Increases in mandibular width by distraction osteogenesis have recently been shown to be an acceptable and stable treatment option for deficiencies, and also, in the oral rehabilitation, where one of the major problems is the alveolar bone loss, and adjacent soft tissues.Aim: The aim of this study is to evaluate the influence of hyperbaric oxygen therapy (HBOT), on the osseointegration of implants retained partial mandibular overdenture after reconstruction of mandibular deficiency by distraction osteogenesis. Methods: This study was conducted on eight male patients with a lack of the anterior mandibular jaw bone due to anterior marginal mandibulectomy, and partially edentulous maxillary arch (different classes), selected from the maxillofacial outpatient clinic, Faculty of Dentistry, Misr University for Science and Technology, (mean age 43 years, minimum 35 years and maximum 51 years). For all patient, distraction the insufficient alveolar ridge by using an Extraosseous Track Alveolar Distractor (KLS Martin, Germany), after consolidation period, patients received maxillary and mandibular conventional acrylic partial dentures prior to implant insertion. Then, each patient received two endoosseous implants in the mandibular interforaminal region, (following two stage surgical protocols), to retain partial mandibular overdentures. Patients were randomly divided by closed envelops, into two equal groups. Group I; Patients were received hyperbaric oxygen therapy (HBOT), on a protocol of five sequential sessions (study group), while Group II; Patients were received no hyperbaric oxygen therapy (HBOT), as a control group. Ball attachments were screwed to the implants, after four months of surgery. All patients received new mandibular removable partial overdentures were retained by two implants, and designed as Kennedy class IV partial overdentures, to fitted partial mandibular overdentures. Marginal bone height changes and bone density were assessed using cone beam computed tomography(CBCT); at time of prosthetic loading, then after six, and twelve months.Results: Decrease in marginal bone height and increase in bone density through a follow-up period (one year) were observed in both groups , however; group I; that received HBOT revealed less marginal bone resorption and more increase in bone density than group II. Conclusion: After mandibular reconstruction by distraction osteogenesis, hyperbaric oxygen therapy effective treatment, and improve osseointegration around implants retained partial ovedentures, as it associated with increased bone density and reduced marginal bone loss after one year follow up.