various hydrothermal treatment regimes. Different additives, such as citric acid, cysteine, glicine, polyetylene glycol, triethanolamine, chitosan, etc., were tested on purpose to obtain good yield of pure phase and monodispersed Nps with average size of <TEX>${\leq}20nm$</TEX>. Transmission electron microscopy (TEM), X-ray diffraction, energy dispersive X-ray spectroscopy (EDX), <TEX>$M\ddot{o}ssbauer$</TEX> spectroscopy down to cryogenic temperatures, magnetic measurements and inductively coupled plasma mass spectrometry were employed in this study.

Effect of polyacrylic acid addition on structure, magnetic and adsorption properties of manganese ferrite nanoparticles

A facile hydrothermal method is used to synthesize manganese ferrite nanoparticles with the addition of polyacrylic acid (PAA). PAA addition does not largely decrease the magnetic performance of MnFe2O4 nanoparticles, but highly enhance the adsorption properties for methylene blue (MB) dye. It demonstrates that the concentration of negative –COO− groups in the solution determines the adsorption capacity of MnFe2O4 nanoparticles for MB. The maximum MB adsorption capacity was 44.9mg/g, and the adsorption kinetics of MB match well with the pseudo-second-order model. To reveal the influence mechanism of PAA addition on the properties of manganese ferrite nanoparticles, two different synthetic routes are designed by changing the adding method of PAA with the different mass ratio of PAA to MnFe2O4. Here, the second synthetic route is easier and simpler to operate than the first one. Moreover, with the PAA addition, the adsorption capacity for the samples synthesized by synthetic route 2 increases by 43.4%, which is much higher than that (28.6%) of the samples synthesized by synthetic route 1. Synthetic route 1 reveals that PAA acting as a reducing agent participates in the reaction on the formation of MnFe2O4 ferrites. Herein, the Fe3+ ions bound by PAA chains are reduced to Fe2+ ions. This work clearly points out that the PAA addition contributes to enhancing the adsorption properties of ferrite nanoparticles for organic dye, which provides guidance to the adsorption study on the similar adsorbents for the removal of organic contaminant from the wastewater.