Ameloblastoma is a slow-growing locally aggressive, benign odontogenic epithelium with a greater tendency for recurrence and involves aggressive bone loss and teeth. It is believed to be derived from cell rests of the enamel organ, either remnants of dental lamina or Hertwig's sheath, the epithelial rest of Malassez. The most common site of preference is the mandibular molar and ramus area than the anterior and premolar region. The article presents two case series of unicystic ameloblastoma of a 25 year female who had a localized swelling in the left side of the mandible which resembled a keratocystic odontogenic tumor clinically and radiographically. Based on histopathological examination the final diagnosis was unicystic ameloblastoma with the mural pattern. The second case report presented a 32-year female with a diffuse swelling in the left lower jaw which histopathologically revealed ameloblastoma with the plexiform variant. The case series presented certain unique features of female predilection and a multilocular variant with mural and plexiform pattern unicystic ameloblastoma. Both the patient was surgically managed more conservatively with enucleation and cauterization as cystic types are found to be less aggressive compared to solid variants of ameloblastoma. They were on a regular follow period postoperatively.