Ships with a high center of gravity and at relatively fast speed, such as container vessels, may experience significant heel during turning at a rudder angle of 35°. Accurate prediction of the maneuvering motion of such ships requires consideration of roll motion in addition to surge, sway, and yaw motions. This study applies the 4-Degrees of Freedom (4-DOF) Maneuvering Modeling Group (MMG) method, developed by one of the authors, as a practical simulation method that includes the roll-coupling effect, to predict the maneuvering of a Kriso Container Ship (KCS). To validate the accuracy of the maneuvering simulations, the results are compared with those obtained from free-running model tests for turning and zig-zag maneuvers. Furthermore, to capture the effect of speed on maneuvering, the free-running tests are conducted by varying the approach speed of the ship model. The test results reveal that the advance in turning and the overshoot angle in zig-zag maneuvers increase with speed, while the tactical diameter decreases. The simulation results obtained using the 4-DOF MMG method are consistent with the free-running test results with practical accuracy. Therefore, the 4-DOF MMG method proves useful in predicting the maneuvering of ships, such as container ships, at fast speeds.