Management Approach Research Articles

An Optimization Approach for Energy Management of Hybrid Vehicles Based on Dynamic Programming and Cuckoo Search

An Optimization Approach for Energy Management of Hybrid Vehicles Based on Dynamic Programming and Cuckoo Search

Integrated Approach for Management of Spondylodiscitis: Surgical and Medical Approach

Introduction: Spinal infections, constituting a small percentage of musculoskeletal infections, often necessitate surgical intervention combined with antimicrobial therapy in advanced stages for effective management and improved patient outcomes. The study aimed to share experiences in managing severe and complicated spondylodiscitis (SD) using a combined approach of antibiotics and surgery and offer recommendations to improve care for challenging SD cases. Methods: The study took place at J P Orthocare Hospital, Ahmedabad, Gujarat, India, focusing on SD patients admitted within a year. It included 21 patients undergoing SD surgery, where experienced spine surgeons performed debridement, histopathological examinations, and culture tests. Antibiotic treatments were based on culture reports and infection specialist recommendations. Neurological status, fusion status, graft position, and instrumentation alignment were monitored using standardized assessments and SPSS 20.0 for statistical analysis (p < 0.05). Result: The study revealed a male predominance (6:1 ratio) among patients, primarily from Ahmedabad district, with lumbosacral vertebral involvement being most common, particularly at L4-S5 (28.57%). Mycobacterium tuberculosis (Rifampin sensitive) was the most prevalent pathogen, followed by Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas. Transformational lumbar interbody fusion with bone graft was the most frequent procedure (28.58%), with patients typically discharged after 72 hours post-surgery after culture and sensitivity report obtained and starting antibiotic after consulting infection specialist. Conclusions: The combined surgical and medical treatment of severe SD enables effective debridement, rapid inflammation resolution, early mobilization, and shorter antibiotic courses. Both tuberculous and pyogenic SD showed improvement. A holistic strategy for multimorbid patients, addressing perioperative health concerns and ensuring extended follow-up, improves management results and patient welfare. Keywords: Spondylodiscitis, Antibiotics, Lumbar Interbody Fusion, Tuberculosis, Surgery

GLP-1 Receptor Agonists Alleviate Diabetic Kidney Injury via β-Klotho-Mediated Ferroptosis Inhibition.

Semaglutide (Smg), a GLP-1 receptor agonist (GLP-1RA), shows renal protective effects in patients with diabetic kidney disease (DKD). However, the exact underlying mechanism remains elusive. This study employs transcriptome sequencing and identifies β-Klotho (KLB) as the critical target responsible for the role of Smg in kidney protection. Smg treatment alleviates diabetic kidney injury by inhibiting ferroptosis in patients, animal models, and HK-2 cells. Notably, Smg treatment significantly increases the mRNA expression of KLB through the activation of the cyclic adenosine monophosphate (cAMP) signaling pathway, specifically through the phosphorylation of protein kinase A (PKA) and cAMP-response element-binding protein (CREB). Subsequently, the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway is activated, reprograming the key metabolic processes of ferroptosis such as iron metabolism, fatty acid synthesis, and the antioxidant response against lipid peroxidation. Suppression of ferroptosis by Smg further attenuates renal inflammation and fibrosis. This work highlights the potential of GLP-1RAs and KLB targeting as promising therapeutic approaches for DKD management.

Thermal Management Approach to Stabilization of Disordered Active Sites for Sabatier Reaction.

The transition metal nanocatalysts containing disordered active sites can potentially achieve efficient Sabatier reactions with high selectivity. However, it remains a challenge to maintain the stability of these active sites in such an exothermic reaction. Here, a thermal management approach is reported to address this challenge. Specifically, an efficient and stable catalytic system is developed by integrating urchin-like Ru nanoparticles with disordered active sites (d-RuNUs) and multi-walled carbon nanotubes (MWCNTs) as heat transfer framework, which achieves a CH4 yield of 3.3mol g-1 h-1 with nearly 100% selectivity in 12h. The characterizations reveal that the thermal-induced crystallization seriously weakens the adsorption of CO2, leading to significant degradation of catalytic performance. The heat transfer simulation confirms that the MWCNTs with high thermal conductivity play a key role in rapidly redistributing the reaction heat, thereby preventing the crystallization of disordered structures. This work elucidates the deactivation mechanism of disordered active sites in exothermic reactions and opens the avenue for local thermal management of non-thermal equilibrium reactions.

Immediate postinjury extracorporeal carbon dioxide removal reduces ventilator requirements and mitigates acute respiratory distress syndrome in swine.

Awareness of ventilator-induced lung injury contributed to increased use of extracorporeal interventions, but not immediately after injury, before acute respiratory distress syndrome (ARDS) ensues. Our objective was to evaluate the role of venovenous extracorporeal carbon dioxide removal (ECCO2R) in management of mechanically ventilated swine with smoke inhalation injury and 40% body surface area burns. Yorkshire swine (n = 29, 43.2 ± 0.5 kg) underwent anesthesia, instrumentation, severe smoke inhalation, and 40% body surface area burns, followed by 72 hours of round-the-clock intensive care unit care with mechanical ventilation, fluids, pressors, bronchoscopic cast removal, computer tomography scans, and arterial blood assays. Within 1 hour after injury, animals received ECCO2R with either MiniLung (Xenios AG, Heilbronn, Germany; n = 10) or Hemolung (ALung Technologies, Pittsburgh, PA; n = 10), or no ECCO2R in injured controls (INJC, n = 12). Immediate postinjury ECCO2R reduced minute ventilation (p < 0.001) and prevented ARDS in 37.5% of MiniLung and 11.1% of Hemolung animals. Time to ARDS (partial pressure of arterial oxygen to fraction of inspired oxygen ratio below 300) was shortest (14 ± 2.2 hours) in INJC, intermediate (21.6 ± 3.5 hours) in Hemolung (HEMO), and most delayed in MiniLung (31.1 ± 7.2 hours, p = 0.0121, log-rank test vs. INJC). Driving pressure was lower in MiniLung versus INJC (p < 0.0001) and HEMO versus INJC (p = 0.0005) at 48 hours. Extracorporeal CO2 removal reduced systemic levels of tumor necrosis factor α versus INJC. In swine with severe smoke inhalation and burns, immediate postinjury ECCO2R reduced ventilator settings, delayed or prevented ARDS, and reduced its severity. Proactive early percutaneous ECCO2R initiation via simplified, purpose-built devices should be considered as a low-maintenance lung injury management approach with significant disease modifying clinical benefit potential.

Autopsy-Based Cross-Sectional Observational Study On Carotid Artery Injury In Non-Penetrative Neck Trauma

Background: Non-penetrative neck trauma poses a significant risk of carotid artery injury, which can lead to severe consequences. Diagnosis of carotid artery injury in non-penetrative trauma remains challenging due to delayed clinical presentation. Research on non-penetrative mechanisms of injury is relatively less common compared to penetrating trauma. This study aims to analyse patterns of vascular injuries in compression injuries to the neck, focusing on non-penetrative trauma. Materials and Methods: A cross-sectional study was conducted in a Forensic Medicine Department of Government Stanley medical college, Chennai, over a one-year period, analysing 150 cases of non-penetrative neck trauma. Post-mortem data, including gross and histopathological findings, were collected and analysed. Results &amp; Discussion: Among the 150 cases studied, hanging was the most prevalent cause of blunt cervical trauma. The majority of cases affected individuals were between the age group 21 and 40 years, with male preponderance. Gross examination revealed intimal tears in a proportion of cases, with histopathological examination identifying a higher prevalence of injuries. Posterior knot ligatures were predominant in both complete and partial hanging cases, correlating with a higher incidence of carotid body hemorrhage. The association between posterior knot position and carotid body hemorrhage emphasizes specific vulnerabilities in hanging cases. Conclusion: The findings of the study emphasize the importance of forensic investigations in identifying vascular injuries, guiding injury prevention strategies, and informing medicolegal proceedings. Further research is needed to enhance diagnostic and management approaches in clinical and forensic practice.

Three 3D graphics engineering technologies for fallow deer antlers characterization in ecology and management approaches

Numerous studies focus on creating 3D-models of biological elements for geometric evaluation using CAD tools. A crucial aspect is to obtain accurate geometrical data that is easy to obtain and cost-effective for analysis. The main objective is to evaluate the geometrical accuracy of 3D-models obtained with three graphical techniques of three-dimensional geometrical documentation that characterise the fallow deer antlers in an accurate 3D-model, which is used as input data in biological analyses estimating hunting quality, asymmetry and volume. Three technologies are evaluated: structured light scanning, multi-image photogrammetry (SfM), Structure from Motion, and spatial photogrammetric restitution using two photographs in a CAD system. The geometric accuracy of the 3D-models obtained and the deviation between relevant points of the antler structure, in the main beam, in the main tines and palm, are estimated. Subsequently, the suitability of each 3D-model is studied according to the type of biological application for which it is intended. Based on the results, solid and axial 3D-models, the applicability of the three techniques for the study of biological parameters such as hunting quality, asymmetry and volume is discussed. It concludes on the most appropriate procedure to define the digital characterisation of the antler, depending on the type of biological study to be carried out in order to obtain accurate results. Characterising a geometrically complex structure such as the fallow deer antler in a 3D-model quickly and accurately can help to quantify various biomarkers in populations of specimens, making it possible to infer internal and external influencing factors.

Cerebrospinal Fluid Leak Prevention in Intradural Spine Surgery: A Long Series Analysis of Closure with Non-Penetrating Titanium Clips

Background/Objectives: Postoperative cerebrospinal fluid (CSF) fistulas remain a significant concern in spinal neurosurgery, particularly following dural closure. The incidence of dural tears during spinal surgery is estimated between 1.6% and 10%. While direct suturing remains the gold standard, it has a failure rate of 5–10%. Various materials and techniques have been used to enhance dural closure. This study aims to assess the effectiveness of non-penetrating titanium clips (AnastoClip®) for dural closure in intradural spinal lesion surgeries. Methods: A prospective analysis was conducted on 272 patients who were operated on for intradural spinal lesions from August 2017 to December 2023. Dural closure was performed using non-penetrating titanium clips with sealant, and, in select cases, autologous grafts. Postoperative care included early mobilization and routine MRI to assess outcomes. A comparative analysis was performed with a cohort of 81 patients treated with traditional sutures. Results: Among the 272 patients, postoperative CSF leaks occurred in 32 cases (11.76%), requiring various management approaches. Thirteen cases required surgical revision, while others resolved with external lumbar drainage or fluid aspiration. Compared to the suture group, which had a fistula rate of 23.46%, the titanium clip group had a significantly lower fistula rate. Logistic regression analysis did not find statistically significant associations between fistula risk and clinical factors. Conclusions: Non-penetrating titanium clips provide an effective alternative to sutures for dural closure, reducing CSF leak rates. They preserve dural integrity, reduce operative time, and avoid imaging artifacts, making them a viable advancement in spinal surgery with outcomes comparable to, or better than, traditional techniques.

Using IT in Area Suitability Modeling To Plan Urban Areas: Case of Kabul City, Afghanistan

The goal of this work was to determine the optimal locations for urban growth in Kabul city using an integrated GIS-AHP model and Land Suitability Analysis (LSA). The study’s findings demonstrated that GIS-AHP is a useful approach for urban planning and ecological management. Maps were normalized using the pairwise comparison matrix technique using the generated criteria. Each model’s weights were created by comparing them according to their relative importance. Weight Age Average (OWA) and Weighted Linear Combination (WLC) were used to combine criteria weights and maps. To assess if a piece of land is suitable for urban development to determine which area was suitable for urban development, six thematic layers—slope, road, land use, river, settlement, and elevation—were used. AHP calculated their weighted scores based on the pairwise comparison. The linear combination approach was used to multiply each factor’s weight and score, and the outcome was then multiplied to make the urban development appropriate. 45.3 square kilometers of land were deemed highly suitable, 191.77 square kilometers were deemed fairly acceptable, 72.14 square kilometers were deemed marginally suitable, and 0.79 square kilometers were deemed unsuitable.

Project management and partner banking as tools for the recovery concept in Ukraine

The main purpose of this study is to investigate the effect of project management and partnership banking. Due to the shortage of investment, Ukraine always needs to plan for financial resources. All over the world, partnership banking is becoming an increasingly common and attractive type of investment in projects. In the conditions of modern Ukraine, with the need to restore industrial and infrastructure construction projects, one can predict significant growth in the construction services market and the need for investment. In this study, the ways of possible increasing investment in the construction industry have been discussed based on the use of a logical-structural approach in project management and partnership banking as a source of investment.

Areca nut husk biochar prepared through a low-cost kiln for the adsorptive elimination of nickel and manganese from water: a farmer-friendly approach for agro-residue management

Areca nut husk biochar prepared through a low-cost kiln for the adsorptive elimination of nickel and manganese from water: a farmer-friendly approach for agro-residue management

Clinical Pearls: Good Psychiatric Management for Borderline Personality Disorder and Transference-Focused Psychotherapy.

Good psychiatric management (GPM) for borderline personality disorder is a generalist strategic case management approach used by helping professionals of different training backgrounds to work with patients with borderline personality disorder. GPM includes a flexibly administered once-weekly psychotherapy for which a brief introductory course in GPM alone is considered sufficient preparation. GPM integrates concepts from specialized evidence-based treatments for borderline personality disorder, including transference-focused psychotherapy (TFP). This article describes the TFP elements that John Gunderson acknowledged as influential to his development of GPM. A basic introduction to TFP is provided, and elements in GPM that interweave with TFP's theoretical foundation are elucidated and then illustrated in a clinical vignette that captures the GPM clinician's interventions influenced by these ideas. The vignette is then used to illustrate clinical tools informed by TFP principles and common to both GPM and TFP.

Intraspecific variability of rice root knot nematodes across diverse agroecosystems for sustainable management

In the rice agroecosystems of Southeast Asia, rice root knot nematode (Meloidogyne graminicola) significantly impairs yield, representing a major species within the ‘graminis-group’ known for its morphological similarities with other root knot nematodes (RKNs). This study delves into the variations in reproductive potential, morphology, morphometrics, and genetic diversity among thirty RKN populations in rice across three distinct agroecological zones in Jharkhand, India. Despite notable differences in reproductive potential among the populations, morphological and morphometric correlations to reproductive potential were inconclusive. However, male and juvenile morphometrics were crucial for identifying intraspecific variability. Genetic analysis utilizing five molecular markers (ITS, 18 S rRNA, D2-D3 of 28 S, COX-I, and COX-II) affirmed the populations as M. graminicola, with ITS marker revealing significant intraspecific variability. Phylogenetic analysis underscored the close relationship between M. oryzae and M. graminicola, distinct from other mitotic RKN species. Low genetic distance and nucleotide diversity, coupled with high haplotype diversity, negative Tajima’s D, and Fu’s Fs of haplotype network analysis, suggested that all M. graminicola populations are expanding. These findings highlight the urgent need for comprehensive management strategies against M. graminicola, providing valuable insights for growers, extension officials, and plant breeders to develop targeted management approaches and resistance breeding programs.

Fuzzy repetitive scheduling for construction projects considering risk preferences and time-cost tradeoffs

PurposeThe purpose of this study is to develop a novel approach that addresses time-cost tradeoffs in repetitive construction projects while considering the uncertainty in activity durations and the risk preferences of planners.Design/methodology/approachOur study involves work in three aspects. Firstly, it employs triangular fuzzy numbers to represent activity durations in different units, which facilitates the management of scenarios characterized by limited historical data or the presence of ambiguous information. Secondly, it introduces a fuzzy chance-constrained programming model, which is aimed at minimizing the project budget while ensuring that the risks associated with cost overruns and schedule delays are confined to specified limits. Thirdly, it advances an enhanced genetic algorithm, integrating an electromagnetism-like mechanism and a scheduling repair process, to improve the efficiency and effectiveness of the optimization process.FindingsA real-life street renovation project was analyzed to demonstrate the applicability of the proposed algorithm. The analysis explored three common types of risk preferences: risk-averse, risk-neutral and risk-loving. The results indicate that the proposed algorithm surpasses existing fuzzy repetitive scheduling methods in terms of risk management. It effectively generates schedules that align with the risk preferences of planners and provides worst-case estimates of project performance.Originality/valueThis research makes a significant contribution to the field by developing a fuzzy chance-constrained programming model and an associated optimization algorithm that is specifically designed for time-cost tradeoffs in repetitive construction projects. A key distinction is that this study considers the risk preferences of planners, which sets it apart from previously developed models. As a result, it provides a practical approach for effective risk management.

THE ANALYSIS STUDY OF DIAGNOSIS AND MANAGEMENT OF ACUTE CORONARY SYNDROME: A COMPREHENSIVE SYSTEMATIC REVIEW

Introduction: Acute coronary syndrome (ACS) represents a spectrum of conditions with significant morbidity and mortality rates worldwide. Optimal management of ACS is critical, involving a combination of pharmacological therapies, interventional procedures, and comprehensive rehabilitation programs. This systematic review evaluates various management strategies for ACS, focusing on their efficacy, safety, and clinical outcomes to guide improved patient care practices. Methods: This systematic review was conducted in adherence to PRISMA 2020 guidelines. A comprehensive literature search was performed in major databases, including PubMed, ScienceDirect, Embase, Cochrane Library, Web of Science, studies published from 2018 onwards that evaluated ACS management strategies. Inclusion criteria were original research articles providing insights into treatment methods such as medication regimens, surgical interventions, and supportive therapies. The studies were assessed for bias across parameters like temporal precedence, participant selection, confounding factor handling, and retention rates. Results: From an initial set of 1916 publications, eight studies met the inclusion criteria after thorough screening. These studies highlighted various ACS management approaches, revealing that pharmacological treatments combined with early revascularization strategies improved patient survival and reduced complication rates. Assessment of bias showed consistent rigor in administration protocols and outcome assessments across the majority of studies. However, participant retention and confounding factor management were areas where inconsistencies were observed. The overall findings suggest that a multidisciplinary approach encompassing medication, timely intervention, and structured rehabilitation yields the best patient outcomes. Conclusion: This systematic review underscores the importance of comprehensive, multidisciplinary management in ACS care. Effective treatment strategies should address timely diagnosis, therapeutic interventions, and follow-up plans that include patient education and rehabilitation. Further research is needed to refine management protocols and overcome challenges in confounding factor control and participant retention for future studies.

Energy efficient weed control in high density planting rainfed cotton

An experiment utilizing a split-plot design was done to ascertain the optimal plant population and weed management strategies for enhancing yield, net income, and energy efficiency in high-density rainfed cotton cultivation. The primary plot treatments comprised three spacing configurations: 100x10 cm, 150x50x10 cm, and 175x50x10 cm. Six weed management approaches were evaluated as subplot treatments, with each treatment replicated three times throughout the 2023-24 rabi season. These practices included power weeding on 20 and 45 days after sowing (DAS), intercropping with black gram, hand weeding on 20 and 45 DAS, herbicide application of Metolachlor (pre-emergence) on 5 DAS, and a combination of Pyrithiobac sodium plus Quizalofop ethyl (post-emergence) on 20 DAS, along with weedy check and weed-free check. The 100 x 10 cm spacing combined with power weeding proved superior, achieving higher yield parameters, greater yield, increased income (Rs. 67238/ha), a benefit-cost ratio of 2.27, energy productivity of 0.38 Kg/MJ, net energy productivity of 30334 MJ/ha, and an energy use efficiency of 4.0 in high-density planting. The narrow-row spacing (100x10 cm) with power weeding also optimized plant population and enhanced per-plant productivity. This configuration also supported proper soil tilling and aeration, enabling a higher uptake of inputs with minimum energy expenditure for weeding, leading to improved overall performance.

Grassland biome fragmentation analysis using sentinal-2 images and support vector machine learning model in South Africa

The grassland biome, which is classified as a terrestrial ecosystem, contributes significantly to carbon sequestration. About one third of this ecosystem covers the land surface in south Africa and faces the danger of being eradicated. Much of the pressure is attributed to by synthetic initiatives that seeks to expand the economy of the country thereby meeting the demands of cumulative population. Mining, agriculture, and human settlement are the main characters. Given the paucity of research on the threatened ecosystem, the support vector machine learning algorithm (SVM) is employed to investigate fragmentation from 2016 to 2023. We used Sentinel-2A/B satellite images to learn more about spatial and temporal patterns, as well as the distribution of fragmentation in the grassland biome, using the Google Earth Engine platform. The findings revealed that grassland occupied 66% of the area in 2016, decreased to 52% in 2019, and then increased to 59% by 2023. The inconsistency in the pattern or trend of the grassland class is likely attributable to the expansion of the other classes. The SVM model indicated an overall classification accuracy of 97.62%, 97.66% and 98.58% in 2016, 2019, and 2023, respectively. In contrast, the models developed to relate LAI to NDVI, MSAVI2, OSAVI, and NDRE produced R2 values of 0.6396, 0.6325, 0.6387, and 0.6344, respectively. An in-depth understanding of the fragmentation patterns observed in grasslands yields valuable information for the formulation of conservation strategies, sustainable land-use planning, and climate-resilient management approaches aimed at safeguarding South Africa's distinctive grassland ecosystems.

Emerging concepts of CMV in transplantation

AbstractCytomegalovirus (CMV) infections continue to be associated with significant morbidity and mortality following solid organ transplantation and haemopoietic stem cell transplantation. Advances in understanding the biology of CMV in the immunosuppressed host will translate into improved management approaches and better clinical outcomes. Updated definitions of resistant and refractory CMV infections will lead to more consistent reporting of CMV outcomes, better inform appropriate antiviral strategies and influence clinical trial design. Improved knowledge of the immunological control of CMV in the immunosuppressed host has led to novel diagnostics, emerging therapeutic cellular therapies and the development of an informed rationale for prophylactic and pre‐emptive strategies. As the boundaries of transplantation are extended, new patterns of CMV infection are being recognised. Finally, recent studies support the use of novel antiviral therapies in transplant recipients in the appropriate clinical setting. In this review, we provide an update on important new and emerging concepts in the management of CMV in immunosuppressed transplant recipients.

Motivation for knowledge management approach and future prospects: A review of perspectives in Bangladeshi organisations

Purpose: Knowledge management is becoming an area of interest for striving towards extensive organisational development. The key to organisational development in the current business environment depends on how much knowledge is shared to accommodate the resources. The article aims to investigate the use of knowledge-sharing approaches by organisations in Bangladesh, where the concept is relatively new and explore the deficiencies and gaps in this area. Research Methodology: The study is purely qualitative. For this review article, 40 articles about knowledge sharing and management have been reviewed to develop an understanding of the concept of KM and its application in the context of MNEs in Bangladesh. Results: As knowledge management is a new concept in Bangladesh and other developing countries, there is limited study about KM and KS. It is therefore crucial to develop an understanding of the concept of having a strong position in the competitive business environment. Hence, the need to address the gaps, barriers and challenges of knowledge sharing and knowledge management extends beyond literature and proceeds to accommodate the concepts further extending towards research in this field. Contribution: With the emergence of the concept of knowledge management, organisations are becoming more aware of the need to encourage KS and address the limitations. It is important to develop innovative methods, and processes to bring about positive changes in organisational demography, practices and policies. Furthermore, better knowledge management will enhance the profitability and performance of organisations in countries like Bangladesh and other developing countries. Novelty: As the concept is relatively new in Bangladesh, it is possible to expand its scope further in different industrial contexts. It is also possible to explore the use of knowledge-sharing tools for organisational development.

Guillain-Barré Syndrome in Africa: Understanding, Addressing, and Empowering.

Guillain-Barré Syndrome (GBS) is a spectrum of peripheral neuropathies characterized by rapid symmetrical limb weakness and sensory symptoms. GBS can be life-threatening and requires intensive care, particularly for patients with imminent respiratory failure. In Africa, limited research and high therapy costs pose challenges. This literature review aims to comprehensively address GBS in Africa to improve understanding and outcomes. This literature review aims to provide an extensive overview of GBS in Africa, encompassing its clinical presentation, impact, management approaches, and challenges faced. It also highlights the need for increased research and awareness to enhance patient care and outcomes. A comprehensive review of existing literature on GBS in Africa was conducted, focusing on clinical presentation, diagnosis, management, and its impact on patients and communities. Data sources included medical databases, research articles, and reports. Data was scoured from databases such as PubMed, Medline and Embase. A total of four hundred and fifty-five articles and case studies were screened, with broader topic margins into GBS and different triggers, demographics, statistics, and variations in treatments across the world. These articles were further screened to match our inclusion criteria which focused on articles published after 2000 and which gave clearer insights into the presentations and situation of GBS in the African continent. GBS in Africa is characterized by a range of clinical presentations, with limited diagnostic resources and healthcare infrastructure. Patients often face long intervals between symptom onset and hospitalization, impacting outcomes. The syndrome's impact extends beyond physical symptoms, affecting patients' quality of life, employment, and community roles. Management involves immunotherapy, physiotherapy, and psychosocial support, but high therapy costs and incomplete recovery pose challenges. Research in Africa has grown in recent years but remains limited compared to other regions. Efforts are needed to expand research capacity, introduce early screening programs, and improve healthcare infrastructure. GBS presents a significant healthcare challenge in Africa, with the potential for severe clinical outcomes. This literature review underscores the importance of enhancing research, awareness, and healthcare infrastructure. African-led research initiatives offer hope for improved patient outcomes and healthcare system strengthening. By advocating for increased government support and resources, Africa can address the pressing needs of GBS patients and foster a brighter and healthier future for affected individuals on the continent.